PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28464017-2	2017	Current techniques limit radiosynthesis to analogs of the COX-2 inhibitors with fluorine-18 added via a carbon chain, or on an aromatic position which renders the radiolabeled analog less specific towards COX-2, resulting in tracers with low in vivo stability or specificity.	Fluorine-18	80-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63	
30663092-4	2019	So the radiosynthesis of a fluorine-18-labelled COX-2 inhibitor [18 F]1b, a close derivative of valdecoxib, was performed with 18 FBIC and 1-ethynyl-4-(methylsulfonyl)benzene, providing [18 F]1b in up to 40% RCY after purification in 85 minutes.	Fluorine-18	27-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53	
30108944-5	2018	The introduction of a 4-fluorophenyl substituent resulted in retained high COX-2 affinity, making these compounds together with the feasible one step reaction promising candidates for the development of fluorine-18 labelled radiotracers.	Fluorine-18	203-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80