PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29074416-0 2018 Clonidine preconditioning improved cerebral ischemia-induced learning and memory deficits in rats via ERK1/2-CREB/ NF-kappaB-NR2B pathway. Clonidine 0-9 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 125-129 29074416-10 2018 In conclusion, clonidine could improve the learning and memory ability of rats with cerebral ischemia, and NR2B, ERK1/2, CREB, NF-kappaB were involved in this effect. Clonidine 15-24 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 107-111 29074416-8 2018 In the Western blotting assay, clonidine treatment led to significant up-regulation of the expression level of NR2B and Phospho-NR2B in the hippocampus of the rats when compared with the cerebral ischemia group. Clonidine 31-40 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 111-115 29074416-8 2018 In the Western blotting assay, clonidine treatment led to significant up-regulation of the expression level of NR2B and Phospho-NR2B in the hippocampus of the rats when compared with the cerebral ischemia group. Clonidine 31-40 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 128-132 27806917-0 2016 Clonidine preconditioning alleviated focal cerebral ischemic insult in rats via up-regulating p-NMDAR1 and down-regulating NMDAR2A / p-NMDAR2B. Clonidine 0-9 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 135-142 27806917-8 2016 Remarkably, clonidine treatment led to significant down-regulation of p-NMDAR2B and NMDAR2A in addition to enhancement of the expression level of p-NMDAR1 in cortex. Clonidine 12-21 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 72-79 27806917-9 2016 This is the first report illustrating the neuroprotective role of clonidine may be mediated through modulation of the expression levels of p-NMDAR2B, NMDAR2A and p-NMDAR1 during cerebral ischemia. Clonidine 66-75 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 141-148