PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8396008-8 1993 On the other hand, the inhibition of cAMP accumulation by the alpha 2-adrenergic agonist clonidine decreased NPY secretion. Clonidine 89-98 neuropeptide Y Rattus norvegicus 109-112 7756634-2 1995 Microinjections of NPY and l-adrenaline alone into the NTS induced neuronal c-Fos IR in parts of the NTS-dmnX complex, while clonidine had no action. Clonidine 125-134 neuropeptide Y Rattus norvegicus 19-22 7756634-4 1995 Coinjections of NPY and l-adrenaline or clonidine into the NTS reduced the NPY-induced increase in c-Fos IR. Clonidine 40-49 neuropeptide Y Rattus norvegicus 75-78 1359017-7 1992 On the other hand, the alpha 2-adrenergic agonist clonidine by itself did not affect cAMP accumulation stimulated by isoproterenol but significantly potentiated NPY action. Clonidine 50-59 neuropeptide Y Rattus norvegicus 161-164 8413845-4 1993 The alpha 2 agonist clonidine decreased evoked release of NPY, while the alpha 2 antagonist yohimbine increased the potassium-evoked release. Clonidine 20-29 neuropeptide Y Rattus norvegicus 58-61 19912776-4 1990 The catecholamine uptake blocker desipramine and the alpha(2)-adrenergic receptor agonist clonidine inhibited accumulation of newly synthesized catecholamines, but only after prolonged exposure to drug; NPY synthesis and accumulation were unaltered by these treatments. Clonidine 90-99 neuropeptide Y Rattus norvegicus 203-206 1878751-0 1991 Rapid decrease in neuropeptide Y gene expression in rat adrenal gland induced by the alpha 2-adrenoceptor agonist, clonidine. Clonidine 115-124 neuropeptide Y Rattus norvegicus 18-32 1878751-1 1991 1 The mechanism of regulation of the neuropeptide Y (NPY) gene by pharmacological treatment with the alpha 2-adrenenoceptor agonist, clonidine, was investigated by quantitative Northern blot analysis of the effects of this drug on the NPY mRNA levels in rat adrenal gland and medulla oblongata/pons. Clonidine 133-142 neuropeptide Y Rattus norvegicus 37-51 1878751-1 1991 1 The mechanism of regulation of the neuropeptide Y (NPY) gene by pharmacological treatment with the alpha 2-adrenenoceptor agonist, clonidine, was investigated by quantitative Northern blot analysis of the effects of this drug on the NPY mRNA levels in rat adrenal gland and medulla oblongata/pons. Clonidine 133-142 neuropeptide Y Rattus norvegicus 53-56 1878751-1 1991 1 The mechanism of regulation of the neuropeptide Y (NPY) gene by pharmacological treatment with the alpha 2-adrenenoceptor agonist, clonidine, was investigated by quantitative Northern blot analysis of the effects of this drug on the NPY mRNA levels in rat adrenal gland and medulla oblongata/pons. Clonidine 133-142 neuropeptide Y Rattus norvegicus 235-238 1878751-2 1991 2 In the adrenal gland, clonidine-treatment (50 microgram kg-1, s.c., once daily) resulted in decrease in the amount of NPY mRNA to 44 +/- 10% of the control level in 24 h and then its increase to 162 +/- 16% of the control level after 5 days. Clonidine 24-33 neuropeptide Y Rattus norvegicus 120-123 1878751-6 1991 4 The recovery/increase in the NPY mRNA level in the adrenal gland after 5 days treatment with clonidine was similar to its increase after treatment with reserpine (0.5 mg kg-1, i.p., once daily). Clonidine 95-104 neuropeptide Y Rattus norvegicus 31-34 1878751-8 1991 6 These results suggest that clonidine suppresses NPY gene expression in the adrenal gland, probably at the level of transcription, by activation of the alpha 2-adrenoceptor. Clonidine 29-38 neuropeptide Y Rattus norvegicus 50-53 1658840-7 1991 Similarly, prior administration of the anti-NPY antiserum attenuated the depressor effect of the central antihypertensive agents, alpha-MNE and clonidine, whereas inactivated antiserum or control normal rabbit serum were not able to attenuate these effects. Clonidine 144-153 neuropeptide Y Rattus norvegicus 44-47 1699553-0 1990 Neuropeptide Y and galanin enhance the inhibitory effects of clonidine on norepinephrine release from medulla oblongata of rats. Clonidine 61-70 neuropeptide Y Rattus norvegicus 0-26 1699553-5 1990 A combination of clonidine and low concentration of NPY (1 X 10(-9) mol/L) resulted in an increase in the inhibitory action of clonidine on stimulation-evoked