PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7772042-14 1995 Thus ABAH is an effective and selective inhibitor that should be useful for determining the contribution of myeloperoxidase to oxidant-mediated reactions of neutrophils. 4-aminobenzhydrazide 5-9 myeloperoxidase Homo sapiens 108-123 11738154-7 2001 Adding the MPO inhibitors 4-aminobenzoic acid hydrazide (ABAH) and indomethacin to the granulocytes, the generation of superoxide anion increased and the decreasing effect of the steroids on superoxide production was inhibited. 4-aminobenzhydrazide 26-55 myeloperoxidase Homo sapiens 11-14 11738154-7 2001 Adding the MPO inhibitors 4-aminobenzoic acid hydrazide (ABAH) and indomethacin to the granulocytes, the generation of superoxide anion increased and the decreasing effect of the steroids on superoxide production was inhibited. 4-aminobenzhydrazide 57-61 myeloperoxidase Homo sapiens 11-14 10801811-12 2000 When HL-60 cells were incubated with methimazole or 4-aminobenzoic acid hydrazide, which are inhibitors of myeloperoxidase, they no longer underwent H(2)O(2)-induced apoptosis. 4-aminobenzhydrazide 52-81 myeloperoxidase Homo sapiens 107-122 9020887-0 1997 Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. 4-aminobenzhydrazide 48-77 myeloperoxidase Homo sapiens 29-44 9020887-4 1997 In this investigation we show that, in the presence of hydrogen peroxide, ABAH irreversibly inactivates myeloperoxidase. 4-aminobenzhydrazide 74-78 myeloperoxidase Homo sapiens 104-119 9020887-5 1997 ABAH was oxidized by myeloperoxidase, and kinetic analysis of the inactivation conformed to that for a mechanism-based inhibitor. 4-aminobenzhydrazide 0-4 myeloperoxidase Homo sapiens 21-36 9020887-9 1997 In the presence of oxygen, ABAH and hydrogen peroxide initially converted myeloperoxidase into compound III, which subsequently lost haem absorbance. 4-aminobenzhydrazide 27-31 myeloperoxidase Homo sapiens 74-89 9020887-11 1997 We propose that myeloperoxidase oxidizes ABAH to a radical that reduces the enzyme to its ferrous intermediate. 4-aminobenzhydrazide 41-45 myeloperoxidase Homo sapiens 16-31 11981455-5 2002 Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2). 4-aminobenzhydrazide 60-89 myeloperoxidase Homo sapiens 37-40 11981455-5 2002 Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2). 4-aminobenzhydrazide 60-89 myeloperoxidase Homo sapiens 237-240 11981455-5 2002 Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2). 4-aminobenzhydrazide 91-95 myeloperoxidase Homo sapiens 37-40 11981455-5 2002 Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2). 4-aminobenzhydrazide 91-95 myeloperoxidase Homo sapiens 237-240 10994875-3 2000 Myeloperoxidase-mediated apoptosis induction is inhibited by SOD, catalase, 4-aminobenzoyl hydrazide, taurine and DMSO. 4-aminobenzhydrazide 76-100 myeloperoxidase Homo sapiens 0-15 10092633-3 1999 4-Aminobenzoic acid hydrazide (ABAH) is a mechanism-based inhibitor of myeloperoxidase that is oxidized to radical intermediates that cause enzyme inactivation. 4-aminobenzhydrazide 0-29 myeloperoxidase Homo sapiens 71-86 10092633-3 1999 4-Aminobenzoic acid hydrazide (ABAH) is a mechanism-based inhibitor of myeloperoxidase that is oxidized to radical intermediates that cause enzyme inactivation. 4-aminobenzhydrazide 31-35 myeloperoxidase Homo sapiens 71-86 10092633-10 1999 ABAH was oxidized by myeloperoxidase without added hydrogen peroxide because it underwent auto-oxidation. 