PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32222974-0	2020	Water-soluble variant of human Lynx1 positively modulates synaptic plasticity and ameliorates cognitive impairment associated with alpha7-nAChR dysfunction.	Water	0-5	Ly6/neurotoxin 1	Homo sapiens	31-36	
32648941-6	2021	A water-soluble form of Lynx1, ws-Lynx1, was expressed in E. coli, its 1 H-NMR structure and binding to several nAChRs determined.	Water	2-7	Ly6/neurotoxin 1	Homo sapiens	24-29	
32648941-6	2021	A water-soluble form of Lynx1, ws-Lynx1, was expressed in E. coli, its 1 H-NMR structure and binding to several nAChRs determined.	Water	2-7	Ly6/neurotoxin 1	Homo sapiens	34-39	
22332355-0	2011	[Bacterial expression of water-soluble domain of Lynx1, endogenic neuromodulator of human nicotinic acetylcholine receptors].	Water	25-30	Ly6/neurotoxin 1	Homo sapiens	49-54	
30397527-5	2018	In addition, we have demonstrated that the Lynx1 expression decrease, as well as the blockade of the long-term potentiation underlying learning and memory, caused by Abeta1-42, may be prevented by incubation with a water-soluble Lynx1 analogue.	Water	215-220	Ly6/neurotoxin 1	Homo sapiens	43-48	
30397527-5	2018	In addition, we have demonstrated that the Lynx1 expression decrease, as well as the blockade of the long-term potentiation underlying learning and memory, caused by Abeta1-42, may be prevented by incubation with a water-soluble Lynx1 analogue.	Water	215-220	Ly6/neurotoxin 1	Homo sapiens	229-234	
30397527-6	2018	Our findings suggest that the water-soluble Lynx1 analogue may be a promising agent for the improvement of cognitive deficits in neurodegenerative diseases.	Water	30-35	Ly6/neurotoxin 1	Homo sapiens	44-49	
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	Ly6/neurotoxin 1	Homo sapiens	84-89	
27460145-3	2016	We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates alpha3, alpha4, alpha5, alpha6, alpha7, beta2, and beta4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain.	Water	53-58	Ly6/neurotoxin 1	Homo sapiens	91-99	
23585571-0	2013	Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.	Water	0-5	Ly6/neurotoxin 1	Homo sapiens	14-19	
31150435-0	2019	Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of alpha7 nicotinic acetylcholine receptors.	Water	0-5	Ly6/neurotoxin 1	Homo sapiens	31-36	
31150435-8	2019	The recombinant water-soluble variant of Lynx1 without a GPI-anchor (ws-Lynx1) inhibited the growth of A549 cells causing cell cycle arrest via modulation of alpha7-nAChRs and activation of different intracellular signaling cascades, including PKC/IP3, MAP/ERK, p38, and JNK pathways.	Water	16-21	Ly6/neurotoxin 1	Homo sapiens	41-46	
31150435-8	2019	The recombinant water-soluble variant of Lynx1 without a GPI-anchor (ws-Lynx1) inhibited the growth of A549 cells causing cell cycle arrest via modulation of alpha7-nAChRs and activation of different intracellular signaling cascades, including PKC/IP3, MAP/ERK, p38, and JNK pathways.	Water	16-21	Ly6/neurotoxin 1	Homo sapiens	72-77	
27417718-1	2016	With the use of surface plasmon resonance (SPR) it was shown that ws-Lynx1, a water-soluble analog of the three-finger membrane-bound protein Lynx1, that modulates the activity of brain nicotinic acetylcholine receptors (nAChRs), interacts with the acetylcholine-binding protein (AChBP) with high affinity, K D = 62 nM.	Water	78-83	Ly6/neurotoxin 1	Homo sapiens	69-74	
27417718-1	2016	With the use of surface plasmon resonance (SPR) it was shown that ws-Lynx1, a water-soluble analog of the three-finger membrane-bound protein Lynx1, that modulates the activity of brain nicotinic acetylcholine receptors (nAChRs), interacts with the acetylcholine-binding protein (AChBP) with high affinity, K D = 62 nM.	Water	78-83	Ly6/neurotoxin 1	Homo sapiens	142-147	
21252236-0	2011	NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.	Water	65-70	Ly6/neurotoxin 1	Homo sapiens	95-100	
21252236-3	2011	We report for the first time the NMR spatial structure for the water-soluble domain of human LYNX1 lacking a GPI anchor (ws-LYNX1) and its concentration-dependent activity on nicotinic acetylcholine receptors (nAChRs).	Water	63-68	Ly6/neurotoxin 1	Homo sapiens	93-98	
21252236-3	2011	We report for the first time the NMR spatial structure for the water-soluble domain of human LYNX1 lacking a GPI anchor (ws-LYNX1) and its concentration-dependent activity on nicotinic acetylcholine receptors (nAChRs).	Water	63-68	Ly6/neurotoxin 1	Homo sapiens	124-129