PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28551099-6	2017	In the in vivo study, alpha7-nAChR knockout (alpha7-KO) reversed the beneficial effects of nicotine on motor deficits, dopaminergic neuron loss, astrocyte and microglia activation, and reduced striatal dopamine release induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	230-274	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	22-34	
23938346-0	2013	The alpha7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	61-65	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	4-16	
21406211-3	2011	However, the alterations in gene expression of nAChR subunits using an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model remain unclear.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	77-121	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	47-52	
21406211-3	2011	However, the alterations in gene expression of nAChR subunits using an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model remain unclear.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	123-127	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	47-52	
21406211-4	2011	In the present study, we profile the time course of nAChR alpha7, alpha4 and beta2 subunit expression levels using a comparative RT-PCR approach after acute MPTP injection.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	157-161	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	52-57	
21406211-4	2011	In the present study, we profile the time course of nAChR alpha7, alpha4 and beta2 subunit expression levels using a comparative RT-PCR approach after acute MPTP injection.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	157-161	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	58-72	
21406211-6	2011	(1) MPTP treatment transiently increased nAChR alpha7 (after last injection of MPTP 3 and 24 h), alpha4 and beta2 (24 h) mRNA expression in the substantia nigra (SN) and striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-8	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	41-46	
21406211-6	2011	(1) MPTP treatment transiently increased nAChR alpha7 (after last injection of MPTP 3 and 24 h), alpha4 and beta2 (24 h) mRNA expression in the substantia nigra (SN) and striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	79-83	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	41-46	
21406211-8	2011	(3) In the acute MPTP model, time-courses of altered expression for nAChR alpha7, alpha4 and beta2 subunits closely mirrored the deficits observed in animal motor activity.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	17-21	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	68-73	
21406211-8	2011	(3) In the acute MPTP model, time-courses of altered expression for nAChR alpha7, alpha4 and beta2 subunits closely mirrored the deficits observed in animal motor activity.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	17-21	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	74-88	
21406211-10	2011	These changes followed or paralleled MPTP-induced elevation in the levels of alpha7, alpha4 and beta2 mRNAs.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	37-41	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	77-91	
22624500-0	2012	alpha7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	104-108	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	0-39	
22624500-3	2012	The objective of the present study was to determine whether nicotine-induced neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model occurs via alpha7-nAChR-mediated inhibition of astrocytes.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	100-144	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	175-187