PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30718161-2	2019	Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators.	Urea	165-169	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	212-217	
28697302-0	2017	Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators.	Urea	83-87	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	99-104	
28697302-2	2017	Previously reported urea containing molecules as GIRK1/2 preferring activators have had significant pharmacokinetic (PK) liabilities.	Urea	20-24	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	49-54	
31953327-6	2020	Computational models predicted a GAT1508-binding site validated by experimental mutagenesis experiments, providing insights into how urea-based compounds engage distant GIRK1 residues required for channel activation.	Urea	133-137	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	169-174