PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21185297-1 2011 Arginine vasopressin (AVP) is involved in the homeostatic responses numerous life-threatening conditions, for example, the promotion of water conservation during periods of dehydration, and the activation of the hypothalamo-pituitary adrenal axis by emotional stress. Water 136-141 arginine vasopressin Rattus norvegicus 9-20 21858088-0 2011 Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain. Water 47-52 arginine vasopressin Rattus norvegicus 13-24 21858088-0 2011 Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain. Water 47-52 arginine vasopressin Rattus norvegicus 104-115 20576681-6 2010 Time course studies in rat IMCD suspensions showed maximum phosphorylation within 1 min of dDAVP exposure, consistent with the time course of vasopressin-stimulated phosphorylation of the vasopressin-sensitive water channel aquaporin-2 at Ser256. Water 210-215 arginine vasopressin Rattus norvegicus 142-153 20694542-2 2010 In the present study, we aimed to investigate the interaction between the generation of NO and vasopressin (AVP) and corticosterone release after 3 days of water deprivation in rats. Water 156-161 arginine vasopressin Rattus norvegicus 95-106 20694542-2 2010 In the present study, we aimed to investigate the interaction between the generation of NO and vasopressin (AVP) and corticosterone release after 3 days of water deprivation in rats. Water 156-161 arginine vasopressin Rattus norvegicus 108-111 20694542-8 2010 Three days of water deprivation increased significantly the corticosterone levels in plasma (p<0.01) and AVP levels in hypothalamus and plasma (p<0.01), but not in pituitary, which showed a significant decrease. Water 14-19 arginine vasopressin Rattus norvegicus 108-111 20694542-10 2010 L-NAME injection abolished significantly (p<0.01) the elevation of plasma corticosterone and hypothalamic AVP levels induced by water deprivation. Water 131-136 arginine vasopressin Rattus norvegicus 109-112 20694542-11 2010 These findings showed that in water-deprived rats, nitric oxide synthase inhibition by L-NAME inhibits corticosterone and vasopressin release, suggesting a potent stimulatory role of NO. Water 30-35 arginine vasopressin Rattus norvegicus 122-133 20576681-6 2010 Time course studies in rat IMCD suspensions showed maximum phosphorylation within 1 min of dDAVP exposure, consistent with the time course of vasopressin-stimulated phosphorylation of the vasopressin-sensitive water channel aquaporin-2 at Ser256. Water 210-215 arginine vasopressin Rattus norvegicus 188-199 20738873-0 2010 Computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis. Water 75-80 arginine vasopressin Rattus norvegicus 28-39 20738873-2 2010 AVP participates to the hydromineral homeostasis (HH) by controlling water excretion at the level of the kidneys. Water 69-74 arginine vasopressin Rattus norvegicus 0-3 21468191-1 2010 When the concentration of sodium (Na(+)) in arterial plasma (P(Na)) declines sufficiently to inhibit the release of vasopressin, water will be excreted promptly when the vast majority of aquaporin 2 water channels (AQP2) have been removed from luminal membranes of late distal nephron segments. Water 129-134 arginine vasopressin Rattus norvegicus 116-127 20371268-7 2010 Plasma AVP concentration curve as a function of water deprivation (WD) time showed a marked increase, reaching its maximal levels within half the time of controls and another significant difference after VCT. Water 48-53 arginine vasopressin Rattus norvegicus 7-10 20576679-2 2010 We investigated in vivo and in vitro whether vasopressin-induced water reabsorption could be attenuated by ANG II AT1 receptor blockade (losartan). Water 65-70 arginine vasopressin Rattus norvegicus 45-56 20597365-4 2010 These data for the first time show that furosemide not only decreases sodium reabsorption, but also blocks some componentin molecular mechanism of vasopressin-dependent increase of the osmotic permeability of water. Water 209-214 arginine vasopressin Rattus norvegicus 147-158 20007345-1 2010 Vasopressin influences salt and water transport in renal epithelia. Water 32-37 arginine vasopressin Rattus norvegicus 0-11 20089674-1 2010 The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269. Water 65-70 arginine vasopressin Rattus norvegicus 14-25 20089674-1 2010 The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269. Water 139-144 arginine vasopressin Rattus norvegicus 14-25 19996160-1 2010 Vasopressin is a peptide hormone that regulates renal water excretion in part through its actions on the collecting duct. Water 54-59 arginine vasopressin Rattus norvegicus 0-11 18255192-2 2009 Activation of hypothalamic neurons in the supraoptic nucleus that release anti-diuretic arginine-vasopressin in plasma provides water retention. Water 128-133 arginine vasopressin Rattus norvegicus 97-108 20065504-8 2009 In experimental preascitic cirrhosis NaCl retention in the ascending limb of Henle"s loop increases medullary interstitial tonicity leading to vasopressin-independent water back-diffusion in thin descending limb of Henle"s loop and collecting duct. Water 167-172 arginine vasopressin Rattus norvegicus 143-154 19415169-8 2009 Brain water content, however, responded to hyponatraemia with an increase from 77.55 +/- 1.00% to 78.45 +/- 0.94% (p < 0.01), and it was further augmented to 79.35 +/- 0.80% (p < 0.0005) by icv AVP pretreatment. Water 6-11 arginine vasopressin Rattus norvegicus 200-203 18836965-2 2009 These results suggest that VP increases the influx of water from the perlymph to the basal cells via aquaporin (AQP) 2 and causes the formation of endolymphatic hydrops. Water 54-59 arginine vasopressin Rattus norvegicus 27-29 19209902-1 2009 Vasopressin-mediated control of water permeability in the renal collecting duct occurs in part through regulation of the distribution of aquaporin-2 (AQP2) between the apical plasma membrane and intracellular membrane compartments. Water 32-37 arginine vasopressin Rattus norvegicus 0-11 19106215-8 2009 Water restriction for 6 d increased plasma arginine vasopressin (AVP), ACTH, and adrenal and plasma corticosterone in both groups. Water 0-5 arginine vasopressin Rattus norvegicus 52-63 18987488-8 2009 These data suggest that control of water balance or aquaretic drugs might have beneficial effects on splanchnic hemodynamics and portal pressure in advanced liver disease, possibly by stimulating endogenous vasopressin release. Water 35-40 arginine vasopressin Rattus norvegicus 207-218 18843259-1 2009 Trafficking of the water channel aquaporin-2 to the apical plasma membrane of the collecting duct is mediated by arginine vasopressin, rendering the cell permeable to water. Water 19-24 arginine vasopressin Rattus norvegicus 122-133 18843259-1 2009 Trafficking of the water channel aquaporin-2 to the apical plasma membrane of the collecting duct is mediated by arginine vasopressin, rendering the cell permeable to water. Water 167-172 arginine vasopressin Rattus norvegicus 122-133 18578860-9 2008 Our study on time course and correlations among water metabolism, degeneration and apoptosis of vasopressin neurons suggested that there should be an efficient therapeutic window in which irreversible CDI might be prevented by anti-apoptosis. Water 48-53 arginine vasopressin Rattus norvegicus 96-107 19053774-1 2008 Vasopressin (AVP) is a hormone that stimulates an increase in water permeability through activation of V2 receptors in the kidney. Water 62-67 arginine vasopressin Rattus norvegicus 0-11 19258663-3 2008 Increased vasopressin secretion stimulates water retention by renal actions, while oxytocin is natriuretic, partly by stimulating cardiac atrial natriuretic peptide (ANP) secretion. Water 43-48 arginine vasopressin Rattus norvegicus 10-21 19180911-7 2008 CONCLUSION: Vasopressin may down-regulate the expression of AQP7 mRNA in the endolymphatic sac and induce a decreased absorption of endolymph, which decreases the water permeability in the potassium ions recycle pathway in the organ of Corti and disturbs the circulation of endolymph, resulting in endolymphatic hydrops. Water 163-168 arginine vasopressin Rattus norvegicus 12-23 18667481-1 2008 Vasopressin regulates water excretion through effects on the renal collecting duct. Water 22-27 arginine vasopressin Rattus norvegicus 0-11 18417545-2 2008 We investigated the mechanisms of AVP-induced cell swelling in isolated, perfused rat inner medullary collecting ducts (IMCDs) using quantitative video microscopy and fluorescence-based measurements of transepithelial water transport. Water 218-223 arginine vasopressin Rattus norvegicus 34-37 18417545-4 2008 When a transepithelial osmolality gradient was imposed by addition of NaCl to the bath, AVP significantly increased both water flux and cell height. Water 121-126 arginine vasopressin Rattus norvegicus 88-91 18417545-5 2008 When the osmolality gradient was imposed by addition of mannitol, AVP increased water flux but not cell height, suggesting that AVP-induced cell swelling requires a NaCl gradient and is not merely dependent on the associated water flux. Water 80-85 arginine vasopressin Rattus norvegicus 66-69 18417545-5 2008 When the osmolality gradient was imposed by addition of mannitol, AVP increased water flux but not cell height, suggesting that AVP-induced cell swelling requires a NaCl gradient and is not merely dependent on the associated water flux. Water 225-230 arginine vasopressin Rattus norvegicus 66-69 18417545-5 2008 When the osmolality gradient was imposed by addition of mannitol, AVP increased water flux but not cell height, suggesting that AVP-induced cell swelling requires a NaCl gradient and is not merely dependent on the associated water flux. Water 225-230 arginine vasopressin Rattus norvegicus 128-131 18417545-11 2008 We conclude that the AVP-induced cell height increase is dependent on basolateral solute uptake via NKCC1 and changes in actin organization via myosin II, but is not dependent specifically on increased apical water entry. Water 209-214 arginine vasopressin Rattus norvegicus 21-24 18824919-11 2008 CONCLUSION: In this endotoxic model, dose-targeted arginine vasopressin infusion increased lipopolysaccharide-induced renal dysfunction without affecting renal blood flow and glomerular function, but with particular disruption of aquaporin-2/V2 receptor networking, consecutive decreased salt and water handling ability. Water 297-302 arginine vasopressin Rattus norvegicus 60-71 18596208-1 2008 In the renal collecting duct, vasopressin controls transport of water and solutes via regulation of membrane transporters such as aquaporin-2 (AQP2) and the epithelial urea transporter UT-A. Water 64-69 arginine vasopressin Rattus norvegicus 30-41 18434616-8 2008 Suppression of arginine vasopressin release by high water intake is protective. Water 52-57 arginine vasopressin Rattus norvegicus 24-35 17940875-1 2008 Arginine vasopressin (AVP) is known to a neuropeptide that plays important roles in water conservation, sodium homeostasis, and in the regulation of serum osmolality. Water 84-89 arginine vasopressin Rattus norvegicus 9-20 17940875-1 2008 Arginine vasopressin (AVP) is known to a neuropeptide that plays important roles in water conservation, sodium homeostasis, and in the regulation of serum osmolality. Water 84-89 arginine vasopressin Rattus norvegicus 22-25 18310451-6 2008 Finally, central administration of an antiserum specific to obestatin resulted in an exaggerated basal vasopressin release and an increased vasopressin response to overnight water deprivation. Water 174-179 arginine vasopressin Rattus norvegicus 140-151 18519091-8 2008 Suppression of arginine vasopressin release by high water intake is protective. Water 52-57 arginine vasopressin Rattus norvegicus 24-35 18288441-7 2008 These results demonstrate the important role of vasopressin in the development of the disturbances in brain water and electrolyte balance in response to general cerebral hypoxia. Water 108-113 arginine vasopressin Rattus norvegicus 48-59 19388360-14 2008 These data provide further support that vasopressin (AVP) and V1a receptors can control water flux through astrocytic plasma membranes by regulating AQP4 expression. Water 88-93 arginine vasopressin Rattus norvegicus 40-51 18287043-1 2008 By phosphoproteome analysis, we identified a phosphorylation site, serine 264 (pS264), in the COOH terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2). Water 137-142 arginine vasopressin Rattus norvegicus 115-126 17956998-1 2008 Vasopressin acts on the inner medullary collecting duct (IMCD) in the kidney to regulate water and urea transport. Water 89-94 arginine vasopressin Rattus norvegicus 0-11 18179782-3 2008 Arginine vasopressin (AVP) promotes renal water reabsorption via the V(2) receptor (V(2)R) and its levels are increased in CHF. Water 42-47 arginine vasopressin Rattus norvegicus 0-20 19388361-5 2008 Administration of the vasopressin antagonist (SR49059) reduced brain water content and sodium shift following MCAo. Water 69-74 arginine vasopressin Rattus norvegicus 22-33 18655905-9 2008 These results demonstrate the important role of AVP in the development of the disturbances in brain water and electrolyte balance in response to general cerebral hypoxia. Water 100-105 arginine vasopressin Rattus norvegicus 48-51 17204593-7 2007 On the other hand, an early effect of water or saline consumption on VP secretion in PEG-treated rats was not observed, in contrast to recent findings in dehydrated rats. Water 38-43 arginine vasopressin Rattus norvegicus 69-71 17956998-4 2008 Among the 30 transcripts with the greatest signals on the arrays were 3 water channels: aquaporin-2, aquaporin-3, and aquaporin-4, all of which have been reported to be targets for regulation by vasopressin. Water 72-77 arginine vasopressin Rattus norvegicus 195-206 17626156-1 2007 In renal epithelia, vasopressin influences salt and water transport, chiefly via vasopressin V(2) receptors (V(2)Rs) linked to adenylyl cyclase. Water 52-57 arginine vasopressin Rattus norvegicus 20-31 17573101-0 2007 Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats. Water 146-151 arginine vasopressin Rattus norvegicus 0-11 17573101-0 2007 Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats. Water 146-151 arginine vasopressin Rattus norvegicus 131-142 17573101-2 2007 A stainless steel cannula was implanted into the medial septal area (MSA) of male Holtzman rats AVP injection enhanced water and sodium intake in a dose-dependent manner. Water 119-124 arginine vasopressin Rattus norvegicus 96-99 17573101-3 2007 Pretreatment with V(1) antagonist injected into the MSA produced a dose-dependent reduction, whereas prior injection of V(2) antagonist increased, in a dose-dependent manner, the water and sodium responses elicited by the administration of AVP. Water 179-184 arginine vasopressin Rattus norvegicus 240-243 17573101-4 2007 Both AT(1) and AT(2) antagonists administered into the MSA elicited a concentration-dependent decrease in water and sodium intake induced by AVP, while simultaneous injection of the two antagonists was more effective in decreasing AVP responses. Water 106-111 arginine vasopressin Rattus norvegicus 141-144 17573101-5 2007 These results also indicate that the increase in water and sodium intake induced by AVP was mediated primarily by MSA AT(1) receptors. Water 49-54 arginine vasopressin Rattus norvegicus 84-87 17609209-11 2007 Anti-NERP IgGs canceled plasma vasopressin reduction in response to water loading, indicating that NERPs could be potent endogenous suppressors of vasopressin release. Water 68-73 arginine vasopressin Rattus norvegicus 31-42 17609209-11 2007 Anti-NERP IgGs canceled plasma vasopressin reduction in response to water loading, indicating that NERPs could be potent endogenous suppressors of vasopressin release. Water 68-73 arginine vasopressin Rattus norvegicus 147-158 17626240-1 2007 Water reabsorption in the renal collecting duct is regulated by arginine vasopressin (AVP). Water 0-5 arginine vasopressin Rattus norvegicus 73-84 17537436-5 2007 Plasma osmolality, vasopressin (AVP), adrenocorticotropic hormone (ACTH) and corticosterone were elevated by water restriction and reduced after drinking in both models. Water 109-114 arginine vasopressin Rattus norvegicus 19-30 16985212-1 2007 We recently identified a novel phosphorylation site, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2). Water 123-128 arginine vasopressin Rattus norvegicus 101-112 17466712-1 2007 OBJECTIVE: Maternal water restriction (WR) may induce offspring plasma hypertonicity and enhanced vasopressin secretory responses. Water 20-25 arginine vasopressin Rattus norvegicus 98-109 17598476-1 2007 Principal mechanism of the transepithelial water permeability increase in the kidney collecting ducts in response to vasopressin involves insertion of aquaporin 2 (AQP2) into the apical membrane. Water 43-48 arginine vasopressin Rattus norvegicus 117-128 17412804-4 2007 During release, VP travels through the blood stream to specific receptor targets located in the kidney in which it increases the permeability of the collecting ducts to water, reducing the renal excretion of water, thus promoting water conservation. Water 169-174 arginine vasopressin Rattus norvegicus 16-18 17412804-4 2007 During release, VP travels through the blood stream to specific receptor targets located in the kidney in which it increases the permeability of the collecting ducts to water, reducing the renal excretion of water, thus promoting water conservation. Water 208-213 arginine vasopressin Rattus norvegicus 16-18 16896188-1 2007 Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption. Water 67-72 arginine vasopressin Rattus norvegicus 0-11 16481069-6 2006 The robust increase in vesicular glutamate transporter-2 mRNA and immunoreactivity after salt loading suggests that the cellular levels of vesicular glutamate transporter-2 in vasopressin neurons are regulated by alterations in water-electrolyte balance. Water 228-233 arginine vasopressin Rattus norvegicus 176-187 17385429-1 2006 The role of AQP2,3 and intracellular calcium in vasopressin-induced increase in the water permeability of the basolateral cell membrane in microdissected rat kidney OMCD was studied. Water 84-89 arginine vasopressin Rattus norvegicus 48-59 16807403-4 2006 For suppression of the effect of AVP physiologically, water intake was increased in PCK rats, a model of PKD, and the effect on renal morphology, cellular mechanism, and function was determined. Water 54-59 arginine vasopressin Rattus norvegicus 33-36 16807403-6 2006 In PCK rats, increased water intake for 10 wk reduced urinary AVP excretion (68.3%), and urine osmolality fell below 290 mOsmol/kg. Water 23-28 arginine vasopressin Rattus norvegicus 62-65 16396942-12 2006 AVP deficiency significantly increased urine output and solute-free water clearance and decreased urine osmolality. Water 68-73 arginine vasopressin Rattus norvegicus 0-3 17070001-1 2006 Vasopressin regulates water excretion from the kidney by increasing water permeability of the collecting duct as a hormone secreted from the posterior pituitary. Water 22-27 arginine vasopressin Rattus norvegicus 0-11 17070001-1 2006 Vasopressin regulates water excretion from the kidney by increasing water permeability of the collecting duct as a hormone secreted from the posterior pituitary. Water 68-73 arginine vasopressin Rattus norvegicus 0-11 16449354-1 2006 Vasopressin increases urine concentration by stimulating plasma membrane accumulation of aquaporin-2 (AQP2) in collecting duct principal cells, allowing bulk water flow across the collecting duct from lumen to interstitium down an osmotic gradient. Water 158-163 arginine vasopressin Rattus norvegicus 0-11 16449382-1 2006 The inner medullary collecting duct (IMCD) is an important site of vasopressin-regulated water and urea transport. Water 89-94 arginine vasopressin Rattus norvegicus 67-78 16339345-8 2006 Attenuation of brain water content with 7.5% HS treatment coincides with attenuated serum AVP levels, and we speculate that this may represent one additional mechanism by which osmotherapy attenuates edema associated with ischemic stroke. Water 21-26 arginine vasopressin Rattus norvegicus 90-93 16020523-0 2005 Inhibition of vasopressin secretion when dehydrated rats drink water. Water 63-68 arginine vasopressin Rattus norvegicus 14-25 16984090-0 2006 Hydruric response in Wistar and vasopressin-deficient Brattleboro rats to water load under conditions of increased brain serotonin level. Water 74-79 arginine vasopressin Rattus norvegicus 32-43 16133124-2 2005 Recently, we have shown that water deprivation leads to the activation of vasopressin (VP) secretion and expression of Bcl-2 and caspase-9 apototic proteins in the hypothalamus of the rat brain. Water 29-34 arginine vasopressin Rattus norvegicus 74-85 16133124-2 2005 Recently, we have shown that water deprivation leads to the activation of vasopressin (VP) secretion and expression of Bcl-2 and caspase-9 apototic proteins in the hypothalamus of the rat brain. Water 29-34 arginine vasopressin Rattus norvegicus 87-89 16113688-3 2005 Vasopressin (AVP) is of major importance in the pathogenesis of water retention and hyponatremia in cirrhosis. Water 64-69 arginine vasopressin Rattus norvegicus 0-11 16646520-0 2006 Vasopressin and nitric oxide synthesis after three days of water or food deprivation. Water 59-64 arginine vasopressin Rattus norvegicus 0-11 16646520-5 2006 Plasma osmolality and vasopressin levels were significantly elevated in water deprived (362.8 +/- 7.1 mOsm/kg H2O, 17.3 +/- 2.7 pg/ml, respectively, p < 0.001) rats, but not in food deprived (339.9 +/- 5.0, 1.34 +/- 0.28) rats, compared to the controls (326.1 +/- 4.1, 1.47 +/- 0.32). Water 72-77 arginine vasopressin Rattus norvegicus 22-33 16249312-3 2006 By binding to V2-type receptors located in the kidney, VP decreases the amount of water lost in urine. Water 82-87 arginine vasopressin Rattus norvegicus 55-57 16020523-1 2005 The present study determined whether vasopressin (VP) secretion is inhibited by an oropharyngeal signal associated with swallowing fluids when dehydrated rats drink water, as it is when dehydrated dogs are used as experimental subjects (Thrasher, TN, Keil LC, and Ramsay DJ. Water 165-170 arginine vasopressin Rattus norvegicus 37-48 16020523-1 2005 The present study determined whether vasopressin (VP) secretion is inhibited by an oropharyngeal signal associated with swallowing fluids when dehydrated rats drink water, as it is when dehydrated dogs are used as experimental subjects (Thrasher, TN, Keil LC, and Ramsay DJ. Water 165-170 arginine vasopressin Rattus norvegicus 50-52 16020523-3 2005 VP levels in systemic plasma (pVP) fell rapidly when rats drank water after overnight water deprivation. Water 64-69 arginine vasopressin Rattus norvegicus 0-2 16020523-3 2005 VP levels in systemic plasma (pVP) fell rapidly when rats drank water after overnight water deprivation. Water 86-91 arginine vasopressin Rattus norvegicus 0-2 15687250-1 2005 Arginine vasopressin (AVP), acting through a cAMP second messenger system, regulates osmotic water permeability (Pf) of the collecting duct. Water 93-98 arginine vasopressin Rattus norvegicus 9-20 16107579-4 2005 In response to 36-h water deprivation, GD rats demonstrated significantly greater urine flow rate and decreased urine osmolality as compared with control rats at comparable serum osmolality and plasma vasopressin concentrations. Water 20-25 arginine vasopressin Rattus norvegicus 201-212 15840771-1 2005 Circulating vasopressin levels change in hydrated and dehydrated conditions and thus control osmotic water permeability (P(f)) of the inner medullary collecting duct (IMCD). Water 101-106 arginine vasopressin Rattus norvegicus 12-23 15644488-1 2005 Vasopressin-stimulated insertion of the aquaporin 2 (AQP2) water channel into the plasma membrane of kidney collecting duct principal cells is a key event in the urinary concentrating mechanism. Water 59-64 arginine vasopressin Rattus norvegicus 0-11 15948635-8 2005 A significant increase in plasma AVP level was observed after water deprivation and simultaneous water and food deprivation, while no change was found after food deprivation. Water 62-67 arginine vasopressin Rattus norvegicus 33-36 15840033-2 2005 Although the expressional alteration of the kidney-specific apical water channel, aquaporin 2 (AQP2), in the collecting duct has been demonstrated to be involved in the development of hyponatremia and the subsequent physiologic reaction that is resistant to arginine vasopressin (AVP; vasopressin escape) in SIADH, the complete pathogenesis of and the appropriate medical treatment for hyponatremia have yet to be elucidated. Water 67-72 arginine vasopressin Rattus norvegicus 285-296 16115460-8 2005 Moreover, water deprivation, while increasing the activity of AVP neurons, reduces plasma apelin concentrations and induces an intra-neuronal pile up of the peptide, thereby decreasing the inhibitory effect of apelin on AVP release and preventing additional water loss at the kidney level. Water 10-15 arginine vasopressin Rattus norvegicus 62-65 15585668-0 2005 Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. Water 67-72 arginine vasopressin Rattus norvegicus 47-58 16115460-8 2005 Moreover, water deprivation, while increasing the activity of AVP neurons, reduces plasma apelin concentrations and induces an intra-neuronal pile up of the peptide, thereby decreasing the inhibitory effect of apelin on AVP release and preventing additional water loss at the kidney level. Water 10-15 arginine vasopressin Rattus norvegicus 220-223 16115460-8 2005 Moreover, water deprivation, while increasing the activity of AVP neurons, reduces plasma apelin concentrations and induces an intra-neuronal pile up of the peptide, thereby decreasing the inhibitory effect of apelin on AVP release and preventing additional water loss at the