PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24650522-5 2014 The mechanism by which C2-ceramide impairs signaling would seem to involve a negative feedback of activated S6K via phosphorylation of insulin receptor substrate-1 at Ser636/639, since S6K inhibitor can block this phenomenon. N-acetylsphingosine 23-34 ribosomal protein S6 kinase B1 Homo sapiens 108-111 24650522-5 2014 The mechanism by which C2-ceramide impairs signaling would seem to involve a negative feedback of activated S6K via phosphorylation of insulin receptor substrate-1 at Ser636/639, since S6K inhibitor can block this phenomenon. N-acetylsphingosine 23-34 ribosomal protein S6 kinase B1 Homo sapiens 185-188 25813876-7 2015 alpha-Syn overexpression also inhibited PP2A activity, while the PP2A agonist C2 ceramide suppressed both S6K1 activation and IRS-1 Ser636 phosphorylation upon alpha-Syn overexpression. N-acetylsphingosine 78-89 ribosomal protein S6 kinase B1 Homo sapiens 106-110