PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19386536-6 2009 The formation of molecular clusters by means of the 1,2,3,9-tetrahydro-4H-carbazol-4-one wrapped up with water molecules leads to the weakness of the interaction between the polar solvents and the 1,2,3,9-tetrahydro-4H-carbazol-4-one, hence, the accuracy of pK(b) has been enhanced. Water 105-110 AKT serine/threonine kinase 1 Homo sapiens 258-263 19513559-0 2009 Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt. Water 60-65 AKT serine/threonine kinase 1 Homo sapiens 168-171 18334937-12 2008 Moreover, EGCG attenuated the reduced activation and expression of ERK, p38 MAPK, and Akt induced by H(2)O(2). Water 101-106 AKT serine/threonine kinase 1 Homo sapiens 86-89 33898501-1 2021 Fubaiju Hot-Water Extracts Against ARPE-19 Cell Oxidative Damage by Activating PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway. Water 12-17 AKT serine/threonine kinase 1 Homo sapiens 84-87 17405146-7 2007 We also demonstrate that p34 (a component of the Arp2/3 complex), WASP/WAVE proteins, actin, alpha-tubulin, Rac, Cdc42, vinculin, and focal adhesion kinase are detected in water-shocked myelin purified from brain. Water 172-177 AKT serine/threonine kinase 1 Homo sapiens 108-111 16788862-5 2006 Furthermore, c-Myc expression repressed the activation of Akt induced by the toxic agents doxorubicin, cisplatin and H(2)O(2), and also by the physiological agonists PDGF and insulin. Water 117-122 AKT serine/threonine kinase 1 Homo sapiens 58-61 16339203-4 2006 In this study we demonstrated that local testicular heat treatment of adult monkey with water at 43 C for 30 min once daily for 2 consecutive days was capable of activating reexpression of ck-18 in Sertoli cells, which was coincident with activation of ERK1/2 and Akt kinases. Water 88-93 AKT serine/threonine kinase 1 Homo sapiens 264-267 11590144-6 2001 Furthermore, the downstream effector of PI3K, protein kinase B/AKT, is activated by NRG in the presence of H(2)O(2), and protein kinase B/AKT activation is inhibited by LY294002. Water 107-112 AKT serine/threonine kinase 1 Homo sapiens 63-66 18967255-6 1998 On the other hand, the low stabilization of OH(-) in the mixed solvents relative to that in water and the electrostatic effect are the main factors in determining the solvent effect on pK(b). Water 92-97 AKT serine/threonine kinase 1 Homo sapiens 185-190 34982299-0 2022 Deep Sea Water Alleviates Tau Phosphorylation and Cognitive Impairment via PI3K/Akt/GSK-3beta Pathway. Water 9-14 AKT serine/threonine kinase 1 Homo sapiens 80-83 17827719-0 2007 Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells. Water 0-5 AKT serine/threonine kinase 1 Homo sapiens 83-86 11598110-7 2001 Interestingly, the H(2)O(2)-induced activation of Akt was entirely mediated by upstream stimulation of PI 3"-kinase activity, since treatment of 3T3-L1 adipocytes with the PI 3"-kinase inhibitors wortmannin or LY294002 completely blocked the subsequent activation of Akt by exogenous H(2)O(2). Water 19-24 AKT serine/threonine kinase 1 Homo sapiens 50-53 11598110-7 2001 Interestingly, the H(2)O(2)-induced activation of Akt was entirely mediated by upstream stimulation of PI 3"-kinase activity, since treatment of 3T3-L1 adipocytes with the PI 3"-kinase inhibitors wortmannin or LY294002 completely blocked the subsequent activation of Akt by exogenous H(2)O(2). Water 19-24 AKT serine/threonine kinase 1 Homo sapiens 267-270 31894254-0 2020 Anti-platelet activity of mineral-balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk. Water 52-57 AKT serine/threonine kinase 1 Homo sapiens 92-95 33174561-2 2020 While the pKb is typically defined in reference to the bulk aqueous phase, several studies have suggested that this value can differ significantly at the air-water interface (which can have significant ramifications for particle surface chemistry and aerosol growth modeling). Water 158-163 AKT serine/threonine kinase 1 Homo sapiens 10-13 32449613-3 2020 Instead, irradiation generates the IR700 radical anion, leading to acid-base reactions with nearby water molecules (i. e., calculated pKb for the radical anion is 7.7) to produce hydrophobic ligand-released dyes. Water 99-104 AKT serine/threonine kinase 1 Homo sapiens 134-137 31612523-10 2020 Mechanism analysis indicated that morphine alleviated serum deprivation and H2 O2 -induced angiogenesis inhibition via reducing oxidative stress and damage, and activating Akt/mTOR/eIF4E signaling. Water 76-81 AKT serine/threonine kinase 1 Homo sapiens 172-175 30519270-0 2018 Manilkara zapota (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways. Water 36-41 AKT serine/threonine kinase 1 Homo sapiens 127-131 30571108-8 2019 Unlike the water-free conformation I", three water molecules appear around Mg2+ in the water-occupied conformation I, which can finally exert an influence on the catalytic mechanism of Akt1. Water 11-16 AKT serine/threonine kinase 1 Homo sapiens 185-189 30571108-8 2019 Unlike the water-free conformation