kidney level. Water 258-263 arginine vasopressin Rattus norvegicus 62-65 15710610-1 2005 Calmodulin plays a critical role in regulation of renal collecting duct water permeability by vasopressin. Water 72-77 arginine vasopressin Rattus norvegicus 94-105 15585668-1 2005 Vasopressin and ANG II, which are known to play a major role in renal water and sodium reabsorption, are mainly coupled to the cAMP/PKA and phosphoinositide pathways, respectively. Water 70-75 arginine vasopressin Rattus norvegicus 0-11 15585668-3 2005 We therefore hypothesized that vasopressin-induced water reabsorption could be attenuated by ANG II AT(1) receptor blockade in rats. Water 51-56 arginine vasopressin Rattus norvegicus 31-42 15458969-10 2005 Water deprivation significantly increased osmolality and hematocrit, as well as plasma protein and vasopressin concentrations. Water 0-5 arginine vasopressin Rattus norvegicus 99-110 15840033-2 2005 Although the expressional alteration of the kidney-specific apical water channel, aquaporin 2 (AQP2), in the collecting duct has been demonstrated to be involved in the development of hyponatremia and the subsequent physiologic reaction that is resistant to arginine vasopressin (AVP; vasopressin escape) in SIADH, the complete pathogenesis of and the appropriate medical treatment for hyponatremia have yet to be elucidated. Water 67-72 arginine vasopressin Rattus norvegicus 267-278 15607625-1 2004 Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension. Water 135-140 arginine vasopressin Rattus norvegicus 0-11 15610244-16 2005 It is concluded that the increase in water reabsorption in the CD is an adaptive response of the kidney to a long period of food deprivation and is mediated via a vasopressin-independent mechanism. Water 37-42 arginine vasopressin Rattus norvegicus 163-174 15607625-1 2004 Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension. Water 135-140 arginine vasopressin Rattus norvegicus 13-16 15277036-5 2004 Plasma AVP levels were also increased by caloric stimulation with cold water. Water 71-76 arginine vasopressin Rattus norvegicus 7-10 15347643-1 2004 We have previously demonstrated that vasopressin increases the water permeability of the inner medullary collecting duct (IMCD) by inducing trafficking of aquaporin-2 to the apical plasma membrane and that this response is dependent on intracellular calcium mobilization and calmodulin activation. Water 63-68 arginine vasopressin Rattus norvegicus 37-48 15347643-7 2004 The MLCK inhibitor ML-7 blocked the DDAVP-induced MLC phosphorylation and substantially reduced [Arg8]vasopressin (AVP)-stimulated water permeability. Water 131-136 arginine vasopressin Rattus norvegicus 102-113 15693290-1 2004 OBJECTIVE: Magnocellular neuroendocrine cells of the supraoptic nucleus of the hypothalamus produce and release the hormones vasopressin and oxytocin in response to a variety of stimuli to regulate body water and salt as well as and parturition and lactation. Water 203-208 arginine vasopressin Rattus norvegicus 125-136 15172884-1 2004 Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel. Water 45-50 arginine vasopressin Rattus norvegicus 0-11 15172884-1 2004 Vasopressin (AVP) stimulates collecting duct water reabsorption through cAMP-mediated membrane targeting and increased expression of the aquaporin-2 (AQP2) water channel. Water 156-161 arginine vasopressin Rattus norvegicus 0-11 15300159-5 2004 Analysis of the UT-A1 promoter suggests that vasopressin increases UT-A1 indirectly following a direct effect to increase the transcription of other genes, such as the Na(+)-K(+)-2Cl- cotransporter NKCC2/BSC1 and the aquaporin (AQP) 2 water channel, that begin to increase inner medullary osmolality. Water 235-240 arginine vasopressin Rattus norvegicus 45-56 15231996-7 2004 Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis. Water 10-15 arginine vasopressin Rattus norvegicus 54-57 15231996-7 2004 Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis. Water 10-15 arginine vasopressin Rattus norvegicus 103-106 15231996-7 2004 Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis. Water 10-15 arginine vasopressin Rattus norvegicus 103-106 15231996-7 2004 Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis. Water 10-15 arginine vasopressin Rattus norvegicus 103-106 15003832-0 2004 Effects of angiotensin and vasopressin V(1) receptors on water and sodium intake induced by injection of vasopressin into lateral septal area. Water 57-62 arginine vasopressin Rattus norvegicus 105-116 15003832-5 2004 Water and sodium intake were measured at 0.25, 0.5, 1.0 and 2.0 h. Injection of AVP reduced the water and sodium ingestion vs. control (0.15 M saline). Water 0-5 arginine vasopressin Rattus norvegicus 80-83 15003832-5 2004 Water and sodium intake were measured at 0.25, 0.5, 1.0 and 2.0 h. Injection of AVP reduced the water and sodium ingestion vs. control (0.15 M saline). Water 96-101 arginine vasopressin Rattus norvegicus 80-83 14727685-1 2003 Vasopressin has an important role in water metabolism and its impairment induces some clinical disorders such as diabetes insipidus or syndrome of inappropriate antidiuresis (SIAD). Water 37-42 arginine vasopressin Rattus norvegicus 0-11 15109940-0 2004 Influence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat. Water 85-90 arginine vasopressin Rattus norvegicus 137-148 15109940-3 2004 Both the AT1 and AT2 ligands administered into the LSA elicited a concentration-dependent decrease in the water intake induced by AVP injected into the LSA, but losartan was more effective than CGP42112A. Water 106-111 arginine vasopressin Rattus norvegicus 130-133 15109940-11 2004 These results suggest that facilitator effects of AVP on water intake are mediated through the activation of V1 receptors and that the inhibitory effect requires V2 receptors. Water 57-62 arginine vasopressin Rattus norvegicus 50-53 15109940-13 2004 Based on the present findings, we suggest that the AVP in the LSA may play a role in the control of water and arterial blood pressure balance. Water 100-105 arginine vasopressin Rattus norvegicus 51-54 14726616-9 2003 These results suggest that modulatory effect of galanin on vasopressin and oxytocin release depends on the actual state of water metabolism. Water 123-128 arginine vasopressin Rattus norvegicus 59-70 15171994-4 2004 Corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) that regulate a variety of physiological processes including the hypothalamic-pituitary-adrenal axis (HPA axis), energy and water homeostasis were used as model systems. Water 192-197 arginine vasopressin Rattus norvegicus 50-61 14532164-1 2004 Vasopressin regulates water and solute transport in the renal collecting duct. Water 22-27 arginine vasopressin Rattus norvegicus 0-11 15143508-6 2004 After the water load and injection of 0.005 nmole/100 g body mass of arginine-vasopressin for 2 hr of the study, diuresis in both groups of animals decreased to an equal extent, but in fasting animals this was due mostly to an increase of the osmotic free water. Water 256-261 arginine vasopressin Rattus norvegicus 78-89 12965888-2 2003 We determined the effect of NO on basal and vasopressin (AVP)-stimulated urea (Purea) and water (Pf) permeabilities in isolated, perfused rat IMCD. Water 90-95 arginine vasopressin Rattus norvegicus 44-55 14664791-6 2003 In addition to phenotypic correction, secretion of transgene-derived AVP was enhanced after 24 h water deprivation or hypertonic saline injection, and water diuresis was demonstrated after acute water loading. Water 97-102 arginine vasopressin Rattus norvegicus 69-72 12813157-8 2003 In anaesthetised, water-loaded JP17 rats, hGH was released with VP in response to an acute hypovolumic stimulus (sodium nitrosopentacyano, 400 microg I.V.). Water 18-23 arginine vasopressin Rattus norvegicus 64-66 14688443-0 2003 Regulation of corticosterone production by vasopressin during water restriction and after drinking in rats. Water 62-67 arginine vasopressin Rattus norvegicus 43-54 14688443-3 2003 A strong correlation between changes in plasma VP and corticosterone, but not between plasma ACTH and corticosterone, was observed after drinking induced by 6 days of water restriction. Water 167-172 arginine vasopressin Rattus norvegicus 47-49 14688443-5 2003 Administration of an immunoneutralizing antibody directed against VP resulted in a rapid decrease in plasma corticosterone, but not ACTH, in water-restricted rats, but not in rats receiving water ad libitum. Water 141-146 arginine vasopressin Rattus norvegicus 66-68 12829746-1 2003 Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells by activation of vasopressin V2 receptors and the subsequent translocation of water channels (aquaporin-2, AQP2) from intracellular vesicles into the plasma membrane. Water 39-44 arginine vasopressin Rattus norvegicus 9-20 12899854-9 2003 The AVP response is typical of that of desert rodents, favoring survival under conditions of water-restriction. Water 93-98 arginine vasopressin Rattus norvegicus 4-7 12709058-8 2003 These results suggest that AVP induces the translocation of P-LAP via V2 receptor and P-LAP plays a role in the regulation of excessive AVP level in the renal collecting duct, acting as a negative feedback mechanism for the AVP action of regulating water reabsorption. Water 249-254 arginine vasopressin Rattus norvegicus 27-30 12709058-8 2003 These results suggest that AVP induces the translocation of P-LAP via V2 receptor and P-LAP plays a role in the regulation of excessive AVP level in the renal collecting duct, acting as a negative feedback mechanism for the AVP action of regulating water reabsorption. Water 249-254 arginine vasopressin Rattus norvegicus 136-139 12709058-8 2003 These results suggest that AVP induces the translocation of P-LAP via V2 receptor and P-LAP plays a role in the regulation of excessive AVP level in the renal collecting duct, acting as a negative feedback mechanism for the AVP action of regulating water reabsorption. Water 249-254 arginine vasopressin Rattus norvegicus 136-139 14502981-0 2003 [Vasopressin-dependent water permeability of the basolateral membrane of the kidney outer medullary collecting duct in postnatal ontogenesis in rats]. Water 23-28 arginine vasopressin Rattus norvegicus 1-12 12457460-26 2002 Perinatal malnutrition also affects the responsiveness to water deprivation with alterations in both hypothalamic VP gene expression and regulation of ANP-binding sites. Water 58-63 arginine vasopressin Rattus norvegicus 114-116 12573807-2 2003 Water deprivation significantly increased plasma renin activity (PRA), plasma Angiotensin II (AII), vasopressin (AVP), epinephrine, aldosterone and corticosterone concentrations but did not modify the plasma adrenocorticotropin hormone (ACTH) level. Water 0-5 arginine vasopressin Rattus norvegicus 100-111 12710188-4 2003 On intragastric administration of 10 micrograms of arginine vasopressin or 0.2 microgram of desmopressin, with water in rats, a prolonged and quite obvious antidiuretic response occurred, with a marked increase of reabsorption of the osmotically free water in kidneys. Water 111-116 arginine vasopressin Rattus norvegicus 60-71 12710188-4 2003 On intragastric administration of 10 micrograms of arginine vasopressin or 0.2 microgram of desmopressin, with water in rats, a prolonged and quite obvious antidiuretic response occurred, with a marked increase of reabsorption of the osmotically free water in kidneys. Water 251-256 arginine vasopressin Rattus norvegicus 60-71 12710188-5 2003 A direct correlation has been found between the dose of the intragastrically administered vasopressin in the dose range from 0.1 to 10 micrograms/100 g body weight and a decrease of clearance of the osmotically free water. Water 216-221 arginine vasopressin Rattus norvegicus 90-101 12374804-1 2003 In renal collecting ducts, vasopressin increases the expression of and redistributes aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical membrane, leading to urine concentration. Water 104-109 arginine vasopressin Rattus norvegicus 27-38 11927381-0 2002 Adaptation to sustained high plasma vasopressin in water and electrolyte homeostasis in the rat transgenic for the metallothionein-vasopressin fusion gene. Water 51-56 arginine vasopressin Rattus norvegicus 36-47 12167608-10 2002 Because nNOS is specifically expressed in principal cells of the collecting duct system, the stimulation of nNOS expression by AVP may participate in the control of water reabsorption. Water 165-170 arginine vasopressin Rattus norvegicus 127-130 12176047-1 2002 Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel in the kidney collecting duct. Water 47-52 arginine vasopressin Rattus norvegicus 25-36 12151754-3 2002 In the kidney collecting duct, vasopressin induces the expression of aquaporin-2 (AQP2), resulting in increased water reabsorption. Water 112-117 arginine vasopressin Rattus norvegicus 31-42 12372793-1 2002 AVP increases the osmotic water permeability of renal collecting ducts by inducing the translocation of specific aquaporin-2 (AQP2) water channels from cytoplasmic vesicles to the apical plasma membrane of the principal cells. Water 26-31 arginine vasopressin Rattus norvegicus 0-3 12372793-1 2002 AVP increases the osmotic water permeability of renal collecting ducts by inducing the translocation of specific aquaporin-2 (AQP2) water channels from cytoplasmic vesicles to the apical plasma membrane of the principal cells. Water 132-137 arginine vasopressin Rattus norvegicus 0-3 12206855-6 2002 These results show that vasopressin plays a significant role in elevating vascular tone through vasopressin V(1A) receptors and plays a major role in retaining free water through vasopressin V(2) receptors in this model of congestive heart failure. Water 165-170 arginine vasopressin Rattus norvegicus 24-35 12062361-7 2002 CONCLUSIONS: In CHF, blockade of vasopressin V(1a) and V(2) receptors was associated with increased water excretion, and the combination of conivaptan with ACE inhibition was the only treatment to reduce blood pressure, natriuretic peptide and pulmonary congestion. Water 100-105 arginine vasopressin Rattus norvegicus 33-44 11927381-3 2002 In this study, to investigate whether down-regulation of AVP V2 receptor (V2R), which could possibly be caused by long-standing high plasma AVP, participates in this adaptive mechanism(s), non-peptidic V2R antagonist OPC31260 was administered to reverse the down-regulation, and water loading was performed after V2R antagonist treatment had been withdrawn. Water 279-284 arginine vasopressin Rattus norvegicus 57-60 11788445-5 2002 Moreover, vasopressin-mediated renal water reabsorption, as evaluated by the aquaretic response to selective V(2)-receptor blockade, was significantly increased. Water 37-42 arginine vasopressin Rattus norvegicus 10-21 11575131-0 2001 [Effect of vasopressin on water permeability of epithelial cells in the kidney collecting duct during postnatal ontogenesis in rats]. Water 26-31 arginine vasopressin Rattus norvegicus 11-22 11909609-3 2002 In the rat inner medullary collecting duct basolateral, but not apical, ATP (0.1-100 microM) reversibly inhibited vasopressin-induced increases in water permeability with an IC50 of 1.09 microM. Water 147-152 arginine vasopressin Rattus norvegicus 114-125 12436927-3 2002 Fortunately, the degree of the hyponatremia is limited by a process that counters the water-retaining action of vasopressin, namely "vasopressin escape". Water 86-91 arginine vasopressin Rattus norvegicus 112-123 12436927-3 2002 Fortunately, the degree of the hyponatremia is limited by a process that counters the water-retaining action of vasopressin, namely "vasopressin escape". Water 86-91 arginine vasopressin Rattus norvegicus 133-144 12436927-8 2002 Using this model, we demonstrated that the onset of vasopressin escape (increased urine volume coupled to decreased urine osmolality) coincided temporally with a marked decrease in renal aquaporin-2 (water channel) protein and mRNA expression in renal collecting ducts. Water 200-205 arginine vasopressin Rattus norvegicus 52-63 11711512-11 2001 Extrarenal water losses, partly originating from the lung, were reduced by high plasma vasopressin level. Water 11-16 arginine vasopressin Rattus norvegicus 87-98 11573975-6 2001 Chronic (7-day) studies were performed in which vasopressin levels were elevated either endogenously by water restriction of Sprague-Dawley rats or exogenously through infusion of the vasopressin V2-receptor-selective agonist, dDAVP (1-deamino-8d-arginine-vasopressin), to Brattleboro rats. Water 104-109 arginine vasopressin Rattus norvegicus 48-59 11578610-5 2001 Caloric vestibular stimulation with cold water increased the plasma VP levels to 262% of the control group, which received caloric stimulation with water at 37 degrees C, and stimulation with warm water tended to increase the plasma VP levels. Water 41-46 arginine vasopressin Rattus norvegicus 68-70 11578610-5 2001 Caloric vestibular stimulation with cold water increased the plasma VP levels to 262% of the control group, which received caloric stimulation with water at 37 degrees C, and stimulation with warm water tended to increase the plasma VP levels. Water 41-46 arginine vasopressin Rattus norvegicus 233-235 11826172-1 2002 Arginine vasopressin (AVP) regulates the osmotic water permeability of the kidney collecting duct by inducing exocytotic insertion of aquaporin-2 into apical membrane. Water 49-54 arginine vasopressin Rattus norvegicus 9-20 11826172-1 2002 Arginine vasopressin (AVP) regulates the osmotic water permeability of the kidney collecting duct by inducing exocytotic insertion of aquaporin-2 into apical membrane. Water 49-54 arginine vasopressin Rattus norvegicus 22-25 11826172-11 2002 Pre-incubating the IMCD with an intracellular Ca2+ chelator, BAPTA, prevented AVP-induced intracellular Ca2+ mobilization, apical exocytosis, and increase of osmotic water permeability. Water 166-171 arginine vasopressin Rattus norvegicus 78-81 11786201-4 2001 The correlations observed between plasma osmolality and CAP, and plasma CAP and ACE suggested a contribution of these activities to the restoration of basal water-electrolyte and blood pressure conditions through the hydrolysis of vasopressin, oxytocin, angiotensin I and bradykinin. Water 157-162 arginine vasopressin Rattus norvegicus 231-242 11573986-4 2001 VP expression in magnocellular paraventricular and supraoptic nuclei, and plasma sodium and vasopressin were higher in water-deprived rats, changes which were unaffected by restraint. Water 119-124 arginine vasopressin Rattus norvegicus 0-2 11573986-4 2001 VP expression in magnocellular paraventricular and supraoptic nuclei, and plasma sodium and vasopressin were higher in water-deprived rats, changes which were unaffected by restraint. Water 119-124 arginine vasopressin Rattus norvegicus 92-103 11576341-1 2001 BACKGROUND: In a state of chronic arginine vasopressin (AVP) excess, the action of antidiuresis has been attenuated, resulting in some water diuresis. Water 135-140 arginine vasopressin Rattus norvegicus 43-54 11576341-1 2001 BACKGROUND: In a state of chronic arginine vasopressin (AVP) excess, the action of antidiuresis has been attenuated, resulting in some water diuresis. Water 135-140 arginine vasopressin Rattus norvegicus 56-59 11518698-1 2001 Aquaporin-2 (AQP-2) is the vasopressin-regulated water channel expressed in the apical membrane of principal cells in the collecting duct and is involved in the urinary concentrating mechanism. Water 49-54 arginine vasopressin Rattus norvegicus 27-38 11518698-2 2001 In the rat distal colon, vasopressin stimulates water absorption through an unknown mechanism. Water 48-53 arginine vasopressin Rattus norvegicus 25-36 11504796-1 2001 We compared the effects of dopamine and norepinephrine on vasopressin (AVP)-stimulated increases in osmotic water permeability (Pf) and cAMP accumulation in the rat inner medullary collecting duct (IMCD). Water 108-113 arginine vasopressin Rattus norvegicus 58-69 11884206-0 2001 Colocalization of vasopressin and oxytocin in hypothalamic magnocellular neurons in water-deprived rats. Water 84-89 arginine vasopressin Rattus norvegicus 18-29 11884209-6 2001 The increase of AVP and V(1b)R mRNAs in the choroid plexus further shows the involvement of AVP in the regulation of brain water content and cerebral edema. Water 123-128 arginine vasopressin Rattus norvegicus 16-19 11884209-6 2001 The increase of AVP and V(1b)R mRNAs in the choroid plexus further shows the involvement of AVP in the regulation of brain water content and cerebral edema. Water 123-128 arginine vasopressin Rattus norvegicus 92-95 11411093-8 2001 These results indicate that synthesis and release of NKB, which colocalizes to AVP neurons, are enhanced by water deprivation in the same manner as AVP in the PVN and SON. Water 108-113 arginine vasopressin Rattus norvegicus 79-82 11158210-8 2001 The water-loaded rats were hyponatremic (plasma Na+, 98 to 122 mmol/L) and manifested the expected early natriuresis and diuresis of vasopressin escape. Water 4-9 arginine vasopressin Rattus norvegicus 133-144 11411093-4 2001 Five days after water deprivation, AVP and NKB immunoreactivity decreased drastically, while NKBp-immunoreactivity increased in both the PVN and SON magnocellular neurons. Water 16-21 arginine vasopressin Rattus norvegicus 35-38 11411093-7 2001 After five days of water deprivation, AVP mRNA in the PVN and NKB mRNA in both the PVN and the SON increased considerably. Water 19-24 arginine vasopressin Rattus norvegicus 38-41 11267655-11 2001 Our findings suggest that two promoters regulate transcription of the four UT-A isoforms, and that stimulation of transcription by vasopressin, mediated by cAMP and CRE sequences, and controlled by an intronic promoter, may contribute to the increase in UT-A2 expression during water deprivation. Water 278-283 arginine vasopressin Rattus norvegicus 131-142 11158210-13 2001 These data suggest that several distal sodium reabsorptive mechanisms are upregulated during vasopressin escape; this may help to attenuate the developing hyponatremia resulting from water loading when vasopressin levels are inappropriately elevated. Water 183-188 arginine vasopressin Rattus norvegicus 93-104 10956231-0 2000 Water ingestion provides an early signal inhibiting osmotically stimulated vasopressin secretion in rats. Water 0-5 arginine vasopressin Rattus norvegicus 75-86 11134245-6 2001 Restriction of water intake to increase vasopressin levels also significantly increased TAL ROMK immunolabeling and abundance in immunoblots. Water 15-20 arginine vasopressin Rattus norvegicus 40-51 11155210-0 2001 Vasopressin regulates water flow in a rat cortical collecting duct cell line not containing known aquaporins. Water 22-27 arginine vasopressin Rattus norvegicus 0-11 11174021-4 2001 A high VP level is beneficial in the short term because it limits to some extent the amount of water required for the excretion of a markedly enhanced load of osmoles (mainly glucose). Water 95-100 arginine vasopressin Rattus norvegicus 7-9 11097629-12 2000 This suggests that vasopressin-mediated renal water reabsorption capacity was increased in the cirrhotic rats. Water 46-51 arginine vasopressin Rattus norvegicus 19-30 11097629-13 2000 Semiquantitative immunoblotting revealed that the expression of the vasopressin-regulated water channel aquaporin-2 was unchanged in membrane fractions of both whole kidney and inner medulla from cirrhotic rats. Water 90-95 arginine vasopressin Rattus norvegicus 68-79 11097629-14 2000 Together, these results suggest a relative escape from vasopressin on collecting duct water reabsorption in rats with decompensated liver cirrhosis. Water 86-91 arginine vasopressin Rattus norvegicus 55-66 10956231-1 2000 Dehydrated dogs are known to inhibit secretion of vasopressin (VP) within minutes after drinking water, before plasma osmolality (P(osmol)) diminishes. Water 97-102 arginine vasopressin Rattus norvegicus 50-61 11050685-0 2000 Vasopressin and A1 noradrenaline turnover during food or water deprivation in the rat. Water 57-62 arginine vasopressin Rattus norvegicus 0-11 10751327-1 2000 Aquaporin 2 (AQP2), the vasopressin-regulated water channel, was originally identified in renal collecting duct principal cells. Water 46-51 arginine vasopressin Rattus norvegicus 24-35 10710543-1 2000 Prostaglandin E(2) (PGE(2)) antagonizes the action of arginine vasopressin (AVP) on collecting duct water permeability. Water 100-105 arginine vasopressin Rattus norvegicus 54-74 10710543-1 2000 Prostaglandin E(2) (PGE(2)) antagonizes the action of arginine vasopressin (AVP) on collecting duct water permeability. Water 100-105 arginine vasopressin Rattus norvegicus 76-79 10662729-10 2000 Because rats with common bile duct ligation (CBL) have a reduced vasopressin-mediated water reabsorption compared with normal rats (V: -24%; C(H(2)O): -28%, and 86% downregulation of AQP2), the effect of canrenoate combined with OPC-31260 was tested. Water 86-91 arginine vasopressin Rattus norvegicus 65-76 10662729-13 2000 This strongly supports the view that aldosterone plays a significant role for vasopressin-mediated water reabsorption. Water 99-104 arginine vasopressin Rattus norvegicus 78-89 10614652-5 2000 This receptor down-regulation began by day 2 of water loading, which correlated with the initiation of renal vasopressin escape; by day 3 of water loading, vasopressin V2 receptor expression fell to 43% of DDAVP-treated levels. Water 48-53 arginine vasopressin Rattus norvegicus 109-120 10751223-7 2000 Our studies reveal the role of vasopressin in long-term regulation of UT1 and UT2 expression during water restriction. Water 100-105 arginine vasopressin Rattus norvegicus 31-42 10795926-5 2000 First, physiological elevations of plasma vasopressin concentration seen with 48 h of water restriction reduce blood flow to the inner medulla (via V1 receptors) while maintaining a constancy