PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9857074-1 1998 Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter. ikaros 38-44 granzyme B Homo sapiens 81-91 9857074-3 1998 Granzyme B gene transcription is induced in activated lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-1, and Ikaros binding sites have been shown to be essential in the control of granzyme B promoter activation. ikaros 150-156 granzyme B Homo sapiens 0-10 9857074-3 1998 Granzyme B gene transcription is induced in activated lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-1, and Ikaros binding sites have been shown to be essential in the control of granzyme B promoter activation. ikaros 150-156 granzyme B Homo sapiens 221-231 9857074-6 1998 Mutation of Ikaros or AP-1 binding sites in the context of the granzyme B promoter demonstrated that both sites participate in dexamethasone-mediated inhibition of the granzyme B promoter activity. ikaros 12-18 granzyme B Homo sapiens 63-73 9857074-6 1998 Mutation of Ikaros or AP-1 binding sites in the context of the granzyme B promoter demonstrated that both sites participate in dexamethasone-mediated inhibition of the granzyme B promoter activity. ikaros 12-18 granzyme B Homo sapiens 168-178 7624346-5 1995 Mutational analysis of the human granzyme B promoter reveals that the Ikaros binding site (-143 to -114) and the AP-1/CBF binding site (-103 to -77) are essential for the activation of transcription in phytohemagglutinin-activated peripheral blood lymphocytes, whereas mutation of the Ets binding site does not affect promoter activity in these cells. ikaros 70-76 granzyme B Homo sapiens 33-43