PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8574970-0 1996 Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride blocks the CD4 cell receptor for HIV. 3-hydroxyphthalic anhydride 38-65 beta-lactoglobulin Bos taurus 7-25 10103216-3 1999 Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthalovyl-beta-lactoglobulin [3HP-beta-LG]) was shown to inhibit HIV-1, HIV-2, simian immunodeficiency virus (SIV), herpes simplex virus type 1 and 2, and Chlamydia trachomatis infection in vitro. 3-hydroxyphthalic anhydride 38-65 beta-lactoglobulin Bos taurus 7-25 10103216-3 1999 Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthalovyl-beta-lactoglobulin [3HP-beta-LG]) was shown to inhibit HIV-1, HIV-2, simian immunodeficiency virus (SIV), herpes simplex virus type 1 and 2, and Chlamydia trachomatis infection in vitro. 3-hydroxyphthalic anhydride 38-65 beta-lactoglobulin Bos taurus 87-105 10103216-3 1999 Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthalovyl-beta-lactoglobulin [3HP-beta-LG]) was shown to inhibit HIV-1, HIV-2, simian immunodeficiency virus (SIV), herpes simplex virus type 1 and 2, and Chlamydia trachomatis infection in vitro. 3-hydroxyphthalic anhydride 38-65 beta-lactoglobulin Bos taurus 111-118 9875389-5 1998 Chemical modification of bovine beta-lactoglobulin (beta-LG), the major protein of whey, by hydroxyphthalic anhydride (3HP) led to the generation of a potent HIV-1 inhibitor (designated 3HP-beta-LG) shown to also have activity against herpes simplex virus types 1 and 2 (HSV-1, HSV-2). 3-hydroxyphthalic anhydride 92-117 beta-lactoglobulin Bos taurus 32-50 9875389-5 1998 Chemical modification of bovine beta-lactoglobulin (beta-LG), the major protein of whey, by hydroxyphthalic anhydride (3HP) led to the generation of a potent HIV-1 inhibitor (designated 3HP-beta-LG) shown to also have activity against herpes simplex virus types 1 and 2 (HSV-1, HSV-2). 3-hydroxyphthalic anhydride 92-117 beta-lactoglobulin Bos taurus 52-59 9875389-5 1998 Chemical modification of bovine beta-lactoglobulin (beta-LG), the major protein of whey, by hydroxyphthalic anhydride (3HP) led to the generation of a potent HIV-1 inhibitor (designated 3HP-beta-LG) shown to also have activity against herpes simplex virus types 1 and 2 (HSV-1, HSV-2). 3-hydroxyphthalic anhydride 92-117 beta-lactoglobulin Bos taurus 190-197 9875414-4 1998 Chemical modification of bovine beta-lactoglobulin (beta-LG), the major protein of whey, by hydroxyphthalic anhydride (3HP) led to the generation of a potent HIV-1 inhibitor designated 3HP-beta-LG. 3-hydroxyphthalic anhydride 92-117 beta-lactoglobulin Bos taurus 32-50 9875414-4 1998 Chemical modification of bovine beta-lactoglobulin (beta-LG), the major protein of whey, by hydroxyphthalic anhydride (3HP) led to the generation of a potent HIV-1 inhibitor designated 3HP-beta-LG. 3-hydroxyphthalic anhydride 92-117 beta-lactoglobulin Bos taurus 52-59 9875414-4 1998 Chemical modification of bovine beta-lactoglobulin (beta-LG), the major protein of whey, by hydroxyphthalic anhydride (3HP) led to the generation of a potent HIV-1 inhibitor designated 3HP-beta-LG. 3-hydroxyphthalic anhydride 92-117 beta-lactoglobulin Bos taurus 189-196 31611852-0 2019 The Underlying Mechanism of 3-Hydroxyphthalic Anhydride-Modified Bovine Beta-Lactoglobulin to Block Human Papillomavirus Entry Into the Host Cell. 3-hydroxyphthalic anhydride 28-55 beta-lactoglobulin Bos taurus 72-90 31611852-1 2019 We have previously demonstrated that 3-hydroxyphthalic anhydride (3HP)-modified bovine beta-lactoglobulin (3HP-beta-LG) is highly effective in inhibiting entry of pseudovirus (PsV) of high- and low-risk human papillomavirus (HPV) into the target cell. 3-hydroxyphthalic anhydride 37-64 beta-lactoglobulin Bos taurus 87-105 31611852-1 2019 We have previously demonstrated that 3-hydroxyphthalic anhydride (3HP)-modified bovine beta-lactoglobulin (3HP-beta-LG) is highly effective in inhibiting entry of pseudovirus (PsV) of high- and low-risk human papillomavirus (HPV) into the target cell. 3-hydroxyphthalic anhydride 37-64 beta-lactoglobulin Bos taurus 111-118 31611852-1 2019 We have previously demonstrated that 3-hydroxyphthalic anhydride (3HP)-modified bovine beta-lactoglobulin (3HP-beta-LG) is highly effective in inhibiting entry of pseudovirus (PsV) of high- and low-risk human papillomavirus (HPV) into the target cell. 3-hydroxyphthalic anhydride 66-69 beta-lactoglobulin Bos taurus 87-105 31611852-1 2019 We have previously demonstrated that 3-hydroxyphthalic anhydride (3HP)-modified bovine beta-lactoglobulin (3HP-beta-LG) is highly effective in inhibiting entry of pseudovirus (PsV) of high- and low-risk human papillomavirus (HPV) into the target cell. 3-hydroxyphthalic anhydride 66-69 beta-lactoglobulin Bos taurus 111-118 31611852-1 2019 We have previously demonstrated that 3-hydroxyphthalic anhydride (3HP)-modified bovine beta-lactoglobulin (3HP-beta-LG) is highly effective in inhibiting entry of pseudovirus (PsV) of high- and low-risk human papillomavirus (HPV) into the target cell. 3-hydroxyphthalic anhydride 107-110 beta-lactoglobulin Bos taurus 87-105 31611852-1 2019 We have previously demonstrated that 3-hydroxyphthalic anhydride (3HP)-modified bovine beta-lactoglobulin (3HP-beta-LG) is highly effective in inhibiting entry of pseudovirus (PsV) of high- and low-risk human papillomavirus (HPV) into the target cell. 3-hydroxyphthalic anhydride 107-110 beta-lactoglobulin Bos taurus 111-118 31611852-2 2019 Intravaginally applied 3HP-beta-LG-containing vaginal gel could significantly inhibit HPV infection and reduce viral load in the cervical region. 