PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8283058-3 1994 EAU-susceptible B10.A mice treated with a mAb to IFN-gamma developed much more severe EAU than did the controls and had increased delayed hypersensitivity (DH) responses to IRBP. Water 0-3 retinol binding protein 3, interstitial Mus musculus 173-177 1283051-2 1992 EAU develops when the IRBP-reactive lymphocytes in the regional lymph-nodes are activated. Water 0-3 retinol binding protein 3, interstitial Mus musculus 22-26 1283051-4 1992 In EAU, ten peptide residues p1182-1191 of the IRBP amino acid sequence, were revealed to be sufficiently capable of lymphocyte activation for EAU, and it was also shown that amino acid positions 1182W (tryptophane), 1185G (glycine), 1186V (valine) and 1188P (proline) of IRBP play important roles as the epitopes or agretopes in developing EAU. Water 3-6 retinol binding protein 3, interstitial Mus musculus 47-51 1283051-4 1992 In EAU, ten peptide residues p1182-1191 of the IRBP amino acid sequence, were revealed to be sufficiently capable of lymphocyte activation for EAU, and it was also shown that amino acid positions 1182W (tryptophane), 1185G (glycine), 1186V (valine) and 1188P (proline) of IRBP play important roles as the epitopes or agretopes in developing EAU. Water 143-146 retinol binding protein 3, interstitial Mus musculus 47-51 34603297-8 2021 Adoptive transfer of activated IRBP-specific T cells from untreated EAU mice induced EAU, while EAU was significantly attenuated in mice that received IRBP-specific T cells from SBT-100 treated mice. Water 68-71 retinol binding protein 3, interstitial Mus musculus 31-35 34603297-8 2021 Adoptive transfer of activated IRBP-specific T cells from untreated EAU mice induced EAU, while EAU was significantly attenuated in mice that received IRBP-specific T cells from SBT-100 treated mice. Water 85-88 retinol binding protein 3, interstitial Mus musculus 31-35 34603297-8 2021 Adoptive transfer of activated IRBP-specific T cells from untreated EAU mice induced EAU, while EAU was significantly attenuated in mice that received IRBP-specific T cells from SBT-100 treated mice. Water 96-99 retinol binding protein 3, interstitial Mus musculus 151-155 35367248-3 2022 Herein, moderate-susceptible C57BL/6J mice were immunized with inter-photoreceptor retinoid binding protein (IRBP) 651-670 to develop EAU and were kept together for mating. Water 134-137 retinol binding protein 3, interstitial Mus musculus 63-107 35367248-3 2022 Herein, moderate-susceptible C57BL/6J mice were immunized with inter-photoreceptor retinoid binding protein (IRBP) 651-670 to develop EAU and were kept together for mating. Water 134-137 retinol binding protein 3, interstitial Mus musculus 109-113 3346541-4 1988 We report here the induction of EAU in the mouse, which has hitherto been considered a species refractory to EAU, with two retinal Ag, the retinal soluble Ag and the interphotoreceptor retinoid-binding protein. Water 32-35 retinol binding protein 3, interstitial Mus musculus 166-209 35346946-12 2022 CONCLUSIONS: Succinic acid could worsen EAU induced by IRBP in mice. Water 40-43 retinol binding protein 3, interstitial Mus musculus 55-59 30218573-3 2018 EAU was induced in B10.A mice by immunization with interphotoreceptor retinoid-binding protein (IRBP). Water 0-3 retinol binding protein 3, interstitial Mus musculus 51-94 32652562-3 2020 Using interphotoreceptor retinoid-binding protein (IRBP) peptide-induced EAU in mice, we found increased levels of Th17/Th1 cells in EAU retinae (mean 9.6 +- 4.2%) and in dLNs (mean 8.4 +- 3.9%; P = 0.01) relative to controls. Water 73-76 retinol binding protein 3, interstitial Mus musculus 6-49 32652562-3 2020 Using interphotoreceptor retinoid-binding protein (IRBP) peptide-induced EAU in mice, we found increased levels of Th17/Th1 cells in EAU retinae (mean 9.6 +- 4.2%) and in dLNs (mean 8.4 +- 3.9%; P = 0.01) relative to controls. Water 