PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35242829-10 2022 Furthermore, inhibition of ornithine metabolism by silencing ornithine decarboxylase (ODC) in DMSCs partly abolished the benefits of DMSC transplantation. Ornithine 27-36 ornithine decarboxylase 1 Homo sapiens 61-84 3125950-2 1987 Subcellular fractionation showed the enzyme associated with the post-mitochondrial supernatant fraction in each of the tissues: Specific activities of ODC, defined as alpha-difluoromethylornithine (DFMO)-sensitive decarboxylation of ornithine, in the supernatant fractions of combined inner ear tissues were: guinea pig = 44 +/- 4 pmoles CO2 produced/hour/mg protein, and rat = 133 +/- 30. Ornithine 187-196 ornithine decarboxylase 1 Homo sapiens 151-154 2722995-4 1989 The developed method was applied to the determination of putrescine formed from ornithine by ornithine decarboxylase. Ornithine 80-89 ornithine decarboxylase 1 Homo sapiens 93-116 3420115-8 1988 It was concluded that AIB could partially overcome the ornithine-induced inhibition of ODC activity. Ornithine 55-64 ornithine decarboxylase 1 Homo sapiens 87-90 3342404-5 1988 Kinetic analyses indicated that GTP either lowered the apparent Km of tumor ODC for L-ornithine, increased the Vmax, or had both effects, depending on the tumor examined. Ornithine 84-95 ornithine decarboxylase 1 Homo sapiens 76-79 3145970-4 1988 Inhibition is specific, as a number of substrates and end products of ODC and ADC activities antagonize DFMA and DFMO (i.e. ornithine greater than putrescine = spermidine greater than agmatine). Ornithine 124-133 ornithine decarboxylase 1 Homo sapiens 70-73 35054098-5 2022 In addition, the ratio putrescine/ornithine, representing the activity of ornithine decarboxylase, was significantly increased in patients with active compared to inactive orbitopathy (p = 0.0011, fold change 3.75). Ornithine 34-43 ornithine decarboxylase 1 Homo sapiens 74-97 2554065-1 1989 Ornithine decarboxylase (ODC) catalyzes the formation of putrescine from ornithine, which is the first step in the pathway of mammalian polyamine biosynthesis. Ornithine 73-82 ornithine decarboxylase 1 Homo sapiens 0-23 2554065-1 1989 Ornithine decarboxylase (ODC) catalyzes the formation of putrescine from ornithine, which is the first step in the pathway of mammalian polyamine biosynthesis. Ornithine 73-82 ornithine decarboxylase 1 Homo sapiens 25-28 2796972-1 1989 Production of polyamines such as putrescine (PUT), spermidine (SPD) and spermine (SPM) primarily from ornithine by ornithine decarboxylase (ODC) is correlated with cell proliferation. Ornithine 102-111 ornithine decarboxylase 1 Homo sapiens 115-138 2796972-1 1989 Production of polyamines such as putrescine (PUT), spermidine (SPD) and spermine (SPM) primarily from ornithine by ornithine decarboxylase (ODC) is correlated with cell proliferation. Ornithine 102-111 ornithine decarboxylase 1 Homo sapiens 140-143 3595616-0 1987 L-ornithine-induced inactivation of mammalian ornithine decarboxylase in vitro. Ornithine 0-11 ornithine decarboxylase 1 Homo sapiens 46-69 3931086-2 1985 At concentrations of 0.5 mM and above alpha-difluoromethyl ornithine (DFMO), which inhibits ornithine decarboxylase and the conversion of ornithine to putrescine, significantly attenuated the mitogenic effect of prolactin. Ornithine 59-68 ornithine decarboxylase 1 Homo sapiens 92-115 2871896-5 1986 This major inhibition was completely reversed in the presence of 0.5 mM putrescine, the product of ODC-mediated catabolism of ornithine. Ornithine 126-135 ornithine decarboxylase 1 Homo sapiens 99-102 6381100-4 1984 Selective inactivation of the two types of ODC by the (R)-enantiomer is in agreement with the stereochemistry reported for ornithine decarboxylation by the enzyme. Ornithine 123-132 