of blood flow to the outer medulla. Water 86-91 arginine vasopressin Rattus norvegicus 42-53 10662729-0 2000 Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockade. Water 37-42 arginine vasopressin Rattus norvegicus 10-21 10662729-1 2000 Previous studies have suggested that mineralocorticoids are needed for a normal action of vasopressin on collecting duct osmotic water permeability. Water 129-134 arginine vasopressin Rattus norvegicus 90-101 10614652-7 2000 This study demonstrates that vasopressin V2 receptor binding capacity is down-regulated during renal escape from vasopressin-induced antidiuresis and suggests that both vasopressin-dependent mechanisms as well as vasopressin-independent mechanisms associated with water loading are involved in this receptor down-regulation. Water 264-269 arginine vasopressin Rattus norvegicus 29-40 10614652-7 2000 This study demonstrates that vasopressin V2 receptor binding capacity is down-regulated during renal escape from vasopressin-induced antidiuresis and suggests that both vasopressin-dependent mechanisms as well as vasopressin-independent mechanisms associated with water loading are involved in this receptor down-regulation. Water 264-269 arginine vasopressin Rattus norvegicus 113-124 10614652-7 2000 This study demonstrates that vasopressin V2 receptor binding capacity is down-regulated during renal escape from vasopressin-induced antidiuresis and suggests that both vasopressin-dependent mechanisms as well as vasopressin-independent mechanisms associated with water loading are involved in this receptor down-regulation. Water 264-269 arginine vasopressin Rattus norvegicus 113-124 10751327-2 2000 However, our recent description of AQP2 in the vas deferens indicated that this water channel may have extra-renal functions, possibly related to sperm concentration in the male reproductive tract. Water 80-85 arginine vasopressin Rattus norvegicus 47-50 10719760-2 2000 Water deprivation caused comparable dehydration, increased plasma VP (pVP), and decreased posterior pituitary (PP) VP content in 4-, 15-, and 28-month-old rats. Water 0-5 arginine vasopressin Rattus norvegicus 66-68 10644880-1 2000 BACKGROUND: Stimulation of arginine vasopressin results in an immediate redistribution of water channels (aquaporin 2; AQP2) in the apical membrane of the collecting ducts, leading to water reabsorption. Water 90-95 arginine vasopressin Rattus norvegicus 36-47 10719760-4 2000 The elevated pVP in the water-deprived aged rats indicates that even without an increase in VP mRNA content, PP VP storage was adequate to maintain elevated pVP. Water 24-29 arginine vasopressin Rattus norvegicus 14-16 10638636-7 2000 (-)-Bremazocine was slightly more potent in suppressing vasopressin in 24-h water-deprived males than females. Water 76-81 arginine vasopressin Rattus norvegicus 56-67 10499190-12 1999 These results suggest that vasopressin elevation in DM contributes to increase urinary concentrating activity and thus to limit water requirements induced by the metabolic derangements of DM. Water 128-133 arginine vasopressin Rattus norvegicus 27-38 10556530-1 1999 The classical short-term effect (within minutes) of arginine vasopressin (AVP) consists in increasing sodium, chloride and water transport in kidney cells. Water 123-128 arginine vasopressin Rattus norvegicus 61-72 10556530-1 1999 The classical short-term effect (within minutes) of arginine vasopressin (AVP) consists in increasing sodium, chloride and water transport in kidney cells. Water 123-128 arginine vasopressin Rattus norvegicus 74-77 9950956-1 1999 Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256. Water 90-95 arginine vasopressin Rattus norvegicus 55-66 10405197-1 1999 Clinical studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine, and that the excretion increases in response to vasopressin. Water 79-84 arginine vasopressin Rattus norvegicus 57-68 10405197-1 1999 Clinical studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine, and that the excretion increases in response to vasopressin. Water 79-84 arginine vasopressin Rattus norvegicus 168-179 10203352-10 1999 Blood values of arginine vasopressin and aldosterone were significantly increased by water deprivation, whereas they were unchanged by water overloading. Water 85-90 arginine vasopressin Rattus norvegicus 25-36 9988736-1 1999 The antidiuretic hormone arginine-vasopressin (AVP) regulates water reabsorption in renal collecting duct principal cells by inducing a cAMP-dependent translocation of water channels (aquaporin-2, AQP-2) from intracellular vesicles into the apical cell membranes. Water 62-67 arginine vasopressin Rattus norvegicus 34-45 9950956-1 1999 Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256. Water 90-95 arginine vasopressin Rattus norvegicus 68-71 9950956-11 1999 The results indicate that AVP stimulates phosphorylation of AQP2 at Ser256 via activation of PKA, supporting the idea that this is one of the first steps leading to increased water permeability in collecting duct cells. Water 175-180 arginine vasopressin Rattus norvegicus 26-29 10389187-1 1999 A significant increase in the water permeability was found in the rat outer medullary collecting duct (OMCD) cells in presence of 10-7M of vasopressin. Water 30-35 arginine vasopressin Rattus norvegicus 139-150 9894975-1 1999 OBJECTIVE: Recent experimental evidence suggests that centrally released arginine vasopressin plays a significant role in brain capillary water permeability as well as in pathogenesis of vasogenic brain edema. Water 138-143 arginine vasopressin Rattus norvegicus 82-93 10100486-0 1999 Principal cells of the vas deferens are involved in water transport and steroid synthesis in the adult rat. Water 52-57 arginine vasopressin Rattus norvegicus 23-26 10100486-8 1999 Taken together, these observations suggested water transport from the lumen of the vas deferens via the dilated spaces to underlying vascular channels, the function of which may be to concentrate sperm. Water 45-50 arginine vasopressin Rattus norvegicus 83-86 10100486-15 1999 In summary, principal cells of the vas deferens appear to be involved in synthesis and secretion of steroids and in eliminating water from the lumen of the vas deferens. Water 128-133 arginine vasopressin Rattus norvegicus 35-38 10100486-15 1999 In summary, principal cells of the vas deferens appear to be involved in synthesis and secretion of steroids and in eliminating water from the lumen of the vas deferens. Water 128-133 arginine vasopressin Rattus norvegicus 156-159 9873154-0 1998 Vasopressin induces dopamine release and cyclic AMP efflux from the brain of water-deprived rats: inhibitory effect of vasopressin V2 receptor-mediated phosphorylation. Water 77-82 arginine vasopressin Rattus norvegicus 0-11 9848772-3 1998 Dysregulation of aquaporin-2 (AQP2), the predominant vasopressin-regulated water channel, is known to be associated with a range of congenital and acquired water balance disorders including nephrogenic diabetes insipidus and states of water retention. Water 75-80 arginine vasopressin Rattus norvegicus 53-64 9848772-3 1998 Dysregulation of aquaporin-2 (AQP2), the predominant vasopressin-regulated water channel, is known to be associated with a range of congenital and acquired water balance disorders including nephrogenic diabetes insipidus and states of water retention. Water 156-161 arginine vasopressin Rattus norvegicus 53-64 9815137-1 1998 Cultured renal epithelial cells rapidly downregulate expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2). Water 93-98 arginine vasopressin Rattus norvegicus 71-82 9815132-1 1998 Vesicle targeting proteins ("SNAREs") have been proposed to direct vasopressin-induced trafficking of aquaporin-2 water channels in kidney collecting ducts. Water 114-119 arginine vasopressin Rattus norvegicus 67-78 9612328-1 1998 Elevations of arginine vasopressin (AVP) binding to renal vasopressin V2 receptors (V2R) enhance water and urea reabsorption in the collecting duct epithelium. Water 97-102 arginine vasopressin Rattus norvegicus 23-34 9790367-1 1998 OBJECTIVE: Fetal arginine vasopressin contributes to fetal and amniotic fluid homeostasis by increasing water resorption in the kidney and, at higher plasma levels, circulatory homeostasis by vasopressor effects. Water 104-109 arginine vasopressin Rattus norvegicus 26-37 9736267-4 1998 V2 AVP receptor antagonists correct the impaired water excretion in rats with low-output CF, increase solute free water clearance, correct the hyponatremia in congestive CF patients, and normalize urinary concentrations of the aquaporin-2 (AQP-2) water channels. Water 49-54 arginine vasopressin Rattus norvegicus 3-6 9736267-4 1998 V2 AVP receptor antagonists correct the impaired water excretion in rats with low-output CF, increase solute free water clearance, correct the hyponatremia in congestive CF patients, and normalize urinary concentrations of the aquaporin-2 (AQP-2) water channels. Water 114-119 arginine vasopressin Rattus norvegicus 3-6 9736267-11 1998 In summary, AVP-mediated water retention through collecting duct AQP-2 water channels is important in both low-output CF and high-output states such as cirrhosis and pregnancy. Water 25-30 arginine vasopressin Rattus norvegicus 12-15 9712891-1 1998 Vasopressin is the key regulator of water homeostasis in vertebrates. Water 36-41 arginine vasopressin Rattus norvegicus 0-11 9712891-5 1998 Treatment of CD8 cells with pertussis toxin (PTX) inhibited both the vasopressin-induced increase in water permeability and the redistribution of AQP2 from an intracellular compartment to the apical membrane. Water 101-106 arginine vasopressin Rattus norvegicus 69-80 9689012-1 1998 In the rat cortical collecting duct (CCD), epinephrine inhibits vasopressin (AVP)-dependent water permeability and Na+ reabsorption. Water 92-97 arginine vasopressin Rattus norvegicus 64-75 9648077-0 1998 Low Na+ diet inhibits Na+ and water transport response to vasopressin in rat cortical collecting duct. Water 30-35 arginine vasopressin Rattus norvegicus 58-69 9705577-13 1998 In comparison, control and DOCA-treated rats drinking water showed lower levels of AVP mRNA. Water 54-59 arginine vasopressin Rattus norvegicus 83-86 9705577-16 1998 In rats offered salt solution and water to drink, DOCA effects on AVP mRNA developed before changes occurred in serum sodium levels. Water 34-39 arginine vasopressin Rattus norvegicus 66-69 9688911-1 1998 The hormone arginine vasopressin (AVP) contributes to water retention and vasoconstriction in congestive heart failure (CHF) through effects at the V2 and V1a receptors, respectively. Water 54-59 arginine vasopressin Rattus norvegicus 34-37 9688911-10 1998 These results suggest that AVP plays a major role in water retention through the renal V2R in a rat model of CHF. Water 53-58 arginine vasopressin Rattus norvegicus 27-30 9612336-5 1998 Physiological doses of desmopressin reproduced the effects of water deprivation on mRNA and intracellular protein levels, suggesting that pIgR expression may be regulated by a vasopressin-coupled mechanism. Water 62-67 arginine vasopressin Rattus norvegicus 176-187 9612337-0 1998 Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats. Water 21-26 arginine vasopressin Rattus norvegicus 0-11 9612337-1 1998 To investigate how hypercalcemia blunts renal concentrating ability, alterations in basal and arginine vasopressin (AVP)-elicited osmotic water (Pf) and urea (Purea) permeabilities were measured in isolated perfused terminal inner medullary collecting ducts (IMCD) from control and chronically hypercalcemic rats after dihydrotachysterol (DHT) (M. Levi, L. Peterson, and T. Berl. Water 138-143 arginine vasopressin Rattus norvegicus 103-114 9612328-1 1998 Elevations of arginine vasopressin (AVP) binding to renal vasopressin V2 receptors (V2R) enhance water and urea reabsorption in the collecting duct epithelium. Water 97-102 arginine vasopressin Rattus norvegicus 58-69 10923422-1 1998 OBJECTIVE: To study aquaporin-2 (AQP2) that mediates vasopressin-regulated collecting duct water permeability. Water 91-96 arginine vasopressin Rattus norvegicus 53-64 9528924-7 1998 Moreover, the AVP messenger RNA levels in PVN and SON in the APX group were also significantly lower than in the Sham group after water deprivation for 3 days. Water 130-135 arginine vasopressin Rattus norvegicus 14-17 9841509-1 1998 Previously, we demonstrated that escape from vasopressin-induced antidiuresis ("vasopressin escape") in rats is associated with a large, selective decrease in whole kidney expression of aquaporin-2, the vasopressin-regulated water channel. Water 225-230 arginine vasopressin Rattus norvegicus 45-56 9841509-1 1998 Previously, we demonstrated that escape from vasopressin-induced antidiuresis ("vasopressin escape") in rats is associated with a large, selective decrease in whole kidney expression of aquaporin-2, the vasopressin-regulated water channel. Water 225-230 arginine vasopressin Rattus norvegicus 80-91 9841509-1 1998 Previously, we demonstrated that escape from vasopressin-induced antidiuresis ("vasopressin escape") in rats is associated with a large, selective decrease in whole kidney expression of aquaporin-2, the vasopressin-regulated water channel. Water 225-230 arginine vasopressin Rattus norvegicus 80-91 9841509-2 1998 Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney. Water 148-153 arginine vasopressin Rattus norvegicus 83-94 9841509-2 1998 Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney. Water 217-222 arginine vasopressin Rattus norvegicus 83-94 9841509-2 1998 Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney. Water 217-222 arginine vasopressin Rattus norvegicus 128-139 9841509-2 1998 Here, we show that isolated perfused inner medullary collecting ducts (IMCDs) from vasopressin-escape rats desamino-[D-arginine]vasopressin (DDAVP)/water-loaded have dramatically reduced vasopressin-dependent osmotic water permeabilities [46% of control rats (DDAVP alone)], which coincides with a fall in inner medullary aquaporin-2 protein abundance as measured by immunoblotting in the opposite kidney. Water 217-222 arginine vasopressin Rattus norvegicus 128-139 9841509-6 1998 The decreased cAMP levels can contribute to the demonstrated decrease in collecting duct water permeability in two ways: 1) by causing a decrease in aquaporin-2 expression and 2) by limiting the acute action of vasopressin to increase collecting duct water permeability. Water 89-94 arginine vasopressin Rattus norvegicus 211-222 9841509-6 1998 The decreased cAMP levels can contribute to the demonstrated decrease in collecting duct water permeability in two ways: 1) by causing a decrease in aquaporin-2 expression and 2) by limiting the acute action of vasopressin to increase collecting duct water permeability. Water 251-256 arginine vasopressin Rattus norvegicus 211-222 10026831-1 1998 In animal models of the syndrome of inappropriate antidiuresis (SIADH), sustained administration of vasopressin and water results in free-water retention and progressive hyponatremia for several days, which is then followed by escape from the vasopressin-induced antidiuresis. Water 116-121 arginine vasopressin Rattus norvegicus 243-254 10026831-11 1998 Our results therefore suggest that escape from vasopressin-induced antidiuresis is attributable, at least in part, to a vasopressin-independent and osmolality-independent decrease in aquaporin-2 water channel expression in the renal collecting duct. Water 195-200 arginine vasopressin Rattus norvegicus 47-58 9109429-3 1997 A significant increase in urine volume in the water-loaded rats was observed by the second day of water loading, indicating onset of vasopressin escape. Water 46-51 arginine vasopressin Rattus norvegicus 133-144 9496709-2 1998 AVP regulates the water channel (aquaporin-2:AQP2) through V2 receptors and increases the water permeability of the collecting duct. Water 18-23 arginine vasopressin Rattus norvegicus 0-3 9496709-2 1998 AVP regulates the water channel (aquaporin-2:AQP2) through V2 receptors and increases the water permeability of the collecting duct. Water 90-95 arginine vasopressin Rattus norvegicus 0-3 9435667-1 1997 The aim of this study was to investigate the effects of the antidiuretic hormone arginine vasopressin (AVP), which is released in vivo during dehydration and hypovolemia to prevent further water loss, on the activity of neurons in the subfornical organ (SFO). Water 189-194 arginine vasopressin Rattus norvegicus 90-101 9435667-1 1997 The aim of this study was to investigate the effects of the antidiuretic hormone arginine vasopressin (AVP), which is released in vivo during dehydration and hypovolemia to prevent further water loss, on the activity of neurons in the subfornical organ (SFO). Water 189-194 arginine vasopressin Rattus norvegicus 103-106 9109429-3 1997 A significant increase in urine volume in the water-loaded rats was observed by the second day of water loading, indicating onset of vasopressin escape. Water 98-103 arginine vasopressin Rattus norvegicus 133-144 9109429-8 1997 The results suggest that escape from vasopressin-induced antidiuresis is attributable, at least in part, to a vasopressin-independent decrease in aquaporin-2 water channel expression in the renal collecting duct. Water 158-163 arginine vasopressin Rattus norvegicus 37-48 9109429-8 1997 The results suggest that escape from vasopressin-induced antidiuresis is attributable, at least in part, to a vasopressin-independent decrease in aquaporin-2 water channel expression in the renal collecting duct. Water 158-163 arginine vasopressin Rattus norvegicus 110-121 9119993-1 1997 Aquaporin-2 (AQP2) mediates vasopressin-regulated collecting duct water permeability. Water 66-71 arginine vasopressin Rattus norvegicus 28-39 9119993-12 1997 The results indicate a major role for vasopressin in the upregulation of AQP2 water channels and water retention in experimental CHF in the rat. Water 78-83 arginine vasopressin Rattus norvegicus 38-49 9119993-12 1997 The results indicate a major role for vasopressin in the upregulation of AQP2 water channels and water retention in experimental CHF in the rat. Water 97-102 arginine vasopressin Rattus norvegicus 38-49 9077550-0 1997 Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. Water 95-100 arginine vasopressin Rattus norvegicus 74-85 9138683-19 1997 These results suggest that the central NK3 receptor, probably located in the hypothalamus, is implicated in the renal control of water and electrolyte homeostasis through the release of vasopressin in the conscious saline-loaded rat. Water 129-134 arginine vasopressin Rattus norvegicus 186-197 9124394-2 1997 We determined whether the abrupt decrease in circulating arginine vasopressin (AVP) by giving excess water affects the expression of AQP-2 mRNA and subcellular localization of AQP-2 in collecting duct cells of the dehydrated rats. Water 101-106 arginine vasopressin Rattus norvegicus 66-77 9124394-2 1997 We determined whether the abrupt decrease in circulating arginine vasopressin (AVP) by giving excess water affects the expression of AQP-2 mRNA and subcellular localization of AQP-2 in collecting duct cells of the dehydrated rats. Water 101-106 arginine vasopressin Rattus norvegicus 79-82 9124394-3 1997 The 72-h water deprivation increased plasma AVP levels to 3.1 pg/ml and the expression of AQP-2 mRNA by 336% in rats, which were concomitantly abolished by the 40 ml/kg oral water load. Water 9-14 arginine vasopressin Rattus norvegicus 44-47 9124394-3 1997 The 72-h water deprivation increased plasma AVP levels to 3.1 pg/ml and the expression of AQP-2 mRNA by 336% in rats, which were concomitantly abolished by the 40 ml/kg oral water load. Water 174-179 arginine vasopressin Rattus norvegicus 44-47 9077550-1 1997 During antidiuresis, increases in vasopressin (AVP)-elicited osmotic water permeability in the terminal inner medullary collecting duct (tIMCD) raise luminal calcium concentrations to levels (> or = 5 mM) above those associated with the formation of calcium-containing precipitates in the urine. Water 69-74 arginine vasopressin Rattus norvegicus 34-45 9479425-1 1997 Centrally released arginine vasopressin (AVP) has been implicated in the regulation of the brain water content and is elevated in the cerebrospinal fluid of patients with ischaemic and traumatic brain injuries. Water 97-102 arginine vasopressin Rattus norvegicus 28-39 9039031-3 1997 In hydrated rats, the graded infusion of vasopressin (10-1,000 pg.min 1.kg body wt-1) resulted in a dose-dependent antidiuresis: decreases in urine flow and free water clearance and an increase in urine osmolality. Water 162-167 arginine vasopressin Rattus norvegicus 41-52 9039031-8 1997 In a separate experiment in rats without water hydration and urine collection, infusion of pressor doses of vasopressin (1,000-6,000 pg.min-1.kg body wt-1) resulted in a greater increase in blood pressure in male than in nonestrous female rats. Water 41-46 arginine vasopressin Rattus norvegicus 108-119 8797177-1 1996 Recent studies indicate that centrally released arginine vasopressin (AVP) facilitates brain water permeability in normal and pathological conditions. Water 93-98 arginine vasopressin Rattus norvegicus 57-68 8958221-10 1996 Taken together, our data show that UT1 corresponds to the previously characterized vasopressin-regulated urea transporter in the apical membrane of the terminal IMCD which plays a critical role in renal water conservation. Water 203-208 arginine vasopressin Rattus norvegicus 83-94 8840263-11 1996 However, when plasma from Li-treated PTX rats was used, the AVP induced increase in water permeability (54.7 +/- 11.2%) was not significantly different from that observed in PTX control rats. Water 84-89 arginine vasopressin Rattus norvegicus 60-63 8760244-1 1996 Aquaporin-2 (AQP-2) is the arginine vasopressin-regulated water channel of the renal collecting ducts. Water 58-63 arginine vasopressin Rattus norvegicus 36-47 8865375-7 1996 This could be due to the significantly reduced amount of azosemide excreted in 12 h urine, significantly higher plasma osmolarity, and increased blood vasopressin concentration in the water-deprived rats. Water 184-189 arginine vasopressin Rattus norvegicus 151-162 8793792-4 1996 The only difference between groups thus concerned the water intake-vasopressin axis. Water 54-59 arginine vasopressin Rattus norvegicus 67-78 8643603-6 1996 Immunoblots demonstrated RUT labeling in both plasma membrane and intracellular vesicle-enriched membrane fractions from inner medulla, a subcellular distribution similar to that of the vasopressin-regulated water channel, aquaporin-2. Water 208-213 arginine vasopressin Rattus norvegicus 186-197 9039242-2 1997 Vasopressin, a powerful antidiuretic hormone involved in salt and water homeostasis, is released in response to acute hypoxia. Water 66-71 arginine vasopressin Rattus norvegicus 0-11 9017229-7 1996 These findings suggest that NK-3 receptors in the PVN may be involved in water regulation by stimulation of vasopressin secretion from the posterior pituitary gland, and that vasopressin caused water reabsorbtion via the kidney V2 receptor. Water 73-78 arginine vasopressin Rattus norvegicus 108-119 9017229-7 1996 These findings suggest that NK-3 receptors in the PVN may be involved in water regulation by stimulation of vasopressin secretion from the posterior pituitary gland, and that vasopressin caused water reabsorbtion via the kidney V2 receptor. Water 194-199 arginine vasopressin Rattus norvegicus 175-186 8899896-1 1996 It is now well recognized that systemically released angiotensin II (Ang II) and arginine vasopressin (AVP) act in concert in regulation of blood pressure and water-electrolyte balance. Water 159-164 arginine vasopressin Rattus norvegicus 90-101 8915966-8 1996 The benzenacetamide kappa agonist U-50488 had no effect on the response to 1 pM vasopressin but the kappa antagonist norbinaltorphimine significantly increased the effects of 1 pM vasopressin; this action was exerted earlier on in the initiation of water transport, as norbinaltorphimine did not affect the response to Sp-cAMPS, an activator of cAMP-dependent kinases. Water 249-254 arginine vasopressin Rattus norvegicus 180-191 8880739-6 1996 Water deprivation resulted in elevated basal intranuclear and plasma VP levels. Water 0-5 arginine vasopressin Rattus norvegicus 69-71 8880739-7 1996 Intraperitoneal hypertonic saline (HS) and direct osmotic stimulation of the SON increased VP release into the SON in both the control and water-deprived groups. Water 139-144 arginine vasopressin Rattus norvegicus 91-93 8770171-3 1996 At doses > or = 1 microM, dopamine inhibited arginine vasopressin (AVP)-dependent Na+ and water transport (measured by the unidirectional lumen-to-bath 22Na+ flux and the transepithelial voltage) and osmotic water permeability (Pf). Water 93-98 arginine vasopressin Rattus norvegicus 57-68 8675687-3 1996 In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney. Water 128-133 arginine vasopressin Rattus norvegicus 106-117 8675687-3 1996 In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney. Water 128-133 arginine vasopressin Rattus norvegicus 154-165 8675687-3 1996 In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney. Water 208-213 arginine vasopressin Rattus norvegicus 106-117 8675687-3 1996 In this paper, we demonstrate that the arcades are a site of expression of two proteins, aquaporin-2 (the vasopressin-regulated water channel) and the V2 vasopressin receptor, that are important to regulated water transport in the kidney. Water 208-213 arginine vasopressin Rattus norvegicus 154-165 8675687-8 1996 Thus, these results indicate that the arcades contain the specific proteins associated with vasopressin-regulated water transport, and may be a heretofore unrecognized site of free water absorption. Water 114-119 arginine vasopressin Rattus norvegicus 92-103 8675687-8 1996 Thus, these results indicate that the arcades