NE release. Clonidine 127-136 neuropeptide Y Rattus norvegicus 52-55 2551461-4 1989 In order to further investigate the potential mechanism of this NPY effect, the alpha 2-adrenergic agonist clonidine was administered to normal rats. Clonidine 107-116 neuropeptide Y Rattus norvegicus 64-67 1972138-4 1990 Neuropeptide Y potentiated inhibition of [3H]norepinephrine release by the alpha 2-agonists UK 14,304 and clonidine. Clonidine 106-115 neuropeptide Y Rattus norvegicus 0-14 2838710-3 1988 The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidine (+43%), and pempidine (+82%). Clonidine 115-124 neuropeptide Y Rattus norvegicus 15-18 2538078-4 1989 Either alpha 2-adrenergic receptor blockade (yohimbine) or occupancy (clonidine) prevent NPY inhibition of AVP-stimulated Lp. Clonidine 70-79 neuropeptide Y Rattus norvegicus 89-92 2537374-9 1989 (4) When clonidine, either given centrally in vivo (3.75 nmol) or in vitro (10 nM) the binding of 125I-NPY was reduced (34 and 24%, respectively) in the NTS. Clonidine 9-18 neuropeptide Y Rattus norvegicus 103-106 2732724-3 1989 Furthermore, only a high concentration of NPY (100 nM) had the ability to enhance the inhibitory effects of clonidine on 3H-NA release in synaptosomes isolated from the medulla oblongata of the SH male rat, while 1 nM of NPY was effective in synaptosomes isolated from the medulla oblongata of the normotensive Wistar-Kyoto rat. Clonidine 108-117 neuropeptide Y Rattus norvegicus 42-45 2754431-0 1989 Neuropeptide Y increases the inhibitory effects of clonidine on potassium evoked 3H-noradrenaline but not 3H-5-hydroxytryptamine release from synaptosomes of the hypothalamus and the frontoparietal cortex of the male Sprague-Dawley rat. Clonidine 51-60 neuropeptide Y Rattus norvegicus 0-14 2754431-2 1989 Based on concentration-response curves obtained by analyzing the full-time course of the inhibitory effects of clonidine on 3H-NA and on 3H-5-HT release neuropeptide Y (NPY) (1 nM) was shown to significantly increase the ability of clonidine to inhibit 3H-NA release in synaptosomes isolated from the hypothalamus and from the frontoparietal cortex. Clonidine 111-120 neuropeptide Y Rattus norvegicus 153-167 2754431-2 1989 Based on concentration-response curves obtained by analyzing the full-time course of the inhibitory effects of clonidine on 3H-NA and on 3H-5-HT release neuropeptide Y (NPY) (1 nM) was shown to significantly increase the ability of clonidine to inhibit 3H-NA release in synaptosomes isolated from the hypothalamus and from the frontoparietal cortex. Clonidine 111-120 neuropeptide Y Rattus norvegicus 169-172 2754431-2 1989 Based on concentration-response curves obtained by analyzing the full-time course of the inhibitory effects of clonidine on 3H-NA and on 3H-5-HT release neuropeptide Y (NPY) (1 nM) was shown to significantly increase the ability of clonidine to inhibit 3H-NA release in synaptosomes isolated from the hypothalamus and from the frontoparietal cortex. Clonidine 232-241 neuropeptide Y Rattus norvegicus 153-167 2754431-2 1989 Based on concentration-response curves obtained by analyzing the full-time course of the inhibitory effects of clonidine on 3H-NA and on 3H-5-HT release neuropeptide Y (NPY) (1 nM) was shown to significantly increase the ability of clonidine to inhibit 3H-NA release in synaptosomes isolated from the hypothalamus and from the frontoparietal cortex. Clonidine 232-241 neuropeptide Y Rattus norvegicus 169-172 2455156-4 1987 Furthermore, NPY immunoreactivity (IR) tended to decrease in the rostral part of the dorsomedial medulla 5 min after injection of clonidine (1 microgram) in the alpha-chloralose anaesthetized rat. Clonidine 130-139 neuropeptide Y Rattus norvegicus 13-16 3783148-0 1986 Neuropeptide Y enhances the inhibitory effects of clonidine on 3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat. Clonidine 50-59 neuropeptide Y Rattus norvegicus 0-14 3783148-1 1986 In studies on superfused synaptosomes from the rat medulla oblongata, the inhibitory effects of the alpha 2-adrenergic agonist clonidine (0.1 microM) on potassium (15 mM K+) induced 3H-noradrenaline (NA) release was potentiated by 20%, when neuropeptide Y was added to the system. Clonidine 127-136 neuropeptide Y Rattus norvegicus 241-255