ornithine decarboxylase 1 Homo sapiens 43-46 6379395-3 1984 The virally activated ornithine decarboxylase removes ornithine from participation in the urea cycle by metabolizing ornithine to putrescine which, in turn, is metabolized to spermidine. Ornithine 54-63 ornithine decarboxylase 1 Homo sapiens 22-45 6706914-1 1984 To determine the steric course of the reaction of bacterial ornithine decarboxylase [EC 4.1.1.17], we have carried out the decarboxylation of L-ornithine in 2H2O and that of DL-[2-2H]ornithine in H2O, and obtained putrescine bearing a single deuterium atom in the C-1 position. Ornithine 142-153 ornithine decarboxylase 1 Homo sapiens 60-83 619149-6 1978 From the degree of inhibition of ODC activity in the presence of the various ornithine analogues, it has been possible to delineate some of the structural features of the substrate L-ornithine which are required for binding to the mammalian ODC active site. Ornithine 77-86 ornithine decarboxylase 1 Homo sapiens 33-36 7205870-0 1981 alpha-Ethynyl and alpha-vinyl analogues of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase. Ornithine 43-52 ornithine decarboxylase 1 Homo sapiens 97-120 6414762-1 1983 Decarboxylation of L-ornithine by L-ornithine decarboxylase (ODC; E.C.4.1.1.17.) Ornithine 19-30 ornithine decarboxylase 1 Homo sapiens 34-59 6414762-1 1983 Decarboxylation of L-ornithine by L-ornithine decarboxylase (ODC; E.C.4.1.1.17.) Ornithine 19-30 ornithine decarboxylase 1 Homo sapiens 61-64 619149-6 1978 From the degree of inhibition of ODC activity in the presence of the various ornithine analogues, it has been possible to delineate some of the structural features of the substrate L-ornithine which are required for binding to the mammalian ODC active site. Ornithine 77-86 ornithine decarboxylase 1 Homo sapiens 241-244 619149-6 1978 From the degree of inhibition of ODC activity in the presence of the various ornithine analogues, it has been possible to delineate some of the structural features of the substrate L-ornithine which are required for binding to the mammalian ODC active site. Ornithine 181-192 ornithine decarboxylase 1 Homo sapiens 33-36 619149-6 1978 From the degree of inhibition of ODC activity in the presence of the various ornithine analogues, it has been possible to delineate some of the structural features of the substrate L-ornithine which are required for binding to the mammalian ODC active site. Ornithine 181-192 ornithine decarboxylase 1 Homo sapiens 241-244 33915902-3 2021 Cytoplasmic ornithine, the intermediate product of the urea cycle, is a specific substrate for ornithine decarboxylase (ODC, also known as ODC1) for the production of putrescine and is required for tumor growth. Ornithine 12-21 ornithine decarboxylase 1 Homo sapiens 95-118 33915902-3 2021 Cytoplasmic ornithine, the intermediate product of the urea cycle, is a specific substrate for ornithine decarboxylase (ODC, also known as ODC1) for the production of putrescine and is required for tumor growth. Ornithine 12-21 ornithine decarboxylase 1 Homo sapiens 120-123 33915902-3 2021 Cytoplasmic ornithine, the intermediate product of the urea cycle, is a specific substrate for ornithine decarboxylase (ODC, also known as ODC1) for the production of putrescine and is required for tumor growth. Ornithine 12-21 ornithine decarboxylase 1 Homo sapiens 139-143 33621898-7 2021 The N5-[18F]FPO exhibited fast uptake in HepG2 cells and the cellular uptake ability of N5-[18F]FPO can be inhibited by L-ornithine and DFMO, which indicated that the transport pathway of N5-[18F]FPO is similar to that of L-ornithine, interacting with ODC after being transported into the cell. Ornithine 120-131 ornithine decarboxylase 1 Homo sapiens 252-255 33542926-8 2021 mTORC1 upregulated NF-kappaB activation and