I", three water molecules appear around Mg2+ in the water-occupied conformation I, which can finally exert an influence on the catalytic mechanism of Akt1. Water 45-50 AKT serine/threonine kinase 1 Homo sapiens 185-189 30571108-8 2019 Unlike the water-free conformation I", three water molecules appear around Mg2+ in the water-occupied conformation I, which can finally exert an influence on the catalytic mechanism of Akt1. Water 45-50 AKT serine/threonine kinase 1 Homo sapiens 185-189 30519270-8 2018 Overall analyses revealed that Manilkara zapota leaf water extract can increase percentage of early apoptotic cells, induce the formation of ROS, upregulate c-Jun N-terminal kinase 1 (JNK1) and inducible nitric oxide synthase (iNOS), and reduce Akt1 and vascular endothelial growth factor A (VEGFA) transcriptional activities. Water 53-58 AKT serine/threonine kinase 1 Homo sapiens 245-249 28738491-12 2017 (4) The effect of H(2)O(2) on signaling molecules in PAECs: there was a significant increase in phosphorylation level of Akt in PAECs incubated with H(2)O(2) for 30 minutes compared to that in control PAECs (P<0.01), while there was no significant difference in levels of Akt between H(2)O(2) treated PAECs and control PAECs. Water 149-154 AKT serine/threonine kinase 1 Homo sapiens 275-278 29723208-4 2018 Mathematical models included in RAC were all validated in previous works, and account for growth and metabolism, based on input data characterizing the forcing functions-water temperature, and food quality/quantity. Water 170-175 AKT serine/threonine kinase 1 Homo sapiens 32-35 23875003-4 2013 3xTg-AD mice fed 0.23% w/v lipoic acid in drinking water for 4 weeks showed an insulin mimetic effect that consisted of increased brain glucose uptake, activation of the insulin receptor substrate and of the PI3K/Akt signaling pathway. Water 51-56 AKT serine/threonine kinase 1 Homo sapiens 213-216 28738491-12 2017 (4) The effect of H(2)O(2) on signaling molecules in PAECs: there was a significant increase in phosphorylation level of Akt in PAECs incubated with H(2)O(2) for 30 minutes compared to that in control PAECs (P<0.01), while there was no significant difference in levels of Akt between H(2)O(2) treated PAECs and control PAECs. Water 18-23 AKT serine/threonine kinase 1 Homo sapiens 121-124 28738491-12 2017 (4) The effect of H(2)O(2) on signaling molecules in PAECs: there was a significant increase in phosphorylation level of Akt in PAECs incubated with H(2)O(2) for 30 minutes compared to that in control PAECs (P<0.01), while there was no significant difference in levels of Akt between H(2)O(2) treated PAECs and control PAECs. Water 18-23 AKT serine/threonine kinase 1 Homo sapiens 275-278 28738491-12 2017 (4) The effect of H(2)O(2) on signaling molecules in PAECs: there was a significant increase in phosphorylation level of Akt in PAECs incubated with H(2)O(2) for 30 minutes compared to that in control PAECs (P<0.01), while there was no significant difference in levels of Akt between H(2)O(2) treated PAECs and control PAECs. Water 149-154 AKT serine/threonine kinase 1 Homo sapiens 121-124 28714368-4 2017 Cordyceps militaris hot water extracts containing cordycepin was used to treat human T24 bladder carcinoma cells, and we found that Cordyceps militaris hot water extracts containing cordycepin decreased T24 cell survival in a dose-dependent manner, which was seemingly mediated by activation of A3 adenosine receptor and the subsequent inactivation of Akt pathways, resulting in increases in cleaved Caspase-3 and apoptosis. Water 156-161 AKT serine/threonine kinase 1 Homo sapiens 352-355 28034894-13 2017 CONCLUSIONS: The hypo-osmotic stimulus of water ingestion increases angiopoietin-1 secretion and subsequently activates the Tie-2/Akt/eNOS signaling pathway in RBCs, thereby revealing a novel biological mechanism simultaneously occurring with the osmopressor response. Water 42-47 AKT serine/threonine kinase 1 Homo sapiens 130-133 23526806-10 2013 It is concluded that a higher water content of SAMs formed by enantiopure PGMA(S) and PGMA(R) SAMs arises from the macromolecular chiral conformation adopted by their enantiopure PGMA chains, and it is the decisive reason for the reduced BSA adsorption and cell adhesion as compared to PGMA(rac) SAMs. Water 30-35 AKT serine/threonine kinase 1 Homo sapiens 291-294 22596086-0 2012 Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway. Water 22-27 AKT serine/threonine kinase 1 Homo sapiens 132-135 22886427-7 2012 rhNRG-1 inhibited mPTP and activated Akt in the presence of H(2)O(2) and further protected the cells from H(2)O(2)-induced apoptosis. Water 60-65 AKT serine/threonine kinase 1 Homo sapiens 37-40 21742779-10 2011 Upon exposure to H(2)O(2), Akt was intensely phosphorylated in the first 30 min, concurrently with mammalian target of rapamycin inactivation and autophagy, and it was dephosphorylated at 2 h, when > 50% of the cells were dead. Water 17-22 AKT serine/threonine kinase 1 Homo sapiens 27-30