PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2548610-4 1989 When both IHP and BZF are added to the mixed-spin derivatives (H2O, SCN-, OCN-, and NO2-) of human methemoglobin, the spin equilibrium is shifted toward higher spin by about 700 cal/mol, similar to the spin change detected in derivatives of carp methemoglobin upon addition of IHP alone. Water 63-66 hemoglobin subunit gamma 2 Homo sapiens 99-112 2507476-2 1989 Researchers have suggested that the increased longitudinal relaxation rates (1/T1) of solvent water protons often found in melanoma result either from the paramagnetism of stable free radicals occurring in melanin or from that of methemoglobin in nonacute hemorrhagic regions of the tumor. Water 94-99 hemoglobin subunit gamma 2 Homo sapiens 230-243 35105914-8 2022 Our system, based on the paramagnetic behavior that deoxyhemoglobin or methemoglobin containing RBCs experience when suspended in water after applying a magnetic field, uses a combination of magnets and microfluidics and has the ability to track the movement of thousands of red cells in a short period of time. Water 130-135 hemoglobin subunit gamma 2 Homo sapiens 71-84 2544230-5 1989 Our results and most of the findings of earlier studies on the spin-state transitions of aquomethemoglobin, using susceptibility, optical, or EPR measurements, can be explained by the transition of methemoglobin with H2O as ligand (with high-spin state at all temperatures) and methemoglobin with ligand N epsilon of His E7 (with a low-spin ground state). Water 217-220 hemoglobin subunit gamma 2 Homo sapiens 93-106 2544230-5 1989 Our results and most of the findings of earlier studies on the spin-state transitions of aquomethemoglobin, using susceptibility, optical, or EPR measurements, can be explained by the transition of methemoglobin with H2O as ligand (with high-spin state at all temperatures) and methemoglobin with ligand N epsilon of His E7 (with a low-spin ground state). Water 217-220 hemoglobin subunit gamma 2 Homo sapiens 198-211 16881-1 1977 The hemoglobin oxidation Bohr effect is larger than the ligation Bohr effect, even when the former is corrected for any ionization of the water molecule bound to the ferric iron of methemoglobin. Water 138-143 hemoglobin subunit gamma 2 Homo sapiens 181-194 3607227-4 1987 We then investigate the field strength dependence of the acid-alkaline transition, i.e., the hydrolysis reaction of the water coordinated to the heme iron, in metmyoglobin and methemoglobin. Water 120-125 hemoglobin subunit gamma 2 Homo sapiens 176-189 7225516-0 1981 NMR relaxation of protein and water protons in methemoglobin solutions. Water 30-35 hemoglobin subunit gamma 2 Homo sapiens 47-60 7225447-1 1981 Reduction of frozen water-glycerol solutions of methemoglobin by thermolysed electrons at 77 degrees K has been studied by Mossbauer spectroscopy. Water 20-25 hemoglobin subunit gamma 2 Homo sapiens 48-61 30099420-7 2018 RESULTS: Results: When studying the content of methemoglobin among adult population in village areas, where well water with a high concentration of nitrates is consumed and in the city where centralized water supply is used, it was observed that rural people have a higher level of methemoglobin. Water 113-118 hemoglobin subunit gamma 2 Homo sapiens 47-60 139771-0 1977 The active center of methemoglobin Hb(H2O) investigated by Mossbauer and susceptibility experiments. Water 38-41 hemoglobin subunit gamma 2 Homo sapiens 21-34 1392-2 1976 The pH dependence of the p-hydroxymercuribenzoate-induced difference spectrum can be accounted for quantitatively by a 5% shift toward higher spin of the aquo form of methemoglobin, a 15% shift toward higher spin of the hydroxide form, and a shift in the apparent pKa for the water to hydroxide transition from 7.92 to 8.04 when mercurial is bound. Water 276-281 hemoglobin subunit gamma 2 Homo sapiens 167-180 13747444-0 1960 [Studies on the stoichiometry and structure of water- or alcohol compounds of