the expression of AST and ODC in response to glutamate and ornithine treatments, whereas rapamycin inhibited the utilization of glutamate and ornithine in hepatocytes. Ornithine 103-112 ornithine decarboxylase 1 Homo sapiens 70-73 32155745-2 2020 In mammalian cells Put is formed exclusively from L-ornithine by ornithine decarboxylase (ODC) and many potent ODC inhibitors are known. Ornithine 50-61 ornithine decarboxylase 1 Homo sapiens 65-88 32094585-3 2020 Here, we show that ornithine capture by the ribosome and the nascent peptide SpeFL controls polyamine synthesis in gamma-proteobacteria by inducing the expression of the ornithine decarboxylase SpeF4, via a mechanism involving ribosome stalling and transcription antitermination. Ornithine 19-28 ornithine decarboxylase 1 Homo sapiens 170-193 32767470-4 2020 In the catalysis axis (pathway), ODC converts ornithine to putrescine. Ornithine 46-55 ornithine decarboxylase 1 Homo sapiens 33-36 32597331-1 2021 Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine. Ornithine 71-80 ornithine decarboxylase 1 Homo sapiens 96-99 32155745-2 2020 In mammalian cells Put is formed exclusively from L-ornithine by ornithine decarboxylase (ODC) and many potent ODC inhibitors are known. Ornithine 50-61 ornithine decarboxylase 1 Homo sapiens 90-93 32155745-2 2020 In mammalian cells Put is formed exclusively from L-ornithine by ornithine decarboxylase (ODC) and many potent ODC inhibitors are known. Ornithine 50-61 ornithine decarboxylase 1 Homo sapiens 111-114 30066894-9 2018 It was postulated that the accumulated ornithine could be channeled via ODC1 to produce polyamines that promoted tumour growth. Ornithine 39-48 ornithine decarboxylase 1 Homo sapiens 72-76 31362455-5 2019 Forty fungal isolates were screened for ODC production, twenty fungal isolates have the higher potency to grow on L-ornithine as sole nitrogen source. Ornithine 114-125 ornithine decarboxylase 1 Homo sapiens 40-43 31362455-9 2019 The enzyme had a maximum activity at 37 C, pH 7.4-7.8 and thermal stability for 20 h at 37 C, and 90 days storage stability at 4 C. A. terreus ODC had a maximum affinity (Km) for l-ornithine, l-lysine and l-arginine (0.95, 1.34 and 1.4 mM) and catalytic efficiency (kcat/Km) (4.6, 2.83, 2.46 x 10-5 mM-1 s-1). Ornithine 182-193 ornithine decarboxylase 1 Homo sapiens 146-149 30634588-6 2019 Results: Our results showed that serum putrescine, directly generated from ornithine by the catalytic action of the biosynthetic enzyme ornithine decarboxylase, was significantly elevated in patients with T2D compared to those without T2D, and that it significantly correlated with the levels of glycosylated hemoglobin (HbA1c). Ornithine 75-84 ornithine decarboxylase 1 Homo sapiens 136-159 30021117-1 2018 Ornithine decarboxylase (ODC) converts C5 ornithine into C4 putrescine, a monomer for polyamide synthesis. Ornithine 42-51 ornithine decarboxylase 1 Homo sapiens 0-23 30021117-1 2018 Ornithine decarboxylase (ODC) converts C5 ornithine into C4 putrescine, a monomer for polyamide synthesis. Ornithine 42-51 ornithine decarboxylase 1 Homo sapiens 25-28 30021117-4 2018 Here, to increase ODC substrate specificity toward ornithine over lysine, molecular modelling and protein network analysis, specifically k-clique community analysis, around the substrate tunnel were performed. Ornithine 51-60 ornithine decarboxylase 1 Homo sapiens 18-21 29419804-1 2018 The fluorinated ornithine analog alpha-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. Ornithine 16-25 ornithine decarboxylase 1 Homo sapiens 133-156 29419804-1 2018 The fluorinated ornithine analog alpha-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. Ornithine 16-25 ornithine decarboxylase 1 Homo sapiens 158-161 29080161-5 2018 We describe the methodology employed