PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8742240-4 1996 There are now a number of substrates reported that have routes of metabolism ascribed specifically to cytochrome P4502C9 (CYP2C9), the isoform mainly responsible for tolbutamide hydroxylation. Tolbutamide 166-177 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 102-120 8742240-4 1996 There are now a number of substrates reported that have routes of metabolism ascribed specifically to cytochrome P4502C9 (CYP2C9), the isoform mainly responsible for tolbutamide hydroxylation. Tolbutamide 166-177 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 122-128 8742240-6 1996 The substrate specificity has been rationalized in terms of a hydrogen bond donor/acceptor model and, by use of molecular modeling, an active site template model for CYP2C9 has been generated. Hydrogen 62-70 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 166-172 27609422-3 2016 Proteins that molecularly interact with PIP1;2 and PIP2;1 were searched to get new insights into regulatory mechanisms of root water transport. Water 127-132 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 40-46 33804761-3 2021 Not only beta-CD, but also gamma-CD, tended to form a water-insoluble aggregate with Toc in aqueous media. Water 54-59 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 9-16 26163575-6 2015 OST1 enhanced PIP2;1 water transport activity when coexpressed in Xenopus laevis oocytes. Water 21-26 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 14-20 26163575-8 2015 This work supports a model whereby ABA-triggered stomatal closure requires an increase in guard cell permeability to water and possibly hydrogen peroxide, through OST1-dependent phosphorylation of PIP2;1 at Ser-121. Water 117-122 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 197-203 24367080-4 2014 Here, we unravel how FaPIP1;1, a fruit-specific PIP1 aquaporin from Fragaria x ananassa, contributes to the modulation of membrane water permeability (Pf) and pH aquaporin regulation. Water 131-136 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 23-27 32287446-0 2015 An efficient synthesis of 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin-2-ones catalyzed by sulfonated beta-CD as a supramolecular catalyst in water. Water 154-159 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 114-121 32287446-1 2015 Sulfonated-beta-cyclodextrin (beta-CD-SO3H) promoted efficient and fast electrophilic substitution reaction of indoles with various isatins reflux in water is reported affording various 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin-2-ones in good to excellent yields in short reaction time. Water 150-155 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 30-37 25266632-5 2014 Our results show that the constitutively silenced PIP1 (35S promoter) plants had decreased PIP1 transcript and protein levels and decreased mesophyll and BS osmotic water permeability (P(f)), mesophyll conductance of CO2, photosynthesis, K(leaf), transpiration, and shoot biomass. Water 165-170 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 50-54 34212318-3 2022 beta-CD, which is normally insoluble in water, is used in demanding wastewater applications by being modified with the help of different agents to be water soluble or transformed into polymeric adsorbents as a result of co-polymerization via cross-linkers. Water 40-45 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 0-7 34626964-4 2022 Therefore, the resultant ZnO/Ag/beta-CD/PAN membrane displays splendid separation performance for oil/dye/water complex emulsions and high flux recovery (>90%). Water 106-111 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 32-39 34212318-3 2022 beta-CD, which is normally insoluble in water, is used in demanding wastewater applications by being modified with the help of different agents to be water soluble or transformed into polymeric adsorbents as a result of co-polymerization via cross-linkers. Water 150-155 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 0-7 34943069-3 2021 DPPH was used as a reactivity model of reactive oxygen species and solubilized in water using beta-cyclodextrin (beta-CD). Water 83-88 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 114-121 34686957-2 2022 In recent years, beta-cyclodextrin (beta-CD)-based polymers and nanosystems have been extensively studied as adsorbents for the purpose of water purification. Water 139-144 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 36-43 34878772-2 2021 The remarkable water adsorption and capture abilities of octopus tentacles inspired the construction of a novel TFC nanofiltration (NF) membrane with octopus arm-sucker morphology using carbon nanotubes (CNTs) and beta-cyclodextrin (beta-CD) during interfacial polymerization (IP). Water 15-20 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 233-240 34817179-2 2021 In this work, properties of heptakis(2,6-O-dimethyl)-beta-cyclodextrin (DM-beta-CD) in vacuo and in water, as well as its ability to bind the antidepressant drug mianserin (MIA) in aqueous solution, are investigated computationally. Water 100-105 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 75-82 34817179-6 2021 Both the B3LYP-GD2 and M062X-GD3 results show that all tested inclusion and noninclusion complexes of MIA:DM-beta-CD in stoichiometry 1:1 are stable in water. Water 152-157 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 109-116 34963947-1 2021 The current study pertains to the synthesis of an EDTA-functionalized beta-cyclodextrin-chitosan (beta-CD-CS-EDTA) composite via a two-step process for the adsorptive removal of toxic heavy metallic ions (i.e., Pb(II), Cu(II), and Ni(II)) and antibiotic micropollutant, i.e., ciprofloxacin (CIP), from water. Water 302-307 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 98-105 34743518-2 2022 The enantiomeric excess (ee) of chiral (E)-isomer (1E) produced was a critical function of all the internal and external factors examined, in particular, the sensitizer structure and the solvent conditions, to afford (R)-1E in record-high