PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16939563-4 2006 Arginine can also be metabolized to urea and ornithine by arginase-1, a pathway that generates L-proline, a substrate for collagen synthesis, and polyamines, which stimulate cellular proliferation. Ornithine 45-54 arginase 1 Homo sapiens 58-68 20661013-3 2010 Arginase-1 (Arg-1) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of arginine to ornithine and urea. Ornithine 103-112 arginase 1 Homo sapiens 0-10 20661013-3 2010 Arginase-1 (Arg-1) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of arginine to ornithine and urea. Ornithine 103-112 arginase 1 Homo sapiens 12-17 17119118-2 2007 The decreased production of nitric oxide (NO) by NOS and the production of ornithine by ARG1 affect immune responses and tissue regeneration at sites of infection, respectively. Ornithine 75-84 arginase 1 Homo sapiens 88-92 21310339-1 2011 Argininemia is caused by a deficiency of arginase 1, which catalyzes the final step in the urea cycle, i.e., the cytosolic hydrolysis of arginine to ornithine and urea. Ornithine 149-158 arginase 1 Homo sapiens 41-51 34943588-1 2021 Arginase-1 catalyzes the conversion of arginine to ornithine and urea. Ornithine 51-60 arginase 1 Homo sapiens 0-10 11370664-8 2001 Ornithine, a product of the reaction catalyzed by arginase and a potent inhibitor of type I arginase, is a poor inhibitor of the type II isozyme. Ornithine 0-9 arginase 1 Homo sapiens 85-100 16455964-4 2006 A significant number of CD11b(+)/Gr-1(+) cells expressing arginase 1 accumulated in T cell zones around the germinal centers of the white pulp of the spleen within 6 h of trauma and lasted for at least 72 h. Increased arginase activity and arginase 1 expression, along with increased [(3)H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were observed exclusively in CD11b(+)/Gr-1(+) cells after traumatic stress. Ornithine 333-344 arginase 1 Homo sapiens 58-68 15811879-1 2005 Arginase 1, an enzyme induced by Th2 cytokines, is a hallmark of alternatively activated macrophages and is responsible for the hydrolysis of L-arginine into ornithine, the building block for the production of polyamines. Ornithine 158-167 arginase 1 Homo sapiens 0-10 33128544-1 2020 Arginase I (ARG1) is a cytosolic enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. Ornithine 87-98 arginase 1 Homo sapiens 12-16 34326456-1 2021 Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, and modulates T-cell-mediated immune response. Ornithine 91-102 arginase 1 Homo sapiens 6-16 34326456-1 2021 Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, and modulates T-cell-mediated immune response. Ornithine 91-102 arginase 1 Homo sapiens 18-23 35281666-1 2022 Arginase deficiency is a rare autosomal recessive urea cycle disorder (UCD) caused by mutations in the ARG1 gene encoding arginase that catalyses the hydrolysis of arginine to ornithine and urea. Ornithine 176-185 arginase 1 Homo sapiens 103-107 33754845-1 2021 Arginase-1, an enzyme that catalyzes the reaction of L-arginine to L-ornithine, is implicated in the tumor immune response and represents an interesting therapeutic target in immuno-oncology. Ornithine 67-78 arginase 1 Homo sapiens 0-10 34599427-0 2022 Arginase-1 Released into CSF After Aneurysmal Subarachnoid Hemorrhage Decreases Arginine/Ornithine Ratio: a Novel Prognostic Biomarker. Ornithine 89-98 arginase 1 Homo sapiens 0-10 34599427-9 2022 The well-known surrogate parameter for arginase acitivity, the L-arginine to L-ornithine ratio (Arg/Orn), correlated with CSF arginase-1 levels. Ornithine 77-88 arginase 1 Homo sapiens 126-136 33500272-3 2021 Pegzilarginase, a human arginase 1 enzyme engineered to have superior stability and enzymatic activity relative to the native human arginase 1 enzyme, depletes systemic arginine by converting it to ornithine and urea. Ornithine 198-207 arginase 1 Homo sapiens 24-34 29487337-3 2018 A novel UPLC-MS method, measuring the conversion of ARG to ornithine (ORN), was developed to determine arginase 1 and arginase 2 inhibition by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and NG-Monomethyl-L-arginine (L-NMMA). Ornithine 59-68 arginase 1 Homo sapiens 103-113 33192610-5 2020 For example, through a combination of steady state measurements and 13C6 15N4-arginine tracing experiments, we report an increase in arginine catabolism into ornithine in humans, suggestive of species-specific arginase 1 activity and nitric oxide synthesis-an observation that may impact the translatability of cardiovascular