protoporphyrin, hemin and methemoglobin]. Water 47-52 hemoglobin subunit gamma 2 Homo sapiens 104-117 5857138-0 1965 [Changes in the methemoglobin concentration in cadaveric blood with special reference to poisoning with spring water]. Water 111-116 hemoglobin subunit gamma 2 Homo sapiens 16-29 14001827-0 1962 Conversion of oxy- to methemoglobin by impurities in distilled water. Water 63-68 hemoglobin subunit gamma 2 Homo sapiens 22-35 20701008-9 2010 CONCLUSIONS: We established a direct correlation between the level of methemoglobin and the nitrate concentrations in water samples. Water 118-123 hemoglobin subunit gamma 2 Homo sapiens 70-83 26285144-4 2016 RESULTS: Fitting of the model to the data allowed determination of the different parameters describing the blood water T1 such as those for the diamagnetic and paramagnetic effects of albumin and hemoglobin, and the contribution of methemoglobin. Water 113-118 hemoglobin subunit gamma 2 Homo sapiens 232-245 25249806-6 2014 CONCLUSION: Early epidemiological studies demonstrated significant associations between high groundwater nitrate levels and elevated methemoglobin levels in infants fed drinking water-diluted formulas. Water 99-104 hemoglobin subunit gamma 2 Homo sapiens 133-146 18155958-10 2008 Mean MetHb was normal when the nitrate concentration in water was below 50mg/l as NO3-, and reached an abnormal level, when the nitrate concentration in water ranged between 50 and 90mg/l as NO3-. Water 56-61 hemoglobin subunit gamma 2 Homo sapiens 5-10 19821985-4 2009 The methemoglobin fraction increased to 5.9 (1.3; 8.4) % with a maximal value of 12.2% on the days of water disinfection (P < 0.001 compared to disinfection-free days). Water 102-107 hemoglobin subunit gamma 2 Homo sapiens 4-17 16986127-2 2007 Hemoglobin has iron in the reduced valance Fe(II) and methemoglobin has iron in the oxidized valance Fe (III), with a free energy capable of producing water from oxygen. Water 151-156 hemoglobin subunit gamma 2 Homo sapiens 54-67 17963777-0 2008 Interaction of methemoglobin with GDA/n-C5H11OH/water assemblies. Water 48-53 hemoglobin subunit gamma 2 Homo sapiens 15-28 17963777-4 2008 Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system. Water 42-45 hemoglobin subunit gamma 2 Homo sapiens 158-171 17963777-4 2008 Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system. Water 227-230 hemoglobin subunit gamma 2 Homo sapiens 10-23 17963777-4 2008 Moreover, methemoglobin and GDA/n-C5H11OH/H2O assemblies can affect their structures and properties and the change in behavior is dependent on the content of methemoglobin and the composition and structure of the GDA/n-C5H11OH/H2O system. Water 227-230 hemoglobin subunit gamma 2 Homo sapiens 158-171 17963777-5 2008 The relationship among the changes in the structure and properties of GDA/n-C5H11OH/H2O assemblies, the content of methemoglobin, and the composition and structure of GDA/n-C5H11OH/H2O assemblies may provide some important theoretical information for elucidation of the interaction between methemoglobin and blood cell membrane and may also be helpful for the cure of some blood diseases. Water 84-87 hemoglobin subunit gamma 2 Homo sapiens 290-303 17963777-5 2008 The relationship among the changes in the structure and properties of GDA/n-C5H11OH/H2O assemblies, the content of methemoglobin, and the composition and structure of GDA/n-C5H11OH/H2O assemblies may provide some important theoretical information for elucidation of the interaction between methemoglobin and blood cell membrane and may also be helpful for the cure of some blood diseases. Water 181-184 hemoglobin subunit gamma 2 Homo sapiens 290-303 14980701-3 2004 In this work we show that also metmyoglobin and methemoglobin can nitrate free tyrosine in the presence of nitrite and H(2)O(2). Water 119-124 hemoglobin subunit gamma 2 Homo sapiens 48-61 10487144-1 1999 Methemoglobin (MetHb) is an oxidation product of hemoglobin in which the sixth coordination position of ferric