contain the specific proteins associated with vasopressin-regulated water transport, and may be a heretofore unrecognized site of free water absorption. Water 181-186 arginine vasopressin Rattus norvegicus 92-103 8675692-4 1996 In terminal IMCDs, arginine vasopressin (AVP)-stimulated osmotic water permeability was significantly reduced in rats fed 8% protein compared to rats fed 18% protein. Water 65-70 arginine vasopressin Rattus norvegicus 28-39 8675692-4 1996 In terminal IMCDs, arginine vasopressin (AVP)-stimulated osmotic water permeability was significantly reduced in rats fed 8% protein compared to rats fed 18% protein. Water 65-70 arginine vasopressin Rattus norvegicus 41-44 8675692-5 1996 In initial IMCDs, AVP-stimulated osmotic water permeability was unaffected by dietary protein. Water 41-46 arginine vasopressin Rattus norvegicus 18-21 8675692-6 1996 Thus, AVP-stimulated osmotic water permeability is significantly reduced in terminal IMCDs but not in initial IMCDs. Water 29-34 arginine vasopressin Rattus norvegicus 6-9 8675692-7 1996 Next, we determined if the amount of immunoreactive aquaporin-2 (AQP2, the AVP-regulated water channel) or AQP3 protein was altered. Water 89-94 arginine vasopressin Rattus norvegicus 75-78 8675692-11 1996 Together, the results suggest that the decrease in AVP-stimulated osmotic water permeability results, at least in part, in the decrease in AQP2 protein. Water 74-79 arginine vasopressin Rattus norvegicus 51-54 8743462-5 1996 We have shown that both parameters do increase when normal rats are submitted to chronic alterations in the water intake/vasopressin axis within the normal range of physiologic regulation. Water 108-113 arginine vasopressin Rattus norvegicus 121-132 8967344-0 1996 Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney. Water 87-92 arginine vasopressin Rattus norvegicus 59-70 8967344-2 1996 In this study, we examined the effect of BUO and release of BUO on the expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2) in rat kidney. Water 111-116 arginine vasopressin Rattus norvegicus 89-100 8818115-1 1996 Aquaporin-2 (AQP-2) has been shown to be a vasopressin-sensitive water channel in collecting duct (CD) cells of the kidney. Water 65-70 arginine vasopressin Rattus norvegicus 43-54 8778848-8 1996 The greater water consumption in females is consistent with other studies demonstrating sex differences in plasma vasopressin levels, as well as differences in vasopressin sensitivity. Water 12-17 arginine vasopressin Rattus norvegicus 114-125 8778848-8 1996 The greater water consumption in females is consistent with other studies demonstrating sex differences in plasma vasopressin levels, as well as differences in vasopressin sensitivity. Water 12-17 arginine vasopressin Rattus norvegicus 160-171 8717072-6 1996 Endothelin can inhibit sodium reabsorption and, in the rat, vasopressin-induced water transport. Water 80-85 arginine vasopressin Rattus norvegicus 60-71 8780219-1 1996 Our previous demonstration of sexual dimorphism in the antidiuretic response to exogenous vasopressin prompted us to investigate the response to moderately high levels of endogenous vasopressin stimulated by water deprivation in conscious rats. Water 208-213 arginine vasopressin Rattus norvegicus 182-193 8780219-3 1996 Plasma concentrations of vasopressin were higher in females than in males after water deprivation, but plasma osmolality did not differ. Water 80-85 arginine vasopressin Rattus norvegicus 25-36 7481879-12 1995 It is therefore suggested that the administration of ANG II enhances AVP gene transcription in the hypothalamus, especially when water intake is limited. Water 129-134 arginine vasopressin Rattus norvegicus 69-72 7573395-1 1995 Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel of the renal collecting duct. Water 60-65 arginine vasopressin Rattus norvegicus 38-49 7573395-6 1995 This increase averaged 2.0-fold in untreated rats and 2.9-fold in rats water loaded for 12 h. Water loading, presumably by suppressing circulating vasopressin levels, decreased the fraction of AQP2 associated with the plasma membrane by 55%, suggesting retrieval of AQP2 from the plasma membrane. Water 71-76 arginine vasopressin Rattus norvegicus 147-158 7573395-6 1995 This increase averaged 2.0-fold in untreated rats and 2.9-fold in rats water loaded for 12 h. Water loading, presumably by suppressing circulating vasopressin levels, decreased the fraction of AQP2 associated with the plasma membrane by 55%, suggesting retrieval of AQP2 from the plasma membrane. Water 94-99 arginine vasopressin Rattus norvegicus 147-158 8542675-3 1995 The acute effect of increasing plasma concentrations of ethanol was evaluated in a water diuretic anaesthetized rat model which inhibits endogenous arginine vasopressin (AVP) release. Water 83-88 arginine vasopressin Rattus norvegicus 157-168 8542675-3 1995 The acute effect of increasing plasma concentrations of ethanol was evaluated in a water diuretic anaesthetized rat model which inhibits endogenous arginine vasopressin (AVP) release. Water 83-88 arginine vasopressin Rattus norvegicus 170-173 8594881-2 1995 In the present studies, we examined the effects of nucleotides (ATP, UTP, and ADP; 10 microM each) on the arginine vasopressin (AVP, 0.1 nM)-stimulated osmotic water permeability (Pf) in in vitro perfused terminal inner medullary collecting ducts (IMCD) of rat. Water 160-165 arginine vasopressin Rattus norvegicus 115-126 7479859-5 1995 Eight days after pituitary stalk transection the NL AVP mRNA diminished in animals given water to drink, whereas in those given 2% saline for 18 h followed by 6 h of water, a treatment repeated on 6 successive days beginning 2 days after surgery, the 0.62-kb AVP mRNA was present. Water 89-94 arginine vasopressin Rattus norvegicus 52-55 7573412-5 1995 Cellubrevin, therefore, is in a position to mediate one or more steps in arginine vasopressin-induced water channel cycling. Water 102-107 arginine vasopressin Rattus norvegicus 82-93 7543252-9 1995 Nevertheless, immunofluorescence studies of inner medullary tissue from Brattleboro rats revealed a marked redistribution of the aquaporin-CD water channels to a predominantly apical and subapical localization in IMCD cells in response to water restriction, similar to the redistribution seen in response to vasopressin. Water 142-147 arginine vasopressin Rattus norvegicus 308-319 7543252-9 1995 Nevertheless, immunofluorescence studies of inner medullary tissue from Brattleboro rats revealed a marked redistribution of the aquaporin-CD water channels to a predominantly apical and subapical localization in IMCD cells in response to water restriction, similar to the redistribution seen in response to vasopressin. Water 239-244 arginine vasopressin Rattus norvegicus 308-319 7543252-11 1995 We conclude that oxytocin can function physiologically as an antidiuretic hormone, mimicking the short-term action of vasopressin on water permeability, albeit with somewhat lower potency. Water 133-138 arginine vasopressin Rattus norvegicus 118-129 7711446-0 1995 Participation of the kidney in the kinetics of arginine vasopressin in the water-loaded rat. Water 75-80 arginine vasopressin Rattus norvegicus 56-67 24283639-5 1995 It can be concluded that AVP plays important roles in the development of antidiuresis after water loading and in the disturbance of the brain water and electrolyte balance following experimental SAH. Water 92-97 arginine vasopressin Rattus norvegicus 25-28 24283639-5 1995 It can be concluded that AVP plays important roles in the development of antidiuresis after water loading and in the disturbance of the brain water and electrolyte balance following experimental SAH. Water 142-147 arginine vasopressin Rattus norvegicus 25-28 7541941-0 1995 Vasopressin increases AQP-CD water channel in apical membrane of collecting duct cells in Brattleboro rats. Water 29-34 arginine vasopressin Rattus norvegicus 0-11 7541941-3 1995 In rats given vasopressin 15 min before death, the number of immunogold particles for AQP-CD in the apical membrane increased significantly (P < 0.002) from 1.8 +/- 0.2 to 10.0 +/- 0.4/microns with a significant decrease (P < 0.05) of cytoplasmic labeling from 32.6 +/- 6.4 to 24.6 +/- 5.6/microns 2, indicating that AQP-CD is the vasopressin-regulated water channel predicted by the "shuttle" hypothesis. Water 359-364 arginine vasopressin Rattus norvegicus 14-25 7740582-1 1995 BACKGROUND AND PURPOSE: Atrial natriuretic peptide (ANP) and arginine vasopressin regulate brain water and electrolytes. Water 97-102 arginine vasopressin Rattus norvegicus 70-81 7540151-0 1995 Identification of Rab3-, Rab5a- and synaptobrevin II-like proteins in a preparation of rat kidney vesicles containing the vasopressin-regulated water channel. Water 144-149 arginine vasopressin Rattus norvegicus 122-133 7540151-1 1995 According to the "shuttle hypothesis", vasopressin increases the water permeability of renal epithelial cells by exocytotic fusion of vesicles containing the water channel AQP-CD with the apical plasma membrane, whereas withdrawal of vasopressin results in endocytotic uptake of AQP-CD. Water 65-70 arginine vasopressin Rattus norvegicus 39-50 7540151-1 1995 According to the "shuttle hypothesis", vasopressin increases the water permeability of renal epithelial cells by exocytotic fusion of vesicles containing the water channel AQP-CD with the apical plasma membrane, whereas withdrawal of vasopressin results in endocytotic uptake of AQP-CD. Water 158-163 arginine vasopressin Rattus norvegicus 39-50 7532304-0 1995 Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Water 22-27 arginine vasopressin Rattus norvegicus 0-11 7532304-1 1995 Water excretion by the kidney is regulated by the peptide hormone vasopressin. Water 0-5 arginine vasopressin Rattus norvegicus 66-77 7532304-2 1995 Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood. Water 26-31 arginine vasopressin Rattus norvegicus 0-11 7532304-2 1995 Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood. Water 95-100 arginine vasopressin Rattus norvegicus 0-11 7532304-6 1995 Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM. Water 65-70 arginine vasopressin Rattus norvegicus 34-45 7532304-9 1995 Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM. Water 42-47 arginine vasopressin Rattus norvegicus 0-11 7532304-11 1995 Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability. Water 173-178 arginine vasopressin Rattus norvegicus 28-39 7532304-12 1995 We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM. Water 43-48 arginine vasopressin Rattus norvegicus 17-28 7532304-12 1995 We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM. Water 136-141 arginine vasopressin Rattus norvegicus 17-28 7746497-3 1995 Three days of water deprivation significantly increased plasma arginine vasopressin and markedly potentiated the expression of PACAP mRNA in ARC. Water 14-19 arginine vasopressin Rattus norvegicus 72-83 7829988-5 1994 Water deprivation for 24 h increased plasma AVP levels to 7.2 pmol/l and increased Uosm to 2160 mOsmol/kg H2O. Water 0-5 arginine vasopressin Rattus norvegicus 44-47 7840248-1 1995 Prolonged fluid restriction in rats is accompanied by functional modifications of the terminal part of the inner medullary collecting duct (IMCD) revealed by a sustained increase in arginine vasopressin (AVP)-independent transepithelial osmotic water permeability (PTE) in vitro. Water 245-250 arginine vasopressin Rattus norvegicus 204-207 7840248-6 1995 However, when IMCDs of thirsted rats were exposed to AVP in vitro, their transcellular Posm (36.0 +/- 2.4 microns/s) was significantly smaller than their PTE determined simultaneously (51.8 +/- 7.1 microns/s), suggesting that part of the water flow may follow a paracellular route. Water 238-243 arginine vasopressin Rattus norvegicus 53-56 7850474-3 1994 Basal plasma vasopressin levels were normal in food deprived rats, but significantly increased in water deprived and simultaneously food and water deprived rats. Water 98-103 arginine vasopressin Rattus norvegicus 13-24 7720345-2 1995 It has been demonstrated that parathyroid hormone can increase adenylate cyclase activity in the rat papilla, produce a small antidiuretic effect and in vitro can interfere with the action of arginine vasopressin on water transport. Water 216-221 arginine vasopressin Rattus norvegicus 201-212 7539496-0 1995 The AQP2 water channel: effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats. Water 9-14 arginine vasopressin Rattus norvegicus 34-45 7539496-7 1995 This behavior is consistent with the idea that AQP2 is the vasopressin-sensitive water channel. Water 81-86 arginine vasopressin Rattus norvegicus 59-70 7810534-8 1995 In PNS rats, plasma AVP was significantly higher than in control rats (control 0.77 +/- 0.10 pg/mL v PNS 2.13 +/- 0.42 pg/mL; P < 0.005, n = 12), even though there were no differences in plasma osmolality (control 292.0 +/- 2.0 mOsm/kg H2O v PNS 290.3 +/- 2.5 mOsm/kg H2O; P = NS, n = 12) or serum sodium concentration (control 142.7 +/- 0.7 v PNS 142.1 +/- 1.1; PNS, n = 12). Water 239-242 arginine vasopressin Rattus norvegicus 20-23 7810534-8 1995 In PNS rats, plasma AVP was significantly higher than in control rats (control 0.77 +/- 0.10 pg/mL v PNS 2.13 +/- 0.42 pg/mL; P < 0.005, n = 12), even though there were no differences in plasma osmolality (control 292.0 +/- 2.0 mOsm/kg H2O v PNS 290.3 +/- 2.5 mOsm/kg H2O; P = NS, n = 12) or serum sodium concentration (control 142.7 +/- 0.7 v PNS 142.1 +/- 1.1; PNS, n = 12). Water 271-274 arginine vasopressin Rattus norvegicus 20-23 7840327-0 1995 Gut-brain signaling of water absorption inhibits vasopressin in rats. Water 23-28 arginine vasopressin Rattus norvegicus 49-60 7840327-1 1995 The mechanism for inhibition of vasopressin (AVP) by gastric water infusion was examined in 24- or 48-h dehydrated conscious rats (n = 136 rats, 255 experiments; mean AVP baseline = 6.3 pg/ml). Water 61-66 arginine vasopressin Rattus norvegicus 32-43 7898322-5 1994 In adrenalectomized rats given an overnight supplement of dexamethasone in their drinking water, the expression of both vasopressin and VIP mRNA in the SCN was elevated the following morning at ZT6 when compared to adrenalectomised rats kept on 0.9% saline. Water 90-95 arginine vasopressin Rattus norvegicus 120-131 7522327-0 1994 Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Water 30-35 arginine vasopressin Rattus norvegicus 58-69 7859070-4 1994 However, the Fos reaction of vasopressin cells in response to either stimulus was greater than that of oxytocin cells in the supraoptic and paraventricular nuclei, and in the perifornical posterior nucleus and nucleus circularis in response to water deprivation. Water 244-249 arginine vasopressin Rattus norvegicus 29-40 7943311-1 1994 Progressive dehydration due to water deprivation and streptozotocin diabetes both produce increased activity of the hypothalamoneurohypophysial system and enhanced vasopressin secretion. Water 31-36 arginine vasopressin Rattus norvegicus 164-175 7524358-1 1994 Vasopressin-regulated water permeability of the kidney collecting duct is a key component of the urine concentration machinery. Water 22-27 arginine vasopressin Rattus norvegicus 0-11 8035321-2 1994 The mechanism of kappa agonist-induced water diuresis is unclear but may involve inhibition of vasopressin secretion and/or an adrenomedullary factor. Water 39-44 arginine vasopressin Rattus norvegicus 95-106 8067465-5 1994 Thus the calculated doses of vasopressin to reduce urine flow and free water clearance, as well as to increase urinary osmolality 50% from their control values, were significantly higher in nonestrous females than in males and estrous females. Water 71-76 arginine vasopressin Rattus norvegicus 29-40 8035321-8 1994 The data suggest that kappa agonists cause a water diuresis by both a central mechanism involving inhibition of vasopressin secretion and a peripheral mechanism involving stimulation of renal alpha-2 receptors. Water 45-50 arginine vasopressin Rattus norvegicus 112-123 8285268-2 1993 Infusion of vasopressin (3-100 pg.kg-1.min) into conscious, chronically instrumented water-loaded rats resulted in a dose-dependent antidiuresis in both male and female rats. Water 85-90 arginine vasopressin Rattus norvegicus 12-23 7933842-1 1994 The present study was undertaken to determine whether a non-peptide arginine vasopressin (AVP) antagonist [5-dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetra hydro-1H- benzazepine] (OPC-31260) improves the impaired water excretion in rats with experimental liver cirrhosis. Water 230-235 arginine vasopressin Rattus norvegicus 90-93 8203619-0 1994 Role of endogenous vasopressin in development of gastric ulcer induced by restraint and water immersion. Water 88-93 arginine vasopressin Rattus norvegicus 19-30 8184959-1 1994 Centrally released vasopressin plays an important role in the regulation of brain water and electrolyte composition and can affect brain intracellular pH and ATP synthesis in vivo. Water 82-87 arginine vasopressin Rattus norvegicus 19-30 8134401-1 1994 Subchronic (30 days) exposure of rats to Co(NO3)2 or NiSO4 (20 mg.kg-1) in drinking water caused suppression of the isolated vas deferens contractile responses to exogenous adenosine 5"-triphosphate (ATP), noradrenaline, and l-phenylephrine, shifting the concentration-response curves to the relevant agonist to the right. Water 84-89 arginine vasopressin Rattus norvegicus 125-128 7905713-0 1994 Vasopressin-independent regulation of collecting duct water permeability. Water 54-59 arginine vasopressin Rattus norvegicus 0-11 7905713-3 1994 In the present studies, the vasopressin-independent osmotic water permeability was sustained at approximately 300 microns/s for at least 90 min. Water 60-65 arginine vasopressin Rattus norvegicus 28-39 7905713-8 1994 These effects were partially blocked by calphostin C, an inhibitor of protein kinase C. These results demonstrate that activation of phosphatidylinositol hydrolysis and/or activation of protein kinase C markedly inhibits osmotic water permeability in isolated perfused IMCD segments, even in the absence of prior stimulation by vasopressin. Water 229-234 arginine vasopressin Rattus norvegicus 328-339 8265605-1 1993 Vasopressin (antidiuretic hormone) regulates body water balance by controlling water permeability of the renal collecting ducts. Water 50-55 arginine vasopressin Rattus norvegicus 0-11 8265605-3 1993 How this occurs is unknown, but indirect evidence exists for the "shuttle" hypothesis, which states that vasopressin causes exocytic insertion of water channel-laden vesicles from the apical cytosol. Water 146-151 arginine vasopressin Rattus norvegicus 105-116 8285268-4 1993 Thus the effective doses of vasopressin (pg.kg-1.min-1) to decrease urine flow to 30 microliters.min-1.100 g-1 (18 +/- 5 in males; 58 +/- 12 in females), to increase urine osmolality to 600 mosmol/kgH2O (35 +/- 5 in males; 119 +/- 15 in females), and to decrease free water clearance to 30 microliters.min-1.100 g-1 (8 +/- 3 in males; 28 +/- 7 in females) were significantly (P < 0.05) lower in males. Water 268-273 arginine vasopressin Rattus norvegicus 28-39 8263761-1 1993 We characterized the endothelin (ET) receptor subtype responsible for the inhibition of vasopressin (AVP)-induced increases in osmotic water permeability (Pf) and cAMP accumulation in rat inner medullary collecting ducts (IMCD). Water 135-140 arginine vasopressin Rattus norvegicus 88-99 8406671-1 1993 Arginine vasopressin is a nine-amino acid neuropeptide hormone important in the regulation of water metabolism. Water 94-99 arginine vasopressin Rattus norvegicus 9-20 8227349-8 1993 During a 72-h water restriction state, the plasma AVP level increased and V2 receptor mRNA decreased in collecting ducts. Water 14-19 arginine vasopressin Rattus norvegicus 50-53 8404613-6 1993 Activation of the magnocellular vasopressinergic system by 60 h of water deprivation increased plasma VP levels from 0.5 +/- 0.1 to 11.8 +/- 0.6 pg/ml, but had no effect on the anterior pituitary CRH receptor concentration in control rats or animals receiving CRH infusion (100 ng/min for 48 h). Water 67-72 arginine vasopressin Rattus norvegicus 102-104 7505413-0 1993 Central administration of senktide, a tachykinin NK-3 agonist, has an antidiuretic action by stimulating AVP release in water-loaded rats. Water 120-125 arginine vasopressin Rattus norvegicus 105-108 8277781-2 1993 Here we describe a simple and sensitive radioimmunohistochemical assay (RIHA) to quantify a peptide, vasopressin (VP), in discrete brain regions of rats with 3-day water deprivation. Water 164-169 arginine vasopressin Rattus norvegicus 101-112 8277781-2 1993 Here we describe a simple and sensitive radioimmunohistochemical assay (RIHA) to quantify a peptide, vasopressin (VP), in discrete brain regions of rats with 3-day water deprivation. Water 164-169 arginine vasopressin Rattus norvegicus 114-116 8277781-7 1993 RIHA with aid of a computer-assisted image analysis system revealed that the VP content was significantly reduced in the paraventricular hypothalamic nucleus (PVN) and supraoptic nucleus (SON) of rats with 3-day water deprivation, whereas a parallel in situ hybridization study further demonstrated that VP mRNAs in the PVN and SON were greatly increased. Water 212-217 arginine vasopressin Rattus norvegicus 77-79 8214031-1 1993 In amphibian bladder, arginine vasopressin (AVP) depolymerizes F-actin in the apical region of the granular cell, promoting fusion of water channel-carrying vesicles with the apical membrane. Water 134-139 arginine vasopressin Rattus norvegicus 31-42 8214031-1 1993 In amphibian bladder, arginine vasopressin (AVP) depolymerizes F-actin in the apical region of the granular cell, promoting fusion of water channel-carrying vesicles with the apical membrane. Water 134-139 arginine vasopressin Rattus norvegicus 44-47 8393623-0 1993 Dual actions of vasopressin and oxytocin in regulation of water permeability in terminal collecting duct. Water 58-63 arginine vasopressin Rattus norvegicus 16-27 8403781-10 1993 Using the servo-control technique, the expected action of 1-desamino-8-D-arginine vasopressin on renal water handling was demonstrated, but the natriuretic effect reported by some workers was not evident. Water 103-108 arginine vasopressin Rattus norvegicus 82-93 8393623-2 1993 Vasopressin and oxytocin were found to have both stimulatory effects (at 0.1 nM) and inhibitory effects (at 10 nM) on osmotic water permeability. Water 126-131 arginine vasopressin Rattus norvegicus 0-11 1337114-1 1992 Vasopressin is thought to play an important role, not only in the metabolism of water and electrolytes, but also in the regulation of renal hemodynamics. Water 80-85 arginine vasopressin Rattus norvegicus 0-11 8393623-7 1993 The oxytocin/vasopressin-receptor antagonist [des-glycinamide9,d(CH2)5(1),O-Me-Tyr2,Thr4,Orn8]vasot ocin, which almost completely blocks vasopressin-induced calcium mobilization, also blocked the ability of 10 nM vasopressin to inhibit osmotic water permeability relative to that found with 0.1 nM vasopressin. Water 244-249 arginine vasopressin Rattus norvegicus 13-24 8393623-9 1993 1) Oxytocin, like vasopressin, has dual effects on osmotic water permeability, increasing it at subnanomolar concentrations and inhibiting it at suprananomolar concentrations. Water 59-64 arginine vasopressin Rattus norvegicus 18-29 8393623-10 1993 2) Oxytocin, like vasopressin, can increase cAMP production, perhaps accounting for the increase in water permeability. Water 100-105 arginine vasopressin Rattus norvegicus 18-29 8484016-2 1993 Administration of exogenous EGF modulates the reabsorption of Na+ and the vasopressin stimulated reabsorption of water in the collecting tubules. Water 113-118 arginine vasopressin Rattus norvegicus 74-85 8484016-7 1993 IN CONCLUSION: it seems unlikely that nephrogenous EGF excreted in the urine plays a physiological role in the regulation of the renal excretion of Na+ and H+ and in the vasopressin stimulated reabsorption of water in the rat. Water 209-214 arginine vasopressin Rattus norvegicus 170-181 8457007-6 1993 Thus, during pregnancy, the lower tonicity of plasma is perceived as normal by both VP and OT neuroendocrine systems enabling excretion of an acute sodium or water load. Water 158-163 arginine vasopressin Rattus norvegicus 84-86 8003705-3 1993 Treatment with TRH resulted in significantly increased hypothalamic vasopressin content in both euhydrated (i.e. given tap water ad libitum) and salt-loaded rats. Water 123-128 arginine vasopressin Rattus norvegicus 68-79 8429910-2 1993 Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes. Water 93-98 arginine vasopressin Rattus norvegicus 46-57 8429910-2 1993 Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes. Water 161-166 arginine vasopressin Rattus norvegicus 46-57 8429910-3 1993 In this nephron segment, vasopressin regulates water permeability by endo- and exocytosis of water channels from or to the apical membrane. Water 47-52 arginine vasopressin Rattus norvegicus 25-36 8380375-1 1993 The contribution of the magnocellular vasopressinergic system to the regulation of ACTH secretion was studied by analysis of hypothalamic-adrenal axis function in rats subjected to water deprivation for 48 h. Water deprivation resulted in marked increases in plasma osmolarity and vasopressin (VP) levels and hypothalamic VP mRNA and immunoreactive (ir) VP in magnocellular neurons. Water 209-214 arginine vasopressin Rattus norvegicus 38-49 7683841-1 1993 The present study was undertaken to examine vasopressin gene expression in response to a normal versus hypertonic sodium chloride (506 mOsm/kg H2O) intake for 7 days in Sprague-Dawley rats. Water 143-146 arginine vasopressin Rattus norvegicus 44-55 7688055-0 1993 Substance P injected into the hypothalamic supraoptic nucleus causes antidiuresis through the release of arginine-vasopressin in water-loaded and