PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29074416-0	2018	Clonidine preconditioning improved cerebral ischemia-induced learning and memory deficits in rats via ERK1/2-CREB/ NF-kappaB-NR2B pathway.	Clonidine	0-9	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	125-129	
29074416-10	2018	In conclusion, clonidine could improve the learning and memory ability of rats with cerebral ischemia, and NR2B, ERK1/2, CREB, NF-kappaB were involved in this effect.	Clonidine	15-24	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	107-111	
29074416-8	2018	In the Western blotting assay, clonidine treatment led to significant up-regulation of the expression level of NR2B and Phospho-NR2B in the hippocampus of the rats when compared with the cerebral ischemia group.	Clonidine	31-40	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	111-115	
29074416-8	2018	In the Western blotting assay, clonidine treatment led to significant up-regulation of the expression level of NR2B and Phospho-NR2B in the hippocampus of the rats when compared with the cerebral ischemia group.	Clonidine	31-40	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	128-132	
27806917-0	2016	Clonidine preconditioning alleviated focal cerebral ischemic insult in rats via up-regulating p-NMDAR1 and down-regulating NMDAR2A / p-NMDAR2B.	Clonidine	0-9	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	135-142	
27806917-8	2016	Remarkably, clonidine treatment led to significant down-regulation of p-NMDAR2B and NMDAR2A in addition to enhancement of the expression level of p-NMDAR1 in cortex.	Clonidine	12-21	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	72-79	
27806917-9	2016	This is the first report illustrating the neuroprotective role of clonidine may be mediated through modulation of the expression levels of p-NMDAR2B, NMDAR2A and p-NMDAR1 during cerebral ischemia.	Clonidine	66-75	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	141-148