PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16178776-1 2005 Steroid sulfatase (STS) is the only well characterized enzyme in human cells that is capable to desulfate estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) as a first step in the conversion of these precursors to active hormones. Estrone 125-128 steroid sulfatase Homo sapiens 0-17 21073915-2 2011 Estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase (STS), while estrone is inversely inactivated into estrone sulfate by estrogen sulfotransferase (EST). Estrone 0-7 steroid sulfatase Homo sapiens 73-90 21356310-4 2011 One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively. Estrone 119-122 steroid sulfatase Homo sapiens 41-58 21356310-4 2011 One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively. Estrone 102-109 steroid sulfatase Homo sapiens 41-58 21356310-4 2011 One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively. Estrone 119-121 steroid sulfatase Homo sapiens 41-58 17061037-1 2007 In the present study, we found that two hormone receptor-positive human breast cancer cell lines, ZR-75-1 and BT-474, naturally expressed steroid sulfatase (STS) protein and had catalytic activity to produce estrone from estrone sulfate (E1S) with a comparable level to those in human breast cancer tissues. Estrone 208-215 steroid sulfatase Homo sapiens 138-155 12659755-1 2003 A series of novel D-ring modified derivatives of estrone was synthesized and tested as inhibitors of steroid sulfatase (STS). Estrone 49-56 steroid sulfatase Homo sapiens 101-118 14623543-1 2003 Steroid sulfatase (STS) hydrolyzes inactive estrone sulfate (E1-S) to estrone (E1), while estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to estrogen sulfates. Estrone 44-51 steroid sulfatase Homo sapiens 0-17 12782580-1 2003 Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone. Estrone 149-156 steroid sulfatase Homo sapiens 114-131 11282280-1 2000 Steroid sulphatase (STS) catalyzes the conversion of oestrone sulphate (E1S) to oestrone (E1) and its action in breast tumours makes a major contribution to in situ oestrogen production in this tissue. Estrone 72-75 steroid sulfatase Homo sapiens 0-18 12413846-1 2002 Estrone sulfate (E1S) is an endogenous prodrug that delivers estrone and, subsequently, estradiol to the target cells following the hydrolysis by the enzyme estrone sulfatase which is active in various tissues including hormone dependent breast cancer cells. Estrone 61-68 steroid sulfatase Homo sapiens 157-174 11282280-1 2000 Steroid sulphatase (STS) catalyzes the conversion of oestrone sulphate (E1S) to oestrone (E1) and its action in breast tumours makes a major contribution to in situ oestrogen production in this tissue. Estrone 53-61 steroid sulfatase Homo sapiens 0-18 2212823-10 1990 These results suggest that estrone sulfate is hydrolyzed mainly by estrone sulfatase in the endometrium and myometrium surrounding leiomyoma nodes and the estrone formed may affect the growth of leiomyoma. Estrone 27-34 steroid sulfatase Homo sapiens 67-84 9920822-1 1999 We report the initial results of a series of molecular modelling studies to investigate the structural properties of non-steroidal inhibitors required for inhibitory activity against the enzyme estrone sulfatase (ES) [the enzyme responsible for the conversion of nonactive (sulfated) estrone to the active (nonsulfated) estrone]. Estrone 284-291 steroid sulfatase Homo sapiens 194-211 9044848-2 1997 The major source of estrogen in breast cancer cells may be the conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Estrone 77-84 steroid sulfatase Homo sapiens 118-135 7696150-2 1995 The high level of estrogen in these tumors is postulated to be due to in situ formation of estrogen, possibly through conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Estrone 132-139 steroid sulfatase Homo sapiens 173-190 10731640-3 2000 Estrone sulfate (E(1)-S) is the predominant estrogen of conjugated equiline estrogens, which is commonly used in hormone replacement therapy, but it should be hydrolyzed by steroid sulfatase (STS) to enter the cells of target tissues. Estrone 17-23 steroid sulfatase Homo sapiens 173-190 10215035-2 1999 The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Estrone 73-80 steroid sulfatase Homo sapiens 114-131 9654650-2 1998 The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Estrone 73-80 steroid sulfatase Homo sapiens 114-131 9009241-2 1996 Several lines of evidence indicate that the major source of estrogen in breast cancer cells may be from conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Estrone 118-125 steroid sulfatase Homo sapiens 159-176 8664170-1 1993 Estrone sulfatase is an important enzyme which catalyzes the production of estrone from estrone sulfate in a variety of human and animal tissues. Estrone 75-82 steroid sulfatase Homo sapiens 0-17 26666359-2 2016 The enzyme steroid sulfatase (STS) cleaves the sulfate group of DHEAS and E1S leading to biosynthesis of endogenous hormones such as testosterone and estrone. Estrone 74-77 steroid sulfatase Homo sapiens 11-28 28429243-2 2017 Two major reactions contribute to E1 plasma concentrations, aromatase (CYP19A1) catalyzed E1 synthesis from androstenedione and steroid sulfatase (STS) catalyzed hydrolysis of estrone conjugates (E1Cs). Estrone 176-183 steroid sulfatase Homo sapiens 128-145 26666359-2 2016 The enzyme steroid sulfatase (STS) cleaves the sulfate group of DHEAS and E1S leading to biosynthesis of endogenous hormones such as testosterone and estrone. Estrone 150-157 steroid sulfatase Homo sapiens 11-28 21859802-3 2012 One such enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone respectively. Estrone 53-60 steroid sulfatase Homo sapiens 17-34 24009850-1 2012 Steroid sulfatase (STS) is responsiblefor the conversion of estrone sulfate to estrone that can stimulate growth in endocrine-dependent tumors such as prostate cancer. Estrone 60-67 steroid sulfatase Homo sapiens 0-17 22542502-1 2012 Steroid sulfatase (STS) catalyzes the hydrolysis of steroid sulfates to estrones, the main source of estrogens in tumors. Estrone 72-80 steroid sulfatase Homo sapiens 0-17 25843211-1 2015 Estrogen sulfamate derivatives were the first irreversible active-site-directed inhibitors of steroid sulfatase (STS), an emerging drug target for endocrine therapy of hormone dependent diseases that catalyzes inter alia the hydrolysis of estrone sulfate to estrone. Estrone 239-246 steroid sulfatase Homo sapiens 94-111