ethanol-anesthetized rats. Water 129-134 arginine vasopressin Rattus norvegicus 105-125 8097684-5 1993 Somatostatin (10(-9) mol/l) also inhibited the increase in water permeability produced by arginine vasopressin, although this inhibitory effect was reduced by a 10-fold increase in arginine vasopressin concentration (5 ng/ml). Water 59-64 arginine vasopressin Rattus norvegicus 99-110 1487697-3 1992 These differences were fully reversed after 7 days of vasopressin replacement in DI rats to restore normal water turnover. Water 107-112 arginine vasopressin Rattus norvegicus 54-65 1490249-0 1992 Role of sodium and water excretion in the antihypertensive effect of vasopressin in the spontaneously hypertensive rat. Water 19-24 arginine vasopressin Rattus norvegicus 69-80 1448828-1 1992 BACKGROUND AND PURPOSE: Injection of arginine vasopressin into the cerebral ventricles in animals with brain injury increased brain water, whereas injection of atrial natriuretic peptide reduced water content. Water 132-137 arginine vasopressin Rattus norvegicus 46-57 1448828-7 1992 RESULTS: The arginine vasopressin V1 receptor antagonist and atrial natriuretic peptide significantly (p < 0.05) reduced water and sodium contents in the posterior edematous regions. Water 124-129 arginine vasopressin Rattus norvegicus 22-33 1388176-1 1992 Endocytic vesicles that are involved in the vasopressin-stimulated recycling of water channels to and from the apical membrane of kidney collecting duct principal cells were isolated from rat renal papilla by differential and Percoll density gradient centrifugation. Water 80-85 arginine vasopressin Rattus norvegicus 44-55 1394607-0 1992 Vasopressin antagonist disrupts the circadian rhythm of water intake on suprachiasmatic injection. Water 56-61 arginine vasopressin Rattus norvegicus 0-11 1394607-1 1992 The present study makes an attempt to find out the action of arginine vasopressin (AVP) and its antagonist d-(CH2)5 Tyr (Me) AVP applied at the suprachiasmatic nuclei (SCN) on the circadian rhythm of water intake. Water 200-205 arginine vasopressin Rattus norvegicus 70-81 1394607-1 1992 The present study makes an attempt to find out the action of arginine vasopressin (AVP) and its antagonist d-(CH2)5 Tyr (Me) AVP applied at the suprachiasmatic nuclei (SCN) on the circadian rhythm of water intake. Water 200-205 arginine vasopressin Rattus norvegicus 83-86 1394607-1 1992 The present study makes an attempt to find out the action of arginine vasopressin (AVP) and its antagonist d-(CH2)5 Tyr (Me) AVP applied at the suprachiasmatic nuclei (SCN) on the circadian rhythm of water intake. Water 200-205 arginine vasopressin Rattus norvegicus 125-128 1394607-5 1992 The findings are suggestive of the involvement of AVP as a mediator of the circadian rhythm of water intake at the level of the neural pacemaker, SCN. Water 95-100 arginine vasopressin Rattus norvegicus 50-53 1328300-0 1992 Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct. Water 43-48 arginine vasopressin Rattus norvegicus 20-31 1328300-2 1992 To characterize direct effects of the recently discovered peptide endothelin (ET) on renal tubule transport, we determined signaling mechanisms for ET effects on vasopressin (AVP)-stimulated water permeability (PF) in rat terminal inner medullary collecting duct (IMCD) perfused in vitro. Water 191-196 arginine vasopressin Rattus norvegicus 162-173 1387020-6 1992 OPC-31260 at doses of 10 to 100 micrograms kg-1, i.v., inhibited the antidiuretic action of exogenously administered AVP in water-loaded, alcohol-anaesthetized rats in a dose-dependent manner. Water 124-129 arginine vasopressin Rattus norvegicus 117-120 1415580-8 1992 Induction of water diuresis was not secondary to an inhibition of vasopressin secretion since it could be demonstrated in homozygous Brattleboro rats in which antidiuresis was produced by the infusion of vasopressin at a rate of 200 microU.kg-1.min-1. Water 13-18 arginine vasopressin Rattus norvegicus 204-215 1320335-0 1992 Kinetics of urea and water permeability activation by vasopressin in rat terminal IMCD. Water 21-26 arginine vasopressin Rattus norvegicus 54-65 1320335-2 1992 To assess whether these transporters may be activated by common mechanisms, we investigated the time course of increase of urea and water permeability in response to vasopressin in isolated perfused terminal IMCD segments. Water 132-137 arginine vasopressin Rattus norvegicus 166-177 1320335-6 1992 The lag periods between vasopressin addition and the initial rise in permeability were the same for urea (34.2 +/- 8.8 s) and water (34.8 +/- 8.9 s) transport activation. Water 126-131 arginine vasopressin Rattus norvegicus 24-35 1320335-9 1992 The results are consistent with the view that the rate-limiting step in vasopressin-induced activation is the same for both the urea carrier and water channel and may lie at a step beyond generation of adenosine 3",5"-cyclic monophosphate. Water 145-150 arginine vasopressin Rattus norvegicus 72-83 1498275-5 1992 With the osmotic gradient oriented as predicted by the model (lumen greater than bath), vasopressin increased the osmotic water permeability from 286 to 852 microns/s. Water 122-127 arginine vasopressin Rattus norvegicus 88-99 1498275-6 1992 Three additional series of experiments confirmed the high water permeability in the presence of vasopressin. Water 58-63 arginine vasopressin Rattus norvegicus 96-107 1351096-12 1992 Clonidine on the other hand increases free water clearance and this effect is mediated through an interaction with the renal actions of vasopressin. Water 43-48 arginine vasopressin Rattus norvegicus 136-147 1613430-4 1992 The ratio of plasma oxytocin:vasopressin reached a significant peak at about 02.00 h which might be related to the feeding activity of the rats, food and water intake being largely confined to the night, as was fluid excretion. Water 154-159 arginine vasopressin Rattus norvegicus 29-40 1324077-1 1992 The magnocellular hypothalamo-neurohypophysial system is, via a release of vasopressin from nerve terminals in the neurohypophysis to the peripheral blood, centrally involved in the regulation of body salt and water homeostasis. Water 210-215 arginine vasopressin Rattus norvegicus 75-86 1342827-0 1992 In vitro action of vasopressin on water absorption by rat colon. Water 34-39 arginine vasopressin Rattus norvegicus 19-30 1342827-2 1992 Vasopressin (10 mM) significantly stimulated water absorption in both the proximal (4.85 +/- 3.78 vs 1.51 +/- 1.16 ml/mg) and distal (10.39 +/- 3.52 vs 7.22 +/- 3.58 ml/mg) colon, which corresponds to an increase of 220% and 50%, respectively. Water 45-50 arginine vasopressin Rattus norvegicus 0-11 1342827-3 1992 The results indicate the need for a study of the possible physiological function of vasopressin in enhancing intestinal water absorption, when it is released in response to plasma hyperosmolarity. Water 120-125 arginine vasopressin Rattus norvegicus 84-95 1814538-5 1991 Significant increases of daily water intake indicated impaired vasopressin release following both types of surgical transection. Water 31-36 arginine vasopressin Rattus norvegicus 63-74 1291859-6 1992 Water permeability in the presence of submaximal concentrations of AVP (20 microU/ml) was also significantly increased with lower concentrations of ethanol (0.12, 0.24 and 0.48 g%) but fell to control levels with higher concentrations. Water 0-5 arginine vasopressin Rattus norvegicus 67-70 1436296-7 1992 In vitro measurements of 3H2O permeability of perfused IMCD of normal rats showed that vasopressin (50 microU/ml) added to the bath increased the diffusional water permeability (43.4 +/- 4.8 vs. 105.6 +/- 9.1 x 10(-5) cm/s), while in acyclovir rats, the control value (58.8 +/- 9.1 x 10(-5) cm/s) did not increase significantly in the presence of vasopressin (71.3 +/- 13.6 x 10(-5) cm/s). Water 158-163 arginine vasopressin Rattus norvegicus 87-98 1661085-0 1991 Endothelin-1 inhibits AVP-stimulated osmotic water permeability in rat inner medullary collecting duct. Water 45-50 arginine vasopressin Rattus norvegicus 22-25 1661085-4 1991 Endothelin, at 10(-10) and 10(-8) M, reversibly inhibited 10(-11) M arginine vasopressin (AVP)-stimulated osmotic water permeability (Pf) by 18 and 24%, respectively. Water 114-119 arginine vasopressin Rattus norvegicus 77-88 1661085-4 1991 Endothelin, at 10(-10) and 10(-8) M, reversibly inhibited 10(-11) M arginine vasopressin (AVP)-stimulated osmotic water permeability (Pf) by 18 and 24%, respectively. Water 114-119 arginine vasopressin Rattus norvegicus 90-93 1657493-4 1991 Urinary excretion of arginine-vasopressin was increased in hyperthyroid and reduced in hypothyroid rats with respect to controls, in response to water deprivation or a hypertonic saline load. Water 145-150 arginine vasopressin Rattus norvegicus 30-41 1684820-6 1991 Administration of the vasopressin receptor antagonist, SK&F 105494, to either dogs or cynomolgus monkeys demonstrated that antagonism of the vasopressin V2 receptor could result in a brisk water diuresis in both species. Water 193-198 arginine vasopressin Rattus norvegicus 22-33 1684820-6 1991 Administration of the vasopressin receptor antagonist, SK&F 105494, to either dogs or cynomolgus monkeys demonstrated that antagonism of the vasopressin V2 receptor could result in a brisk water diuresis in both species. Water 193-198 arginine vasopressin Rattus norvegicus 145-156 1784343-6 1991 A transient increase of water intake was detected on the day of VP-Ab treatment only, which provides direct evidence for at least partial neutralization of vasopressin in the circulation. Water 24-29 arginine vasopressin Rattus norvegicus 156-167 1660261-9 1991 Hormone-induced changes of intracellular water space could sufficiently explain accompanying liver mass changes induced by glucagon, cAMP, adenosine or vasopressin, but not those by phenylephrine and extracellular ATP. Water 41-46 arginine vasopressin Rattus norvegicus 152-163 1687373-5 1991 Stimulation of the vasopressin/oxytocin neurosecretory system by water deprivation increased glutamate content in pituicytes and mitochondria within neurosecretory endings but had little influence on microvesicle glutamate content. Water 65-70 arginine vasopressin Rattus norvegicus 19-30 1659234-3 1991 Vasopressin infusion (0.01 ng.kg-1.min-1) in five dogs resulted in a decrease in free water clearance from 2.90 +/- 0.42 to -0.34 +/- 0.08 ml/min. Water 86-91 arginine vasopressin Rattus norvegicus 0-11 1764817-0 1991 Vasopressin response to haemorrhage in rats: effect of hypoxia and water restriction. Water 67-72 arginine vasopressin Rattus norvegicus 0-11 1764817-2 1991 The aim of the present study was to determine the effect of water restriction and/or hypoxia on the vasopressin response to haemorrhage in conscious rats. Water 60-65 arginine vasopressin Rattus norvegicus 100-111 1653534-1 1991 We have used the isolated perfused tubule technique, measurements of adenosine 3",5"-cyclic monophosphate (cAMP) content in single tubules, and freeze-fracture electron microscopy to study the basis of high vasopressin-independent (basal) osmotic water permeability (Pf) in the terminal inner medullary collecting duct (IMCD) of the rat. Water 247-252 arginine vasopressin Rattus norvegicus 207-218 1764817-7 1991 Water restricted rats had elevated pre-haemorrhage vasopressin levels. Water 0-5 arginine vasopressin Rattus norvegicus 51-62 1764817-9 1991 Water restriction (N - W) or hypoxia (H + W) each augmented the vasopressin response to haemorrhage. Water 0-5 arginine vasopressin Rattus norvegicus 64-75 1764817-12 1991 Hypoxia or water restriction per se augment the vasopressin response to haemorrhage. Water 11-16 arginine vasopressin Rattus norvegicus 48-59 1764817-13 1991 This augmented vasopressin response to haemorrhage is not maintained when hypoxia and water restriction are combined. Water 86-91 arginine vasopressin Rattus norvegicus 15-26 1653534-3 1991 They also showed that the basal Pf of the terminal IMCD is regulated by in vivo factors related to water intake, such that a very high vasopressin-independent Pf can be induced in isolated tubules by prior in vivo thirsting. Water 99-104 arginine vasopressin Rattus norvegicus 135-146 1653534-6 1991 Water loading of the rats suppressed the incidence of clusters almost entirely but did not fully suppress the basal Pf in the terminal IMCD, raising the possibility that a component of transepithelial water transport may occur independently of the vasopressin-regulated IMP clusters. Water 0-5 arginine vasopressin Rattus norvegicus 248-259 1962535-4 1991 Water deprivation increased AVP mRNA in both nuclei as previously reported. Water 0-5 arginine vasopressin Rattus norvegicus 28-31 1962535-8 1991 Plasma AVP and osmolality levels were significantly elevated in water-deprived rats but not in food-deprived rats. Water 64-69 arginine vasopressin Rattus norvegicus 7-10 19215447-4 1991 A high VP output was found to coincide with increased inhibition of OT release: Subcutaneous injection of graded doses of naloxone (30 min prior to decapitation), augmented OT plasma levels significantly more in 24 h water-deprived male rats than in normally hydrated rats. Water 217-222 arginine vasopressin Rattus norvegicus 7-9 1905326-5 1991 In the presence of 10(-8) M arginine vasopressin, urea permeability increased when NaCl was added to raise osmolality from 290 to 490 mOsm/kg H2O but there was no further increase at 690 mOsm/kg H2O. Water 142-145 arginine vasopressin Rattus norvegicus 37-48 1905326-5 1991 In the presence of 10(-8) M arginine vasopressin, urea permeability increased when NaCl was added to raise osmolality from 290 to 490 mOsm/kg H2O but there was no further increase at 690 mOsm/kg H2O. Water 195-198 arginine vasopressin Rattus norvegicus 37-48 1854946-3 1991 The important role in the mechanism of the decrease in the water reabsorption in SHR plays the decrease in the content of vasopressin in the blood and urea in the kidney interstitium while in NR a more marked inhibition of the water reabsorption is caused by the decrease in the concentration of both urea and sodium in the kidney layers. Water 59-64 arginine vasopressin Rattus norvegicus 122-133 1854946-3 1991 The important role in the mechanism of the decrease in the water reabsorption in SHR plays the decrease in the content of vasopressin in the blood and urea in the kidney interstitium while in NR a more marked inhibition of the water reabsorption is caused by the decrease in the concentration of both urea and sodium in the kidney layers. Water 227-232 arginine vasopressin Rattus norvegicus 122-133 1694105-2 1990 After prolonged administration of 2% sodium chloride as drinking water (salt-loading), the treatment increased the levels of VP, OXY, TH, GAL, DYN and CCK mRNA in the PVN and SON. Water 65-70 arginine vasopressin Rattus norvegicus 125-127 1701969-1 1990 Vasopressin action in the renal collecting duct is believed to be mediated by the cycling of water channels in principal and, possibly, intercalated cells. Water 93-98 arginine vasopressin Rattus norvegicus 0-11 2078904-6 1990 These results indicate that ILI in the brain may play a role in the secretion of AVP, and that this mechanism could be operated to control a water-sodium balance. Water 141-146 arginine vasopressin Rattus norvegicus 81-84 2387259-8 1990 The highest basal release of VP was observed in the explants maintained under isotonic conditions (299 mosm/kg H2O). Water 111-114 arginine vasopressin Rattus norvegicus 29-31 2387259-10 1990 Basal VP release was lower in explants maintained in hypertonic medium (greater than 304 mosmol/kg H2O), and these explants did not respond to the acute hypertonic pulse. Water 99-102 arginine vasopressin Rattus norvegicus 6-8 2172546-12 1990 Another function of in vivo IMCD cells, vasopressin-dependent formation of endosomes containing water channels, was absent in the cultured cells. Water 96-101 arginine vasopressin Rattus norvegicus 40-51 1696262-0 1990 Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase. Water 79-84 arginine vasopressin Rattus norvegicus 57-68 1696262-1 1990 The water permeability of the kidney collecting duct epithelium is regulated by vasopressin (VP)-induced recycling of water channels between an intracellular vesicular compartment and the plasma membrane of principal cells. Water 4-9 arginine vasopressin Rattus norvegicus 80-91 1696262-1 1990 The water permeability of the kidney collecting duct epithelium is regulated by vasopressin (VP)-induced recycling of water channels between an intracellular vesicular compartment and the plasma membrane of principal cells. Water 4-9 arginine vasopressin Rattus norvegicus 93-95 2125706-6 1990 Serum vasopressin concentration was increased following water deprivation, and the increase was comparable in all age groups. Water 56-61 arginine vasopressin Rattus norvegicus 6-17 2176710-3 1990 In rats drinking 2% NaCl-water for 0,2,4, or 10 days, or for 10 days and then tap water for 14 days, the levels of VP mRNA in the NIL were altered in a fashion that paralleled changes in the hypothalamus. Water 25-30 arginine vasopressin Rattus norvegicus 115-117 2176710-3 1990 In rats drinking 2% NaCl-water for 0,2,4, or 10 days, or for 10 days and then tap water for 14 days, the levels of VP mRNA in the NIL were altered in a fashion that paralleled changes in the hypothalamus. Water 82-87 arginine vasopressin Rattus norvegicus 115-117 2338532-0 1990 Vasopressin responses to hypoxia in conscious rats: interaction with water restriction. Water 69-74 arginine vasopressin Rattus norvegicus 0-11 2343162-4 1990 Vasopressin and desmopressin reduced water intake, plasma osmolality and plasma Na+ concentration similarly. Water 37-42 arginine vasopressin Rattus norvegicus 0-11 2338532-1 1990 The purpose of this study was to determine the effect of water restriction on the vasopressin response to hypoxia in conscious Long-Evans rats. Water 57-62 arginine vasopressin Rattus norvegicus 82-93 2338532-6 1990 Hypoxia led to a very small and transient increase in vasopressin in the water-replete rats. Water 73-78 arginine vasopressin Rattus norvegicus 54-65 2338532-7 1990 The combination of hypoxia and water restriction led to a greatly augmented vasopressin response at 1 h (60 +/- 16 pmol/l); this response was also not sustained. Water 31-36 arginine vasopressin Rattus norvegicus 76-87 2338532-9 1990 Water restriction, hypoxia and water restriction plus hypoxia all led to decreased pituitary vasopressin content. Water 0-5 arginine vasopressin Rattus norvegicus 93-104 2338532-9 1990 Water restriction, hypoxia and water restriction plus hypoxia all led to decreased pituitary vasopressin content. Water 31-36 arginine vasopressin Rattus norvegicus 93-104 2338532-10 1990 We conclude that the vasopressin response to hypoxia in conscious rats is small and transient, and that concomitant water restriction augments the vasopressin response to acute but not chronic hypoxia. Water 116-121 arginine vasopressin Rattus norvegicus 147-158 35470441-8 2022 Water-exposed females drinking ethanol showed more social investigation as well as significantly higher hypothalamic OXTR, AVP, and AVPR1b gene expression than their counterparts ingesting supersac and AIE females drinking ethanol. Water 0-5 arginine vasopressin Rattus norvegicus 123-126 2334946-8 1990 For both measures of oxytocin and vasopressin mRNA levels, maximum-likelihood estimation indicated that this model adequately described empirical findings obtained from rats drinking tap water or salt water. Water 187-192 arginine vasopressin Rattus norvegicus 34-45 2314632-0 1990 Vasopressin mRNA in parvocellular neurons of the rat suprachiasmatic nucleus exhibits increased poly (A) tail length following water deprivation. Water 127-132 arginine vasopressin Rattus norvegicus 0-11 34281190-3 2021 Vasopressin secretion is maintained in pregnancy and lactation despite reduced osmolality (the principal stimulus for vasopressin secretion) to increase water retention to cope with the cardiovascular demands of pregnancy and lactation. Water 153-158 arginine vasopressin Rattus norvegicus 118-129 34281190-9 2021 Furthermore, supraoptic nucleus DeltaN-TRPV1 mRNA expression was not different between non-pregnant and late-pregnant rats, suggesting that sustained activity of DeltaN-TRPV1 channels might maintain vasopressin neuron activity to increase water retention during pregnancy and lactation. Water 239-244 arginine vasopressin Rattus norvegicus 199-210 2337634-0 1990 [Effects of continuous infusion of vasopressin on circadian rhythms of food and water intake, urine output and electrolyte excretion in Brattleboro rats]. Water 80-85 arginine vasopressin Rattus norvegicus 35-46 2248733-2 1990 The intravenous injection of MCP induced dose-related increases in plasma VP levels in water-loaded rats. Water 87-92 arginine vasopressin Rattus norvegicus 74-76 2934736-2 1985 In general, these peptides, called atrial natriuretic factors (ANFs), oppose the actions of the water-conservatory peptides angiotensin II and vasopressin and are released from the heart in response to atrial stretch as a consequence of increased venous return. Water 96-101 arginine vasopressin Rattus norvegicus 143-154 9691010-0 1998 Decreased vasopressin-mediated renal water reabsorption in rats with compensated liver cirrhosis. Water 37-42 arginine vasopressin Rattus norvegicus 10-21 9691010-1 1998 Experiments were performed to investigate vasopressin type 2 receptor (V2)-mediated renal water reabsorption and the renal expression of the vasopressin-regulated water channel aquaporin-2 (AQP-2) in cirrhotic rats with sodium retention but without ascites. Water 163-168 arginine vasopressin Rattus norvegicus 141-152 9691010-11 1998 Since daily urine flow rate was similar in cirrhotic and sham-operated rats, we suggest that non-vasopressin-mediated water reabsorption is increased in cirrhotic rats probably as a result of an increased corticomedullary gradient due to exaggerated NaCl reabsorption in the thick ascending limb of Henle"s loop. Water 118-123 arginine vasopressin Rattus norvegicus 97-108 34527169-8 2021 The pathways related to these genes were the estrogen signaling pathway, vasopressin-regulated water reabsorption, thyroid hormone synthesis, aldosterone synthesis and secretion, insulin secretion, circadian entrainment, insulin resistance, cholinergic synapse, dopaminergic synapse, cGMP-PKG signaling pathway, cAMP signaling pathway, PI3K-Akt signaling pathway, TNF signaling pathway, and AMPK signaling pathway. Water 95-100 arginine vasopressin Rattus norvegicus 73-84 35051932-1 2022 INTRODUCTION: Water homeostasis is achieved by secretion of peptide hormones arginine vasopressin (AVP) and oxytocin (OXT) that are synthesised by separate populations of magnocellular neurones (MCNs) in the hypothalamus. Water 14-19 arginine vasopressin Rattus norvegicus 86-97 2632718-1 1989 The role of vasopressin in the regulation of body water volume and its distribution to intravascular, interstitial and intracellular compartments, and the importance of particular body water compartments in the pathogenesis of DOCA-salt hypertension were studied in young Brattleboro rats. Water 50-55 arginine vasopressin Rattus norvegicus 12-23 2632718-4 1989 The development of DOCA-salt hypertension was attenuated in the vasopressin-deficient rats, which had a similar level of total body water, slightly increased intracellular water and significantly decreased extracellular fluid volume compared with the hypertensive vasopressin-synthesizing rats. Water 132-137 arginine vasopressin Rattus norvegicus 64-75 2632718-4 1989 The development of DOCA-salt hypertension was attenuated in the vasopressin-deficient rats, which had a similar level of total body water, slightly increased intracellular water and significantly decreased extracellular fluid volume compared with the hypertensive vasopressin-synthesizing rats. Water 172-177 arginine vasopressin Rattus norvegicus 64-75 2632718-5 1989 Consequently, in the vasopressin-deficient rats, the ratio of extracellular fluid volume to intracellular water did not differ from that of controls. Water 106-111 arginine vasopressin Rattus norvegicus 21-32 2792662-0 1989 Blockade of the hydroosmotic effect of vasopressin normalizes water excretion in cirrhotic rats. Water 62-67 arginine vasopressin Rattus norvegicus 39-50 2792662-5 1989 Treatment with the vasopressin antagonist normalized water excretion in 9 of the 10 rats. Water 53-58 arginine vasopressin Rattus norvegicus 19-30 2792662-7 1989 These results indicate that vasopressin hypersecretion is the predominant mechanism of the impairment in water excretion in rats with experimental cirrhosis and ascites. Water 105-110 arginine vasopressin Rattus norvegicus 28-39 2725842-2 1989 Two days of water deprivation resulted in significant increases in hematocrit, plasma osmolality and vasopressin levels, indicating a functional activation of magnocellular vasopressin neurons. Water 12-17 arginine vasopressin Rattus norvegicus 101-112 2700000-6 1989 In rats with 5/6 nephrectomy, we increased experimentally water intake in order to decrease circulating VP levels, urine concentration, and free water reabsorption. Water 58-63 arginine vasopressin Rattus norvegicus 104-106 2546748-4 1989 Naloxone (0.5 mg/kg) significantly enhanced AVP secretion after 72-h water deprivation. Water 69-74 arginine vasopressin Rattus norvegicus 44-47 2725842-2 1989 Two days of water deprivation resulted in significant increases in hematocrit, plasma osmolality and vasopressin levels, indicating a functional activation of magnocellular vasopressin neurons. Water 12-17 arginine vasopressin Rattus norvegicus 173-184 2924145-7 1989 Vasopressin replacement normalized water intake in DI rats, but had no significant effect on NK cell activity. Water 35-40 arginine vasopressin Rattus norvegicus 0-11 2539747-1 1989 Recent micropuncture studies have demonstrated that administration of