for the determination of ODC and ADC activities in plant tissues by detecting the release of (C14) CO2 using (C14) labelled substrates (ornithine or arginine). Ornithine 173-182 ornithine decarboxylase 1 Homo sapiens 62-65 28587687-3 2017 In the traditional pathway for polyamine synthesis, arginase converts arginine into ornithine, which is decarboxylated by ornithine decarboxylase (ODC1) to generate putrescine. Ornithine 84-93 ornithine decarboxylase 1 Homo sapiens 122-145 28679527-1 2017 Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Ornithine 98-107 ornithine decarboxylase 1 Homo sapiens 133-156 28679527-1 2017 Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Ornithine 98-107 ornithine decarboxylase 1 Homo sapiens 158-161 28587687-3 2017 In the traditional pathway for polyamine synthesis, arginase converts arginine into ornithine, which is decarboxylated by ornithine decarboxylase (ODC1) to generate putrescine. Ornithine 84-93 ornithine decarboxylase 1 Homo sapiens 147-151 28587687-7 2017 Additionally, proline is oxidized by proline oxidase to yield pyrroline-5-carboxylate, which undergoes transamination with glutamate to produce ornithine for decarboxylation by ODC1. Ornithine 144-153 ornithine decarboxylase 1 Homo sapiens 177-181 26971935-8 2016 Ornithine decarboxylase (ODC), which decarboxylates ornithine to form putrescine was also reduced. Ornithine 52-61 ornithine decarboxylase 1 Homo sapiens 0-23 28270654-8 2017 An ornithine metabolism imbalance resulting from overexpression of Aurora Kinase A as a result of a single, recurrent heterozygous deletion on chromosome 19, common to all fibrolamellar carcinomas, can lead to a c-Myc and ornithine decarboxylase overexpression that results in ornithine transcarboxylase dysfunction with urea cycle disorder and subsequent hyperammonemia. Ornithine 3-12 ornithine decarboxylase 1 Homo sapiens 222-245 26971935-8 2016 Ornithine decarboxylase (ODC), which decarboxylates ornithine to form putrescine was also reduced. Ornithine 52-61 ornithine decarboxylase 1 Homo sapiens 25-28 26093026-1 2015 Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine. Ornithine 66-75 ornithine decarboxylase 1 Homo sapiens 91-94 23142579-3 2013 The hydrogel was synthesized by embedding the L-ornithine-degrading enzymes L-ornithine aminotransferase (OAT) and L-ornithine decarboxylase (ODC) into a polymer network. Ornithine 46-57 ornithine decarboxylase 1 Homo sapiens 115-140 25140796-1 2014 Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to putrescine and is the rate-limiting enzyme in the polyamine biosynthesis pathway. Ornithine 63-72 ornithine decarboxylase 1 Homo sapiens 0-23 25140796-1 2014 Ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine to putrescine and is the rate-limiting enzyme in the polyamine biosynthesis pathway. Ornithine 63-72 ornithine decarboxylase 1 Homo sapiens 25-28 23904095-12 2014 Not only do amino acids such as ASN and GLN stimulate ODC while inhibiting AZ synthesis, but also amino acids such as lysine, valine, and ornithine, which inhibit ODC activity, increase the synthesis of AZ. Ornithine 138-147 ornithine decarboxylase 1 Homo sapiens 163-166 24649071-3 2014 L-ornithine is a key amino acid in the urea cycle and is converted to putrescine by ornithine decarboxylase (ODC). Ornithine 0-11 ornithine decarboxylase 1 Homo sapiens 84-107 24649071-3 2014 L-ornithine is a key amino acid in the urea cycle and is converted to putrescine by ornithine decarboxylase (ODC). Ornithine 0-11 ornithine decarboxylase 1 Homo sapiens 109-112 23142579-3 2013 The hydrogel was synthesized by embedding the L-ornithine-degrading enzymes L-ornithine aminotransferase (OAT) and L-ornithine decarboxylase (ODC) into a polymer network. Ornithine 46-57 ornithine decarboxylase 1 Homo sapiens 142-145 