PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20201223-6	2009	Likewise, water-insolubility of 17-allylamino-17-demethoxygeldanamycin (17-AAG), a selective Hps90 inhibitor, constrains its use in humans.	Water	10-15	N-methylpurine DNA glycosylase	Homo sapiens	75-78	
10946229-4	2000	Crystal structures of AAG complexed to DNA suggest that the enzyme selects substrate bases through a combination of hydrogen bonding and the steric constraints of the active site, and that the enzyme activates a water molecule for an in-line backside attack of the N-glycosylic bond.	Water	212-217	N-methylpurine DNA glycosylase	Homo sapiens	22-25	
29463369-4	2018	The NCTD-loaded polymeric nanoparticles (MPG/NCTD) formed by self-assembly in water exhibited a mean hydrodynamic diameter of roughly 89 nm.	Water	78-83	N-methylpurine DNA glycosylase	Homo sapiens	41-44	
21877721-8	2011	Finally, our work shows that the natural base adenine (A) is further inserted into the AAG active site than the damaged substrates, which results in the loss of a hydrogen bond with Y127 and misaligns the general base (E125) and water nucleophile to lead to poor nucleophile activation.	Water	229-234	N-methylpurine DNA glycosylase	Homo sapiens	87-90	
33427846-3	2021	Herein, beta-phase anhydrous guanine (beta-AG) microrods were formed in mixed solvents of formamide and water in the presence of small organic molecules such as uric acid, pyrrole (Py), N-methyl-2-pyrrolidone (NMP), N-vinyl-2-pyrrolidone (NVP).	Water	104-109	N-methylpurine DNA glycosylase	Homo sapiens	38-45	
33427846-4	2021	The one-dimensional (1D) assembly of beta-AG microrods form spontaneously in water, which is the first reported highly ordered 1D assembly of organic micro- or nanocrystals in the solution.	Water	77-82	N-methylpurine DNA glycosylase	Homo sapiens	37-44	
33427846-5	2021	The obtained beta-AG microrods obtained in Py system can form reversible 1D assembly in water after being treated in organic solvents such as ethanol, acetone and isopropanol, which have high solubility in water.	Water	88-93	N-methylpurine DNA glycosylase	Homo sapiens	13-20	
33427846-5	2021	The obtained beta-AG microrods obtained in Py system can form reversible 1D assembly in water after being treated in organic solvents such as ethanol, acetone and isopropanol, which have high solubility in water.	Water	206-211	N-methylpurine DNA glycosylase	Homo sapiens	13-20	
33427846-8	2021	The reversible 1D assemblies of guanine microrods in water and organic solvents with high solubility in water indicate that there is a strong interaction between the (100) planes of beta-AG microrods in water.	Water	53-58	N-methylpurine DNA glycosylase	Homo sapiens	182-189	
33427846-8	2021	The reversible 1D assemblies of guanine microrods in water and organic solvents with high solubility in water indicate that there is a strong interaction between the (100) planes of beta-AG microrods in water.	Water	104-109	N-methylpurine DNA glycosylase	Homo sapiens	182-189	
33427846-8	2021	The reversible 1D assemblies of guanine microrods in water and organic solvents with high solubility in water indicate that there is a strong interaction between the (100) planes of beta-AG microrods in water.	Water	104-109	N-methylpurine DNA glycosylase	Homo sapiens	182-189	
29148771-2	2017	Specifically, AAG uses a water molecule activated by a general base and a nonspecific active site lined with aromatic residues to cleave the N-glycosidic bond.	Water	25-30	N-methylpurine DNA glycosylase	Homo sapiens	14-17	
25227799-3	2014	17-AAG has poor water-solubility which is a potential problem for clinical practice.	Water	16-21	N-methylpurine DNA glycosylase	Homo sapiens	3-6	
23862950-3	2013	In this paper, we show calculations of the frequency spectrum for light and heavy water at room temperature using two flexible point charge potentials: SPC-MPG and TIP4P/2005f.	Water	82-87	N-methylpurine DNA glycosylase	Homo sapiens	156-159