high doses of 1-deamino-8-D-arginine vasopressin (dDAVP), a synthetic analogue of vasopressin (AVP), causes desensitization of the thick ascending limb to AVP but may leave unaltered the effect of this hormone on the permeability to water of the collecting duct. Water 303-308 arginine vasopressin Rattus norvegicus 107-118 2539747-1 1989 Recent micropuncture studies have demonstrated that administration of high doses of 1-deamino-8-D-arginine vasopressin (dDAVP), a synthetic analogue of vasopressin (AVP), causes desensitization of the thick ascending limb to AVP but may leave unaltered the effect of this hormone on the permeability to water of the collecting duct. Water 303-308 arginine vasopressin Rattus norvegicus 152-163 2716958-7 1989 VP substitution of the lesioned animals normalized water intake but not plasma osmolality. Water 51-56 arginine vasopressin Rattus norvegicus 0-2 2523076-0 1989 Water intake in rats subjected to hypothalamic immunoneutralization of angiotensin II, atrial natriuretic peptide, vasopressin, or oxytocin. Water 0-5 arginine vasopressin Rattus norvegicus 115-126 2501836-4 1989 Moreover, this abnormal water intake is significantly reversed by treatment with Pitressin, a vasopressin analogue. Water 24-29 arginine vasopressin Rattus norvegicus 94-105 2849664-13 1988 The increase in water excretion at the lower infusion rates would be consistent with the antagonism of the renal effects of vasopressin. Water 16-21 arginine vasopressin Rattus norvegicus 124-135 2736078-3 1989 In the water-sated condition, the group exposed to alcohol prenatally had plasma levels of AVP seven-fold above control levels. Water 7-12 arginine vasopressin Rattus norvegicus 91-94 2736078-7 1989 In the control animals, 24-hr of water deprivation produced the expected increase in AVP, in plasma and urine osmolality, and decrease in urine production. Water 33-38 arginine vasopressin Rattus norvegicus 85-88 2904771-8 1988 Our results suggest that an IAP substrate, probably Gi, 1) is required for signal transduction by renal alpha 2-adrenoceptors, 2) may tonically modulate the response to vasopressin in the CCT but not of parathyroid hormone in the proximal convoluted tubule, and 3) participates in renal water and electrolyte reabsorption independent of exogenous adenylate cyclase stimulation. Water 287-292 arginine vasopressin Rattus norvegicus 169-180 3229009-0 1988 Effect of pH on vasopressin-induced water permeability in collecting ducts of isolated rat papillae. Water 36-41 arginine vasopressin Rattus norvegicus 16-27 3229009-7 1988 In the presence of 50 microU/ml vasopressin, increases in diffusional water permeability of collecting ducts perfused with solutions at pH 5.0, 7.4 or 9.0 did not differ significantly. Water 70-75 arginine vasopressin Rattus norvegicus 32-43 3229009-8 1988 Similarly, increases in diffusional water permeability induced by 200 microU/ml vasopressin were not different when collecting ducts were perfused with solutions at pH 5.0, 7.4 or 9.0. Water 36-41 arginine vasopressin Rattus norvegicus 80-91 3229009-10 1988 The presence of vasopressin (50 microU/ml) in the bathing medium at pH 6.4, 7.4 and 8.4 induced increments in diffusional water permeability of 0.40 +/- 0.21 (n = 14, P greater than 0.05), 1.56 +/- 0.27 (n = 27, P less than 0.001) and 1.67 +/- 0.24 (n = 12, P less than 0.001) microns/s, respectively. Water 122-127 arginine vasopressin Rattus norvegicus 16-27 3229009-13 1988 The presence of vasopressin (200 microU/ml) in the bathing medium at pH 6.4, 7.4 and 8.4 induced increments in diffusional water permeability of 2.16 +/- 0.54 (n = 9, P less than 0.01), 2.55 +/- 0.51 (n = 17, P less than 0.001) and 0.98 +/- 0.34 (n = 11, P less than 0.05) microns/s respectively. Water 123-128 arginine vasopressin Rattus norvegicus 16-27 2844855-0 1988 Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct. Water 66-71 arginine vasopressin Rattus norvegicus 35-46 3062061-11 1988 Thus, the absence of vasopressin in female Brattleboro rats severely affects cardiovascular adaptation to water deprivation. Water 106-111 arginine vasopressin Rattus norvegicus 21-32 2838523-1 1988 UNLABELLED: Vasopressin increases both the urea permeability and osmotic water permeability in the terminal part of the renal inner medullary collecting duct (terminal IMCD). Water 73-78 arginine vasopressin Rattus norvegicus 12-23 2838523-4 1988 Half-maximal increases in urea permeability and osmotic water permeability occurred with 0.01 nM vasopressin. Water 56-61 arginine vasopressin Rattus norvegicus 97-108 2844855-9 1988 ANF appears to act at a site distal to cyclic AMP generation in the chain of events linking vasopressin receptor binding to an increase in osmotic water permeability. Water 147-152 arginine vasopressin Rattus norvegicus 92-103 3216721-0 1988 Vasopressin and oxytocin excretion in the Brown-Norway rat in relation to aging, water metabolism and testosterone. Water 81-86 arginine vasopressin Rattus norvegicus 0-11 3169037-1 1988 In target epithelia, a vasopressin-induced water permeability increase is accompanied by the appearance of intramembranous particle (IMP) clusters, probably representing water-permeable patches, in the apical plasma membrane of responding cells. Water 43-48 arginine vasopressin Rattus norvegicus 23-34 3169037-1 1988 In target epithelia, a vasopressin-induced water permeability increase is accompanied by the appearance of intramembranous particle (IMP) clusters, probably representing water-permeable patches, in the apical plasma membrane of responding cells. Water 170-175 arginine vasopressin Rattus norvegicus 23-34 3420014-9 1988 In contrast, the chronic infusion of AVP in Brattleboro rats resulted in a reduction in water intake which was accompanied by a decreased Bmax. Water 88-93 arginine vasopressin Rattus norvegicus 37-40 2833121-1 1988 Adenosine 3",5"-cyclic monophosphate (cAMP)-dependent protein phosphorylation is considered a key step in the cellular action of vasopressin (AVP) to regulate water permeability in collecting tubules. Water 159-164 arginine vasopressin Rattus norvegicus 129-140 2830903-6 1988 Experiments employing REF52 cells prelabeled with [3H]choline demonstrated that both TPA and vasopressin induce the hydrolysis of cellular choline-containing glycerophospholipids; this was measured by both a decrease in cell-associated phosphatidylcholine radioactivity and an increase in the production of water-soluble [3H]choline-containing metabolites in the culture medium. Water 307-312 arginine vasopressin Rattus norvegicus 93-104 3386517-1 1988 We have studied the effects of two diuretics, selective for renal cortical (furosemide) and inner medullary (vasopressin antagonist) water handling, in rat kidney at 1.5 T and find that furosemide completely dissipates the cortical-inner medullary T2 gradient whereas the vasopressin antagonist has little effect. Water 133-138 arginine vasopressin Rattus norvegicus 109-120 3311989-6 1987 Serum vasopressin was higher in all groups of animals receiving hypertonic saline (1200 mosm/kg H2O; p less than 0.05), but the magnitude of increase was not significantly different in the SHR and WKY at either age. Water 96-99 arginine vasopressin Rattus norvegicus 6-17 2856643-5 1988 During 24 hr and 48 hr water deprivation vasopressin rose from 3.1 +/- 0.3 pg/ml to 7.3 +/- 1.3 pg/ml and 8.4 +/- 0.6 pg/ml (mean +/- SEM), respectively. Water 23-28 arginine vasopressin Rattus norvegicus 41-52 2975142-3 1988 With these considerations in mind, we have attempted to elucidate the possible involvement of the central vasopressin (AVP) and atrial natriuretic factor (ANF) systems in the regulation of the water and ion homeostasis of the brain tissue of rats: Vasopressin-positive vascular connections, investigated by immuno-electronhistochemistry, were found in close or direct contact with brain microvessels. Water 193-198 arginine vasopressin Rattus norvegicus 106-117 3040254-4 1987 The increased volume of both principal and intercalated cells seems to be part of a general hyperplasia and hyperactivity of the collecting duct, which may in some way be related to the effects of lithium on vasopressin-mediated mediated water transport. Water 238-243 arginine vasopressin Rattus norvegicus 208-219 3605388-0 1987 Inhibition of VP and OT release by water in hypovolemia is independent of opioid peptides. Water 35-40 arginine vasopressin Rattus norvegicus 14-16 3658129-6 1987 By its presumed reduction of central and peripheral vasopressin release through lowering the cerebrospinal fluid sodium concentration, it may help in decreasing the brain water content. Water 171-176 arginine vasopressin Rattus norvegicus 52-63 3039112-8 1987 The diuretic effects of full and partial kappa agonists correlated with plasma vasopressin levels in water-deprived rats. Water 101-106 arginine vasopressin Rattus norvegicus 79-90 3496207-6 1987 Treatment of LOBEX rats with 1-desamino-8-D-arginine vasopressin and oxytocin reduced water consumption and allowed for milk ejection and milk intake by the pups but did not restore the suckling-induced rise in PRL. Water 86-91 arginine vasopressin Rattus norvegicus 53-64 3110736-1 1987 I. Preservation of vasopressin-stimulated water and urea pathways in rat papillary collecting duct. Water 42-47 arginine vasopressin Rattus norvegicus 19-30 3110736-3 1987 Arginine vasopressin (AVP) at 10(-9) mol/l increased diffusional water permeability (Pdw) from 101.9 +/- 10.76 to 283.3 +/- 16.67 X 10(-7) cm2 s-1 (n = 8, P less than 0.01) and urea permeability (Purea) from 30.3 +/- 2.24 to 83.5 +/- 7.80 X 10(-7) cm2 s-1 (n = 8, P less than 0.01). Water 65-70 arginine vasopressin Rattus norvegicus 0-20 3110736-3 1987 Arginine vasopressin (AVP) at 10(-9) mol/l increased diffusional water permeability (Pdw) from 101.9 +/- 10.76 to 283.3 +/- 16.67 X 10(-7) cm2 s-1 (n = 8, P less than 0.01) and urea permeability (Purea) from 30.3 +/- 2.24 to 83.5 +/- 7.80 X 10(-7) cm2 s-1 (n = 8, P less than 0.01). Water 65-70 arginine vasopressin Rattus norvegicus 22-25 3830070-8 1986 The administration of AVP to aged rats resulted in a significant decrease in water intake and urinary volume, but AVP administration did not induce any change in the electrolyte balance. Water 77-82 arginine vasopressin Rattus norvegicus 22-25 2951661-7 1986 Seventy-two hr water deprivation (mixed osmotic and volume stimulus) resulted in elevated plasma AVP levels which were unaffected by an IV bolus injection of ANF at doses of 0.06-10 micrograms. Water 15-20 arginine vasopressin Rattus norvegicus 97-100 3830070-9 1986 Therefore, it is concluded that the main cause of the development of polydipsia and polyuria is the decline in renal function but not in neurosecretory activity, although exogenous AVP can effectively reduce water intake and urinary output in aged rats. Water 208-213 arginine vasopressin Rattus norvegicus 181-184 3007740-6 1986 The urinary excretion of vasopressin was not altered by the smaller dose of quinapril but was reduced by the larger dose, which increased water intake and urine excretion. Water 138-143 arginine vasopressin Rattus norvegicus 25-36 3747342-0 1986 Effect of vasopressin antagonist on water excretion in inferior vena cava constriction. Water 36-41 arginine vasopressin Rattus norvegicus 10-21 3747342-1 1986 Elevated levels of plasma arginine vasopressin (AVP) have been suggested to impair water excretion in congestive heart failure. Water 83-88 arginine vasopressin Rattus norvegicus 35-46 3747342-1 1986 Elevated levels of plasma arginine vasopressin (AVP) have been suggested to impair water excretion in congestive heart failure. Water 83-88 arginine vasopressin Rattus norvegicus 48-51 3717373-4 1986 Water deprivation for 48 h increased the plasma vasopressin concentration (PADH) and 24-h urinary vasopressin excretion (UADHV) in SHR and WKY rats, but PMet-Enk was not altered. Water 0-5 arginine vasopressin Rattus norvegicus 48-59 3717373-4 1986 Water deprivation for 48 h increased the plasma vasopressin concentration (PADH) and 24-h urinary vasopressin excretion (UADHV) in SHR and WKY rats, but PMet-Enk was not altered. Water 0-5 arginine vasopressin Rattus norvegicus 98-109 2422957-9 1986 We conclude that conditions that prevail in vivo during antidiuresis, namely hypertonicity of the papillary interstitium, may augment vasopressin responsiveness through increments of collecting tubule cAMP and reductions of PGE2 which could, in concert, maximize water reabsorption in the collecting tubule. Water 263-268 arginine vasopressin Rattus norvegicus 134-145 2941271-2 1986 The effect of ANF on vasopressin secretion was greater in the water-deprived animal. Water 62-67 arginine vasopressin Rattus norvegicus 21-32 3946641-3 1986 However, plasma AVP was reduced to basal levels when the rats were given either free access to drinking water or intragastric water loads that diluted plasma osmolality by only 3-6% despite continued hypovolemia. Water 104-109 arginine vasopressin Rattus norvegicus 16-19 2434770-1 1986 Vasopressin is the primary physiological factor regulating renal water reabsorption in mammals. Water 65-70 arginine vasopressin Rattus norvegicus 0-11 2434770-3 1986 The present studies describe and characterize the pharmacological effects of the potent vasopressin antagonist desGly d(CH2)5D-Tyr(Et)VAVP (SK&F 101926) and related analogs on renal water and solute excretion in conscious rats. Water 186-191 arginine vasopressin Rattus norvegicus 88-99 2434770-6 1986 SK&F 101926 antagonized, in a competitive fashion, exogenous vasopressin-stimulated antidiuresis in conscious water-loaded rats. Water 114-119 arginine vasopressin Rattus norvegicus 65-76 2434777-5 1986 Two days after surgery, sham-lesioned, water-deprived rats displayed decreased vasopressin immunostaining density compared to normal controls, and adipsic AV3V-lesioned rats displayed increased vasopressin immunoreactivity throughout the magnocellular-hypophyseal system. Water 39-44 arginine vasopressin Rattus norvegicus 79-90 2946974-3 1986 Also in the water-deprived rat, this treatment leads to a strong decrease of plasma VP levels. Water 12-17 arginine vasopressin Rattus norvegicus 84-86 3951675-6 1986 Water deprivation for 24 and 48 h significantly elevated both the plasma AVP concentration and the concentration of AVP in the hypothalamus and in the amygdala-temporal cortex samples. Water 0-5 arginine vasopressin Rattus norvegicus 73-76 3951675-6 1986 Water deprivation for 24 and 48 h significantly elevated both the plasma AVP concentration and the concentration of AVP in the hypothalamus and in the amygdala-temporal cortex samples. Water 0-5 arginine vasopressin Rattus norvegicus 116-119 3951675-7 1986 The increases in AVP after water deprivation are limited to these two regions and are quantitatively much lower than after peripheral administration. Water 27-32 arginine vasopressin Rattus norvegicus 17-20 4063831-3 1985 After water deprivation for 24 h, both AVP in plasma and DA in the neurointermediate lobe increased without any changes in AVP in the neurointermediate lobe. Water 6-11 arginine vasopressin Rattus norvegicus 39-42 3899238-5 1985 Collectively the results indicate that although the full development of vasopressin-dependent mechanisms following acute hypotension takes longer when a large proportion of unmyelinated afferent fibres have been destroyed by neonatal treatment with capsaicin, 48 h of water deprivation results in a normal involvement of vasopressin-dependent mechanisms in the maintenance of blood pressure. Water 268-273 arginine vasopressin Rattus norvegicus 72-83 2990759-1 1985 Renal alpha 2-adrenoceptor stimulation by epinephrine infusion reverses cyclic adenosine monophosphate-mediated effects of vasopressin on sodium and water excretion. Water 149-154 arginine vasopressin Rattus norvegicus 123-134 2990759-3 1985 In the presence of alpha 1-adrenoceptor blockade with prazosin (30 nM) alpha 2-adrenoceptor stimulation with epinephrine reversed the cyclic adenosine monophosphate-mediated effects of vasopressin on sodium (P less than 0.05) and water (P less than 0.05) excretion. Water 230-235 arginine vasopressin Rattus norvegicus 185-196 3714834-6 1986 Both vasopressin-deficient homozygous Brattleboro rats and their heterozygous littermates (with preserved vasopressin synthesis) began to consume solid food and water at the age of 16 days and their intake of maternal milk was terminated about the 27th day of age. Water 161-166 arginine vasopressin Rattus norvegicus 5-16 2933129-3 1985 The primary actions of these peptides lead to a reduction in plasma and extracellular fluid volume by eliciting natriuresis and diuresis, and by opposing the action of other peptidergic systems such as the vasopressin and angiotensin systems that promote water retention and enhance drinking behavior. Water 255-260 arginine vasopressin Rattus norvegicus 206-217 4063831-4 1985 Water deprivation for 48-72 h caused further increases in both AVP in plasma and DA in the neurointermediate lobe with a significant decrease in AVP in the neurointermediate lobe. Water 0-5 arginine vasopressin Rattus norvegicus 63-66 4063831-4 1985 Water deprivation for 48-72 h caused further increases in both AVP in plasma and DA in the neurointermediate lobe with a significant decrease in AVP in the neurointermediate lobe. Water 0-5 arginine vasopressin Rattus norvegicus 145-148 4063831-5 1985 Rehydration for 24 h subsequent to 72 h of water deprivation made AVP in plasma and DA in the neurointermediate lobe return to the values of normally hydrated rats, whereas AVP in the neurointermediate lobe was still depressed. Water 43-48 arginine vasopressin Rattus norvegicus 66-69 4063831-5 1985 Rehydration for 24 h subsequent to 72 h of water deprivation made AVP in plasma and DA in the neurointermediate lobe return to the values of normally hydrated rats, whereas AVP in the neurointermediate lobe was still depressed. Water 43-48 arginine vasopressin Rattus norvegicus 173-176 2988346-1 1985 Alpha 2-adrenoceptor agonists attenuate vasopressin-mediated changes in water excretion. Water 72-77 arginine vasopressin Rattus norvegicus 40-51 2988346-5 1985 Vasopressin (10 microU/ml) produced a significant (P less than 0.05) decrease in both water and sodium excretion. Water 86-91 arginine vasopressin Rattus norvegicus 0-11 2988346-7 1985 Alpha 2-Adrenoceptor stimulation with l-epinephrine (28 nM) reversed (P less than 0.05) the effects of vasopressin on water and sodium excretion. Water 118-123 arginine vasopressin Rattus norvegicus 103-114 2988346-11 1985 Thus alpha 2-adrenoceptor stimulation antagonized the effects of vasopressin on both water and sodium excretion at the renal level. Water 85-90 arginine vasopressin Rattus norvegicus 65-76 2412515-8 1985 It is concluded that norepinephrine and vasopressin are important stimulators of the urinary kallikrein excretion only in those circumstances where it is necessary to eliminate an excess of water. Water 190-195 arginine vasopressin Rattus norvegicus 40-51 2485266-0 1985 Interactions between neural mechanisms, the renin-angiotensin system and vasopressin in the maintenance of blood pressure during water deprivation: studies in Long Evans and Brattleboro rats. Water 129-134 arginine vasopressin Rattus norvegicus 73-84 3998146-7 1985 When water-deprived saralasin-treated rats were given a specific antagonist to the vascular action of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, a fall in systemic blood pressure occurred, on average from 102 +/- 5 to 80 +/- 5 mmHg, unaccompanied by dilation of renal arterioles, so that both plasma flow rate (129 +/- 8 vs. 85 +/- 13 nl/min) and SNGFR (31.0 +/- 2.9 vs. 18.2 +/- 4.4 nl/min) decreased. Water 5-10 arginine vasopressin Rattus norvegicus 102-122 3998146-7 1985 When water-deprived saralasin-treated rats were given a specific antagonist to the vascular action of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, a fall in systemic blood pressure occurred, on average from 102 +/- 5 to 80 +/- 5 mmHg, unaccompanied by dilation of renal arterioles, so that both plasma flow rate (129 +/- 8 vs. 85 +/- 13 nl/min) and SNGFR (31.0 +/- 2.9 vs. 18.2 +/- 4.4 nl/min) decreased. Water 5-10 arginine vasopressin Rattus norvegicus 124-127 3998146-7 1985 When water-deprived saralasin-treated rats were given a specific antagonist to the vascular action of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, a fall in systemic blood pressure occurred, on average from 102 +/- 5 to 80 +/- 5 mmHg, unaccompanied by dilation of renal arterioles, so that both plasma flow rate (129 +/- 8 vs. 85 +/- 13 nl/min) and SNGFR (31.0 +/- 2.9 vs. 18.2 +/- 4.4 nl/min) decreased. Water 5-10 arginine vasopressin Rattus norvegicus 144-147 3998146-9 1985 In water-diuretic rats, administration of a moderately pressor dose of AVP (4 mU/kg per min) resulted in a significant rise in kidney blood flow rate (from 8.8 +/- 1.2 to 9.6 +/- 1.3 ml/min). Water 3-8 arginine vasopressin Rattus norvegicus 71-74 4021228-0 1985 Dopaminergic modulation of the renal effect of arginine-vasopressin in water-loaded rats. Water 71-76 arginine vasopressin Rattus norvegicus 56-67 4011400-6 1985 Administration of exogenous vasopressin in water loaded animals caused a similar rise in urine osmolality. Water 43-48 arginine vasopressin Rattus norvegicus 28-39 3989425-4 1985 Significantly fewer neurones showed phasic activity in DI rats which had been pretreated with vasopressin tannate at a dose which significantly reduced urine volume, water intake and plasma osmolality. Water 166-171 arginine vasopressin Rattus norvegicus 94-105 4060971-6 1985 This contrasted with the potent natriuretic and weak kaliuretic action of vasopressin in water loaded Inactin anaesthetised rats. Water 89-94 arginine vasopressin Rattus norvegicus 74-85 3157876-3 1985 3 days of water deprivation resulted in elevated plasma AVP levels (36.1 +/- 4.7 pg AVP/ml) which were significantly reduced following intravenous infusion of 0.02 (21.4 +/- 3.6), 0.2 (15.6 +/- 1.6), and 2.0 (13.9 +/- 3.8) nmol Atriopeptin III. Water 10-15 arginine vasopressin Rattus norvegicus 56-59 3157876-3 1985 3 days of water deprivation resulted in elevated plasma AVP levels (36.1 +/- 4.7 pg AVP/ml) which were significantly reduced following intravenous infusion of 0.02 (21.4 +/- 3.6), 0.2 (15.6 +/- 1.6), and 2.0 (13.9 +/- 3.8) nmol Atriopeptin III. Water 10-15 arginine vasopressin Rattus norvegicus 84-87 3846407-5 1985 The infusion of vasopressin induced significant increases in circulating levels of vasopressin (248.1 +/- 35.2 pg/ml in vasopressin-infused rats (n = 7) compared to 95.5 +/- 14.6 pg/ml in vehicle-infused rats (n = 7), p less than 0.001) and in weight gain (39.6 +/- 1.3 g in vasopressin-infused rats (n = 7) compared to 29.1 +/- 3.3 g in vehicle-infused rats (n = 7), p less than 0.05), and also sustained decreases in water intake and urine volume, but it did not induce any change in urinary sodium excretion. Water 419-424 arginine vasopressin Rattus norvegicus 16-27 3846407-5 1985 The infusion of vasopressin induced significant increases in circulating levels of vasopressin (248.1 +/- 35.2 pg/ml in vasopressin-infused rats (n = 7) compared to 95.5 +/- 14.6 pg/ml in vehicle-infused rats (n = 7), p less than 0.001) and in weight gain (39.6 +/- 1.3 g in vasopressin-infused rats (n = 7) compared to 29.1 +/- 3.3 g in vehicle-infused rats (n = 7), p less than 0.05), and also sustained decreases in water intake and urine volume, but it did not induce any change in urinary sodium excretion. Water 419-424 arginine vasopressin Rattus norvegicus 83-94 3846407-5 1985 The infusion of vasopressin induced significant increases in circulating levels of vasopressin (248.1 +/- 35.2 pg/ml in vasopressin-infused rats (n = 7) compared to 95.5 +/- 14.6 pg/ml in vehicle-infused rats (n = 7), p less than 0.001) and in weight gain (39.6 +/- 1.3 g in vasopressin-infused rats (n = 7) compared to 29.1 +/- 3.3 g in vehicle-infused rats (n = 7), p less than 0.05), and also sustained decreases in water intake and urine volume, but it did not induce any change in urinary sodium excretion. Water 419-424 arginine vasopressin Rattus norvegicus 83-94 3846407-5 1985 The infusion of vasopressin induced significant increases in circulating levels of vasopressin (248.1 +/- 35.2 pg/ml in vasopressin-infused rats (n = 7) compared to 95.5 +/- 14.6 pg/ml in vehicle-infused rats (n = 7), p less than 0.001) and in weight gain (39.6 +/- 1.3 g in vasopressin-infused rats (n = 7) compared to 29.1 +/- 3.3 g in vehicle-infused rats (n = 7), p less than 0.05), and also sustained decreases in water intake and urine volume, but it did not induce any change in urinary sodium excretion. Water 419-424 arginine vasopressin Rattus norvegicus 83-94 4047982-2 1985 The neuropeptide vasopressin is nowadays recognized as a putative neurotransmitter, after years of study on its neurosecretory hormonal aspect in water metabolism. Water 146-151 arginine vasopressin Rattus norvegicus 17-28 6098765-2 1984 In situ incubation of IMCT with 10(-7) M arginine vasopressin (AVP) at 300 mOsm/kg H2O in control normokalemic rats increased cyclic AMP content (fmoles/mm) from 5.68 +/- 1.41 to 30.3 +/- 5.31 (P less than 0.001). Water 83-86 arginine vasopressin Rattus norvegicus 63-66 3995558-2 1985 After water deprivation for two days, control rats displayed characteristic antidiuretic response including a 75% reduction of urinary excretion and a six-fold decrease in vasopressin content of the neural lobe associated with a dramatic depletion of neurosecretory granules in corresponding axons. Water 6-11 arginine vasopressin Rattus norvegicus 172-183 6086885-4 1984 A renal alpha-2 adrenoceptor response was demonstrated by showing that epinephrine could reverse the effect of vasopressin on water and sodium in the presence of beta blockade and alpha-1 destruction by POB. Water 126-131 arginine vasopressin Rattus norvegicus 111-122 6329898-5 1984 The reduction of antidiuretic hormone (ADH) secretion