PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25041941-5 2014 Intraperitoneal injection of vinpocetine (15 mg/kg) inhibited NF-kappaB nuclear translocation and reduced the expression and activation of NLRP3, caspase-1, IL-1beta, IL-18, and TNF-alpha in the RPE of adult rats that received intraocular Alphabeta, as measured by retinal immunohistochemistry and Western blot. vinpocetine 29-40 tumor necrosis factor Rattus norvegicus 178-187 24903676-0 2014 The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1beta and TNF-alpha expression in rat hippocampus. vinpocetine 23-34 tumor necrosis factor Rattus norvegicus 110-119 24903676-5 2014 Results show that vinpocetine and carbamazepine reduced the expression of IL-1beta and TNF-alpha from basal conditions, and the increase in both pro-inflammatory cytokines induced by LPS. vinpocetine 18-29 tumor necrosis factor Rattus norvegicus 87-96 24598438-9 2014 Vinpocetine decreased the levels of NF-kappaB and TNF-alpha 24h and 3 days after reperfusion. vinpocetine 0-11 tumor necrosis factor Rattus norvegicus 50-59 24598438-11 2014 Vinpocetine decreases the expression of NF-kappaB and TNF-alpha and inhibits the inflammatory response after cerebral ischemia-reperfusion. vinpocetine 0-11 tumor necrosis factor Rattus norvegicus 54-63 34415116-8 2021 Also, vinpocetine resulted in a significant increase in the levels of BDNF, synapsin-IIa, DCX, pCREB/CREB, IL-10, and GSH along with significant decrease in TNF-alpha, IL-6, TBARS, number of pyknotic and chromatolytic cells in different brain areas of pre-VPA group. vinpocetine 6-17 tumor necrosis factor Rattus norvegicus 157-166 35451422-7 2022 Also, vinpocetine administration significantly increased the levels of BDNF, ratio of pCREB/ CREB, IL-10, and GSH, and significantly decreased TNF-alpha, IL-6, and TBARS levels in different brain areas. vinpocetine 6-17 tumor necrosis factor Rattus norvegicus 143-152 34706318-7 2022 In addition, the combination of Vinpocetine with EGCG showed more pronounced anti-inflammatory (TNF-alpha, IL-1beta) and antioxidant (MDA, SOD, TAC) effects in comparison to other combinations. vinpocetine 32-43 tumor necrosis factor Rattus norvegicus 96-105 32840391-8 2021 Also, the anti-inflammatory effect of Vinpo was explored by decreasing IL-6 and TNF-alpha levels. vinpocetine 38-43 tumor necrosis factor Rattus norvegicus 80-89 33202281-0 2021 Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis. vinpocetine 0-11 tumor necrosis factor Rattus norvegicus 77-80 33202281-11 2021 CONCLUSION: Vinpo possesses potent ameliorative effects against AP by decreasing oxidative stress, inflammatory process, and apoptosis through regulation of the Sirt1/Nrf2/TNF-alpha pathway. vinpocetine 12-17 tumor necrosis factor Rattus norvegicus 172-181