73-76 retinol binding protein 3, interstitial Mus musculus 51-55 32044663-3 2020 METHODS: EAU was induced in B10R.III mice by immunization with IRBP 161-180, followed by 100 mg/kg/d BBR intragastric administration. Water 9-12 retinol binding protein 3, interstitial Mus musculus 63-67 32044663-16 2020 CONCLUSIONS: BBR inhibited IRBP induced EAU, which was associated with a significant change in the spleen transcriptome and intestinal microbial composition. Water 40-43 retinol binding protein 3, interstitial Mus musculus 27-31 32362310-5 2019 EAU was induced in mouse strain C57BL/6J by interphotoreceptor retinoid- binding protein in complete Freund"s adjuvant and pertussis toxin. Water 0-3 retinol binding protein 3, interstitial Mus musculus 44-88 30218573-3 2018 EAU was induced in B10.A mice by immunization with interphotoreceptor retinoid-binding protein (IRBP). Water 0-3 retinol binding protein 3, interstitial Mus musculus 96-100 30636608-2 2018 Here we compared the differences in morphology, pathology, visual function of the retinal inflammation and Th1/Th17 immune responses in the EAU models induced by the interphotoreceptor retinoid binding protein (IRBP) between the B10.RIII and C57BL/6 strains, using fundus and histological examinations, optical coherence tomography, electroretinography and immunoassays. Water 140-143 retinol binding protein 3, interstitial Mus musculus 166-209 30636608-2 2018 Here we compared the differences in morphology, pathology, visual function of the retinal inflammation and Th1/Th17 immune responses in the EAU models induced by the interphotoreceptor retinoid binding protein (IRBP) between the B10.RIII and C57BL/6 strains, using fundus and histological examinations, optical coherence tomography, electroretinography and immunoassays. Water 140-143 retinol binding protein 3, interstitial Mus musculus 211-215 30636608-6 2018 These data demonstrate distinguishing features of retinal inflammation and T-cell immune responses involved in IRBP-induced EAU between B10.RIII and C57BL/6 strains. Water 124-127 retinol binding protein 3, interstitial Mus musculus 111-115 28267649-2 2017 METHODS: EAU was induced in female B10.RIII mice by Inter-Photoreceptor-Binding-Protein (IRBP) in complete Freund"s adjuvant, boosted by Pertussis toxin. Water 9-12 retinol binding protein 3, interstitial Mus musculus 89-93 27041283-4 2016 METHODS: EAU was induced in C57BL/6 mice by subcutaneous application of IRBP (interphotoreceptor retinoid binding protein) in complete Freunds adjuvant and intraperitoneal application of pertussis toxin. Water 9-12 retinol binding protein 3, interstitial Mus musculus 72-76 27041283-4 2016 METHODS: EAU was induced in C57BL/6 mice by subcutaneous application of IRBP (interphotoreceptor retinoid binding protein) in complete Freunds adjuvant and intraperitoneal application of pertussis toxin. Water 9-12 retinol binding protein 3, interstitial Mus musculus 78-121 26152845-3 2015 Recombinant murine subunits of the RBP-3 protein were purified and used to immunize C57BL/6J mice to induce EAU. Water 108-111 retinol binding protein 3, interstitial Mus musculus 35-40 26400205-3 2016 Three weeks after vector delivery, EAU was induced with a subcutaneous injection of a mixture of interphotoreceptor retinoid binding protein (IRBP) peptide with CFA. Water 35-38 retinol binding protein 3, interstitial Mus musculus 97-140 26400205-3 2016 Three weeks after vector delivery, EAU was induced with a subcutaneous injection of a mixture of interphotoreceptor retinoid binding protein (IRBP) peptide with CFA. Water 35-38 retinol binding protein 3, interstitial Mus musculus 142-146 25716996-5 2015 Tregs isolated from eyes of mice with EAU efficiently suppressed IRBP-specific responses of Teffs from the same eyes. Water 38-41 retinol binding protein 3, interstitial Mus musculus 65-69 24374967-4 2014 Administration of HMGB1 antagonists inhibited severity of EAU