3-hydroxyphthalic anhydride 23-26 beta-lactoglobulin Bos taurus 27-34 31611852-3 2019 However, we still do not understand the underlying molecular mechanism by which 3HP-beta-LG is able to inhibit HPV infection. 3-hydroxyphthalic anhydride 80-83 beta-lactoglobulin Bos taurus 84-91 31611852-4 2019 Here, though, we showed that 3HP-beta-LG did not inactivate HPV PsV, but rather blocked entry of HPV PsV into the target cell via its interaction with virus, not cell. 3-hydroxyphthalic anhydride 29-32 beta-lactoglobulin Bos taurus 33-40 31611852-5 2019 It bound to the positively charged region in the HPV L1 protein, suggesting that 3HP-beta-LG binds to HPV L1 protein through the interaction between the negatively charged region in 3HP-beta-LG and the positively charged region in HPV L1 protein, thus competitively blocking the binding of HPV to the receptor on the basement membrane in vaginal mucosa. 3-hydroxyphthalic anhydride 81-84 beta-lactoglobulin Bos taurus 85-92 31611852-5 2019 It bound to the positively charged region in the HPV L1 protein, suggesting that 3HP-beta-LG binds to HPV L1 protein through the interaction between the negatively charged region in 3HP-beta-LG and the positively charged region in HPV L1 protein, thus competitively blocking the binding of HPV to the receptor on the basement membrane in vaginal mucosa. 3-hydroxyphthalic anhydride 81-84 beta-lactoglobulin Bos taurus 186-193 31611852-5 2019 It bound to the positively charged region in the HPV L1 protein, suggesting that 3HP-beta-LG binds to HPV L1 protein through the interaction between the negatively charged region in 3HP-beta-LG and the positively charged region in HPV L1 protein, thus competitively blocking the binding of HPV to the receptor on the basement membrane in vaginal mucosa. 3-hydroxyphthalic anhydride 182-185 beta-lactoglobulin Bos taurus 85-92 31611852-5 2019 It bound to the positively charged region in the HPV L1 protein, suggesting that 3HP-beta-LG binds to HPV L1 protein through the interaction between the negatively charged region in 3HP-beta-LG and the positively charged region in HPV L1 protein, thus competitively blocking the binding of HPV to the receptor on the basement membrane in vaginal mucosa. 3-hydroxyphthalic anhydride 182-185 beta-lactoglobulin Bos taurus 186-193 31611852-7 2019 When topically applied, 3HP-beta-LG did not enter the host cell or blood circulation. 3-hydroxyphthalic anhydride 24-27 beta-lactoglobulin Bos taurus 28-35 31611852-8 2019 These findings suggest that 3HP-beta-LG targets HPV L1 protein and blocks HPV entry into the host cell, thus being safe and effective for topical application in the treatment of HPV infection. 3-hydroxyphthalic anhydride 28-31 beta-lactoglobulin Bos taurus 32-39 26629967-3 2016 Here, we evaluated the safety of 3-hydroxyphthalic anhydride-modified bovine beta-lactoglobulin, designated JB01, vaginally applied in women infected by high-risk HPV. 3-hydroxyphthalic anhydride 33-60 beta-lactoglobulin Bos taurus 77-95 23518265-1 2013 Previous studies have shown that 3-hydroxyphthalic anhydride-modified bovine beta-lactoglobulin is a promising anti-HIV microbicide candidate. 3-hydroxyphthalic anhydride 33-60 beta-lactoglobulin Bos taurus 77-95 20420669-1 2010 BACKGROUND: Previous studies have shown that 3-hydroxyphthalic anhydride (HP)-modified bovine milk protein, beta-lactoglobulin (beta-LG), is a promising microbicide candidate. 3-hydroxyphthalic anhydride 45-72 beta-lactoglobulin Bos taurus 108-126 20420669-1 2010 BACKGROUND: Previous studies have shown that 3-hydroxyphthalic anhydride (HP)-modified bovine milk protein, beta-lactoglobulin (beta-LG), is a promising microbicide candidate. 3-hydroxyphthalic anhydride 45-72 beta-lactoglobulin Bos taurus 128-135 20420669-1 2010 BACKGROUND: Previous studies have shown that 3-hydroxyphthalic anhydride (HP)-modified bovine milk protein, beta-lactoglobulin (beta-LG), is a promising microbicide candidate. 3-hydroxyphthalic anhydride 74-76 beta-lactoglobulin Bos taurus 108-126 20420669-1 2010 BACKGROUND: Previous studies have shown that 3-hydroxyphthalic anhydride (HP)-modified bovine milk protein, beta-lactoglobulin (beta-LG), is a promising microbicide candidate. 3-hydroxyphthalic anhydride 74-76 beta-lactoglobulin Bos taurus 128-135