4-aminobenzhydrazide 0-4 myeloperoxidase Homo sapiens 21-36 35301114-3 2022 To study temperature-dependent innate immune activity, 4-aminobenzoic hydrazide (4-AH), a myeloperoxidase (MPO) inhibitor, was used to treat VHSV-infected olive flounders reared at a high temperature of 20 C (20VI). 4-aminobenzhydrazide 55-79 myeloperoxidase Homo sapiens 90-105 35301114-3 2022 To study temperature-dependent innate immune activity, 4-aminobenzoic hydrazide (4-AH), a myeloperoxidase (MPO) inhibitor, was used to treat VHSV-infected olive flounders reared at a high temperature of 20 C (20VI). 4-aminobenzhydrazide 55-79 myeloperoxidase Homo sapiens 107-110 27597056-3 2016 4-Aminobenzoic acid hydrazide, a potent inhibitor of peroxidase activity of myeloperoxidase, produced no effect on neutrophil degranulation. 4-aminobenzhydrazide 0-29 myeloperoxidase Homo sapiens 76-91 32758448-8 2020 Finally, treatment of healthy neutrophils with an MPO inhibitor (4-Aminobenzoic acid hydrazide) increased cell viability and delayed apoptosis, highlighting a mechanism whereby MPO mutations affect granulocyte numbers. 4-aminobenzhydrazide 65-94 myeloperoxidase Homo sapiens 50-53 32758448-8 2020 Finally, treatment of healthy neutrophils with an MPO inhibitor (4-Aminobenzoic acid hydrazide) increased cell viability and delayed apoptosis, highlighting a mechanism whereby MPO mutations affect granulocyte numbers. 4-aminobenzhydrazide 65-94 myeloperoxidase Homo sapiens 177-180 30206371-7 2018 Inhibition is also reversed in the presence of 4-aminobenzoic hydrazide, a myeloperoxidase inhibitor, suggesting epithelial cells have a peroxidase to convert Cl- to HOCl. 4-aminobenzhydrazide 47-71 myeloperoxidase Homo sapiens 75-90 28135312-6 2017 PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates. 4-aminobenzhydrazide 111-140 myeloperoxidase Homo sapiens 85-100 28135312-6 2017 PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates. 4-aminobenzhydrazide 142-146 myeloperoxidase Homo sapiens 15-30 28135312-6 2017 PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates. 4-aminobenzhydrazide 142-146 myeloperoxidase Homo sapiens 85-100 19915640-3 2009 Specific MPO inhibitors, salicylhydroxamic acid or (4-aminobenzoyl)hydrazide, are added to measure the activity of other heme-containing peroxidases (mainly hemoglobin and its derivatives) and subtract their contribution from the total plasma peroxidase activity. 4-aminobenzhydrazide 51-76 myeloperoxidase Homo sapiens 9-12 25759268-5 2015 This response was blocked by the irreversible myeloperoxidase inhibitor 4-amino-benzoic acid hydrazide, indicating peroxidase catalytic activity is essential for collagen biosynthesis. 4-aminobenzhydrazide 72-102 myeloperoxidase Homo sapiens 46-61 24632143-4 2014 We determined that in the presence of hydrogen peroxide that 4-ABAH and its isomer 2-ABAH are both slow-tight binding inhibitors of MPO requiring at least two steps, whereas NaN3 and isoniazid-based inhibition has a single observable step. 4-aminobenzhydrazide 61-67 myeloperoxidase Homo sapiens 132-135 21840294-2 2011 We utilized 4-aminobenzoic acid hydrazide which was reported to be a potent irreversible inhibitor of myeloperoxidase to gain insight into the role of reactive metabolites in catalytic inhibition. 4-aminobenzhydrazide 12-41 myeloperoxidase Homo sapiens 102-117 20699435-4 2010 Pretreatment of MPO-high leukemia cells with a MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, or a MPO-specific small interfering RNA (siRNA) abrogated the PTL-induced ROS generation and apoptosis, indicating that MPO plays a crucial role in PTL-induced apoptosis in leukemia cells. 