significantly via mechanisms that include inhibition of IRBP-specific T cell proliferation and their IFN-gamma and IL-17 production. Water 58-61 retinol binding protein 3, interstitial Mus musculus 118-122 25692550-2 2015 EAU was induced in P2Y2+/+ and P2Y2-/- mice by immunization with IRBP peptide or by adoptive transfer of in vitro restimulated semi-purified IRBP-specific enriched T lymphocytes from spleens and lymph nodes isolated from native C57Bl/6 or P2Y2+/+ and P2Y2-/- immunized mice. Water 0-3 retinol binding protein 3, interstitial Mus musculus 65-69 25692550-2 2015 EAU was induced in P2Y2+/+ and P2Y2-/- mice by immunization with IRBP peptide or by adoptive transfer of in vitro restimulated semi-purified IRBP-specific enriched T lymphocytes from spleens and lymph nodes isolated from native C57Bl/6 or P2Y2+/+ and P2Y2-/- immunized mice. Water 0-3 retinol binding protein 3, interstitial Mus musculus 141-145 23674757-8 2013 CD4(+) lymph node cells from IRBP-immunized WT mice transferred EAU to naive wild-type (WT) and miR-155(-/-) mice, while miR-155(-/-) IRBP-specific T cells did not. Water 64-67 retinol binding protein 3, interstitial Mus musculus 29-33 24586644-7 2014 Notch inhibition in mice immunized with IRBP with a gamma-secretase inhibitor (GSI) suppressed EAU progression, even when GSI was administered as late as 13 days after IRBP immunization. Water 95-98 retinol binding protein 3, interstitial Mus musculus 40-44 24150760-5 2013 METHODS: EAU was induced in B10.A mice by immunization with interphotoreceptor retinoid-binding protein (IRBP; 40 mug) in CFA. Water 9-12 retinol binding protein 3, interstitial Mus musculus 60-103 24150760-5 2013 METHODS: EAU was induced in B10.A mice by immunization with interphotoreceptor retinoid-binding protein (IRBP; 40 mug) in CFA. Water 9-12 retinol binding protein 3, interstitial Mus musculus 105-109 23119059-3 2012 METHODS: EAU was induced in B10RIII mice by immunization with interphotoreceptor retinoid-binding protein peptide 161-180 (IRBP(161-180)). Water 9-12 retinol binding protein 3, interstitial Mus musculus 123-127 18838247-2 2008 EAU is induced in B10.RIII mice by immunization with RBP-3 161-180 peptide and intraperitoneal pertussis toxin and is mediated by CD4(+) T cells that generate a clinically monophasic disease peaking approximately 2 weeks post-immunization. Water 0-3 retinol binding protein 3, interstitial Mus musculus 53-58 21850155-3 2011 METHODS: EAU was induced in 18 B10RIII mice with 25 microg of inter-photoreceptor retinoid-binding protein (IRBP) emulsified with complete Freund"s adjuvant (CFA); 18 mice treated with CFA without IRBP served as controls. Water 9-12 retinol binding protein 3, interstitial Mus musculus 62-106 21850155-3 2011 METHODS: EAU was induced in 18 B10RIII mice with 25 microg of inter-photoreceptor retinoid-binding protein (IRBP) emulsified with complete Freund"s adjuvant (CFA); 18 mice treated with CFA without IRBP served as controls. Water 9-12 retinol binding protein 3, interstitial Mus musculus 108-112 21850155-3 2011 METHODS: EAU was induced in 18 B10RIII mice with 25 microg of inter-photoreceptor retinoid-binding protein (IRBP) emulsified with complete Freund"s adjuvant (CFA); 18 mice treated with CFA without IRBP served as controls. Water 9-12 retinol binding protein 3, interstitial Mus musculus 197-201 19696173-2 2010 METHODS: EAU was induced in B10RIII mice by immunization with IRBP(161-180) in complete Freund"s adjuvant and evaluated clinically and pathologically on days 0, 7, 14, 21, and 28. Water 9-12 retinol binding protein 3, interstitial Mus musculus 62-66 19696173-11 2010 Transfer of CD4(+)CD25(+) Treg cells obtained from EAU mice was able to suppress EAU induction by IRBP(161-180) that was not observed after transfer of cells from mice that had received CFA alone, suggesting antigen specificity of the Treg response. Water 51-54 retinol binding protein 3, interstitial