PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17608728-1	2007	We have previously shown that the epidermal growth factor-receptor (EGFR) tyrosine kinase inhibitor PD153035 induces retinoic acid receptor-beta (RAR-beta) expression in malignant cells by mechanisms that are independent of its blocking activity on EGFR (ErbB1) or on any other ErbB receptor (ErbB2, ErbB3, ErbB4).	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	100-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	293-298	
15304097-6	2004	Inhibition of EGFR with PD153035 impairs the MbetaCD-induced phosphorylation of EGFR, HER2, and ERK, but does not impair the alteration of K14, K10, or involucrin gene expression, indicating that other signaling proteins regulate this phenomenon.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	24-32	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90	
9815602-1	1997	PD153035 is reported to be a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase and, to a lesser degree, of the closely related HER2/neu receptor.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	169-186	
11178955-2	2001	AG1478 and PD153035 (also know as AG1517) have been adopted as specific ErbB1 inhibitors based on their high specificity for ErbB1 as compared to ErbB2 in in vitro kinase assays.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	11-19	erb-b2 receptor tyrosine kinase 2	Homo sapiens	146-151	
10318765-10	1999	The EGF-induced increase in the erbB2 cluster size was inhibited by the EGFR-specific tyrosine kinase inhibitor PD153035.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	112-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-37	
9815602-4	1997	In contrast, PD153035 only reduced heregulin-dependent tyrosine phosphorylation in HER2/neu-overexpressing cell lines at significantly higher concentrations (1400-2800 nM).	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	13-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87	
9815602-8	1997	In colony-forming assays, the PD153035 growth-inhibitory activity in cultures driven by endogenous (autocrine) ligand was correlated with EGF receptor number, with higher activity in cells expressing higher numbers of EGF receptors and only minimal activity in cells expressing normal numbers of EGF receptors but high HER2/neu levels.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	30-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	319-323