ee"s of up to 67% upon sensitization with the meta-substituted beta-CD host in water and salt solutions but neither in 50% aqueous ethanol nor with the ortho- and para-substituted hosts. Water 318-323 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 302-309 34885735-5 2021 The results showed that the prepared beta-CD inclusion complexes distributed evenly in the cross-linking structure of FGSA and improved the thickness and water contact angle of the bilayer films. Water 154-159 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 37-44 34560942-2 2021 Copper nanoparticles immobilized-beta-cyclodextrin functionalized reduced graphene oxide (Cu/beta-CD/rGO) were successfully prepared as an efficient extractor of tetracycline (TC), oxytetracycline (OTC) and doxycycline (DC) antibiotics from different environmental water samples. Water 265-270 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 93-100 34560942-7 2021 The Cu/beta-CD/rGO nanocomposite was applied for removing TCs from tap water and the Nile River water samples. Water 71-76 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 7-14 34560942-7 2021 The Cu/beta-CD/rGO nanocomposite was applied for removing TCs from tap water and the Nile River water samples. Water 96-101 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 7-14 33557644-1 2021 The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with beta-cyclodextrin (beta-CD). Water 83-88 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 148-155 34523939-3 2021 Compared to native beta-CD, methylated beta cyclodextrins complexed with cholesterols demonstrated higher mechanical stabilities due to the loss of more high-energy water molecules inside the methylated beta-CD cavities. Water 165-170 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 19-26 34364573-1 2021 The purpose of this study was to use hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen. Water 200-205 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 73-80 34523939-3 2021 Compared to native beta-CD, methylated beta cyclodextrins complexed with cholesterols demonstrated higher mechanical stabilities due to the loss of more high-energy water molecules inside the methylated beta-CD cavities. Water 165-170 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 203-210 34491745-2 2021 beta-Cyclodextrin (beta-CD) is a water-dispersible molecule with a hydrophobic core that can encapsulate and protect non-polar substances. Water 33-38 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 19-26 34497177-6 2021 However, 2,6-di-O-methylated beta-CD (2,6-DMCD) formed a water-soluble inclusion complex with Toc, effectively enhancing its solubility. Water 57-62 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 29-36 34224705-8 2021 The use of beta-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water. Water 118-123 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 11-18 34224705-8 2021 The use of beta-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water. Water 237-242 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 11-18 34224705-8 2021 The use of beta-CD in the synthesis of AuNPs are revealed not only create uniform small sized nanoparticles but these water soluble nanoparticles have very good antibacterial action by inhibiting the growth of bacteria commonly found in water and sensing activity for sensing the concentration of toxic metals in water. Water 313-318 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 11-18 34224705-11 2021 The kapp value of this photocatalytic degradation of textile dyeing waste water in presence of AuNPs was 0.002/min and beta-CD/AuNPs was 0.005/min. Water 74-79 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 119-126 34409609-3 2021 Herein, a high-efficiency and eco-friendly preparation method of an inclusion (allicin@alpha-CD) formed by allicin and alpha-CD was designed, which turned liquid allicin into crystal particles with high-speed stirring (10,000 r/min) at 25 C for 10 min in water. Water 255-260 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 87-95 34216844-1 2021 This study emphases on electrochemical detection of ciprofloxacin in sheep serum and runoff water using silver nanoparticle modified beta-cyclodextrin (Ag-beta-CD) composite. Water 92-97 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 155-162 34409609-3 2021 Herein, a high-efficiency and eco-friendly preparation method of an inclusion (allicin@alpha-CD) formed by allicin and alpha-CD was designed, which turned liquid allicin into crystal particles with high-speed stirring (10,000 r/min) at 25 C for 10 min in water. Water 255-260 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 119-127 34097964-3 2021 PLGA-beta-CD and PEI-BM were synthesized by amidation reaction, the amphipathic polymer nanoparticles with 108.37 +- 1.02 nm were self-assembled in water. Water 148-153 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 5-12 34468866-3 2021 Here, we have studied the interaction between 2-hydroxypropyl beta-CD (HPbetaCD) and three water-soluble drugs, namely naloxone (NX), oxycodone (OC), and tramadol (TR), by isothermal titration calorimetry (ITC) combined with molecular modeling in view of the potential impact on drug release. Water 91-96 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 62-69 35525057-1 2022 beta-cyclodextrin/graphene oxide (GO-beta-CD) was applied for dispersive micro-solid phase extraction (DMSPE) of uranyl ions (UO22+) from water samples and their determination by energy-dispersive (EDXRF) and total-reflection X-ray fluorescence spectrometry (TXRF). Water 138-143 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 37-44 34361559-6 2021 The stability of (BA beta-CD) complex in H2O-EtOH and H2O-DMSO solvents, obtained by different methods, are compared. Water 41-44 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 21-28 34361559-6 2021 The stability of (BA beta-CD) complex in H2O-EtOH and H2O-DMSO solvents, obtained by different methods, are compared. Water 54-57 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 21-28 34071663-5 