PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28546106-3	2017	We improved the solubility of EPL in water by adding beta-CD derivatives.	Water	37-42	beta-carotene oxygenase 1	Mus musculus	53-60	
30704045-3	2019	Based on these considerations, the purpose of this work was to use the strategy of complexation with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) in order to obtain an aqueous preparation of DAS, which is characterized by a low water solubility (6.49 x 10-4 mg/mL).	Water	228-233	beta-carotene oxygenase 1	Mus musculus	137-144	
29803791-3	2018	In this study, an inclusion complex of MLT with 2-hydroxypropyl beta-cyclodextrin (HP-beta-CD) was prepared to improve the water solubility, and the osteogenic differentiation ability of the inclusion complex was investigated in MC3T3-E1 cells.	Water	123-128	beta-carotene oxygenase 1	Mus musculus	86-93	
29803791-5	2018	The water solubility of MLT increased linearly upon addition of HP-beta-CD because of the formation of the inclusion complex.	Water	4-9	beta-carotene oxygenase 1	Mus musculus	67-74	
26222744-4	2015	administration in mice as water-soluble silibinin-hydroxypropyl-beta-cyclodextrin (SLB-HP-beta-CD) lyophilized product.	Water	26-31	beta-carotene oxygenase 1	Mus musculus	90-97	
26845478-4	2016	The water-solubility of SV increased linearly upon the addition of both HP-beta-CD and RM-beta-CD, due to the formation of inclusion complexes.	Water	4-9	beta-carotene oxygenase 1	Mus musculus	75-82	
26845478-4	2016	The water-solubility of SV increased linearly upon the addition of both HP-beta-CD and RM-beta-CD, due to the formation of inclusion complexes.	Water	4-9	beta-carotene oxygenase 1	Mus musculus	90-97	
26845478-8	2016	Accordingly, it is concluded that the inclusion complexation of SV with RM-beta-CD is a potential formulation for bone regenerative therapy to improve water-solubility and osteodifferentiation efficiency.	Water	151-156	beta-carotene oxygenase 1	Mus musculus	75-82	
18955122-5	2009	The inclusion of dioclein in beta-CD increased the water solubility 44% compared to free dioclein.	Water	51-56	beta-carotene oxygenase 1	Mus musculus	29-36	
25662501-4	2015	The resulting C60(OH)10/HP-beta-CD nanoparticles were stable in water and showed no aggregation over a 1 month period.	Water	64-69	beta-carotene oxygenase 1	Mus musculus	27-34	
21596572-6	2011	However, in the case of preparing the inclusion complexes of CDs with ACA by a solid phase "high-speed vibration milling" technique, the average inclusion rates of the obtained water-soluble complexes were calculated as 88+-13% (beta-CD), 70+-1% (Mebeta-CD), and 63+-2% (HPbeta-CD), respectively, by (1)H NMR analysis.	Water	177-182	beta-carotene oxygenase 1	Mus musculus	229-236	
21108456-2	2011	Conjugating PG branches onto beta-CD not only increases its water solubility but also affects its host/guest properties deeply.	Water	60-65	beta-carotene oxygenase 1	Mus musculus	29-36	
23692366-11	2013	Together, our results suggest that beta-CD might represent an important tool for improvement of analgesic and anti-inflammatory profiles of (-)-linalool and other water-insoluble compounds, such as lipophilic monoterpenes or essential oils.	Water	163-168	beta-carotene oxygenase 1	Mus musculus	35-42	
18955122-10	2009	The mechanism underling the increase in bioavailability is probably a consequence of a protective effect of beta-CD against in vivo biodegradation by enzymes and possibly increased water solubility.	Water	181-186	beta-carotene oxygenase 1	Mus musculus	108-115	
17656054-1	2008	The composition comprising the highly water-soluble drug meglumine antimoniate (MA) and beta-cyclodextrin (beta-CD) was shown previously to enhance the absorption of Sb by oral route and render MA orally active in a murine model of cutaneous leishmaniasis.	Water	38-43	beta-carotene oxygenase 1	Mus musculus	107-114	
10596356-5	1999	Thus, the use of glu-beta-CD and glu-glu-beta-CD permitted the stable complexation of the drug in water.	Water	98-103	beta-carotene oxygenase 1	Mus musculus	21-28	
10596356-5	1999	Thus, the use of glu-beta-CD and glu-glu-beta-CD permitted the stable complexation of the drug in water.	Water	98-103	beta-carotene oxygenase 1	Mus musculus	41-48	
10596356-9	1999	Sugar-branched-beta-CD gave a water-soluble and stable complex for dexamethasone and changed the disposition of dexamethasone.	Water	30-35	beta-carotene oxygenase 1	Mus musculus	15-22