19635796-1 2009 Ornithine decarboxylase (ODC) is the first enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescine. Ornithine 126-135 ornithine decarboxylase 1 Homo sapiens 0-23 23917584-6 2013 Based on the investigation of the polyamine metabolite pathway, these data establish that the downstream metabolites of ornithine are increased, potentially implicating ornithine decarboxylase activity in AD pathology. Ornithine 120-129 ornithine decarboxylase 1 Homo sapiens 169-192 22416259-2 2012 This Th2 cytokine induces Arg1 activity, which converts arginine into ornithine, and ornithine can be decarboxylated by ODC to produce putrescine, which is further converted into spermidine and spermine. Ornithine 85-94 ornithine decarboxylase 1 Homo sapiens 120-123 20831369-2 2011 Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to polyamines. Ornithine 58-67 ornithine decarboxylase 1 Homo sapiens 0-23 20831369-2 2011 Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to polyamines. Ornithine 58-67 ornithine decarboxylase 1 Homo sapiens 25-28 22033378-6 2012 L-Ornithine is substrate of ornithine decarboxylase (ODC) - one of the key enzymes of polyamine biosynthesis and a validated target for therapeutic intervention - producing putrescine, which in turn is converted to spermidine by condensing with an aminopropyl group from decarboxylated S-adenosylmethionine. Ornithine 0-11 ornithine decarboxylase 1 Homo sapiens 28-51 22033378-6 2012 L-Ornithine is substrate of ornithine decarboxylase (ODC) - one of the key enzymes of polyamine biosynthesis and a validated target for therapeutic intervention - producing putrescine, which in turn is converted to spermidine by condensing with an aminopropyl group from decarboxylated S-adenosylmethionine. Ornithine 0-11 ornithine decarboxylase 1 Homo sapiens 53-56 20512387-2 2011 The PAs are synthesized by a metabolic process which involves arginase (ARG), which catalyzes the enzymatic hydrolysis of L-arginine (L-Arg) to L-ornithine and urea, and ornithine decarboxylase (ODC), which catalyzes the enzymatic decarboxylation of L-ornithine in putrescine. Ornithine 250-261 ornithine decarboxylase 1 Homo sapiens 170-193 19635796-1 2009 Ornithine decarboxylase (ODC) is the first enzyme involved in polyamine biosynthesis, and it catalyzes the decarboxylation of ornithine to putrescine. Ornithine 126-135 ornithine decarboxylase 1 Homo sapiens 25-28 15901937-7 2005 Ornithine decarboxylase (ODC), which catalyzes the conversion of ornithine to putrescine, fulfilled these prerequisites. Ornithine 65-74 ornithine decarboxylase 1 Homo sapiens 0-23 17494634-4 2007 ODC mRNA expression was also increased by ornithine and polyamines, and gene silencing of ODC by siRNA decreased ornithine transport activity and its cytotoxicity. Ornithine 42-51 ornithine decarboxylase 1 Homo sapiens 0-3 17494634-4 2007 ODC mRNA expression was also increased by ornithine and polyamines, and gene silencing of ODC by siRNA decreased ornithine transport activity and its cytotoxicity. Ornithine 113-122 ornithine decarboxylase 1 Homo sapiens 90-93 17494634-5 2007 In addition, the mRNA of nuclear protein c-myc was also increased in 5-FMO- and ornithine-treated hTERT-RPE cells, and gene silencing of c-myc prevented the induction of CAT-1 and ODC. Ornithine 80-89 ornithine decarboxylase 1 Homo sapiens 180-183 16513374-5 2006 Proliferation of breast cancer cells was assessed from the activity of ornithine decarboxylase (ODC) using [(14)C] labeled ornithine. Ornithine 71-80 ornithine decarboxylase 1 Homo sapiens 96-99 16168128-2 2005 Ornithine decarboxylase converts ornithine to putrescine and is the rate-limiting step in polyamine synthesis.alpha-Difluoromethylornithine (DFMO) irreversibly inhibits ornithine decarboxylase and MDA-MB-435 human breast