PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30290222-0	2018	Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition.	idebenone	0-9	SHC adaptor protein 1	Homo sapiens	68-71	
33045613-0	2020	Novel idebenone analogs block Shc"s access to insulin receptor to improve insulin sensitivity.	idebenone	6-15	SHC adaptor protein 1	Homo sapiens	30-33	
30290222-8	2018	Multiple assays of target engagement demonstrate that idebenone physically interacts with Shc protein.	idebenone	54-63	SHC adaptor protein 1	Homo sapiens	90-93	
30290222-11	2018	Thus, idebenone is the first-in-class member of a novel category of insulin-sensitizing and cytoprotective agents, the Shc inhibitors.	idebenone	6-15	SHC adaptor protein 1	Homo sapiens	119-122	
30290222-6	2018	Of the 7 drugs, idebenone dose-dependently bound Shc protein in the 50-100 nM range, and induced insulin sensitivity and cytoprotection in this same 100 nM range that clinically dosed idebenone reaches in human plasma.	idebenone	16-25	SHC adaptor protein 1	Homo sapiens	49-52