4-aminobenzhydrazide 71-100 myeloperoxidase Homo sapiens 16-19 26774631-3 2015 Studies were carried out on HL-60 cell line, which were preincubated with the MPO inhibitor 4-aminobenzoic acid hydrazide (ABAH), or antioxidant N-acetyl-L-cysteine (NAC), followed by incubation at different concentrations of etoposide (1-10 mM) for 4 hours. 4-aminobenzhydrazide 92-121 myeloperoxidase Homo sapiens 78-81 26774631-3 2015 Studies were carried out on HL-60 cell line, which were preincubated with the MPO inhibitor 4-aminobenzoic acid hydrazide (ABAH), or antioxidant N-acetyl-L-cysteine (NAC), followed by incubation at different concentrations of etoposide (1-10 mM) for 4 hours. 4-aminobenzhydrazide 123-127 myeloperoxidase Homo sapiens 78-81 15893945-6 2005 In addition, an inhibitor of MPO enzyme, 4-aminobenzohydrazide, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells. 4-aminobenzhydrazide 41-62 myeloperoxidase Homo sapiens 29-32 16632121-13 2006 Inhibition of myeloperoxidase activity with 4-aminobenzoic acid hydrazide (4-ABAH) had minimal influence on the phototoxicity of VP in HL-60 cells in the absence of ascorbate. 4-aminobenzhydrazide 44-73 myeloperoxidase Homo sapiens 14-29 16632121-13 2006 Inhibition of myeloperoxidase activity with 4-aminobenzoic acid hydrazide (4-ABAH) had minimal influence on the phototoxicity of VP in HL-60 cells in the absence of ascorbate. 4-aminobenzhydrazide 75-81 myeloperoxidase Homo sapiens 14-29 17875773-6 2007 Preincubation of myeloid leukemic cells with the MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, and the heme biosynthesis inhibitor, succinylacetone, resulted in inhibition of the intracellular MPO activity, ROS production, and induction of apoptosis following addition of EGCG. 4-aminobenzhydrazide 73-102 myeloperoxidase Homo sapiens 49-52 17875773-6 2007 Preincubation of myeloid leukemic cells with the MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, and the heme biosynthesis inhibitor, succinylacetone, resulted in inhibition of the intracellular MPO activity, ROS production, and induction of apoptosis following addition of EGCG. 4-aminobenzhydrazide 73-102 myeloperoxidase Homo sapiens 202-205 17440118-3 2007 Human alveolar epithelial cells (A549) were cocultured with activated neutrophils, and we observed a significant reduction of NER in the A549 cells, which was abrogated by addition of the myeloperoxidase (MPO) inhibitor 4-aminobenzoic acid hydrazide. 4-aminobenzhydrazide 220-249 myeloperoxidase Homo sapiens 188-203 17440118-3 2007 Human alveolar epithelial cells (A549) were cocultured with activated neutrophils, and we observed a significant reduction of NER in the A549 cells, which was abrogated by addition of the myeloperoxidase (MPO) inhibitor 4-aminobenzoic acid hydrazide. 4-aminobenzhydrazide 220-249 myeloperoxidase Homo sapiens 205-208 15893945-6 2005 In addition, an inhibitor of MPO enzyme, 4-aminobenzohydrazide, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells. 4-aminobenzhydrazide 41-62 myeloperoxidase Homo sapiens 91-94 15893945-6 2005 In addition, an inhibitor of MPO enzyme, 4-aminobenzohydrazide, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells. 4-aminobenzhydrazide 41-62 myeloperoxidase Homo sapiens 91-94 16024637-4 2005 Methimazole, 4-aminobenzoic acid hydrazide, or azide inhibits the reaction, suggesting that it is mediated by the cellular myeloperoxidase, an enzyme naturally present in large amounts in HL-60 cells. 4-aminobenzhydrazide 13-42 myeloperoxidase Homo sapiens 123-138