in jerboas fed a water-enriched diet compared to those on a dry diet (75 +/- 25 pM versus 372 +/- 86 pM) was accompanied by an increase in the number of liver vasopressin receptors (2.79 +/- 0.53 versus 1.25 +/- 0.14 pmol [3H]vasopressin bound/mg protein). Water 71-76 arginine vasopressin Rattus norvegicus 213-224 6329898-5 1984 The reduction of antidiuretic hormone (ADH) secretion in jerboas fed a water-enriched diet compared to those on a dry diet (75 +/- 25 pM versus 372 +/- 86 pM) was accompanied by an increase in the number of liver vasopressin receptors (2.79 +/- 0.53 versus 1.25 +/- 0.14 pmol [3H]vasopressin bound/mg protein). Water 71-76 arginine vasopressin Rattus norvegicus 280-291 6728146-7 1984 It is hypothesized that vasopressin, by regulating the water permeability of the brain capillaries, the choroid plexus, and the cerebrospinal fluid absorption structures, plays an important role in controlling the brain fluid and electrolyte balance during the course of SAH. Water 55-60 arginine vasopressin Rattus norvegicus 24-35 6472554-0 1984 Vasopressin fails to restore postnatally the stunted brain development in the Brattleboro rat, but affects water metabolism permanently. Water 107-112 arginine vasopressin Rattus norvegicus 0-11 6546972-0 1984 Cardiovascular response to vasopressin vasopressor antagonist administration during water deprivation in the rat. Water 84-89 arginine vasopressin Rattus norvegicus 27-38 6546972-9 1984 Water deprivation for 48 h increased plasma vasopressin concentrations from 0.7 +/- 0.1 to 2.8 +/- 0.1 microU/ml and increased blood pressure from 112 +/- 2 to 123 +/- 1 mm Hg. Water 0-5 arginine vasopressin Rattus norvegicus 44-55 6739224-1 1984 The effect of [1-(beta-mercapto-beta,beta- cyclopentamethylene -propionic acid)2-0- ethyltyrosine ,4-valine] arginine vasopressin on the water metabolism was studied in rat. Water 137-142 arginine vasopressin Rattus norvegicus 118-129 6704587-7 1984 Since it is well known that the mechanism of water- or alcohol-induced diuresis is an inhibition of vasopressin release, the present results suggest that naloxone could prevent this inhibition. Water 45-50 arginine vasopressin Rattus norvegicus 100-111 6142809-1 1984 Water deprivation in gerbils and rats for 5 and 3 days respectively resulted in the same degree of dehydration of the animals and similar depletion of the neurohypophyseal vasopressin stores. Water 0-5 arginine vasopressin Rattus norvegicus 172-183 6699783-0 1984 Central effects of dopamine on vasopressin release in the normally hydrated and water-loaded rat. Water 80-85 arginine vasopressin Rattus norvegicus 31-42 6689019-1 1983 Vasopressin and oxytocin are nonapeptide hormones that regulate water metabolism and lactation, respectively. Water 64-69 arginine vasopressin Rattus norvegicus 0-11 6657001-0 1983 Vasopressin release induced by water deprivation: effects of centrally administered saralasin. Water 31-36 arginine vasopressin Rattus norvegicus 0-11 6313759-22 1983 Therefore, increased antidiuretic response to VP in the kidneys of CPMD-treated DI rats is due to enhanced osmotic driving force for water reabsorption (lumen-to-interstitium osmotic gradient) in collecting tubules, rather than due to increased VP-dependent water permeability of tubular epithelium. Water 133-138 arginine vasopressin Rattus norvegicus 46-48 6688929-5 1983 Intraperitoneal administration of the AVP analogue (30 micrograms/kg body wt) decreased the mean urinary osmolality in rats after 24 h of fluid deprivation from 3,098 +/- 140 to 797 +/- 155 mosmol/kg H2O (P less than 0.001). Water 200-203 arginine vasopressin Rattus norvegicus 38-41 6313759-22 1983 Therefore, increased antidiuretic response to VP in the kidneys of CPMD-treated DI rats is due to enhanced osmotic driving force for water reabsorption (lumen-to-interstitium osmotic gradient) in collecting tubules, rather than due to increased VP-dependent water permeability of tubular epithelium. Water 258-263 arginine vasopressin Rattus norvegicus 46-48 6635259-0 1983 Vasopressin-like peptides in the rat brain: immunologic and chromatographic behavior and their response to water deprivation. Water 107-112 arginine vasopressin Rattus norvegicus 0-11 6869538-4 1983 Vasopressin (Pitressin tannate in oil, 5 U/kg subcutaneously) increased UPGEV and decreased urine volume (V) in rats on ad libitum water intake but did not alter UPGEV during water deprivation. Water 131-136 arginine vasopressin Rattus norvegicus 0-11 6869538-12 1983 Conversely, the marked increase in UPGEV induced by administration of vasopressin during water diuresis may serve to suppress the antidiuretic response and thus play a role in the mediation of escape from physiologically inappropriate antidiuresis. Water 89-94 arginine vasopressin Rattus norvegicus 70-81 6407335-4 1983 Both groups of rats suppressed AVP secretion appropriately when water loaded. Water 64-69 arginine vasopressin Rattus norvegicus 31-34 6875967-1 1983 Vasopressin enhanced the absorption of water and Na+ across everted sacs of rat colon descendens but had no effect on absorption across the colon ascendens. Water 39-44 arginine vasopressin Rattus norvegicus 0-11 6888661-8 1983 On the third day in culture, increasing the osmolality of the culture medium from 295 to 315 mosm/kg H2O by the addition of NaCl resulted in a 2.5-fold increase in VP release from the explants with sham lesions, but did not significantly alter VP release from the explants with AV3V lesions. Water 101-104 arginine vasopressin Rattus norvegicus 164-166 6867069-4 1983 When water-deprived and tested 48 hr later, vasopressin-treated rats found the water tube reliably faster than controls. Water 5-10 arginine vasopressin Rattus norvegicus 44-55 6856043-5 1983 Animals with knife cuts and ad libitum access to food and water had significantly higher plasma osmolality (310 +/- 2 mosm/kg), and plasma vasopressin concentration (2.02 +/- 0.5 microunits/ml) than controls (306 +/- 1 mosm/kg and 0.60 +/- 0.04 microunits/ml, respectively). Water 58-63 arginine vasopressin Rattus norvegicus 139-150 6856043-7 1983 However, rats with knife cuts deprived of water only had significantly higher plasma osmolality (358 +/- 8 mosm/kg), sodium (164 +/- 19 mEq/l) and vasopressin (17.7 +/- 4 microunits/ml), than similarly treated control animals (317 +/- 1 mosm/kg, 145.5 +/- 1.0 mEq/1, 5.5 +/- 3 microunits/ml, respectively). Water 42-47 arginine vasopressin Rattus norvegicus 147-158 6132339-1 1983 The water permeability of collecting ducts is greatly increased by the antidiuretic hormone, vasopressin. Water 4-9 arginine vasopressin Rattus norvegicus 93-104 6132339-3 1983 IMP aggregates have also been related to an increase in water permeability of two other vasopressin-sensitive epithelia, the amphibian urinary bladder and the amphibian epidermis, and it has been proposed that these specialized membrane domains might represent specific water-permeable membrane patches, induced by the hormone in their respective epithelia. Water 56-61 arginine vasopressin Rattus norvegicus 88-99 6838716-1 1983 Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later. Water 115-120 arginine vasopressin Rattus norvegicus 28-39 6838716-1 1983 Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later. Water 115-120 arginine vasopressin Rattus norvegicus 41-44 6838716-1 1983 Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later. Water 165-170 arginine vasopressin Rattus norvegicus 28-39 6838716-1 1983 Rats injected with arginine vasopressin (AVP) immediately after exposure to a novel open-field environment found a water tube faster than saline injected rats, when water-deprived 48 h later. Water 165-170 arginine vasopressin Rattus norvegicus 41-44 24010174-3 1983 In addition, if these lesioned animals were water-deprived (48 h), the usual vasopressin release observed in sham-lesioned and normal controls was markedly blunted. Water 44-49 arginine vasopressin Rattus norvegicus 77-88 6616568-0 1983 Changes in hypothalamic and extra-hypothalamic vasopressin content of water-deprived rats. Water 70-75 arginine vasopressin Rattus norvegicus 47-58 6616568-3 1983 Pituitary VP decreased from 71.1 to 8.7 ng/mg, and plasma VP rose from 3.6 to 19.3 pg/ml during water deprivation. Water 96-101 arginine vasopressin Rattus norvegicus 58-60 6616568-5 1983 In extrahypothalamic sites VP-immunoreactivity in water-deprived rats was visibly reduced in periventricular thalamus and septum. Water 50-55 arginine vasopressin Rattus norvegicus 27-29 6674655-0 1983 Conditions for secretion of vasopressin in pressor amounts in water-replete rats. Water 62-67 arginine vasopressin Rattus norvegicus 28-39 6674655-1 1983 Conditions for secretion of pressor amounts of vasopressin were sought in conscious, water-replete rats. Water 85-90 arginine vasopressin Rattus norvegicus 47-58 6648028-5 1983 For comparison, oral water loading and 24-hour dehydration were used to suppress and stimulate endogenous vasopressin secretion in Long-Evans (LE) rats, and the effects on urine osmolality and IPC were examined. Water 21-26 arginine vasopressin Rattus norvegicus 106-117 7162034-0 1982 Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats. Water 51-56 arginine vasopressin Rattus norvegicus 19-30 7137381-4 1982 Progressive increases in urine flow and decreases in urine osmolality and free water reabsorption occurred in vasopressin-treated animals. Water 79-84 arginine vasopressin Rattus norvegicus 110-121 6867069-4 1983 When water-deprived and tested 48 hr later, vasopressin-treated rats found the water tube reliably faster than controls. Water 79-84 arginine vasopressin Rattus norvegicus 44-55 7113593-3 1982 Ethanol anaesthesia and water loading in Long Evans suppressed plasma vasopressin levels and was associated with an antidiuretic response to oxytocin. Water 24-29 arginine vasopressin Rattus norvegicus 70-81 6295751-5 1982 More prolonged elevation of plasma AVP levels by water restriction for 48 h, on the other hand, increased the responsiveness by 38 to 81%, which was restored to basal levels by ad libitum intake of water for another 48 h (positive feedback regulation). Water 49-54 arginine vasopressin Rattus norvegicus 35-38 6295751-5 1982 More prolonged elevation of plasma AVP levels by water restriction for 48 h, on the other hand, increased the responsiveness by 38 to 81%, which was restored to basal levels by ad libitum intake of water for another 48 h (positive feedback regulation). Water 198-203 arginine vasopressin Rattus norvegicus 35-38 7084115-3 1982 However, the induction of VP release caused by the addition of NaCl (sufficient to yield a 10 mosmol/kg H2O increase in culture medium osmolality) was not reduced by NE in concentrations as high as 10(-5) M. An alpha-adrenergic receptor mediation of the inhibition of VP release by NE was suggested by the ability of phentolamine and phenoxybenzamine, but not propranolol, to block this effect. Water 104-107 arginine vasopressin Rattus norvegicus 26-28 7044934-0 1982 Interaction between effects of insulin and vasopressin on renal excretion of water and sodium in rats. Water 77-82 arginine vasopressin Rattus norvegicus 43-54 7078362-8 1982 It is suggested that the water-conserving effect of vasopressin 1 day after the dietary change was suppressed by the very high PGE2 production, resulting in normal renal water excretion. Water 25-30 arginine vasopressin Rattus norvegicus 52-63 7078362-8 1982 It is suggested that the water-conserving effect of vasopressin 1 day after the dietary change was suppressed by the very high PGE2 production, resulting in normal renal water excretion. Water 170-175 arginine vasopressin Rattus norvegicus 52-63 6121047-4 1982 Water loading (10 ml/kg) and EKC (0.5 mg/kg) diminished plasma vasopressin levels equally 60 min after treatment. Water 0-5 arginine vasopressin Rattus norvegicus 63-74 7091310-5 1982 Water injection decreased serum AVP in diabetics (as in normals), but only to 5.8 +/- 1.0 pg/ml. Water 0-5 arginine vasopressin Rattus norvegicus 32-35 7120025-2 1982 In water-loaded rats, vasopressin induced a dose-related increase in total urinary prostaglandin E and prostaglandin F excretion and a decrease in total urine output. Water 3-8 arginine vasopressin Rattus norvegicus 22-33 6753486-2 1981 Plasma AVP was decreased following hydration with 10 ml of water (1.0 +/- 0.3 pg/ml, mean +/- S.E.M.) Water 59-64 arginine vasopressin Rattus norvegicus 7-10 7188584-4 1981 Plasma concentrations of AVP were significantly elevated in DOCa hypertensive rats compared with normotensive control rats, whether or not they received 1% sodium chloride solution or demineralized water to drink. Water 198-203 arginine vasopressin Rattus norvegicus 25-28 7030085-9 1981 These results indicate that the hypotensive effect of water restriction in the two-kidney one-clip hypertensive rat model may be mediated, at least in part, through elevated circulating levels of vasopressin that subsequently inhibit renin release. Water 54-59 arginine vasopressin Rattus norvegicus 196-207 6121047-10 1982 EKC also blocked vasopressin-stimulated water flow in the toad bladder, a model of the renal distal tubule and collecting duct. Water 40-45 arginine vasopressin Rattus norvegicus 17-28 6758651-2 1982 It has been demonstrated through the use of new techniques that the action of vasopressin on the kidneys is not limited to changing the water permeability of distal tubules and collecting ducts. Water 136-141 arginine vasopressin Rattus norvegicus 78-89 6753486-3 1981 as compared to controls (6.1 +/- 2.0 pg/ml), while withdrawal of water for 48 hours stimulated AVP release (29 +/- 8 pg/ml). Water 65-70 arginine vasopressin Rattus norvegicus 95-98 7326874-9 1981 The results suggest that vasopressin is not essential for the development of renal hypertension but the absolute levels of blood pressure achieved in 1K-1C hypertension are volume-dependent and thus influenced by the water-retaining properties of vasopressin. Water 217-222 arginine vasopressin Rattus norvegicus 247-258 7324506-3 1981 Following the administration of the aminoglycoside gentamicin to rats for five days, a decrease in concentrating ability was demonstrated, caused by impaired vasopressin-mediated water transport. Water 179-184 arginine vasopressin Rattus norvegicus 158-169 7291218-3 1981 Drinking was also reduced by the two drugs in 24 hr water-deprived heterozygotes, which have detectable levels of vasopressin. Water 52-57 arginine vasopressin Rattus norvegicus 114-125 7006848-10 1981 These studies clearly demonstrate that circulating AVP contributes to the maintenance of AP during water deprivation in the anesthetized rat. Water 99-104 arginine vasopressin Rattus norvegicus 51-54 7212090-1 1981 Normal rats (N) and rats with hereditary hypothalamic diabetes insipidus (DI) were employed to examine the role of arginine vasopressin (AVP) in the reduction of water intake and urine output during hypoxic exposure. Water 162-167 arginine vasopressin Rattus norvegicus 115-135 7212090-1 1981 Normal rats (N) and rats with hereditary hypothalamic diabetes insipidus (DI) were employed to examine the role of arginine vasopressin (AVP) in the reduction of water intake and urine output during hypoxic exposure. Water 162-167 arginine vasopressin Rattus norvegicus 137-140 7209515-1 1981 Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. Water 150-155 arginine vasopressin Rattus norvegicus 30-41 7209515-1 1981 Four new synthetic analogs of vasopressin (antidiuretic hormone) can antagonize the antidiuretic response to intravenous vasopressin in anesthetized, water-loaded rats. Water 150-155 arginine vasopressin Rattus norvegicus 121-132 7446731-1 1980 Vasopressin increases the permeability of collecting ducts to water. Water 62-67 arginine vasopressin Rattus norvegicus 0-11 7269990-4 1981 After extraction of the hormone from plasma and cerebrospinal fluid the vasopressin concentration was determined by means of the antidiuretic bioassay in the water-loaded rat. Water 158-163 arginine vasopressin Rattus norvegicus 72-83 7446731-8 1980 Accordingly, quantitation of CDLM clusters may serve as an end point for the study of vasopressin-induced water permeability. Water 106-111 arginine vasopressin Rattus norvegicus 86-97 7449837-1 1980 Water deprivation, drinking water containing 2% NaCl, or systemic injection with histamine or nicotine markedly increased plasma levels of vasopressin in rats. Water 28-33 arginine vasopressin Rattus norvegicus 139-150 6457847-6 1980 Measured in this system, the circulating levels of plasma vasopressin, in healthy adults after 18h dehydration, was 4.0 +/- 0.3 pg/ml (mean +/- SEM; n = 4) and fell to 0.6 +/- 0.1 pg/ml following a water load. Water 198-203 arginine vasopressin Rattus norvegicus 58-69 6903427-8 1980 In the rat vasopressin-induced changes in kallikrein excretion were positively correlated with changes in sodium and potassium excretion and negatively correlated with changes in free water clearance. Water 184-189 arginine vasopressin Rattus norvegicus 11-22 7218660-4 1980 Following the acute water load, plasma vasopressin levels, as measured by radioimmunoassay, was 1.08 pg/ml in the control rats, a value significantly lower than values obtained after the water load in rats deprived of glucocorticoid hormone for 1 day (2.5 +/- 0.2 pg/ml, P less than 0.01) and 14 days (2.4 +/- 0.3 pg/ml, P less than 0.01). Water 20-25 arginine vasopressin Rattus norvegicus 39-50 7386111-0 1980 Effects of intraventricular injection of Sar1-Ala8-angiotensin II on plasma vasopressin level increased by angiotensin II and by water deprivation in conscious rats. Water 129-134 arginine vasopressin Rattus norvegicus 76-87 7386111-1 1980 The effects of intraventricular injection of Sar1-Ala8-angiotensin II (A specific antagonist of angiotensin II) on the plasma vasopressin level increased by intraventricular injection of angiotensin II and by water deprivation (46 h) were examined in conscious male rats with an indwelling cannula in the third cerebral ventricle. Water 209-214 arginine vasopressin Rattus norvegicus 126-137 732944-0 1978 Evolution of vasopressin levels in the hypothalamo-posthypophysial system of the rat during rehydration following water deprivation. Water 114-119 arginine vasopressin Rattus norvegicus 13-24 456315-2 1979 Nicotinic blocking agents, hexamethonium, tetraethylammonium chloride, and trimethaphan, blocked VP release in response to the addition of sufficient NaCl to yield a 10 mosm/kg H2O increase in culture medium osmolality. Water 177-180 arginine vasopressin Rattus norvegicus 97-99 744129-8 1978 It is concluded that elevated vasopressin in plasma may be an important factor in the incomplete water diuresis in adrenal insufficiency. Water 97-102 arginine vasopressin Rattus norvegicus 30-41 7215069-5 1981 On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold. Water 69-74 arginine vasopressin Rattus norvegicus 84-95 7215069-5 1981 On the second to third day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased six-fold and the plasma vasopressin concentration was increased two and one-half-fold. Water 69-74 arginine vasopressin Rattus norvegicus 152-163 612134-0 1977 The effect of intraventricular 6-hydroxydopamine on the content of oxytocin and vasopressin in the hypothalamus and pituitary gland of water-deprived rats. Water 135-140 arginine vasopressin Rattus norvegicus 80-91 612134-1 1977 The effect of intraventricular 6-hydroxydopamine on the content of oxytocin and vasopressin in the hypothalamus and pituitary gland of water deprived rats. Water 135-140 arginine vasopressin Rattus norvegicus 80-91 1195561-1 1975 The antidiuretic action of a number of vasopressin analogues has been measured in the rat and man in water diuresis. Water 101-106 arginine vasopressin Rattus norvegicus 39-50 896887-0 1977 Vasopressin administration in the first month of life: effects of growth and water metabolism in hypothalamic diabetes insipidus rats. Water 77-82 arginine vasopressin Rattus norvegicus 0-11 896887-7 1977 Six weeks following vasopressin treatment, homozygous, diabetes insipidus rats which had received vasopressin had increased 24 hr water intakes and decreased urine osmolalities compared to control, homozygous rats, Heterozygous rats also had decreased urine osmolalities resulting from vasopressin six weeks after the cessation of vasopressin treatment. Water 130-135 arginine vasopressin Rattus norvegicus 98-109 896887-7 1977 Six weeks following vasopressin treatment, homozygous, diabetes insipidus rats which had received vasopressin had increased 24 hr water intakes and decreased urine osmolalities compared to control, homozygous rats, Heterozygous rats also had decreased urine osmolalities resulting from vasopressin six weeks after the cessation of vasopressin treatment. Water 130-135 arginine vasopressin Rattus norvegicus 98-109 896887-7 1977 Six weeks following vasopressin treatment, homozygous, diabetes insipidus rats which had received vasopressin had increased 24 hr water intakes and decreased urine osmolalities compared to control, homozygous rats, Heterozygous rats also had decreased urine osmolalities resulting from vasopressin six weeks after the cessation of vasopressin treatment. Water 130-135 arginine vasopressin Rattus norvegicus 98-109 836992-4 1977 3 The daily administration of 5 mg chlorpropamide combined with chlorothiazide in the drinking water (4 mg/1) to Pitressin-treated DI rats potentiated the response to small doses of vasopressin (25 and 50 mu Pitressin/24 hours). Water 95-100 arginine vasopressin Rattus norvegicus 182-193 187379-3 1976 Sodium and water permeability effects of vasopressin have been shown in toad bladder to have different dose response characteristics. Water 11-16 arginine vasopressin Rattus norvegicus 41-52 187379-5 1976 Maximum water transport occurs at a higher dose of vasopressin (100 mU/ml) over a concentration range associated with hormone-stimulated adenylate cyclase activity. Water 8-13 arginine vasopressin Rattus norvegicus 51-62 187379-6 1976 The water transport response to low doses of vasopressin may be potentiated by aldosterone treatment, an effect that can be related to the inhibition of tissue phosphodiesterase activity and subsequent increased cyclic AMP concentrations. Water 4-9 arginine vasopressin Rattus norvegicus 45-56 187379-7 1976 In steroid depleted conditions the cyclic AMP medicate efflux of mitochondrial calcium ions, that occurs at low doses of vasopressin, may prevent the release of membrane bound calcium ions and thus inhibit the water permeability effect of the hormone. Water 210-215 arginine vasopressin Rattus norvegicus 121-132 139628-4 1976 In this group, vasopressin lowered the TF/P Na+ ratio and raised the TF/P K+ ratio in the initial part of the distal tubules of the superficial nephrons, but raised water absorption only beyond the initial part of the distal tubules. Water 165-170 arginine vasopressin Rattus norvegicus 15-26 139628-5 1976 Vasopressin reduced the urine flow by 72% in 30-day-old rats by raising water reabsorption beyond the initial part of the distal tubules. Water 72-77 arginine vasopressin Rattus norvegicus 0-11 837423-3 1977 Light and electron microsopic examination of choroid plexuses from lateral ventricles of water-deprived and subcutaneously or intravenously vasopressin administered rats reveal morphologic changes typical for vasopressin responsive fluid transporting epithelia during hormonal stimulation. Water 89-94 arginine vasopressin Rattus norvegicus 209-220 187624-5 1977 In a control group, bolus injections of 200 muU of vasopressin caused a rise in urinary osmolality (Uosm) from 124 +/- 6 to 253 +/- 20 mosmol/kg H2O (P less than 0.005). Water 145-148 arginine vasopressin Rattus norvegicus 51-62 187624-6 1977 In a group treated with 2 mg/kg of indomethacin the same dose of vasopressin caused a significantly greater (P less than 0.001) rise in Uosm from 124 +/- 7 to 428 +/- 19 mosmol/kg H2O. Water 180-183 arginine vasopressin Rattus norvegicus 65-76 1034911-2 1976 Arginine vasopressin was infused into the V. portae and into the V. cava of unanesthetized rats in water diuresis. Water 99-104 arginine vasopressin Rattus norvegicus 9-20 808606-2 1975 Effects on vasopressin-stimulated water loss from isolated toad bladder. Water 34-39 arginine vasopressin Rattus norvegicus 11-22 808606-4 1975 These compounds were shown to inhibit both the oxytocin-induced smooth muscle contraction in the isolated rat uterus and the vasopressin-induced water loss from the isolated toad bladder. Water 145-150 arginine vasopressin Rattus norvegicus 125-136 1127864-6 1975 After administration of exogenous vasopressin, V fell to 311 plus or minus 157 mul/min/kg or 5.2 plus or minus se 3.8% of the filtered load of water and U/Posm rose from 0.658 plus or minus se 0.043 to 2.124 plus or minus 0.454. Water 143-148 arginine vasopressin Rattus norvegicus 34-45 1171984-4 1975 From 2, [3-thienylalanine]-8-lysine-vasopressin was obtained by removing the Boc-protecting groups with trifluoroacetic acid and ethylcarbamoyl (Ec) protecting groups in refluxing liquid NH3 followed by oxidative cyclization in H2O-MeOH using ICH2CH2I. Water 228-231 arginine vasopressin Rattus norvegicus 36-47 4780695-10 1973 The stimulation of hepatic glucose output by vasopressin is discussed in connexion with the release of glucose and water from the liver. Water 115-120 arginine vasopressin Rattus norvegicus 45-56 4358411-13 1972 on the serosal surface also inhibits the transport of water facilitated by vasopressin in the toad bladder. Water 54-59 arginine vasopressin Rattus norvegicus 75-86 5016043-13 1972 The evidence is discussed that the action of vasopressin involves factors apart from increasing the permeability of the distal nephron to water and urea. Water 138-143 arginine vasopressin Rattus norvegicus 45-56 4262062-0 1971 [Short term effects of arginine-vasopressin on water consumption in the rat]. Water 47-52 arginine vasopressin Rattus