PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34581498-0 2021 Design, Synthesis and Biological Evaluation of Urea-based ROCK2 inhibitors. Urea 47-51 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 58-63 34581498-1 2021 A series of urea-based ROCK2 inhibitors were design and synthesized. Urea 12-16 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 23-28 34581498-3 2021 The study results showed that the urea derivatives exhibited certain ROCK2 inhibitory activity. Urea 34-38 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 69-74 25882521-0 2015 Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor"s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations. Urea 34-38 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 45-49 25882521-0 2015 Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor"s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations. Urea 34-38 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 100-105 25882521-3 2015 Computational results suggested that substitution containing positive charge attached to the middle phenyl ring, or electropositive group in urea linker was favored for both activity and ROCK2/PKA selectivity. Urea 141-145 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 187-192