Mus musculus 98-102 20128648-2 2010 METHODS: B10RIII mice were immunized with 50 microg IRBP(161-180) in complete Freund"s adjuvant (CFA) to induce EAU. Water 112-115 retinol binding protein 3, interstitial Mus musculus 52-56 20057909-3 2009 METHODS: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund"s adjuvant (CFA) and evaluated by clinical and histopathologic observation. Water 9-12 retinol binding protein 3, interstitial Mus musculus 116-120 20057909-7 2009 RESULTS: Results showed that EAU was successfully induced by IRBP161-180. Water 29-32 retinol binding protein 3, interstitial Mus musculus 61-65 22219644-2 2011 METHODS: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund"s adjuvant and evaluated with clinical and histopathologic observation. Water 9-12 retinol binding protein 3, interstitial Mus musculus 71-114 22219644-2 2011 METHODS: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund"s adjuvant and evaluated with clinical and histopathologic observation. Water 9-12 retinol binding protein 3, interstitial Mus musculus 116-120 20739617-4 2010 Nevertheless, IRBP-specific T cells pre-exposed to PD-L1(hi) RPE cells displayed substantial suppressor activity, which strongly inhibited the activation of fresh IRBP-Teffs in response to subsequent antigenic challenge and when transferred into naive mice, inhibited the induction of EAU by IRBP-Teff transfer. Water 285-288 retinol binding protein 3, interstitial Mus musculus 14-18 20057909-3 2009 METHODS: EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund"s adjuvant (CFA) and evaluated by clinical and histopathologic observation. Water 9-12 retinol binding protein 3, interstitial Mus musculus 71-114 18757507-4 2008 METHODS: EAU was induced in B10.RIII mice by immunization with the peptide RBP-3(161-180). Water 9-12 retinol binding protein 3, interstitial Mus musculus 75-80 18629448-2 2008 EAU can be induced in mice by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP) in complete Freund"s adjuvant (CFA) or by IRBP-pulsed mature dendritic cells, and can be driven either by a Th17 or a Th1 effector response, depending on the model. Water 0-3 retinol binding protein 3, interstitial Mus musculus 113-117 18629448-2 2008 EAU can be induced in mice by immunization with the retinal antigen interphotoreceptor retinoid binding protein (IRBP) in complete Freund"s adjuvant (CFA) or by IRBP-pulsed mature dendritic cells, and can be driven either by a Th17 or a Th1 effector response, depending on the model. Water 0-3 retinol binding protein 3, interstitial Mus musculus 161-165 17525198-2 2007 METHODS: EAU was induced in C57BL/6 (B6) mice by transfer of activated T cells specific for the interphotoreceptor-binding protein (IRBP) 1-20 peptide. Water 9-12 retinol binding protein 3, interstitial Mus musculus 96-130 17911600-5 2007 Vaccinated mice were highly protected from EAU induced by immunization with IRBP for at least 10 wk after vaccination. Water 43-46 retinol binding protein 3, interstitial Mus musculus 76-80 17525198-2 2007 METHODS: EAU was induced in C57BL/6 (B6) mice by transfer of activated T cells specific for the interphotoreceptor-binding protein (IRBP) 1-20 peptide. Water 9-12 retinol binding protein 3, interstitial Mus musculus 132-136 16943228-7 2007 CONCLUSION: These findings show that natural CD4+CD25+ regulatory T cells possess the ability to inhibit activation of IRBP-reactive T cells that have been already sensitised in vivo, and adoptive transfer of these cells ameliorates EAU even in the effector phase. Water 233-236 retinol binding protein 3, interstitial Mus musculus 119-123 17593005-12 2007 The splenocytes isolated from EAU- and GSNO-treated mice had lower antigen-specific T-cell proliferation in response to IRBP protein, and their cytokine production was inhibited. Water 30-33 retinol binding protein 3, interstitial Mus musculus 120-124 16741709-3 2007 Here, we show that early LPS-activated