cancer metastasis to the lung without blocking orthotopic tumor growth. Ornithine 33-42 ornithine decarboxylase 1 Homo sapiens 0-23 16168128-2 2005 Ornithine decarboxylase converts ornithine to putrescine and is the rate-limiting step in polyamine synthesis.alpha-Difluoromethylornithine (DFMO) irreversibly inhibits ornithine decarboxylase and MDA-MB-435 human breast cancer metastasis to the lung without blocking orthotopic tumor growth. Ornithine 33-42 ornithine decarboxylase 1 Homo sapiens 169-192 19440939-6 2009 Cell ODC activities were assayed using 14CO2 generation from 14C-labeled L-ornithine. Ornithine 73-84 ornithine decarboxylase 1 Homo sapiens 5-8 19440939-8 2009 After cell lysis, ODC activity was determined using 14C-labeled L-ornithine. Ornithine 64-75 ornithine decarboxylase 1 Homo sapiens 18-21 19440939-9 2009 ODC activity was estimated by the 14CO2 generated from 14C-labeled L-ornithine, as generated d.p.m. Ornithine 67-78 ornithine decarboxylase 1 Homo sapiens 0-3 18330478-1 2008 Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis that decarboxylates ornithine to putrescine, has become a promising target for cancer research. Ornithine 102-111 ornithine decarboxylase 1 Homo sapiens 0-23 18330478-1 2008 Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis that decarboxylates ornithine to putrescine, has become a promising target for cancer research. Ornithine 102-111 ornithine decarboxylase 1 Homo sapiens 25-28 17575112-4 2007 Structural analysis of the crystal structure of human ODC disclosed an additional hydrophobic pocket surrounding the epsilon-amino group of its substrate ornithine. Ornithine 154-163 ornithine decarboxylase 1 Homo sapiens 54-57 15901937-7 2005 Ornithine decarboxylase (ODC), which catalyzes the conversion of ornithine to putrescine, fulfilled these prerequisites. Ornithine 65-74 ornithine decarboxylase 1 Homo sapiens 25-28 15190062-2 2004 The virus encodes a homolog of eukaryotic ornithine decarboxylase (ODC) that was previously demonstrated to be capable of decarboxylating l-ornithine. Ornithine 138-149 ornithine decarboxylase 1 Homo sapiens 42-65 15190062-2 2004 The virus encodes a homolog of eukaryotic ornithine decarboxylase (ODC) that was previously demonstrated to be capable of decarboxylating l-ornithine. Ornithine 138-149 ornithine decarboxylase 1 Homo sapiens 67-70 15190062-3 2004 However, the active site of this enzyme contains a key amino acid substitution (Glu for Asp) of a residue that interacts with the delta-amino group of ornithine analogs in the x-ray structures of ODC. Ornithine 151-160 ornithine decarboxylase 1 Homo sapiens 196-199 12859253-3 2003 Purified human ODC-catalysed ornithine decarboxylation is highly stereospecific. Ornithine 29-38 ornithine decarboxylase 1 Homo sapiens 15-18 12859253-10 2003 D-DFMO was a more potent inhibitor (IC50 approximately 7.5 microM) when compared with D-ornithine (IC50 approximately 1.5 mM) of ODC-catalysed L-ornithine decarboxylation. Ornithine 86-97 ornithine decarboxylase 1 Homo sapiens 129-132 12859253-10 2003 D-DFMO was a more potent inhibitor (IC50 approximately 7.5 microM) when compared with D-ornithine (IC50 approximately 1.5 mM) of ODC-catalysed L-ornithine decarboxylation. Ornithine 143-154 ornithine decarboxylase 1 Homo sapiens 129-132 10668504-14 1999 They are synthesised from putrescine, which is a key regulatory molecule formed from ornithine by ornithine decarboxylase, a highly inducible and regulated enzyme. Ornithine 85-94 ornithine decarboxylase 1 Homo sapiens 98-121 11736657-5 2001 Kinetic studies of ODC showed that N. glutinosa ODC decarboxylated both l-ornithine and l-lysine with K(m) values of 562 microM and 1592 microM at different optimal pH values of 8.0 and 6.8 respectively. Ornithine 72-83 ornithine decarboxylase 1 