PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21625555-0 2011 Modeling a new water channel that allows SET9 to dimethylate p53. Water 15-20 tumor protein p53 Homo sapiens 61-64 21130866-8 2011 FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2). Water 238-243 tumor protein p53 Homo sapiens 111-114 21130866-8 2011 FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2). Water 238-243 tumor protein p53 Homo sapiens 154-157 22197648-0 2012 Water"s potential role: Insights from studies of the p53 core domain. Water 0-5 tumor protein p53 Homo sapiens 53-56 22197648-5 2012 We examined seven wild/mutant X-ray structures and observed two types of water-network hydration in three "hot hydration centers" (DNA- or small molecule- binding surfaces of the p53 core domain). Water 73-78 tumor protein p53 Homo sapiens 179-182 22197648-9 2012 The particular environment created by different water molecules around the p53 core domain also partly explains the structural vulnerabilities of this protein. Water 48-53 tumor protein p53 Homo sapiens 75-78 20847049-9 2010 Molecular dynamics simulations suggest that (i) solvation of phospho-Ser(215) and phospho-Ser(269) by positive charged residues or solvent water leads to local unfolding, which is accompanied by local destabilization of the N-terminal loop and global destabilization of p53, and (ii) the double alanine 215/269 mutation disrupts hydrogen bonding normally stabilized by both Ser(215) and Ser(269). Water 139-144 tumor protein p53 Homo sapiens 270-273 18260647-5 2008 The lack of formation of a water channel is due to the positioning of the methyl substituent of the SET7/9.p53-Lys4-N(Me)H 2 (+).AdoMet complex. Water 27-32 tumor protein p53 Homo sapiens 107-110 18260647-2 2008 After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+). Water 116-121 tumor protein p53 Homo sapiens 30-33 18260647-2 2008 After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+). Water 116-121 tumor protein p53 Homo sapiens 153-156 18260647-2 2008 After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+). Water 116-121 tumor protein p53 Homo sapiens 153-156 18260647-2 2008 After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+). Water 116-121 tumor protein p53 Homo sapiens 153-156 18260647-2 2008 After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+). Water 180-185 tumor protein p53 Homo sapiens 30-33 18260647-2 2008 After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+). Water 180-185 tumor protein p53 Homo sapiens 153-156 18260647-2 2008 After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+). Water 180-185 tumor protein p53 Homo sapiens 153-156 18260647-2 2008 After formation of the SET7/9.p53-Lys4-NH 3 (+).AdoMet complex, the following events occur: (i) the appearance of a water channel, (ii) a depronation of p53-Lys4-NH 3 (+) via this water channel into the aqueous solvent, and (iii) AdoMet methylation of p53-Lys4-NH 2 to form p53-Lys4-N(Me)H 2 (+). Water 180-185 tumor protein p53 Homo sapiens 153-156 18260647-4 2008 Without a water channel, the substrate p53-Lys4-N(Me)H is not available because the proton dissociation p53-Lys4-N(Me)H 2 (+) --> p53-Lys4-N(Me)H + H (+) does not occur. Water 10-15 tumor protein p53 Homo sapiens 39-42 18260647-4 2008 Without a water channel, the substrate p53-Lys4-N(Me)H is not available because the proton dissociation p53-Lys4-N(Me)H 2 (+) --> p53-Lys4-N(Me)H + H (+) does not occur. Water 10-15 tumor protein p53 Homo sapiens 104-107 18260647-4 2008 Without a water channel, the substrate p53-Lys4-N(Me)H is not available because the proton dissociation p53-Lys4-N(Me)H 2 (+) --> p53-Lys4-N(Me)H + H (+) does not occur. Water 10-15 tumor protein p53 Homo sapiens 104-107 19548636-3 2009 We used the Orru three component reaction (O-3CR) along with a rapid and efficient, recently discovered amidation reaction to dramatically improve the water solubility of our recently discovered low molecular weight p53/mdm2 antagonists. Water 151-156 tumor protein p53 Homo sapiens 216-219 18723490-0 2008 Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Water 44-49 tumor protein p53 Homo sapiens 33-36 18478141-1 2008 The newly synthesized water-soluble cyclodiphosphazane ligands and their gold(I) complexes inhibit HeLa cell proliferation by activating p53 protein and inducing apoptosis. Water 22-27 tumor protein p53 Homo sapiens 137-140 18086774-0 2007 Adduction of human p53 gene by fecal water: an in vitro biomarker of mutagenesis in the human large bowel. Water 37-42 tumor protein p53 Homo sapiens 19-22 