PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19064630-6 2009 To better understand the mechanism by which PUVA treatment induces p53, we exposed human skin fibroblasts with PUVA under conditions that differentially produce monoadducts and ICLs and found that psoralen-induced ICLs induced phosphorylation of the Ser-15 site of p53 and apoptosis much more effectively than psoralen-induced monoadducts. Ficusin 310-318 tumor protein p53 Homo sapiens 67-70 16225614-0 2005 Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo. Ficusin 72-80 tumor protein p53 Homo sapiens 108-111 24845152-6 2014 These results suggest that psoralen induces apoptosis in cancer cells via mechanisms that involve caspase-3, p53, Bax, and Bcl-2 pathway. Ficusin 27-35 tumor protein p53 Homo sapiens 109-112 19064630-0 2009 Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner. Ficusin 0-8 tumor protein p53 Homo sapiens 76-79 19064630-6 2009 To better understand the mechanism by which PUVA treatment induces p53, we exposed human skin fibroblasts with PUVA under conditions that differentially produce monoadducts and ICLs and found that psoralen-induced ICLs induced phosphorylation of the Ser-15 site of p53 and apoptosis much more effectively than psoralen-induced monoadducts. Ficusin 197-205 tumor protein p53 Homo sapiens 67-70 19064630-6 2009 To better understand the mechanism by which PUVA treatment induces p53, we exposed human skin fibroblasts with PUVA under conditions that differentially produce monoadducts and ICLs and found that psoralen-induced ICLs induced phosphorylation of the Ser-15 site of p53 and apoptosis much more effectively than psoralen-induced monoadducts. Ficusin 197-205 tumor protein p53 Homo sapiens 265-268