PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7562397-7 1995 We demonstrate here that the oral administration of propentofylline, idebenone and trimethylquinone derivative, potent in vitro NGF synthesis stimulators, induced the increase in NGF protein and mRNA, and in choline acetyltransferase activity, in basal forebrain-lesioned and aged rats, but not in intact young rats. idebenone 69-78 choline O-acetyltransferase Rattus norvegicus 208-233 8058112-5 1994 We demonstrate here that the oral administration of idebenone, a potent in vitro nerve growth factors synthesis stimulator, induced an increase in nerve growth factor protein and mRNA, and in choline acetyltransferase activity, in basal forebrain lesioned rats, but not in intact rats. idebenone 52-61 choline O-acetyltransferase Rattus norvegicus 192-217 8058112-7 1994 These results suggest that idebenone stimulated nerve growth factor synthesis in vivo and ameliorates the behavioral deficits which were accompanied with the recovery of the reduced choline acetyltransferase activity in the basal forebrain-lesioned rats. idebenone 27-36 choline O-acetyltransferase Rattus norvegicus 182-207