2021 A water-in-oil reverse microemulsion method was utilized to encapsulate ginsenoside CK via the hydrophobic cavity of beta-CD. Water 2-7 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 117-124 34361559-3 2021 In this paper, NMR results for the molecular complex formation between BA and beta-CD ((BA beta-CD)) in D2O-DMSO-d6 and in D2O-EtOH have shown that the stability of the complex in the H2O-DMSO-d6 varies within the experimental error, while decreases in H2O-EtOH. Water 184-187 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 78-85 34361559-3 2021 In this paper, NMR results for the molecular complex formation between BA and beta-CD ((BA beta-CD)) in D2O-DMSO-d6 and in D2O-EtOH have shown that the stability of the complex in the H2O-DMSO-d6 varies within the experimental error, while decreases in H2O-EtOH. Water 184-187 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 91-98 34361559-3 2021 In this paper, NMR results for the molecular complex formation between BA and beta-CD ((BA beta-CD)) in D2O-DMSO-d6 and in D2O-EtOH have shown that the stability of the complex in the H2O-DMSO-d6 varies within the experimental error, while decreases in H2O-EtOH. Water 253-256 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 78-85 34361559-3 2021 In this paper, NMR results for the molecular complex formation between BA and beta-CD ((BA beta-CD)) in D2O-DMSO-d6 and in D2O-EtOH have shown that the stability of the complex in the H2O-DMSO-d6 varies within the experimental error, while decreases in H2O-EtOH. Water 253-256 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 91-98 34361559-4 2021 Changes in the Gibbs energy of BA resolvation in water and water-dimethylsulfoxide mixtures have been obtained and have been used in the analysis of the reagent solvation contributions into the Gibbs energy changes of the (BA beta-CD) molecular complex formation. Water 49-54 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 226-233 34361559-4 2021 Changes in the Gibbs energy of BA resolvation in water and water-dimethylsulfoxide mixtures have been obtained and have been used in the analysis of the reagent solvation contributions into the Gibbs energy changes of the (BA beta-CD) molecular complex formation. Water 59-64 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 226-233 34203003-2 2021 In the first step, a functional electrospun fiber mat composed of poly(acrylic acid) (PAA) and beta-cyclodextrin (beta-CD) was obtained, showing high water insolubility and great adhesion increased by means of a thermal crosslinking process (denoted as PAA + beta-CD). Water 150-155 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 114-121 35500463-2 2022 The sensor was composed of flexible reference electrode, pH response electrode and K+ selective electrode, which were prepared through printing beta-CD functionalized graphene (beta-CD/RGO) water suspension on conductive PET substrate with microelectronic printer. Water 190-195 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 144-151 35500463-2 2022 The sensor was composed of flexible reference electrode, pH response electrode and K+ selective electrode, which were prepared through printing beta-CD functionalized graphene (beta-CD/RGO) water suspension on conductive PET substrate with microelectronic printer. Water 190-195 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 177-188 35367247-8 2022 Altogether, the LT-HP-beta-CD represents a potential carrier for enhancing the water solubility and oral bioavailability of LT coupled with antitumor activity enhancement. Water 79-84 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 22-29 35490765-1 2022 The current work aimed to enhance the oral bioavailability of water-insoluble drug Artemisinin (ART) by the inclusion of ART with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and then loaded with porous starch (PS). Water 62-67 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 166-173 35384203-3 2022 The POM/beta-CD hybrid can be dispersed in water and interact at a water/oil interface with ligands dissolved in an oil phase through electrostatic or host-guest interactions, thereby generating POM-surfactants (POMSs) having pH, redox, and guest-competitive responsiveness, respectively. Water 43-48 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 8-15 35384203-3 2022 The POM/beta-CD hybrid can be dispersed in water and interact at a water/oil interface with ligands dissolved in an oil phase through electrostatic or host-guest interactions, thereby generating POM-surfactants (POMSs) having pH, redox, and guest-competitive responsiveness, respectively. Water 67-72 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 8-15 35631996-7 2022 The water-soluble excipient (HP-beta-CD) effectively enhance the dissolution rate of BDP from composite particles. Water 4-9 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 32-39 35566207-3 2022 The appended beta-CD units in OFP-CD enabled the forming of host-guest complexes with dabsyl chloride moieties in water, resulting in fluorescence quenching of the oligofluorene through intermolecular energy transfer. Water 114-119 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 13-20 35424977-1 2022 Among the cyclodextrins screened for the synthesis of 2-hydroxy-1,2-diphenylethanone (benzoin) in water, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) exhibited the highest yield in the benzoin condensation reactions, and HP-beta-CD can be recycled several times with little loss of activity through the addition of fresh VB1. Water 98-103 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 143-150 35311602-1 2022 AIM: To prepare ecdysterone(ES)/hydroxypropyl-beta-cyclodextrin(HP-beta-CD) inclusion complex, thus improving the water solubility and bioavailability of ES. Water 114-119 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 67-74 35306010-6 2022 Also, the fragrance-released beta-CD-Cel composite film showed high transparency, strong water resistance, and good flexibility. Water 89-94 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 29-36