PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9374797-7 1997 Second, the hypotensive effect of intravenous clonidine is absent in genetically engineered mice in which a defective alpha 2AAR has been substituted for the normal one. Clonidine 46-55 adrenergic receptor, alpha 2a Mus musculus 118-128 10217548-16 1999 In a [35S]-GTPgammaS incorporation assay, moxonidine and clonidine were alpha2A-adrenoceptor agonists (pEC50/intrinsic activity relative to noradrenaline): moxonidine (5.74/0.85) and clonidine (7.57/0.32). Clonidine 57-66 adrenergic receptor, alpha 2a Mus musculus 72-92 11677796-6 2001 alpha 2A-receptors mediate the central antihypertensive action of the alpha 2-agonists, clonidine and moxonidine. Clonidine 88-97 adrenergic receptor, alpha 2a Mus musculus 0-8 10381806-16 1999 Conversely, absence of clonidine efficacy in D79N-alpha2a mice implies that alpha2aAR activation enables clonidine-induced antinociception. Clonidine 105-114 adrenergic receptor, alpha 2a Mus musculus 76-85 28230659-4 2017 The Ca decrease was shorter after inhibition of the Na/K pump with ouabain (10 and 100 muM) but prolonged when the alpha2A adrenoceptors were activated with clonidine (1 and 10 nM) or epinephrine (10 nM). Clonidine 157-166 adrenergic receptor, alpha 2a Mus musculus 115-122 28955200-0 2017 Cingulate Alpha-2A Adrenoceptors Mediate the Effects of Clonidine on Spontaneous Pain Induced by Peripheral Nerve Injury. Clonidine 56-65 adrenergic receptor, alpha 2a Mus musculus 10-18 28955200-9 2017 This blocking of cingulate alpha2A adrenoceptors activity abolished the CPP induced by clonidine (0.5 mg/kg intraperitoneally) but not the effects on PWTs at day 7. Clonidine 87-96 adrenergic receptor, alpha 2a Mus musculus 27-34 28955200-10 2017 However, clonidine applied systemically or specifically to the ACC at day 14 increased the PWTs but failed to induce CPP; this negative effect was reversed by the overexpression of cingulate alpha2A adrenoceptors. Clonidine 9-18 adrenergic receptor, alpha 2a Mus musculus 191-198 28955200-11 2017 These results suggest that cingulate alpha2A adrenoceptors are necessary for the analgesic effects of clonidine on spontaneous pain. Clonidine 102-111 adrenergic receptor, alpha 2a Mus musculus 37-44 23712005-2 2013 It is known that imidazoline and alpha2-adrenoceptors are involved in clonidine antinociception. Clonidine 70-79 adrenergic receptor, alpha 2a Mus musculus 33-53 26254859-6 2015 The alpha2A-AR agonist clonidine was less effective in alpha2A-KO mice in both assays. Clonidine 23-32 adrenergic receptor, alpha 2a Mus musculus 4-14 26254859-6 2015 The alpha2A-AR agonist clonidine was less effective in alpha2A-KO mice in both assays. Clonidine 23-32 adrenergic receptor, alpha 2a Mus musculus 4-11 19276088-5 2009 Clonidine-induced alpha(2A)AR desensitization, but not receptor phosphorylation, was attenuated by blockade of endocytosis with concanavalin A, indicating a critical role for internalization of alpha(2A)AR in desensitization to this ligand. Clonidine 0-9 adrenergic receptor, alpha 2a Mus musculus 194-205 19126537-5 2009 Prolonged treatment with either DAMGO or clonidine induced a mutual cross-desensitization between micro and alpha2A receptor-mediated current inhibition. Clonidine 41-50 adrenergic receptor, alpha 2a Mus musculus 108-115 18691636-5 2008 The activation of alpha2-adrenoceptors by clonidine did not affect sIPSCs in PCs at postnatal days (P) 8-10, when PCs showed a few sIPSCs and interneurons in the molecular layer (MLIs) did not cause action potential (AP). Clonidine 42-51 adrenergic receptor, alpha 2a Mus musculus 18-38 16417582-9 2006 In an "in vivo" test, the alpha(2)AR agonist clonidine (0.1 mg/kg) caused a significantly greater reduction of locomotor activity in NET-KO mice than in wild-type mice, showing the relevance of our findings at the functional level. Clonidine 45-54 adrenergic receptor, alpha 2a Mus musculus 26-36 15265636-15 2004 These results indicate that clonidine and guanabenz impaired memory processes in a mouse passive avoidance paradigm through the selective activation of the alpha2A-adrenoceptor subtype. Clonidine 28-37 adrenergic receptor, alpha 2a Mus musculus 156-176 23499689-4 2013 Clonidine, moxonidine and rilmenidine inhibited the EFS-induced gastric contractions in a concentration dependent manner in WT, alpha2B- and alpha2C-adrenoceptor KO mice, whereas they had no or only weak effect in alpha2A-adrenoceptor KO mice. Clonidine 0-9 adrenergic receptor, alpha 2a Mus musculus 214-221 21333706-5 2011 (iii) Clonidine and ST-91 inhibited the electrically induced gastric contractions in C57BL/6 wild type mice as well as in alpha(2B)- and alpha(2C)-adrenoceptor deficient mice in a concentration-dependent manner; however, neither of them was effective in alpha(2A)-deficient mice. Clonidine 6-15 adrenergic receptor, alpha 2a Mus musculus 254-262 19276088-4 2009 We discovered a more rapid desensitization of Ca(2+) current suppression by clonidine than guanfacine, which paralleled a more marked receptor phosphorylation and endocytosis of alpha(2A)AR evoked by clonidine than by guanfacine. Clonidine 76-85 adrenergic receptor, alpha 2a Mus musculus 178-189 19276088-4 2009 We discovered a more rapid desensitization of Ca(2+) current suppression by clonidine than guanfacine, which paralleled a more marked receptor phosphorylation and endocytosis of alpha(2A)AR evoked by clonidine than by guanfacine. Clonidine 200-209 adrenergic receptor, alpha 2a Mus musculus 178-189 19276088-5 2009 Clonidine-induced alpha(2A)AR desensitization, but not receptor phosphorylation, was attenuated by blockade of endocytosis with concanavalin A, indicating a critical role for internalization of alpha(2A)AR in desensitization to this ligand. Clonidine 0-9 adrenergic receptor, alpha 2a Mus musculus 18-29