bone marrow derived DC (early DC, eDC), when administered subcutaneously to mice in vivo, promote tolerance to EAU induced via immunisation with interphotoreceptor retinol binding protein (IRBP) peptide 161-180. Water 150-153 retinol binding protein 3, interstitial Mus musculus 184-226 15804764-3 2005 METHODS: EAU was induced in B10.RIII mice by immunization with interphotoreceptor retinoid-binding protein (IRBP) using routine methods, but without treatment with pertussis toxin (PTX). Water 9-12 retinol binding protein 3, interstitial Mus musculus 63-106 17003437-4 2006 METHODS: EAU was induced in OPN-null and wild-type (WT) mice by immunization with interphotoreceptor retinoid-binding protein (IRBP). Water 9-12 retinol binding protein 3, interstitial Mus musculus 82-125 17003437-4 2006 METHODS: EAU was induced in OPN-null and wild-type (WT) mice by immunization with interphotoreceptor retinoid-binding protein (IRBP). Water 9-12 retinol binding protein 3, interstitial Mus musculus 127-131 16751983-12 2006 Susceptibility to EAU is related to the intrinsic capacity to mount higher inflammatory reactions and increased production of anti-IRBP IgG2a isotype is not necessarily a marker of this immunologic profile. Water 18-21 retinol binding protein 3, interstitial Mus musculus 131-135 16186359-3 2005 In CCR5-deficient mice, we examined the role of CCR5 in the development of EAU induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) peptide. Water 75-78 retinol binding protein 3, interstitial Mus musculus 108-151 16186359-3 2005 In CCR5-deficient mice, we examined the role of CCR5 in the development of EAU induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) peptide. Water 75-78 retinol binding protein 3, interstitial Mus musculus 153-157 15972638-2 2005 EAU-susceptible B10.RIII mice immunized with the retinal autoantigen interphotoreceptor retinoid binding protein in CFA and treated with anti-CD40L Ab (MR1) had reduced incidence and severity of disease. Water 0-3 retinol binding protein 3, interstitial Mus musculus 69-112 15914623-4 2005 METHODS: EAU was induced either by immunizing B10.RIII mice with the 161-180 peptide or by adoptive transfer of interphotoreceptor retinoid-binding protein (IRBP)-specific uveitogenic T cells. Water 9-12 retinol binding protein 3, interstitial Mus musculus 112-155 15914623-4 2005 METHODS: EAU was induced either by immunizing B10.RIII mice with the 161-180 peptide or by adoptive transfer of interphotoreceptor retinoid-binding protein (IRBP)-specific uveitogenic T cells. Water 9-12 retinol binding protein 3, interstitial Mus musculus 157-161 15804764-3 2005 METHODS: EAU was induced in B10.RIII mice by immunization with interphotoreceptor retinoid-binding protein (IRBP) using routine methods, but without treatment with pertussis toxin (PTX). Water 9-12 retinol binding protein 3, interstitial Mus musculus 108-112 10930316-2 2000 We have previously shown that IFN-gamma-deficient mice (GKO) on the C57BL/6 background are equally susceptible to interphotoreceptor retinoid binding protein (IRBP)-induced EAU as the wild type (WT). Water 173-176 retinol binding protein 3, interstitial Mus musculus 114-157 14599843-8 2003 Primed T cells of IRBP-/- mice transferred an exacerbated form of EAU to nai;ve wild type recipients. Water 66-69 retinol binding protein 3, interstitial Mus musculus 18-22 12593862-3 2003 EAU was induced in B10.A mice with IRBP immunization and the eyes were enucleated for histological examination on days 0, 3, 7, 15, and 21 after immunization. Water 0-3 retinol binding protein 3, interstitial Mus musculus 35-39 12605265-3 2003 METHODS: B10.A mice were immunized with 50 micro g of interphotoreceptor retinoid binding protein (IRBP) emulsified in complete Freund"s adjuvant in order to induce EAU. Water 165-168 retinol binding protein 3, interstitial Mus musculus 54-97 12605265-3 2003 METHODS: B10.A mice were immunized with 50 micro