iron is bound to a water molecule or to a hydroxyl group. Water 130-135 hemoglobin subunit gamma 2 Homo sapiens 0-13 11834210-4 2001 Subsequently, we demonstrate that fractions containing anthocyanins lower ROS (reactive oxygen species) and methemoglobin production in human erythrocytes treated with H(2)O(2.) Water 168-173 hemoglobin subunit gamma 2 Homo sapiens 108-121 10487144-1 1999 Methemoglobin (MetHb) is an oxidation product of hemoglobin in which the sixth coordination position of ferric iron is bound to a water molecule or to a hydroxyl group. Water 130-135 hemoglobin subunit gamma 2 Homo sapiens 15-20 9518571-4 1998 It is assumed that methemoglobin affects the structural and physicochemical parameters of lipid-water interface. Water 96-101 hemoglobin subunit gamma 2 Homo sapiens 19-32 9132576-1 1996 Health effects associated with ingestion of nitrate-contaminated water have included methemoglobinemia (i.e., blue baby syndrome) in infants and spontaneous abortions in laboratory animals and livestock; however, only one study in humans has reported an association between increased methemoglobin levels and spontaneous abortion. Water 65-70 hemoglobin subunit gamma 2 Homo sapiens 85-98 9285046-2 1997 These methemoglobin-containing red cell granules were very effective for detecting and absorbing cyanide in water. Water 108-113 hemoglobin subunit gamma 2 Homo sapiens 6-19 34241395-2 2021 Using microwave dielectric spectroscopy, we have assessed the amount of water associated with hydration shells of methemoglobin as a function of its concentration in the presence or absence of ions. Water 72-77 hemoglobin subunit gamma 2 Homo sapiens 114-127 8599674-1 1995 For hydrated metmyoglobin, methemoglobin, and lysozyme powders, the freezable water fraction of between approximately 0.3-0.4 g water/g protein up to approximately 0.7-0.8 g water/g protein has been fully vitrified by cooling at rates up to approximately 1500 K min-1 and the influence of cooling rate characterized by x-ray diffractograms. Water 78-83 hemoglobin subunit gamma 2 Homo sapiens 27-40 7651120-2 1995 Longitudinal water proton relaxation rates of methemoglobin solutions show a strong dependence on temperature and pH. Water 13-18 hemoglobin subunit gamma 2 Homo sapiens 46-59 1458575-0 1992 Quantitative determination of methemoglobin by measuring the solvent-water proton-nuclear magnetic resonance relaxation rate. Water 69-74 hemoglobin subunit gamma 2 Homo sapiens 30-43 1458575-1 1992 We report a new method for the quantitative determination of human methemoglobin (metHb) based on the measurement of the solvent-water proton-nuclear magnetic resonance (NMR) relaxation rate R1 [normalized to 1 mmol/L hemoglobin (Hb) concentration]. Water 129-134 hemoglobin subunit gamma 2 Homo sapiens 67-80 34241395-4 2021 Within the concentration range of 5-10 g/dl of methemoglobin, ions play an important role in defining the free-to-bound water ratio competing with hemoglobin to recruit water molecules for the hydration shell. Water 120-125 hemoglobin subunit gamma 2 Homo sapiens 47-60 34241395-4 2021 Within the concentration range of 5-10 g/dl of methemoglobin, ions play an important role in defining the free-to-bound water ratio competing with hemoglobin to recruit water molecules for the hydration shell. Water 169-174 hemoglobin subunit gamma 2 Homo sapiens 47-60 34241395-7 2021 The theoretical evaluation of the ratio of free and bound water for the hemoglobin concentration in the absence of ions corresponds with the experimental results and shows that the methemoglobin molecule binds about 1400 water molecules. Water 58-63 hemoglobin subunit gamma 2 Homo sapiens 181-194 34241395-7 2021 The theoretical evaluation of the ratio of free and bound water for the hemoglobin concentration in the absence of ions corresponds with the experimental results and shows that the methemoglobin molecule binds about 1400 water molecules. Water 221-226 hemoglobin subunit gamma 2 Homo sapiens 181-194