PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35597499-15 2022 This strategy identified the toxic target, ABL1, and the potential toxic mechanism of psoralen. Ficusin 86-94 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 43-47 35597499-9 2022 Based on the above experimental results, ABL1 is a potential direct target of psoralen-induced hepatotoxicity. Ficusin 78-86 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 41-45 35597499-13 2022 In summary, we speculated that when psoralen causes hepatotoxicity, it acts on the direct target ABL1, resulting in a decrease in Nrf2 expression, an increase in ROS levels and a reduction in mTOR expression, which may cause cell death. Ficusin 36-44 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 97-101