Homo sapiens 19-22 11736657-5 2001 Kinetic studies of ODC showed that N. glutinosa ODC decarboxylated both l-ornithine and l-lysine with K(m) values of 562 microM and 1592 microM at different optimal pH values of 8.0 and 6.8 respectively. Ornithine 72-83 ornithine decarboxylase 1 Homo sapiens 48-51 11259671-5 2001 The cytostatic action of the NO donor agents as well as alpha-difluoromethylornithine (DFMO), a known ODC inhibitor, was prevented by addition of putrescine but not ornithine. Ornithine 76-85 ornithine decarboxylase 1 Homo sapiens 102-105 10623504-2 2000 Ornithine decarboxylase (ODC, EC 4.1.1.17) performs the first step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine. Ornithine 117-126 ornithine decarboxylase 1 Homo sapiens 0-23 10623504-2 2000 Ornithine decarboxylase (ODC, EC 4.1.1.17) performs the first step in polyamine biosynthesis, the decarboxylation of ornithine to putrescine. Ornithine 117-126 ornithine decarboxylase 1 Homo sapiens 25-28 12774850-6 2003 In contrast, we identified polyamine biosynthesis as a cellular target of aspirin, since the treatment of HT-29 Glc(-/+) cells with aspirin reduced the flux of L-ornithine through ornithine decarboxylase, an effect that could not be explained by an acute action of the drug on the ornithine decarboxylase catalytic activity. Ornithine 160-171 ornithine decarboxylase 1 Homo sapiens 180-203 11222476-5 2001 TGF-beta(1) also stimulated L-ornithine catabolism by elevating ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT) activity. Ornithine 28-39 ornithine decarboxylase 1 Homo sapiens 64-87 11222476-5 2001 TGF-beta(1) also stimulated L-ornithine catabolism by elevating ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT) activity. Ornithine 28-39 ornithine decarboxylase 1 Homo sapiens 89-92 9719479-4 1998 L-ornithine, a substrate for ODC, retroinhibits arginase. Ornithine 0-11 ornithine decarboxylase 1 Homo sapiens 29-32 9686762-6 1998 Furthermore, thrombin stimulated L-ornithine metabolism by inducing ornithine decarboxylase (ODC) mRNA expression and activity. Ornithine 33-44 ornithine decarboxylase 1 Homo sapiens 68-91 9686762-6 1998 Furthermore, thrombin stimulated L-ornithine metabolism by inducing ornithine decarboxylase (ODC) mRNA expression and activity. Ornithine 33-44 ornithine decarboxylase 1 Homo sapiens 93-96 9719479-11 1998 The inhibitory effect of DFMO upon arginase, one step upstream of the ODC reaction in the metabolic conversion of L-arginine to polyamines, is of potential physiological importance, since it could alter the production of ornithine and thus its metabolism in pathways other than the ODC pathway. Ornithine 221-230 ornithine decarboxylase 1 Homo sapiens 70-73 9719479-11 1998 The inhibitory effect of DFMO upon arginase, one step upstream of the ODC reaction in the metabolic conversion of L-arginine to polyamines, is of potential physiological importance, since it could alter the production of ornithine and thus its metabolism in pathways other than the ODC pathway. Ornithine 221-230 ornithine decarboxylase 1 Homo sapiens 282-285 34560100-7 2021 We also note a correlation between the presence of ancestral ODC and ornithine/arginine auxotrophy, and link this with a known symbiotic dependence on exogenous ornithine produced by species using the arginine deiminase system. Ornithine 69-78 ornithine decarboxylase 1 Homo sapiens 61-64 7929646-1 1994 Polyamines are derived from ornithine by the actions of ornithine decarboxylase (ODC), which is the rate-limiting step in this pathway. Ornithine 28-37 ornithine decarboxylase 1 Homo sapiens 56-79 7929646-1 1994 Polyamines are derived from ornithine by the actions of ornithine decarboxylase (ODC), which is the rate-limiting step in this pathway. Ornithine 28-37 ornithine decarboxylase 1 Homo