norvegicus 32-43 5092545-0 1971 The effects of substituting solutions of urea, glucose and potassium chloride for drinking water on the neurohypophysial vasopressin content of rats. Water 91-96 arginine vasopressin Rattus norvegicus 121-132 5468280-0 1970 Vasopressin content and neurosecretory material in the hypothalamo-neurohypophyseal system of rats under different states of water metabolism. Water 125-130 arginine vasopressin Rattus norvegicus 0-11 5814896-0 1969 [Vasopressin-water equivalent under different starting conditions in the conscious rat]. Water 13-18 arginine vasopressin Rattus norvegicus 1-12 5657333-3 1968 During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. Water 30-35 arginine vasopressin Rattus norvegicus 7-18 5657333-4 1968 In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance. Water 55-60 arginine vasopressin Rattus norvegicus 30-41 4174334-0 1968 The effect of vasopressin on the urinary electrolytes in water-loaded rats. Water 57-62 arginine vasopressin Rattus norvegicus 14-25 5242868-2 1968 The vasopressin-water-equivalent and vasopressin clearance by the kidney. Water 16-21 arginine vasopressin Rattus norvegicus 4-15 6058314-0 1967 Intravenous infusion of vasopressin to increase the sensitivity of its assay in the water-ethanol loaded rat. Water 84-89 arginine vasopressin Rattus norvegicus 24-35 6049001-0 1967 Transient saluresis due to lysine-vasopressin administration in the conscious water diuretic rat. Water 78-83 arginine vasopressin Rattus norvegicus 34-45 5234143-3 1966 injection of vasopressin: the vasopressin water equivalent. Water 42-47 arginine vasopressin Rattus norvegicus 13-24 1143633-3 1975 Before 2% NaCl was substituted for the drinking water, vasopressin treatment significantly decreased food and water intake (p smaller than 0.05) and daily weight gain (p smaller than 0.01), but no significant effect on plasma osmolality or on neurohypophysial content of vasopressin and oxytocin could be demonstrated. Water 48-53 arginine vasopressin Rattus norvegicus 55-66 1143633-3 1975 Before 2% NaCl was substituted for the drinking water, vasopressin treatment significantly decreased food and water intake (p smaller than 0.05) and daily weight gain (p smaller than 0.01), but no significant effect on plasma osmolality or on neurohypophysial content of vasopressin and oxytocin could be demonstrated. Water 110-115 arginine vasopressin Rattus norvegicus 55-66 5234143-3 1966 injection of vasopressin: the vasopressin water equivalent. Water 42-47 arginine vasopressin Rattus norvegicus 30-41 13657188-0 1959 [Effect of adrenal cortex hormones on the vasopressin action in water diuresis in intact rats]. Water 64-69 arginine vasopressin Rattus norvegicus 42-53 5861834-0 1965 The effect of vasopressin on water distribution in the rat kidney. Water 29-34 arginine vasopressin Rattus norvegicus 14-25 13561335-0 1958 [Effect of vasopressin on the elimination of water load, sodium and potassium in weanling rats]. Water 45-50 arginine vasopressin Rattus norvegicus 11-22 13424324-0 1957 Effect of purified vasopressin and oxytocin on water and sodium excretion in hypophysectomized rats. Water 47-52 arginine vasopressin Rattus norvegicus 19-30 13424317-0 1956 Effect of vasopressin and oxytocin on the excretion of water and electrolytes (Na, C1 and K) in the albino rat. Water 55-60 arginine vasopressin Rattus norvegicus 10-21 13348671-0 1956 [Effects of vasopressin on the renal water and salt excretion in rats in changing the salt concentration of drinking water and resection of kidney parenchyma]. Water 37-42 arginine vasopressin Rattus norvegicus 12-23 13348671-0 1956 [Effects of vasopressin on the renal water and salt excretion in rats in changing the salt concentration of drinking water and resection of kidney parenchyma]. Water 117-122 arginine vasopressin Rattus norvegicus 12-23 33633156-1 2021 Vasopressin (AVP) increases water permeability in the renal collecting duct through the regulation of aquaporin-2 (AQP2) trafficking. Water 28-33 arginine vasopressin Rattus norvegicus 0-11 33666805-4 2021 In vivarium rats, urine osmolality (1010 +- 137 mOsm/kg H2O) and the concentration of vasopressin are high, this causes an increase in the reabsorption of solute-free water. Water 167-172 arginine vasopressin Rattus norvegicus 86-97 33666805-5 2021 Thus, oxytocin increases saluresis, which, against the background of a high level of endogenous vasopressin, increases the water reabsorption in the collecting ducts. Water 123-128 arginine vasopressin Rattus norvegicus 96-107 13865067-0 1962 Effect of vasopressin structural modifications on rat renal excretion of Na, K, and water. Water 84-89 arginine vasopressin Rattus norvegicus 10-21 33633156-11 2021 Together, these findings suggest that OLE antagonizes vasopressin action through stimulation of the CaSR indicating that this extract may be beneficial to attenuate disorders characterized by abnormal CaSR signaling and affecting renal water reabsorption. Water 236-241 arginine vasopressin Rattus norvegicus 54-65 33532897-4 2021 The results showed that BAO and BC time-dependently increased neurological scores and that BC also increased water contents in the medulla at 2 h and in the pontine at 8 h. Moreover, plasma VP level increased significantly at BAO-8 h, CCAO and BC-2 h but not at BC-8 h; however, VP expressions increased in the supraoptic nucleus (SON) at BC-8 h. The neurological scores were highly correlated with pontine water contents and plasma VP levels. Water 109-114 arginine vasopressin Rattus norvegicus 190-192 33532897-4 2021 The results showed that BAO and BC time-dependently increased neurological scores and that BC also increased water contents in the medulla at 2 h and in the pontine at 8 h. Moreover, plasma VP level increased significantly at BAO-8 h, CCAO and BC-2 h but not at BC-8 h; however, VP expressions increased in the supraoptic nucleus (SON) at BC-8 h. The neurological scores were highly correlated with pontine water contents and plasma VP levels. Water 407-412 arginine vasopressin Rattus norvegicus 190-192 32812807-1 2020 BACKGROUND: The most profound effect of vasopressin on the kidney is to increase water reabsorption through V2-receptor (V2R) stimulation, but there are also data suggesting effects on calcium transport. Water 81-86 arginine vasopressin Rattus norvegicus 40-51 32390535-1 2020 Background Arginine vasopressin dependent antidiuresis plays a key role in water-sodium retention in heart failure. Water 75-80 arginine vasopressin Rattus norvegicus 20-31 32560242-2 2020 Aquaporin-2 (AQP2), a vasopressin-regulated water channel protein, is known to be selectively excreted into the urine through exosomes (UE-AQP2), and its renal expression is decreased in nephrotic syndrome. Water 44-49 arginine vasopressin Rattus norvegicus 22-33 32295252-0 2020 Aldosterone Decreases Vasopressin-Stimulated Water Reabsorption in Rat Inner Medullary Collecting Ducts. Water 45-50 arginine vasopressin Rattus norvegicus 22-33 32209611-1 2020 Magnocellular neurosecretory cells are intrinsically osmosensitive and can be activated by increases in blood osmolality, triggering the release of antidiuretic hormone vasopressin (VP) to promote water retention. Water 197-202 arginine vasopressin Rattus norvegicus 169-180 32209611-1 2020 Magnocellular neurosecretory cells are intrinsically osmosensitive and can be activated by increases in blood osmolality, triggering the release of antidiuretic hormone vasopressin (VP) to promote water retention. Water 197-202 arginine vasopressin Rattus norvegicus 182-184 32295252-2 2020 However, the direct effect of aldosterone on vasopressin-regulated water and urea permeability in the rat inner medullary collecting duct (IMCD) has not been tested. Water 67-72 arginine vasopressin Rattus norvegicus 45-56 32295252-15 2020 This study is the first to show a direct effect of aldosterone to inhibit vasopressin-stimulated osmotic water permeability and urea permeability in perfused rat IMCDs. Water 105-110 arginine vasopressin Rattus norvegicus 74-85 31994353-8 2020 Urine vasopressin in ipragliflozin-treated rats was negatively and positively associated with fluid balance and TcH2O, respectively. Water 112-117 arginine vasopressin Rattus norvegicus 6-17 32477601-4 2020 In the kidneys of non-anesthetized rats, which received a water load of 2 ml per 100 g of body weight, three effects of vasopressin were revealed: 1) increased reabsorption of water and sodium, 2) increased excretion of potassium ions, and 3) increased excretion of sodium ions. Water 58-63 arginine vasopressin Rattus norvegicus 120-131 32477601-4 2020 In the kidneys of non-anesthetized rats, which received a water load of 2 ml per 100 g of body weight, three effects of vasopressin were revealed: 1) increased reabsorption of water and sodium, 2) increased excretion of potassium ions, and 3) increased excretion of sodium ions. Water 176-181 arginine vasopressin Rattus norvegicus 120-131 31994353-11 2020 In conclusion, the SGLT2 inhibitor ipragliflozin induced a sustained glucosuria, diuresis, and natriuresis, with compensatory increases in fluid intake and vasopressin-induced TcH2O in proportion to the reduced fluid balance to maintain BFV. Water 176-181 arginine vasopressin Rattus norvegicus 156-167 29932826-3 2018 We recently reported that the inner medullary collecting duct (IMCD), which functions in the regulation of water-reabsorption, via the actions of vasopressin, expresses many of the enzymes that can modulated K-acetylation. Water 107-112 arginine vasopressin Rattus norvegicus 146-157 30870430-2 2019 We previously reported that high water intake (HWI) reduced urine osmolality and urinary arginine vasopressin, improved renal function, and reduced the kidney/body weight ratio in PCK rats, an orthologous model of human PKD. Water 33-38 arginine vasopressin Rattus norvegicus 98-109 30788735-0 2019 Correlation between Urinary Excretion of Arginine-Vasopressin and Renal Reabsorption of Sodium and Water. Water 99-104 arginine vasopressin Rattus norvegicus 50-61 30788735-2 2019 In experiments on unanesthetized rats, water load (5 ml/100 g body weight) almost completely blocked secretion of arginine-vasopressin. Water 39-44 arginine vasopressin Rattus norvegicus 123-134 30788735-3 2019 Injection of arginine-vasopressin in a dose of 0.1 nmol/100 g body weight after water load enhanced reabsorption of solute-free water and renal excretion of Na+, K+, and Mg2+ by 13.3, 5.5, and 5.0 times, respectively; urinary excretion of Ca2+ remained unchanged. Water 80-85 arginine vasopressin Rattus norvegicus 22-33 30788735-3 2019 Injection of arginine-vasopressin in a dose of 0.1 nmol/100 g body weight after water load enhanced reabsorption of solute-free water and renal excretion of Na+, K+, and Mg2+ by 13.3, 5.5, and 5.0 times, respectively; urinary excretion of Ca2+ remained unchanged. Water 128-133 arginine vasopressin Rattus norvegicus 22-33 30788735-4 2019 It was found that urinary excretion of arginine-vasopressin directly correlated with reabsorption of solute-free water and renal sodium excretion. Water 113-118 arginine vasopressin Rattus norvegicus 48-59 31447686-1 2019 Arginine vasopressin (AVP) mediates water reabsorption in the kidney collecting ducts through regulation of aquaporin-2 (AQP2). Water 36-41 arginine vasopressin Rattus norvegicus 9-20 29932826-8 2018 The acetylated proteins were expressed in all compartments of the cell and were enriched in pathways including glycolysis and vasopressin-regulated water reabsorption. Water 148-153 arginine vasopressin Rattus norvegicus 126-137 29932826-9 2018 In the vasopressin-regulated water reabsorption pathway, eight proteins were acetylated, including the novel identification of the basolateral water channel, AQP3, acetylated at K282; 215 proteins were phosphorylated in this IMCD cohort, including AQP2 peptides that were phosphorylated at four serines: 256, 261, 264, and 269. Water 29-34 arginine vasopressin Rattus norvegicus 7-18 29932826-9 2018 In the vasopressin-regulated water reabsorption pathway, eight proteins were acetylated, including the novel identification of the basolateral water channel, AQP3, acetylated at K282; 215 proteins were phosphorylated in this IMCD cohort, including AQP2 peptides that were phosphorylated at four serines: 256, 261, 264, and 269. Water 143-148 arginine vasopressin Rattus norvegicus 7-18 30166555-1 2018 The neurohormones arginine-vasopressin (AVP) and oxytocin (OT) synthesised in supraoptic and paraventricular nuclei of neurohypophysis regulate lactation, systemic water homeostasis and nociception. Water 164-169 arginine vasopressin Rattus norvegicus 27-38 27593225-1 2016 Vasopressin (AVP) regulates the body salt-water balance. Water 42-47 arginine vasopressin Rattus norvegicus 0-11 29863081-5 2018 Interestingly, administration of YKS-containing water rescued attenuation of vasopressin-induced increase in serum corticosterone. Water 48-53 arginine vasopressin Rattus norvegicus 77-88 28843412-1 2018 In the syndrome of inappropriate antidiuretic hormone secretion (SIADH), hyponatremia is limited by onset of vasopressin-escape caused by loss of the water channel aquaporin-2 in the renal collecting duct despite high circulating vasopressin. Water 150-155 arginine vasopressin Rattus norvegicus 109-120 28843412-3 2018 Using single-tubule RNA-Seq, full transcriptomes were determined in microdissected cortical collecting ducts of vasopressin-treated rats at 1, 2, and 4 days after initiation of oral water loading in comparison to time-control rats without water loading. Water 239-244 arginine vasopressin Rattus norvegicus 112-123 29224666-2 2017 Studies in rats and mice have shown that vasopressin produced by magnocellular neurosecretory cells (MNCs) that project to the neurohypophysis is released into the blood circulation where it serves as an antidiuretic hormone to promote water reabsorption from the kidney. Water 236-241 arginine vasopressin Rattus norvegicus 41-52 29224666-4 2017 In this chapter, we review recent cellular and network level studies in rodents that have provided insight into how circadian rhythms in vasopressin mediate changes in water intake behavior and renal water conservation that protect the body against dehydration during sleep. Water 168-173 arginine vasopressin Rattus norvegicus 137-148 29224666-4 2017 In this chapter, we review recent cellular and network level studies in rodents that have provided insight into how circadian rhythms in vasopressin mediate changes in water intake behavior and renal water conservation that protect the body against dehydration during sleep. Water 200-205 arginine vasopressin Rattus norvegicus 137-148 28924378-8 2017 On the other hand, there are also other operative mechanisms when water is used as rehydration fluid that produce milder renal damage that is not fully corrected by vasopressin blockade. Water 66-71 arginine vasopressin Rattus norvegicus 165-176 28298358-1 2017 The gene encoding the aquaporin-2 water channel is regulated transcriptionally in response to vasopressin. Water 34-39 arginine vasopressin Rattus norvegicus 94-105 28336818-5 2017 When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. Water 21-26 arginine vasopressin Rattus norvegicus 158-169 27593225-1 2016 Vasopressin (AVP) regulates the body salt-water balance. Water 42-47 arginine vasopressin Rattus norvegicus 13-16 27568834-0 2016 Imidafenacin exerts the antidiuretic effect by enhancing vasopressin-related responses in orally water-loaded rats. Water 97-102 arginine vasopressin Rattus norvegicus 57-68 27568834-2 2016 The cholinergic and vasopressin systems are known to interact, for example, in the suppression of vasopressin-induced water reabsorption through muscarinic stimulation in the renal collecting duct. Water 118-123 arginine vasopressin Rattus norvegicus 20-31 27568834-2 2016 The cholinergic and vasopressin systems are known to interact, for example, in the suppression of vasopressin-induced water reabsorption through muscarinic stimulation in the renal collecting duct. Water 118-123 arginine vasopressin Rattus norvegicus 98-109 27306979-1 2016 The antidiuretic hormone vasopressin (AVP) regulates renal salt and water reabsorption along the distal nephron and collecting duct system. Water 68-73 arginine vasopressin Rattus norvegicus 25-36 26388582-4 2015 The possibility of renal secretion of hyaluronidase into the blood as a mechanism of antidiuretic activity of vasopressin and its role in the regulation of water metabolism are discussed. Water 156-161 arginine vasopressin Rattus norvegicus 110-121 26503226-1 2015 BACKGROUND: Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus. Water 99-104 arginine vasopressin Rattus norvegicus 12-32 26503226-1 2015 BACKGROUND: Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus. Water 99-104 arginine vasopressin Rattus norvegicus 34-37 26503226-1 2015 BACKGROUND: Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus. Water 132-137 arginine vasopressin Rattus norvegicus 12-32 26503226-1 2015 BACKGROUND: Arginine vasopressin (AVP), a neuropeptide hormone that functions in the regulation of water homeostasis by controlling water re-absorption at kidneys, is synthesised in supraoptic nucleus and paraventricular nucleus of the hypothalamus. Water 132-137 arginine vasopressin Rattus norvegicus 34-37 27053647-5 2016 Recurrent heat-induced dehydration with ad libitum water repletion resulted in plasma and urinary hyperosmolarity with stimulation of the vasopressin (copeptin) levels and resulted in mild tubular injury and renal oxidative stress. Water 51-56 arginine vasopressin Rattus norvegicus 138-149 26791475-1 2016 The present study aimed to investigate the potential physiological role of vasopressin and the incretin hormone of the gastrointestinal tract (glucagon-like peptide-1; GLP-1) in the regulation of the water-salt balance in a hyperosmolar state as a result of sodium loadings. Water 200-205 arginine vasopressin Rattus norvegicus 75-86 25855780-2 2015 Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we hypothesized that if expressed in the CD, P2Y12-R may play a role in renal handling of water in health and in nephrogenic diabetes insipidus. Water 74-79 arginine vasopressin Rattus norvegicus 48-59 26101342-8 2015 The plasma vasopressin response to a 6-hour water restriction also increased. Water 44-49 arginine vasopressin Rattus norvegicus 11-22 24759153-3 2014 In clinical practice, inadvertent rapid correction frequently occurs due to water diuresis, when vasopressin action suddenly ceases. Water 76-81 arginine vasopressin Rattus norvegicus 97-108 25278460-1 2015 Beside its hormonal function in salt and water homeostasis, vasopressin released into distinct brain areas plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state. Water 41-46 arginine vasopressin Rattus norvegicus 60-71 25157454-0 2014 Apelin counteracts vasopressin-induced water reabsorption via cross talk between apelin and vasopressin receptor signaling pathways in the rat collecting duct. Water 39-44 arginine vasopressin Rattus norvegicus 19-30 25063824-2 2014 This response is beneficial because this type of activity potentiates vasopressin secretion from axon terminals in the neurohypophysis and thus promotes homoeostatic water reabsorption from the kidney. Water 166-171 arginine vasopressin Rattus norvegicus 70-81 25043186-1 2014 Homeostatic control of extracellular fluid osmolality in rats requires a parallel excitation of vasopressin (VP) and oxytocin (OT) neurosecretory neurons by osmoreceptor afferents to regulate the amount of water and sodium in the urine under normal conditions. Water 206-211 arginine vasopressin Rattus norvegicus 96-107 25043186-1 2014 Homeostatic control of extracellular fluid osmolality in rats requires a parallel excitation of vasopressin (VP) and oxytocin (OT) neurosecretory neurons by osmoreceptor afferents to regulate the amount of water and sodium in the urine under normal conditions. Water 206-211 arginine vasopressin Rattus norvegicus 109-111 24770738-2 2014 Intracellular reorganization of transepithelial barrier for osmotic water transport depended on the capacity of rats to the synthesis of endogenous vasopressin. Water 68-73 arginine vasopressin Rattus norvegicus 148-159 24598363-2 2014 Short-term regulation of water transport is dependent on vasopressin-induced phosphorylation of aquaporin-2 (AQP2) at Ser256. Water 25-30 arginine vasopressin Rattus norvegicus 57-68 23532834-3 2013 The subject of this study was a search for vasopressin and vasotocin analogues with selective effects on renal water, sodium and potassium excretion. Water 111-116 arginine vasopressin Rattus norvegicus 43-54 24305472-9 2014 We also provide ancillary in vitro data in rat inner-medullary-collecting-duct suspensions showing that tolvaptan can block vasopressin"s effects on phosphorylation of the water channel AQP2 in vitro. Water 172-177 arginine vasopressin Rattus norvegicus 124-135 23955305-2 2013 Using real-time RT-PCR, we tested the assumption that renal HA may be involved in the long-term effect of vasopressin on water reabsorption. Water 121-126 arginine vasopressin Rattus norvegicus 106-117 23955305-9 2013 It is suggested that vasopressin is able to inhibit the synthesis of HA and concomitantly promote its degradation in the interstitium of the renal papilla, thereby facilitating water flow between elements of the renal countercurrent system. Water 177-182 arginine vasopressin Rattus norvegicus 21-32 23852264-1 2013 Arginine-vasopressin (AVP) facilitates water reabsorption by renal collecting duct principal cells and thereby fine-tunes body water homeostasis. Water 39-44 arginine vasopressin Rattus norvegicus 0-20 23852264-1 2013 Arginine-vasopressin (AVP) facilitates water reabsorption by renal collecting duct principal cells and thereby fine-tunes body water homeostasis. Water 39-44 arginine vasopressin Rattus norvegicus 22-25 23852264-1 2013 Arginine-vasopressin (AVP) facilitates water reabsorption by renal collecting duct principal cells and thereby fine-tunes body water homeostasis. Water 127-132 arginine vasopressin Rattus norvegicus 0-20 23852264-1 2013 Arginine-vasopressin (AVP) facilitates water reabsorption by renal collecting duct principal cells and thereby fine-tunes body water homeostasis. Water 127-132 arginine vasopressin Rattus norvegicus 22-25 23852264-7 2013 The cells are suitable for elucidating molecular mechanisms underlying the control of AQP2 and thus to discover novel drug targets for the treatment of diseases associated with dysregulation of AVP-mediated water reabsorption. Water 207-212 arginine vasopressin Rattus norvegicus 194-197 22984091-1 2012 BACKGROUND: Arginine vasopressin, which promotes the reabsorption of renal water is increased in chronic heart failure. Water 75-80 arginine vasopressin Rattus norvegicus 21-32 23188468-2 2013 While experimental data show vasopressin V(1A) receptors to regulate aquaporin (AQP)4 water channel dependent brain water movement, the specific role in vasogenic and cytotoxic edema formation remains unclear. Water 86-91 arginine vasopressin Rattus norvegicus 29-40 23188468-2 2013 While experimental data show vasopressin V(1A) receptors to regulate aquaporin (AQP)4 water channel dependent brain water movement, the specific role in vasogenic and cytotoxic edema formation remains unclear. Water 116-121 arginine vasopressin Rattus norvegicus 29-40 22700868-4 2012 Vasopressin enhanced the rate of lung edema clearance by 30% as compared with untreated control rats (from 0.49 +- 0.02 to 0.64 +- 0.02 ml/h), whereas V(2) receptor antagonists significantly decreased the ability of the lung to clear water (from 0.64 +- 0.02 to 0.31 +- 0.06 ml/h; P < 0.0001). Water 234-239 arginine vasopressin Rattus norvegicus 0-11 22645945-6 2012 After vasopressin injection solute-free water reabsorption was 1.5-fold higher in rats fed diet II. Water 40-45 arginine vasopressin Rattus norvegicus 6-17 23401969-1 2012 The investigation deals with effect of analogues of conopressin S--a peptide of the vasopressin family with amino acid replacement in the 2nd and 4th positions (characteristic of invertebrate peptides)--on transport of water and ions in the rat kidney. Water 219-224 arginine vasopressin Rattus norvegicus 84-95 23078817-1 2012 This review describes the discovery of rat aquaporin 2 AQP2 as a vasopressin-regulated water channel, and subsequent isolation of human AQP2. Water 87-92 arginine vasopressin Rattus norvegicus 65-76 22060896-0 2012 Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation. Water 123-128 arginine vasopressin Rattus norvegicus 95-106 21907406-9 2011 It may be presumed that the orexins can play a physiological role in the regulation of the water metabolism by reducing the effect of increased vasopressin release caused by monoaminergic compounds. Water 91-96 arginine vasopressin Rattus norvegicus 144-155 23171819-1 2012 BACKGROUND: In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane. Water 64-69 arginine vasopressin Rattus norvegicus 42-53 23171819-1 2012 BACKGROUND: In the renal collecting duct, vasopressin regulates water permeability by a process that involves stimulation of adenylyl cyclase activity, cAMP production and subsequent translocation of water channel aquaporin-2 (AQP2) into the apical plasma membrane. Water 200-205 arginine vasopressin Rattus norvegicus 42-53 22330181-1 2012 The antidiuretic hormone vasopressin (VP) promotes water reabsorption from the kidney and levels of circulating VP are normally related linearly to plasma osmolality, aiming to maintain the latter close to a predetermined set point. Water 51-56 arginine vasopressin Rattus norvegicus 25-36 22330181-1 2012 The antidiuretic hormone vasopressin (VP) promotes water reabsorption from the kidney and levels of circulating VP are normally related linearly to plasma osmolality, aiming to maintain the latter close to a predetermined set point. Water 51-56 arginine vasopressin Rattus norvegicus 38-40