PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8321415-0 1993 Combined administration of growth-hormone-releasing hormone and clonidine restores defective growth hormone secretion in old dogs. Clonidine 64-73 somatotropin Canis lupus familiaris 93-107 7921231-7 1994 The GH responses to both clonidine and growth hormone-releasing hormone became impaired. Clonidine 25-34 somatotropin Canis lupus familiaris 4-6 9160547-0 1994 Growth hormone response to clonidine in the nervous pointer dog model of anxiety. Clonidine 27-36 somatotropin Canis lupus familiaris 0-14 9160547-2 1994 The growth hormone response to oral clonidine (100 micrograms/kg) was investigated in the adult nervous pointer dog, a genetic animal model of anxiety. Clonidine 36-45 somatotropin Canis lupus familiaris 4-18 9160547-3 1994 Compared with placebo, clonidine produced significant increases in plasma levels of growth hormone; however, there were no differences in the growth hormone (GH) responses to clonidine in the nervous compared with the normal pointer dogs. Clonidine 23-32 somatotropin Canis lupus familiaris 84-98 7761697-0 1995 Growth hormone responses to growth hormone-releasing hormone and clonidine in dogs with Cushing"s syndrome. Clonidine 65-74 somatotropin Canis lupus familiaris 0-14 7761697-4 1995 Similarly, the GH response to clonidine was inhibited in the dogs with hyperadrenocorticism, the mean GH peak being 9.3 (3.3) ng ml-1 compared with 135.6 (43.3) ng ml-1 in the control dogs. Clonidine 30-39 somatotropin Canis lupus familiaris 15-17 7761697-4 1995 Similarly, the GH response to clonidine was inhibited in the dogs with hyperadrenocorticism, the mean GH peak being 9.3 (3.3) ng ml-1 compared with 135.6 (43.3) ng ml-1 in the control dogs. Clonidine 30-39 somatotropin Canis lupus familiaris 102-104 2301821-0 1990 Orally administered clonidine as a secretagogue of growth hormone and as a thymotrophic agent in dogs of various ages. Clonidine 20-29 somatotropin Canis lupus familiaris 51-65 2301821-2 1990 Significant (P less than 0.05) increase in plasma GH concentration was detected at all dosages tested in young dogs and in response to all but the lowest dose tested in the old dogs fed the clonidine-containing diet. Clonidine 190-199 somatotropin Canis lupus familiaris 50-52 2301821-3 1990 Old dogs had plasma GH concentration that exceeded that of young dogs when higher doses of clonidine were used. Clonidine 91-100 somatotropin Canis lupus familiaris 20-22 6322493-2 1984 GH deficiency was evidenced in all dogs by an absence of increase in GH levels in response to clonidine administration. Clonidine 94-103 somatotropin Canis lupus familiaris 0-2 2505465-0 1989 Prolonged fasting or clonidine can restore the defective growth hormone secretion in old dogs. Clonidine 21-30 somatotropin Canis lupus familiaris 57-71 3611950-7 1987 After provocative stimulation with clonidine in the normals there was a progressive rise of growth hormone levels that was similar in the sedentary and physically conditioned animals. Clonidine 35-44 somatotropin Canis lupus familiaris 92-106 2950711-8 1987 The GH responses to clonidine were significantly reduced at 9 and 16 weeks of oestradiol and MPA treatment. Clonidine 20-29 somatotropin Canis lupus familiaris 4-6 2950711-14 1987 The oestradiol-MPA induced GH overproduction is associated with a reduced responsiveness of GH to clonidine and is not accompanied by GH responsiveness to TRH. Clonidine 98-107 somatotropin Canis lupus familiaris 27-29 2950711-14 1987 The oestradiol-MPA induced GH overproduction is associated with a reduced responsiveness of GH to clonidine and is not accompanied by GH responsiveness to TRH. Clonidine 98-107 somatotropin Canis lupus familiaris 92-94 2950711-14 1987 The oestradiol-MPA induced GH overproduction is associated with a reduced responsiveness of GH to clonidine and is not accompanied by GH responsiveness to TRH. Clonidine 98-107 somatotropin Canis lupus familiaris 92-94 2495755-7 1989 The stimulatory effect of clonidine upon GH secretion was reduced in dogs with benign or malignant disease as compared to controls matched for the effect of progestin exposure. Clonidine 26-35 somatotropin Canis