PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32557012-0 2021 Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway. idebenone 0-9 superoxide dismutase 2, mitochondrial Mus musculus 106-110 32557012-13 2021 In particular, the expression of SIRT3, SOD2, and NLRP3 was significantly regulated in the idebenone treatment groups compared with the HFD group both in vivo and in vitro. idebenone 91-100 superoxide dismutase 2, mitochondrial Mus musculus 40-44 32557012-15 2021 CONCLUSIONS: We demonstrated that idebenone acted as a mitochondrial protective agent by inhibiting the activation of NLPR3 via the SIRT3-SOD2-mtROS pathway. idebenone 34-43 superoxide dismutase 2, mitochondrial Mus musculus 138-142