disease studies carried out in non-human primates (NHPs). Ornithine 158-167 arginase 1 Homo sapiens 210-220 32721242-1 2020 Background: Arginase I, encoded by the ARG1 gene, is an enzyme that catalyzes the conversion of arginine to ornithine in the urea cycle; mutations in this gene has recently been reported to be associated with dilated cardiomyopathy (DCM) in Pakistan. Ornithine 108-117 arginase 1 Homo sapiens 39-43 32418491-1 2020 Arginase-1, which converts the amino acid L-arginine into L-ornithine and urea, is a promising new drug target for cancer immunotherapy, as it has a role in the regulation of T-cell immunity in the tumor microenvironment. Ornithine 58-69 arginase 1 Homo sapiens 0-10 32647818-1 2020 Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea. Ornithine 99-110 arginase 1 Homo sapiens 0-10 30890279-1 2019 AIM: Arginase-1 (Arg-1) metabolizes l-arginine to l-ornithine and urea. Ornithine 50-61 arginase 1 Homo sapiens 5-15 30890279-1 2019 AIM: Arginase-1 (Arg-1) metabolizes l-arginine to l-ornithine and urea. Ornithine 50-61 arginase 1 Homo sapiens 17-22 29487337-3 2018 A novel UPLC-MS method, measuring the conversion of ARG to ornithine (ORN), was developed to determine arginase 1 and arginase 2 inhibition by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and NG-Monomethyl-L-arginine (L-NMMA). Ornithine 70-73 arginase 1 Homo sapiens 103-113 26537638-1 2015 Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-ornithine and compete with nitric oxide synthases for l-Arginine. Ornithine 85-96 arginase 1 Homo sapiens 0-10 27479442-6 2016 Cell surface-immobilized K6-InaK-N/ARG1 presented an arginase activity of 10.7 U/OD600 under the optimized conditions of 40 C, pH 10.0 and 1 mM Mn2+, which could convert more than 95% of L-Arginine (L-Arg) to L-Ornithine (L-Orn) in 16 hours. Ornithine 209-220 arginase 1 Homo sapiens 35-39 27479442-6 2016 Cell surface-immobilized K6-InaK-N/ARG1 presented an arginase activity of 10.7 U/OD600 under the optimized conditions of 40 C, pH 10.0 and 1 mM Mn2+, which could convert more than 95% of L-Arginine (L-Arg) to L-Ornithine (L-Orn) in 16 hours. Ornithine 209-214 arginase 1 Homo sapiens 35-39 26475291-1 2016 Arginase 1 (Arg1) limits the availability of l-arginine for producing nitric oxide (NO) and ornithine, a substrate for polyamine synthesis. Ornithine 92-101 arginase 1 Homo sapiens 0-10 26475291-1 2016 Arginase 1 (Arg1) limits the availability of l-arginine for producing nitric oxide (NO) and ornithine, a substrate for polyamine synthesis. Ornithine 92-101 arginase 1 Homo sapiens 12-16 26971935-5 2016 Real-time PCR analysis revealed in APPwt cells significant decreases of ARG1 and ARG2 which are responsible for lysing arginine into ornithine and urea; this reduction was followed by significantly lower enzyme activity. Ornithine 133-142 arginase 1 Homo sapiens 72-76 24911253-1 2014 Arginase-1 is an enzyme that catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle. Ornithine 69-78 arginase 1 Homo sapiens 0-10 23847624-5 2013 The arginases (Arg1 and Arg2) metabolize l-arginine to generate l-ornithine and urea and increased expression of arginase has been proposed as a mechanism of reduced eNOS activity secondary to the depletion of l-arginine. Ornithine 64-75 arginase 1 Homo sapiens 15-19 23375628-3 2013 Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing. Ornithine 101-110 arginase 1 Homo sapiens 0-10 23375628-3 2013 Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing. Ornithine 101-110 arginase 1 Homo sapiens 12-16 22411759-1 2012 BACKGROUND: The hemolytic products cell-free oxyhemoglobin (FHb) and arginase-1 reduce nitric oxide (NO) bioavailability by scavenging NO and by degrading the NO precursor arginine to ornithine, respectively. Ornithine 184-193 arginase 1 Homo sapiens 69-79 22416259-2 2012 This Th2 cytokine induces Arg1 activity, which converts arginine into ornithine, and ornithine can be decarboxylated by ODC to produce putrescine, which is further converted into spermidine and spermine. Ornithine 70-79 arginase 1 Homo sapiens 26-30 26358771-1 2015 Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine. Ornithine 112-121 arginase 1 Homo sapiens 47-57 26358771-1 2015 Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine. Ornithine 112-121 arginase 1 Homo sapiens 59-63 25797592-4 2015 A strong correlation was also observed between HM and mRNA expression levels of arginase 1, an enzyme that catalyzes the conversion of arginine to ornithine. Ornithine 147-156 arginase 1 Homo sapiens 80-90