sapiens 81-84 2317797-7 1990 Enzyme kinetic data indicated that the multiple forms of ODC can have different affinities for L-ornithine and that GTP can "normalize" the aberrant kinetic properties of these forms. Ornithine 95-106 ornithine decarboxylase 1 Homo sapiens 57-60 34935905-6 2022 Given that ODC is highly expressed in the ovaries during ovulation but otherwise exhibits low activity in most tissues, we hypothesized that periovulatory supplementation of L-ornithine, the substrate of ODC, might be suitable for delivering putrescine specifically to the ovaries. Ornithine 174-185 ornithine decarboxylase 1 Homo sapiens 204-207 9480841-2 1998 Ornithine decarbolylase (ODC) catalyzes the first step of polyamine biosynthesis converting ornithine to putrescine. Ornithine 92-101 ornithine decarboxylase 1 Homo sapiens 0-23 9480841-2 1998 Ornithine decarbolylase (ODC) catalyzes the first step of polyamine biosynthesis converting ornithine to putrescine. Ornithine 92-101 ornithine decarboxylase 1 Homo sapiens 25-28 9468343-9 1998 After 4 days of treatment with 100 mM L-valine, L-ornithine flux through ornithine decarboxylase was significantly higher as well as putrescine and spermidine cellular uptakes in treated cells. Ornithine 48-59 ornithine decarboxylase 1 Homo sapiens 73-96 8462726-6 1993 Sulfhydryl compounds (dithiothreitol and glutathione) or quinone-reducing agents (ascorbic acid) prevented the inactivation of ODC; L-ornithine, but not other amino acids, also protected partially ODC. Ornithine 132-143 ornithine decarboxylase 1 Homo sapiens 127-130 8462726-6 1993 Sulfhydryl compounds (dithiothreitol and glutathione) or quinone-reducing agents (ascorbic acid) prevented the inactivation of ODC; L-ornithine, but not other amino acids, also protected partially ODC. Ornithine 132-143 ornithine decarboxylase 1 Homo sapiens 197-200 8462122-2 1993 The compounds competed with ornithine for the substrate binding site of ODC, but resulted in progressive and apparently irreversible inactivation of the enzyme. Ornithine 28-37 ornithine decarboxylase 1 Homo sapiens 72-75 34796899-4 2021 A previous crystal structure of an ODC-APA complex indicated that APA non-covalently binds ODC and its cofactor pyridoxal 5-phosphate (PLP) and functions by competing with the ODC substrate ornithine for binding to the catalytic site. Ornithine 190-199 ornithine decarboxylase 1 Homo sapiens 35-38 34796899-4 2021 A previous crystal structure of an ODC-APA complex indicated that APA non-covalently binds ODC and its cofactor pyridoxal 5-phosphate (PLP) and functions by competing with the ODC substrate ornithine for binding to the catalytic site. Ornithine 190-199 ornithine decarboxylase 1 Homo sapiens 91-94 34796899-4 2021 A previous crystal structure of an ODC-APA complex indicated that APA non-covalently binds ODC and its cofactor pyridoxal 5-phosphate (PLP) and functions by competing with the ODC substrate ornithine for binding to the catalytic site. Ornithine 190-199 ornithine decarboxylase 1 Homo sapiens 176-179 34560100-7 2021 We also note a correlation between the presence of ancestral ODC and ornithine/arginine auxotrophy, and link this with a known symbiotic dependence on exogenous ornithine produced by species using the arginine deiminase system. Ornithine 161-170 ornithine decarboxylase 1 Homo sapiens 61-64 34472307-1 2021 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthetic pathway of polyamines and catalyzes the decarboxylation of ornithine to produce putrescine. Ornithine 125-134 ornithine decarboxylase 1 Homo sapiens 0-23 34472307-1 2021 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthetic pathway of polyamines and catalyzes the decarboxylation of ornithine to produce putrescine. Ornithine 125-134 ornithine decarboxylase 1 Homo sapiens 25-28