PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12230409-1	2002	The major insecticide imidacloprid (IMI) is known to be metabolized by human cytochrome P450 3A4 with NADPH by imidazolidine hydroxylation and dehydrogenation to give 5-hydroxy-imidacloprid and the olefin, respectively, and by nitroimine reduction and cleavage to yield the nitrosoimine, guanidine, and urea derivatives.	Urea	303-307	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-96	
26360322-6	2016	Incubations of UR-144 and XLR-11 with recombinant CYP enzymes revealed that UR-144 and XLR-11 are extensively metabolized by CYP3A4 at the tetramethylcyclopropyl (TMCP) moiety, but also CYP1A2 and CYP2C19 showed activity.	Urea	15-17	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	125-131	
26360322-6	2016	Incubations of UR-144 and XLR-11 with recombinant CYP enzymes revealed that UR-144 and XLR-11 are extensively metabolized by CYP3A4 at the tetramethylcyclopropyl (TMCP) moiety, but also CYP1A2 and CYP2C19 showed activity.	Urea	76-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	125-131	
26360322-7	2016	Inhibition of CYP3A4 in HLM attenuated the metabolism of UR-144 and XLR-11, while inhibition of the other CYP enzymes in HLM had only minor effects.	Urea	57-59	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	14-20	
26360322-8	2016	Thus, CYP3A4 is the major contributor to the CYP mediated metabolism of UR-144 and XLR-11 with minor contributions from CYP1A2.	Urea	72-74	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	6-12	
16899515-5	2006	CYP3A4 activity increased by 27% postdialysis (P = 0.002 compared with predialysis) and was significantly inversely related to plasma blood urea nitrogen concentration (rs= -0.50, P = 0.012), but not to several middle molecules.	Urea	140-144	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6