lupus familiaris 41-43 6382895-5 1984 All dogs secreted similar, normal amounts of GH in response to clonidine administration. Clonidine 63-72 somatotropin Canis lupus familiaris 45-47 6141513-1 1984 In previous studies we have shown that the alpha 2 -adrenergic receptor agonist clonidine (CLON) releases growth hormone (GH) in conscious dogs, an effect abolished by the selective alpha 2-receptor antagonist yohimbine (YOH) and by reserpine, but not by the alpha 1-receptor antagonist prazosin (1). Clonidine 80-89 somatotropin Canis lupus familiaris 106-120 6141513-1 1984 In previous studies we have shown that the alpha 2 -adrenergic receptor agonist clonidine (CLON) releases growth hormone (GH) in conscious dogs, an effect abolished by the selective alpha 2-receptor antagonist yohimbine (YOH) and by reserpine, but not by the alpha 1-receptor antagonist prazosin (1). Clonidine 80-89 somatotropin Canis lupus familiaris 122-124 6141513-1 1984 In previous studies we have shown that the alpha 2 -adrenergic receptor agonist clonidine (CLON) releases growth hormone (GH) in conscious dogs, an effect abolished by the selective alpha 2-receptor antagonist yohimbine (YOH) and by reserpine, but not by the alpha 1-receptor antagonist prazosin (1). Clonidine 91-95 somatotropin Canis lupus familiaris 106-120 6141513-1 1984 In previous studies we have shown that the alpha 2 -adrenergic receptor agonist clonidine (CLON) releases growth hormone (GH) in conscious dogs, an effect abolished by the selective alpha 2-receptor antagonist yohimbine (YOH) and by reserpine, but not by the alpha 1-receptor antagonist prazosin (1). Clonidine 91-95 somatotropin Canis lupus familiaris 122-124 6141513-2 1984 In the present work intravenous (iv) administration of CLON in conscious dogs evoked a dose-related rise in plasma GH at doses of 2-8 /micrograms/Kg, but not at 16 and 32 /micrograms/Kg. Clonidine 55-59 somatotropin Canis lupus familiaris 115-117 6141513-3 1984 Acute pretreatment with the selective inhibitor of norepinephrine (NE) synthesis, DU-18288, or with a potent antagonist of presynaptic alpha 2-receptors, mianserin abolished the GH rise induced by CLON (4 /micrograms/Kg iv). Clonidine 197-201 somatotropin Canis lupus familiaris 178-180 7283239-0 1981 Clonidine or xylazine as provocative tests for growth hormone secretion in the dog. Clonidine 0-9 somatotropin Canis lupus familiaris 47-61 7304077-17 1981 Clonidine administration to hypopituitary dogs resulted in absent or poor GH increment. Clonidine 0-9 somatotropin Canis lupus familiaris 74-76 6248808-0 1980 Sites at which clonidine acts to affect blood pressure and the secretion of renin, growth hormone and ACTH. Clonidine 15-24 somatotropin Canis lupus familiaris 83-97 6248808-1 1980 To further define the sites in the brain at which clonidine acts to lower blood pressure, inhibit renin secretion, inhibit ACTH secretion, and stimulate growth hormone secretion, small doses of this drug were infused into the vertebral arteries, into the carotid arteries and intravenously in pentobarbital-anesthetized dogs. Clonidine 50-59 somatotropin Canis lupus familiaris 153-167 6248808-3 1980 Intracarotid clonidine, 2 microgram/kg, decreased plasma ACTH and corticoids and increased plasma growth hormone, whereas the same dose had no effect on these hormones when given intravenously or when given intravertebrally after occlusion of the basilar artery. Clonidine 13-22 somatotropin Canis lupus familiaris 98-112 6248808-8 1980 The data support the conclusion that clonidine acts rostral to the pons to decrease ACTH secretion and increase growth hormone secretion, whereas it acts on the medulla or adjacent hindbrain to lower blood pressure. Clonidine 37-46 somatotropin Canis lupus familiaris 112-126 11370235-4 1976 Clonidine, an alpha-agonist which penetrates the brain, increased plasma growth hormone secretion. Clonidine 0-9 somatotropin Canis lupus familiaris 73-87 11370235-7 1976 The increase in plasma growth hormone concentration produced by intravenous L-dopa and clonidine was prevented by administration of phentolamine or phenoxybenzamine directly into the third ventricle. Clonidine 87-96 somatotropin Canis lupus familiaris 23-37