PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3691641-1 1987 The effects of treatment with reserpine and/or the selective alpha 2-adrenoreceptor agonists clonidine and oxymetazoline on tissue levels of neuropeptide Y (NPY)-like immunoreactivity (-LI) and noradrenaline (NA) were studied in the guinea-pig. Clonidine 93-102 pro-neuropeptide Y Cavia porcellus 141-155 3691641-1 1987 The effects of treatment with reserpine and/or the selective alpha 2-adrenoreceptor agonists clonidine and oxymetazoline on tissue levels of neuropeptide Y (NPY)-like immunoreactivity (-LI) and noradrenaline (NA) were studied in the guinea-pig. Clonidine 93-102 pro-neuropeptide Y Cavia porcellus 157-160 3691641-2 1987 Clonidine treatment was associated with an increase in the levels of NPY-LI in the right atrium in a time- and dose-dependent manner. Clonidine 0-9 pro-neuropeptide Y Cavia porcellus 69-72 3691641-3 1987 A significant (45%) elevation of the right atrial content of NPY-LI was present 2 h after administration of clonidine (50 micrograms kg-1 s.c.). Clonidine 108-117 pro-neuropeptide Y Cavia porcellus 61-64 3691641-4 1987 After 24 h of repeated clonidine treatment the atrial levels of NPY-LI had increased by 95%. Clonidine 23-32 pro-neuropeptide Y Cavia porcellus 64-67 3691641-5 1987 Following chronic clonidine treatment for two weeks, however, the right atrial NPY levels were similar to those in control animals. Clonidine 18-27 pro-neuropeptide Y Cavia porcellus 79-82 3691641-7 1987 The levels of NPY-LI were also increased in the gastrocnemius muscle, spleen and adrenal gland after clonidine treatment while no changes were detected in the vas deferens or hypothalamus. Clonidine 101-110 pro-neuropeptide Y Cavia porcellus 14-17 3691641-8 1987 The reserpine-induced reduction of NPY-LI in the right atrium, spleen, gastrocnemius muscle and adrenal gland was markedly inhibited by concomitant clonidine treatment while no effect was observed on NA depletion. Clonidine 148-157 pro-neuropeptide Y Cavia porcellus 35-38 3691641-9 1987 The adrenoreceptor antagonists phentolamine, prazosin and yohimbine all inhibited the increase in cardiac content of NPY-LI seen after clonidine treatment. Clonidine 135-144 pro-neuropeptide Y Cavia porcellus 117-120 3691641-11 1987 The reserpine-induced increase in content of NPY-LI in the stellate ganglion was also inhibited by clonidine and oxymetazoline. Clonidine 99-108 pro-neuropeptide Y Cavia porcellus 45-48 3028832-1 1986 Clonidine (10 micrograms X kg-1) reduced by almost 50% the increase in plasma neuropeptide (NPY)-like immunoreactivity (-LI) induced by preganglionic nerve stimulation at 8 Hz. Clonidine 0-9 pro-neuropeptide Y Cavia porcellus 92-95