PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3582495-1 1987 PAF-acether (platelet-activating factor) and adrenaline synergized to induce aggregation of human platelets in whole blood and in platelet-rich plasma (PRP) irrespective of the use of citrate, of heparin or acid-citrate dextrose (ACD) as anticoagulants, whereas the partial adrenoceptor agonist clonidine imitated adrenaline in a limited number of cases and only when blood was collected in ACD. Clonidine 295-304 PCNA clamp associated factor Homo sapiens 0-3 3582495-0 1987 Potentiation and inhibition by clonidine of PAF-acether-induced human platelet activation. Clonidine 31-40 PCNA clamp associated factor Homo sapiens 44-47 3582495-4 1987 Added before adrenaline or before adrenaline plus PAF-acether, clonidine reduced the aggregation to the level of that due to PAF-acether alone irrespective of cyclooxygenase inhibition with aspirin. Clonidine 63-72 PCNA clamp associated factor Homo sapiens 50-53 3582495-4 1987 Added before adrenaline or before adrenaline plus PAF-acether, clonidine reduced the aggregation to the level of that due to PAF-acether alone irrespective of cyclooxygenase inhibition with aspirin. Clonidine 63-72 PCNA clamp associated factor Homo sapiens 125-128 3582495-5 1987 The alpha 2-adrenoceptor antagonist yohimbine blocked the synergistic effects of adrenaline or clonidine associated to PAF-acether, reducing aggregation to that due to PAF-acether alone. Clonidine 95-104 PCNA clamp associated factor Homo sapiens 119-122 3582495-5 1987 The alpha 2-adrenoceptor antagonist yohimbine blocked the synergistic effects of adrenaline or clonidine associated to PAF-acether, reducing aggregation to that due to PAF-acether alone. Clonidine 95-104 PCNA clamp associated factor Homo sapiens 168-171 3582495-6 1987 Clonidine has dual effects on human platelets, since it can imitate adrenaline and synergize with PAF-acether in some subjects, and can also block aggregation induced by adrenaline alone or in combination with PAF-acether. Clonidine 0-9 PCNA clamp associated factor Homo sapiens 98-101 3582495-6 1987 Clonidine has dual effects on human platelets, since it can imitate adrenaline and synergize with PAF-acether in some subjects, and can also block aggregation induced by adrenaline alone or in combination with PAF-acether. Clonidine 0-9 PCNA clamp associated factor Homo sapiens 210-213