g of interphotoreceptor retinoid binding protein (IRBP) emulsified in complete Freund"s adjuvant in order to induce EAU. Water 165-168 retinol binding protein 3, interstitial Mus musculus 99-103 10930316-2 2000 We have previously shown that IFN-gamma-deficient mice (GKO) on the C57BL/6 background are equally susceptible to interphotoreceptor retinoid binding protein (IRBP)-induced EAU as the wild type (WT). Water 173-176 retinol binding protein 3, interstitial Mus musculus 159-163 9785606-3 1998 Development of EAU induced by the interphotoreceptor retinoid binding protein (IRBP) was abolished almost completely by either TBI or Cy treatment, followed by SBMT, instituted one week after priming. Water 15-18 retinol binding protein 3, interstitial Mus musculus 34-77 10549650-8 1999 The propensity of B10.RIII mice to mount a more polarized Th1 response to IRBP than other strains may contribute to their ability to develop EAU without pertussis adjuvant. Water 141-144 retinol binding protein 3, interstitial Mus musculus 74-78 10502060-4 1999 In vivo, IRBP-immunized mice were treated with a high dose of the antibody, and the EAU induction was examined both clinically and pathologically. Water 84-87 retinol binding protein 3, interstitial Mus musculus 9-13 10072507-10 1999 Interestingly, pregnant mice that received an infusion of IRBP-primed lymphoid cells from nonpregnant donors also developed reduced EAU, suggesting that pregnancy suppresses not only the generation, but also the function of mature uveitogenic effector T cells. Water 132-135 retinol binding protein 3, interstitial Mus musculus 58-62 9785606-3 1998 Development of EAU induced by the interphotoreceptor retinoid binding protein (IRBP) was abolished almost completely by either TBI or Cy treatment, followed by SBMT, instituted one week after priming. Water 15-18 retinol binding protein 3, interstitial Mus musculus 79-83 9396229-7 1997 The proliferation response of lymph node cells from TGF-beta 1 injected mice with IRBP-induced EAU was suppressed compared with phosphate buffered saline (PBS)-injected mice. Water 95-98 retinol binding protein 3, interstitial Mus musculus 82-86 9647215-4 1998 IL-12 p40-deficient mice (12KO) were resistant to EAU induced with the uveitogenic retinal Ag interphotoreceptor retinoid binding protein (IRBP). Water 50-53 retinol binding protein 3, interstitial Mus musculus 94-137 9647215-4 1998 IL-12 p40-deficient mice (12KO) were resistant to EAU induced with the uveitogenic retinal Ag interphotoreceptor retinoid binding protein (IRBP). Water 50-53 retinol binding protein 3, interstitial Mus musculus 139-143 9486417-6 1998 We report here that all the peptides are immunogenic but only one peptide, K2, which consisted of IRBP201-216 residues, induces EAU in various mice carrying H-2Ak. Water 128-131 retinol binding protein 3, interstitial Mus musculus 98-102 9129978-15 1997 We conclude that the presence of the B27 gene is associated with a decreased incidence and slower rate of onset of EAU following immunization with IRBP; however, EAU may be more severe in the HLA-B27 expressing animals who do develop disease. Water 115-118 retinol binding protein 3, interstitial Mus musculus 147-151 8918692-2 1996 EAU is induced by immunization of B10.A mice with interphotoreceptor retinoid-binding protein (IRBP). Water 0-3 retinol binding protein 3, interstitial Mus musculus 50-93 8918692-2 1996 EAU is induced by immunization of B10.A mice with interphotoreceptor retinoid-binding protein (IRBP). Water 0-3 retinol binding protein 3, interstitial Mus musculus 95-99 8918692-3 1996 Pre-treatment with synthetic peptide 518-529 derived from IRBP prevented IRBP-mediated EAU. Water 87-90 retinol binding protein 3, interstitial Mus musculus 58-62 8918692-3 1996 Pre-treatment with synthetic peptide 518-529 derived from IRBP prevented IRBP-mediated EAU. Water 87-90 retinol binding protein 3, interstitial Mus musculus 73-77