PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17710582-8	2007	There was a reduction in IL-10, TNF-alpha, and IL-6 production with increasing doses of clonidine and hydralazine by placentas in preeclampsia.	Clonidine	88-97	interleukin 6	Homo sapiens	47-51	
16436856-8	2006	Perineural clonidine, but not saline, partially reversed the hypersensitivity, accompanied by reduced concentrations of interleukin 6 and interleukin 1beta in the sciatic nerve.	Clonidine	11-20	interleukin 6	Homo sapiens	120-133	
16612254-9	2006	CONCLUSION: Our data suggest that the antihypertensive drugs clonidine and hydralazine can stimulate production of the circulating anti-inflammatory cytokine IL-10, whereas furosemide and diazoxide inhibit the production of this cytokine and the proinflammatory cytokines TNF-alpha and IL-6 by placentas and PBMCs.	Clonidine	61-70	interleukin 6	Homo sapiens	286-290	
22987052-12	2012	In local circulation, clonidine decreases IL-6 (P = 0.044) but does not influence IL-1beta (P = 0.113).	Clonidine	22-31	interleukin 6	Homo sapiens	42-46	
15271731-6	2004	For patients in the clonidine group, production of IL-1RA, IL-6, and IL-8 was significantly less increased at the end of the surgical procedure and at 12 and 24 h after surgery.	Clonidine	20-29	interleukin 6	Homo sapiens	59-63	
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Clonidine	197-206	interleukin 6	Homo sapiens	90-94	
10825337-6	2000	In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels.	Clonidine	58-67	interleukin 6	Homo sapiens	111-115	
10825337-6	2000	In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels.	Clonidine	194-203	interleukin 6	Homo sapiens	111-115	
10825337-7	2000	These results show that clonidine modulates the IL-6 response related to surgical stress.	Clonidine	24-33	interleukin 6	Homo sapiens	48-52	
10825337-9	2000	Clonidine 0.15 mg given as oral premedication resulted in the reduced Interleukin-6 production in response to total abdominal hysterectomy.	Clonidine	0-9	interleukin 6	Homo sapiens	70-83	
23047422-6	2013	In contrast, clonidine at <10(-9) M increased IL-6, while at >10(-5) M increased IL-1beta and decreased TNF-alpha levels.	Clonidine	13-22	interleukin 6	Homo sapiens	49-53	
19890745-8	2009	We demonstrated significant reduction (P < 0.05) in levels of procalcitonin and interleukin-6 in the preoperative clonidine group compared with the preoperative levobupivacaine and control groups.	Clonidine	117-126	interleukin 6	Homo sapiens	83-96