PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10677633-1	2000	The present study investigated the effect of clonidine on the basal and inducible c-jun and c-fos mRNA expression in the nucleus tractus solitarius (middle, mNTS, and rostral, rNTS) and the rostral ventrolateral medulla (caudal, cRVLM, and rostral, rRVLM).	Clonidine	45-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97	
10677633-5	2000	Clonidine attenuated the increases in c-fos in the mNTS and cRVLM and c-jun gene expression in the mNTS and rRVLM caused by NP-evoked hypotension and also reduced the basal expression of c-jun mRNA in the mNTS and rRVLM.	Clonidine	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-43	
10677633-6	2000	These findings establish a causal link between clonidine inhibition of c-fos expression in brainstem and its hypotensive action, and provide the first evidence that clonidine attenuates the expression of the closely linked c-jun gene in neurons implicated in centrally mediated hypotension.	Clonidine	47-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76	
7624831-0	1995	NMDA antagonists and clonidine block c-fos expression during morphine withdrawal.	Clonidine	21-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42	
9295196-0	1997	Atipamezole-precipitated clonidine withdrawal induces c-Fos expression in rat central nervous system.	Clonidine	25-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-59	
9295196-5	1997	The brains of the clonidine-atipamezole group showed massive c-Fos expression (especially in di- and telencephalon) while the other groups showed either background levels of c-Fos-immunopositive cells (saline-saline and clonidine-saline groups) or a slight increase over background in selected areas (saline-atipamezole group).	Clonidine	18-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-66	
8544995-0	1995	Effect of administration of high dose intrathecal clonidine or morphine prior to sciatic nerve section on c-Fos expression in rat lumbar spinal cord.	Clonidine	50-59	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-111	
8544995-1	1995	The effects of moderate and high intrathecal doses of clonidine, an alpha 2 adrenoceptor agonist, or a high dose of morphine on sciatic nerve section-induced expression of c-Fos-like immunoreactivity was studied in laminae I and II of the dorsal horn and laminae VIII and IX of the ventral horn of rat lumbar spinal cord.	Clonidine	54-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	172-177	
8544995-2	1995	c-Fos-like immunoreactivity was examined by immunohistochemistry in normal rats (group 1), rats implanted with an intrathecal catheter with its tip on the lumbar spinal cord (group 2), injected with 10 micrograms (group 3) or 50 micrograms (group 4) clonidine intrathecally 3 h before being killed.	Clonidine	250-259	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5	
8544995-6	1995	The level of c-Fos-like immunoreactivity after 10 or 50 micrograms intrathecal clonidine was similar as in the intrathecal catheter group.	Clonidine	79-88	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18	
8544995-8	1995	Pretreatment with 10 or 10 micrograms clonidine did not reduce sciatic nerve section-induced expression of c-Fos-like immunoreactivity, but instead caused a significant bilateral increase in c-Fos-like immunoreactivity.	Clonidine	38-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	191-196	
9295196-8	1997	In the three brainstem structures the number of c-Fos-positive cells was elevated 8-10-fold in the clonidine-atipamezole group compared to the other groups.	Clonidine	99-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53	
9295196-10	1997	An increased number of c-Fos-positive neurons was also noted in the dorsal horn and intermediate layers of the thoracic spinal cord in the clonidine-atipamezole group compared to a sham-operated atipamezole-injected group.	Clonidine	139-148	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-28	
9295196-11	1997	In the RVL, 59% of c-Fos-positive cells contained alpha2A-adrenergic receptor-like immunoreactivity in clonidine-atipamezole treated (withdrawing) rats.	Clonidine	103-112	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	19-24	
9295196-12	1997	In addition, one-third of the tyrosine hydroxylase (TH)-immunopositive cells in RVL were also c-Fos-positive in clonidine withdrawing rats where no TH-positive cells were also c-Fos-positive in RVL of control groups.	Clonidine	112-121	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-99	
9295196-17	1997	In conclusion, administration of the selective alpha2-antagonist atipamezole to rats chronically treated with the alpha2-adrenergic agonist clonidine triggers a powerful withdrawal syndrome associated with massive CNS expression of c-Fos protein.	Clonidine	140-149	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	232-237	
7756634-4	1995	Coinjections of NPY and l-adrenaline or clonidine into the NTS reduced the NPY-induced increase in c-Fos IR.	Clonidine	40-49	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-104	
7542145-14	1995	C-Fos expression induced by naltrexone-precipitated withdrawal was examined in the brainstem of freely moving morphine-dependent rats pretreated with clonidine or saline before injection of the opioid antagonist.	Clonidine	150-159	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5	
19120051-14	2009	Clonidine (60 microg/kg) or ethanol (1 g/kg) alone increased, but their combination decreased, c-Fos levels in LC, while inconsistent c-Fos responses were observed in cerebellum.	Clonidine	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-100	
1327843-0	1992	Expression of Fos-like immunoreactivity by yohimbine and clonidine in the rat brain.	Clonidine	57-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17	
33188843-6	2021	The ingestive behavior was not significantly affected by PHE treatment in the DR. CLO treatment increased Fos expression in the arcuate nucleus (ARC) and paraventricular nucleus of the hypothalamus (PVN) in rats that were allowed to eat during the experimental recording (AF group).	Clonidine	82-85	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-109	
33188843-9	2021	However, double-labeled POMC/Fos cells were absent in the ARC of the WAF group, although an increase in Fos expression was observed in non-POMC cells after CLO injections in the WAF group.	Clonidine	156-159	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-107	
18838113-8	2008	Four experiments with unilateral clonidine injections into the A7 region and with Fos immunohistochemistry used as a marker of cell activity revealed that the percentage of Fos-positive A7 cells was significantly reduced on the injected side.	Clonidine	33-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	173-176