PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21406211-3 2011 However, the alterations in gene expression of nAChR subunits using an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model remain unclear. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 77-121 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 47-52 22624500-0 2012 alpha7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 104-108 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 0-39 22624500-3 2012 The objective of the present study was to determine whether nicotine-induced neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model occurs via alpha7-nAChR-mediated inhibition of astrocytes. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 100-144 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 175-187 23938346-0 2013 The alpha7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 61-65 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 4-16 21406211-3 2011 However, the alterations in gene expression of nAChR subunits using an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model remain unclear. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 123-127 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 47-52 21406211-4 2011 In the present study, we profile the time course of nAChR alpha7, alpha4 and beta2 subunit expression levels using a comparative RT-PCR approach after acute MPTP injection. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 157-161 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 52-57 21406211-4 2011 In the present study, we profile the time course of nAChR alpha7, alpha4 and beta2 subunit expression levels using a comparative RT-PCR approach after acute MPTP injection. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 157-161 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 58-72 21406211-6 2011 (1) MPTP treatment transiently increased nAChR alpha7 (after last injection of MPTP 3 and 24 h), alpha4 and beta2 (24 h) mRNA expression in the substantia nigra (SN) and striatum. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 4-8 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 41-46 21406211-6 2011 (1) MPTP treatment transiently increased nAChR alpha7 (after last injection of MPTP 3 and 24 h), alpha4 and beta2 (24 h) mRNA expression in the substantia nigra (SN) and striatum. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 79-83 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 41-46 21406211-8 2011 (3) In the acute MPTP model, time-courses of altered expression for nAChR alpha7, alpha4 and beta2 subunits closely mirrored the deficits observed in animal motor activity. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 17-21 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 68-73 21406211-8 2011 (3) In the acute MPTP model, time-courses of altered expression for nAChR alpha7, alpha4 and beta2 subunits closely mirrored the deficits observed in animal motor activity. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 17-21 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 74-88 21406211-10 2011 These changes followed or paralleled MPTP-induced elevation in the levels of alpha7, alpha4 and beta2 mRNAs. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 37-41 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 77-91 28551099-6 2017 In the in vivo study, alpha7-nAChR knockout (alpha7-KO) reversed the beneficial effects of nicotine on motor deficits, dopaminergic neuron loss, astrocyte and microglia activation, and reduced striatal dopamine release induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 230-274 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 22-34