PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32350039-0	2020	Idebenone Has Distinct Effects on Mitochondrial Respiration in Cortical Astrocytes Compared to Cortical Neurons Due to Differential NQO1 Activity.	idebenone	0-9	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	132-136	
32350039-3	2020	NAD(P)H:quinone oxidoreductase 1 (NQO1) appears to be the main intracellular enzyme catalyzing idebenone reduction.	idebenone	95-104	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	0-32	
32350039-3	2020	NAD(P)H:quinone oxidoreductase 1 (NQO1) appears to be the main intracellular enzyme catalyzing idebenone reduction.	idebenone	95-104	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	34-38	
32350039-5	2020	Using primary rat cortical cells pooled from both sexes, we tested the hypotheses that the level of endogenous NQO1 activity limits the ability of neurons, but not astrocytes, to use idebenone as an electron donor to support mitochondrial respiration.	idebenone	183-192	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	111-115	
32350039-6	2020	We then tested the prediction that NQO1 induction by pharmacological activation of the transcription factor nuclear erythroid 2-related factor 2 (Nrf2) enables idebenone to bypass Complex I in cells with poor NQO1 expression.	idebenone	160-169	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	35-39	
32350039-8	2020	Importantly, idebenone supported mitochondrial oxygen consumption in the presence of a Complex I inhibitor in astrocytes but not neurons, and this ability was reversed by inhibiting NQO1.	idebenone	13-22	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	182-186	
32350039-11	2020	Carnosic acid-idebenone combination treatment promoted NQO1-dependent Complex I bypass activity in these cells.	idebenone	14-23	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	55-59	
32350039-12	2020	Thus, combination drug strategies targeting NQO1 may promote the repurposing of idebenone for additional disorders.SIGNIFICANCE STATEMENT Idebenone is used clinically to treat loss of visual acuity in Leber"s hereditary optic neuropathy.	idebenone	138-147	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	44-48	
32350039-16	2020	Our results suggest that idebenone behaves as an NQO1-dependent prodrug, raising the possibility that lack of neuronal NQO1 activity has contributed to the limited efficacy of idebenone in neurodegenerative disease treatment.	idebenone	25-34	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	49-53	
32350039-17	2020	Combination therapy with drugs able to safely induce NQO1 in neurons, as well as other brain cell types, may be able to unlock the neuroprotective therapeutic potential of idebenone or related quinones.	idebenone	172-181	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	53-57