PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6158365-0	1980	Effects of intracerebroventricular administration of tonin on water intake and blood pressure in the rat.	Water	62-67	kallikrein 1-related peptidase C2	Rattus norvegicus	53-58	
12044607-5	2002	Central microinjection of tonin produced a transient (10-20 min) elevation of blood pressure and heart rate and induced water and saline intake within the first 10 min after injection.	Water	120-125	kallikrein 1-related peptidase C2	Rattus norvegicus	26-31	
12044607-8	2002	Our data suggest that tonin may be an alternative pathway to Ang II generation in the brain and could participate in the physiological effects exerted by Ang II such as water and saline intake and blood pressure elevation.	Water	169-174	kallikrein 1-related peptidase C2	Rattus norvegicus	22-27	
1334431-2	1992	We found 16 equivalent water sites conserved in trypsin/ogen, chymotrypsin/ogen, elastase, kallikrein, thrombin, rat tonin and rat mast cell protease, and 5 additional water sites in enzymes which share the primary specificity of trypsin.	Water	23-28	kallikrein 1-related peptidase C2	Rattus norvegicus	117-122	
2821276-5	1987	The refined model of tonin consists of 227 amino acid residues out of the 235 in the complete molecule, 149 water molecules, and one zinc ion.	Water	108-113	kallikrein 1-related peptidase C2	Rattus norvegicus	21-26	
20180641-0	2010	Increased blood pressure and water intake in transgenic mice expressing rat tonin in the brain.	Water	29-34	kallikrein 1-related peptidase C2	Rattus norvegicus	76-81	
6158365-1	1980	Intracerebroventricular administration of tonin, an enzyme which releases angiotensin II directly from various substrates, stimulated water intake and increased blood pressure in the rat.	Water	134-139	kallikrein 1-related peptidase C2	Rattus norvegicus	42-47	
6165574-0	1980	The effects of intracerebroventricular administration of tonin on water drinking and blood pressure in rats.	Water	66-71	kallikrein 1-related peptidase C2	Rattus norvegicus	57-62	
6165574-1	1980	Intraventricular administration of tonin, an enzyme which forms angiotensin II directly from a natural protein substrate (angiotensinogen), stimulated water drinking and increased systemic blood pressure in rats.	Water	151-156	kallikrein 1-related peptidase C2	Rattus norvegicus	35-40	
6165574-4	1980	These results indicate that the central effects of tonin on water drinking and systemic blood pressure are mediated via the direct formation of angiotensin II in the brain, and suggest the possibility that the tonin-angiotensin II system in the central nervous system might be important in controlling water balance and blood pressure.	Water	60-65	kallikrein 1-related peptidase C2	Rattus norvegicus	51-56