PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11699936-0 2001 The nootropic drug vinpocetine inhibits veratridine-induced [Ca2+]i increase in rat hippocampal CA1 pyramidal cells. vinpocetine 19-30 carbonic anhydrase 2 Rattus norvegicus 61-64 11699936-3 2001 Since apoptotic and necrotic cell damage is always preceded by an increase in [Ca2+]i, this study investigated the effect of vinpocetine on [Ca2+]i increases in acute brain slices. vinpocetine 125-136 carbonic anhydrase 2 Rattus norvegicus 141-144 11699936-8 2001 Preperfusion and continuous administration of vinpocetine (10 microM) significantly inhibited the elevation in [Ca2+]i induced by veratridine (10 microM). vinpocetine 46-57 carbonic anhydrase 2 Rattus norvegicus 112-115 11699936-11 2001 We have concluded that vinpocetine, at a pharmacologically relevant concentration, can decrease pathologically high [Ca2+]i levels in individual rat hippocampal CA1 pyramidal neurons; this effect might contribute to the neuroprotective property of the drug. vinpocetine 23-34 carbonic anhydrase 2 Rattus norvegicus 117-120