PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10908734-3	2000	U-69593 (a kappa-opioid agonist: >/=100 nM) significantly inhibited the nicotine-induced increase of tyrosine hydroxylase (TH, a rate-limiting enzyme in biosynthesis of catecholamine) enzyme activity and TH mRNA levels.	U 69593	0-7	tyrosine hydroxylase	Rattus norvegicus	104-124	
10908734-3	2000	U-69593 (a kappa-opioid agonist: >/=100 nM) significantly inhibited the nicotine-induced increase of tyrosine hydroxylase (TH, a rate-limiting enzyme in biosynthesis of catecholamine) enzyme activity and TH mRNA levels.	U 69593	0-7	tyrosine hydroxylase	Rattus norvegicus	126-128	
10908734-3	2000	U-69593 (a kappa-opioid agonist: >/=100 nM) significantly inhibited the nicotine-induced increase of tyrosine hydroxylase (TH, a rate-limiting enzyme in biosynthesis of catecholamine) enzyme activity and TH mRNA levels.	U 69593	0-7	tyrosine hydroxylase	Rattus norvegicus	207-209	
10908734-7	2000	Moreover, U-69593 (>/=100 nM) significantly inhibited the nicotine-induced increase of both the TH protein level and intracellular catecholamine levels.	U 69593	10-17	tyrosine hydroxylase	Rattus norvegicus	99-101