18086774-1 2007 A polymerase arrest assay was designed to determine sites of adduction in the human p53 gene induced by incubation with fecal water. Water 126-131 tumor protein p53 Homo sapiens 84-87 18086774-2 2007 Significant formation of adducts was observed on p53 DNA after a 2-h incubation in fecal water from 10 of 17 samples studied. Water 89-94 tumor protein p53 Homo sapiens 49-52 16510697-1 2006 In this study, a cationic water-soluble ceramide analog L-threo-C6-pyridinium-ceramide-bromide (L-t-C6-Pyr-Cer), which exhibits high solubility and bioavailability, inhibited the growth of various human head and neck squamous cell carcinoma (HNSCC) cell lines at low IC50 concentrations, independent of their p53 status. Water 26-31 tumor protein p53 Homo sapiens 309-312 16930632-5 2006 This prompted us to study the association of three p53 polymorphisms with arsenic induced keratosis in a population exposed to arsenic through drinking water. Water 152-157 tumor protein p53 Homo sapiens 51-54 17133770-3 2006 Environmentally induced alterations in p53 protein have been reported to contribute to pathogenesis of leukemia in soft-shell clam Mya arenaria inhabiting polluted water, suggesting that p53 proteins can also be used as pollution markers. Water 164-169 tumor protein p53 Homo sapiens 39-42 15850555-4 2005 In the presence of 50 microM H(2)O(2), arrest was observed in the G2-phase of the cell cycle, along with p53-independent apoptosis. Water 29-34 tumor protein p53 Homo sapiens 105-108 16272802-6 2005 As for the association with environmental factors, p53 mutations occurred with higher frequency in patients with a daily intake of spicy foods and in those who used unboiled well water in the low-incidence area. Water 179-184 tumor protein p53 Homo sapiens 51-54 16272802-8 2005 Thus, higher frequency of spicy food intake and use of unboiled well water may be risk factors of esophageal cancer via p53 mutations in China. Water 69-74 tumor protein p53 Homo sapiens 120-123 10942736-12 2000 Deferoxamine, a metal chelator, inhibited p53 activation by chelating Cr(V) to make it incapable of generating radicals from H(2)O(2). Water 125-130 tumor protein p53 Homo sapiens 42-45 12962703-3 2003 HA sensitized both p53 wild type and mutated glioma cells to 0.25 mM H(2)O(2). Water 69-74 tumor protein p53 Homo sapiens 19-22 11447225-7 2001 Also serine 20-phosphorylated p53 was coimmunoprecipitated with Plk3 in cells treated with H(2)O(2). Water 91-96 tumor protein p53 Homo sapiens 30-33 11447225-8 2001 Furthermore, although H(2)O(2) strongly induced serine 15 phosphorylation of p53, it failed to induce serine 20 phosphorylation in Plk3-dificient Daudi cells. Water 22-27 tumor protein p53 Homo sapiens 77-80 9812585-1 1997 Expression of P53 protein was determined in the process and the end of induction of malignant transformation in human fetal lung cells, with organic extract from tap water in a river of City G, to study its molecular mechanism. Water 166-171 tumor protein p53 Homo sapiens 14-17 8027368-8 1994 Fragments of the p53 gene were successfully amplified up to 408 base pairs in water boiled extracts, up to 647 in Chelex boiled preparates, and up to 984 in proteinase K digested and proteinase K digested-Chelex boiled samples, although with decreased sensitivity in the last case. Water 78-83 tumor protein p53 Homo sapiens 17-20 33036527-8 2020 After c-myc silenced cells were treated with PM2.5 water soluble solution, The mRNA levels of c-myc, c-fos, and k-ras decreased by 84.1%, 45.4%, and 54.6% (P<0.05) , p53 increased by 192.9% (P<0.05) , and the expression of Caspase-3, Caspase-8, and Caspase-9 decreased by 24.4%, 36.1%, 60.9% (P<0.05) . Water 51-56 tumor protein p53 Homo sapiens 166-169 34887234-5 2021 The prediction was that treated water would result in increased cell proliferation, that more cells would enter the cell cycle growth phase, and that there would be increased expression of genes (NANOG, OCT4 and SOX2) associated with improved cell growth and decreased expression of genes (p16, p21, and p53) associated with a decline in cell growth. Water 32-37 tumor protein p53 Homo sapiens 304-307 32489012-2 2020 The sixteen resulting architectures are water-stable and optically pure, and exhibit improved antiproliferative selectivity against colon cancer cells (HCT116 p53 +/+ ) with respect to the non-cancerous ARPE-19 cell line. Water 40-45 tumor protein p53 Homo sapiens 159-162 32650545-0 2020 Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions. Water 45-50 tumor protein p53 Homo sapiens 