PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12044168-5 2002 To allow ion flux across the membrane Vpu would be required to assemble in homooligomers to form functional water-filled pores. Water 108-113 Vpu Human immunodeficiency virus 1 38-41 9708891-2 1998 A pentameric bundle of unconstrained helices (residues 6-28 of Vpu) with a water filled pore was initially assembled in a membrane mimetic octane/water system. Water 75-80 Vpu Human immunodeficiency virus 1 63-66 11259297-3 2001 Langmuir monolayers of mixtures of Vpu and the phospholipid 1,2-dilignoceroyl-sn-glycero-3-phosphocholine (DLgPC) at the water-air interface were studied by synchrotron radiation-based x-ray reflectivity over a range of mole ratios at constant surface pressure and for several surface pressures at a maximal mole ratio of Vpu/DLgPC. Water 121-126 Vpu Human immunodeficiency virus 1 35-38 9708891-2 1998 A pentameric bundle of unconstrained helices (residues 6-28 of Vpu) with a water filled pore was initially assembled in a membrane mimetic octane/water system. Water 146-151 Vpu Human immunodeficiency virus 1 63-66 9108308-2 1997 Models of Vpu channels formed by bundles of N = 4, 5 or 6 transmembrane helices have been developed by restrained molecular dynamics and refined by 100 ps simulations with water molecules within the pore. Water 172-177 Vpu Human immunodeficiency virus 1 10-13