PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17785440-6	2007	In T cells, Pu.1 chromatin at the URE was open and the same transcription factor binding sites were occupied as in B cells.	Urea	34-37	Spi-1 proto-oncogene	Homo sapiens	12-16	
22343522-3	2012	In this study a significant group of the high-risk MDS patients, as well as MDS cell lines, displayed downregulation of PU.1 expression within CD34+ cells, which was associated with DNA methylation of the URE.	Urea	205-208	Spi-1 proto-oncogene	Homo sapiens	120-124	
27010793-5	2016	Repression of the PU.1 gene involves both DNA methylation at the URE and its histone H3 lysine-K9 methylation and deacetylation as well as the H3K27 methylation at additional DNA elements and the promoter.	Urea	65-68	Spi-1 proto-oncogene	Homo sapiens	18-22	
27010793-6	2016	The GATA-1-mediated inhibition of PU.1 gene transcription in human AML-EL mediated through the URE represents important mechanism that contributes to PU.1 downregulation and leukemogenesis that is sensitive to DNA demethylation therapy.	Urea	95-98	Spi-1 proto-oncogene	Homo sapiens	34-38	
27010793-6	2016	The GATA-1-mediated inhibition of PU.1 gene transcription in human AML-EL mediated through the URE represents important mechanism that contributes to PU.1 downregulation and leukemogenesis that is sensitive to DNA demethylation therapy.	Urea	95-98	Spi-1 proto-oncogene	Homo sapiens	150-154	
22231443-0	2012	Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer.	Urea	93-96	Spi-1 proto-oncogene	Homo sapiens	31-35	
22231443-0	2012	Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer.	Urea	93-96	Spi-1 proto-oncogene	Homo sapiens	87-92	
22343522-4	2012	AZA treatment in vitro significantly demethylated URE, leading to upregulation of PU.1 followed by derepression of its transcriptional targets and onset of myeloid differentiation.	Urea	50-53	Spi-1 proto-oncogene	Homo sapiens	82-86	
22343522-6	2012	Our data collectively support the importance of modifying the URE chromatin structure as a regulatory mechanism of AZA-mediated activation of PU.1 and induction of the myeloid program in MDS.	Urea	62-65	Spi-1 proto-oncogene	Homo sapiens	142-146	
19966852-5	2010	Here, we identified nuclear factor-kappaB (NF-kappaB) to activate PU.1 expression through a novel site within the URE.	Urea	114-117	Spi-1 proto-oncogene	Homo sapiens	66-70	
19890096-3	2010	Here, we sequenced the URE sequences of PU.1 in 120 AML patients.	Urea	23-26	Spi-1 proto-oncogene	Homo sapiens	40-44