164-167 32457871-0 2020 Hybrid Molecular Dynamics for Elucidating Cooperativity Between Halogen Bond and Water Molecules During the Interaction of p53-Y220C and the PhiKan5196 Complex. Water 81-86 tumor protein p53 Homo sapiens 123-126 32457871-3 2020 In this study, the Y220C-PhiKan5196 complex of p53 protein was adopted as a model, and the functions of three water molecules that formed hydrogen bonds with halogen atoms were analyzed by the simulation method governed by the hybrid quantum mechanical/molecular mechanical molecular dynamics. Water 110-115 tumor protein p53 Homo sapiens 47-50 31908576-5 2020 In cultured VSMCs, hydrogen peroxide (H2O2) dose-dependently induced senescence, which was associated with increased numbers of senescence-associated beta-galactosidase-positive cells, decreased expression of SMP30, and activation of p53-p21 and p16 pathways. Water 38-42 tumor protein p53 Homo sapiens 234-237 32065645-0 2020 Expression of Concern: "Cadmium Induces Intracellular Ca2+- and H2O2-Dependent Apoptosis through JNK- and p53-Mediated Pathways in Skin Epidermal Cell line". Water 64-68 tumor protein p53 Homo sapiens 106-109 31566298-6 2020 Furthermore, aging markers such as senescence-associated beta-galactosidase p53, p21Cip1/WAF1 , and p16INK4A were upregulated under H2 O2 exposure and galangin could reverse its effects. Water 132-137 tumor protein p53 Homo sapiens 76-79 31368879-4 2020 RESULTS: New water soluble derivatives showed a micromolar cytotoxicity for cultured human tumor cell lines in the dark, including the subline with an altered drug response due to p53 inactivation. Water 13-18 tumor protein p53 Homo sapiens 180-183 30252476-6 2018 In both complexes, we observe significant changes in the water local density as the two proteins approach, supporting the existence of a clear dewetting transition in the case of MDM2-p53, with an onset distance of 5.6-7.6 A. Water 57-62 tumor protein p53 Homo sapiens 184-187 27383327-8 2016 Water-solvable vitamin E Trolox significantly promoted MCF7 cell proliferation in vitro, while reducing intracellular ROS level and p53 expression. Water 0-5 tumor protein p53 Homo sapiens 132-135 28027428-4 2017 We found that the water extract of P. koraiensis pinecones exhibits significant cytotoxic activity, with IC50 values ranging from 0.62 to 1.73 mg/ml in four human lung cancer cell lines, A549, H1264, H1299, and Calu-6, irrespective of their p53 status. Water 18-23 tumor protein p53 Homo sapiens 241-244 27418282-3 2016 By quantifying the number of hydrate water molecules, we provide a microscopic description for the interactions of water with a wild-type p53 TAD and two p53 TAD peptides. Water 37-42 tumor protein p53 Homo sapiens 138-141 27418282-3 2016 By quantifying the number of hydrate water molecules, we provide a microscopic description for the interactions of water with a wild-type p53 TAD and two p53 TAD peptides. Water 37-42 tumor protein p53 Homo sapiens 154-157 27418282-3 2016 By quantifying the number of hydrate water molecules, we provide a microscopic description for the interactions of water with a wild-type p53 TAD and two p53 TAD peptides. Water 115-120 tumor protein p53 Homo sapiens 138-141 27418282-3 2016 By quantifying the number of hydrate water molecules, we provide a microscopic description for the interactions of water with a wild-type p53 TAD and two p53 TAD peptides. Water 115-120 tumor protein p53 Homo sapiens 154-157 25706509-3 2015 The dynamics of water in the interdomain region between an E3 ubiquitin ligase (MDM2) and three different peptides derived from the tumor suppressor protein p53 are studied using molecular dynamics. Water 16-21 tumor protein p53 Homo sapiens 157-160 26421917-3 2015 Here we consider an IDR of the tumor suppressor p53 protein, p53CTD, as an important example related to carcinogenesis and analyze its binding to four targets accompanying the formation of target-dependent structures (i.e., helix, sheet, and two different coils) using our statistical-mechanical method combined with molecular models for water. Water 338-343 tumor protein p53 Homo sapiens 48-51 23863845-6 2013 Contrary to our previously studied wild-type (wt) p53-DNA complexes showing non-canonical Hoogsteen A/T base pairs of the DNA helix that lead to local minor-groove narrowing and enhanced electrostatic interactions with p53, the current structures display Watson-Crick base pairs associated with direct or water-mediated hydrogen bonds with p53 at the minor groove. Water 305-310 tumor protein p53 Homo sapiens 50-53