PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25041941-5	2014	Intraperitoneal injection of vinpocetine (15 mg/kg) inhibited NF-kappaB nuclear translocation and reduced the expression and activation of NLRP3, caspase-1, IL-1beta, IL-18, and TNF-alpha in the RPE of adult rats that received intraocular Alphabeta, as measured by retinal immunohistochemistry and Western blot.	vinpocetine	29-40	tumor necrosis factor	Rattus norvegicus	178-187	
34415116-8	2021	Also, vinpocetine resulted in a significant increase in the levels of BDNF, synapsin-IIa, DCX, pCREB/CREB, IL-10, and GSH along with significant decrease in TNF-alpha, IL-6, TBARS, number of pyknotic and chromatolytic cells in different brain areas of pre-VPA group.	vinpocetine	6-17	tumor necrosis factor	Rattus norvegicus	157-166	
24903676-0	2014	The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1beta and TNF-alpha expression in rat hippocampus.	vinpocetine	23-34	tumor necrosis factor	Rattus norvegicus	110-119	
24903676-5	2014	Results show that vinpocetine and carbamazepine reduced the expression of IL-1beta and TNF-alpha from basal conditions, and the increase in both pro-inflammatory cytokines induced by LPS.	vinpocetine	18-29	tumor necrosis factor	Rattus norvegicus	87-96	
24598438-9	2014	Vinpocetine decreased the levels of NF-kappaB and TNF-alpha 24h and 3 days after reperfusion.	vinpocetine	0-11	tumor necrosis factor	Rattus norvegicus	50-59	
24598438-11	2014	Vinpocetine decreases the expression of NF-kappaB and TNF-alpha and inhibits the inflammatory response after cerebral ischemia-reperfusion.	vinpocetine	0-11	tumor necrosis factor	Rattus norvegicus	54-63	
35451422-7	2022	Also, vinpocetine administration significantly increased the levels of BDNF, ratio of pCREB/ CREB, IL-10, and GSH, and significantly decreased TNF-alpha, IL-6, and TBARS levels in different brain areas.	vinpocetine	6-17	tumor necrosis factor	Rattus norvegicus	143-152	
32840391-8	2021	Also, the anti-inflammatory effect of Vinpo was explored by decreasing IL-6 and TNF-alpha levels.	vinpocetine	38-43	tumor necrosis factor	Rattus norvegicus	80-89	
34706318-7	2022	In addition, the combination of Vinpocetine with EGCG showed more pronounced anti-inflammatory (TNF-alpha, IL-1beta) and antioxidant (MDA, SOD, TAC) effects in comparison to other combinations.	vinpocetine	32-43	tumor necrosis factor	Rattus norvegicus	96-105	
33202281-0	2021	Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis.	vinpocetine	0-11	tumor necrosis factor	Rattus norvegicus	77-80	
33202281-11	2021	CONCLUSION: Vinpo possesses potent ameliorative effects against AP by decreasing oxidative stress, inflammatory process, and apoptosis through regulation of the Sirt1/Nrf2/TNF-alpha pathway.	vinpocetine	12-17	tumor necrosis factor	Rattus norvegicus	172-181