PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35066031-0 2022 Ecological and AhR-mediated risk assessment of polycyclic aromatic hydrocarbons and polybrominated diphenyl ethers on multiple aquatic species in river water: A combined chemical analysis and in silico approach. Water 152-157 aryl hydrocarbon receptor Homo sapiens 15-18 8437114-3 1993 AHR-16329, a representative sulfamate, has an acidic (sulfonamide, pKa 8.9) and basic (imidazole, pKa 6.0) group and has desirable physicochemical properties for topical intraocular pressure lowering: good water solubility below pH 6.0, a CHCl3/buffer ratio of 0.5 at pH 7.0 and a Kl against CA-II of 7 nM. Water 206-211 aryl hydrocarbon receptor Homo sapiens 0-3 35066031-2 2022 In this manuscript, the ecological and AhR-mediated risk of sixteen polycyclic aromatic hydrocarbons (PAHs) and six polybrominated diphenyl ethers (PBDEs) in surface water of Dongjiang River, Southern China was evaluated using chemical analysis and in silico approaches. Water 166-171 aryl hydrocarbon receptor Homo sapiens 39-42 35066031-8 2022 This study is the first attempt to assess AhR-mediated risk of river water in multiple aquatic organisms. Water 69-74 aryl hydrocarbon receptor Homo sapiens 42-45 30849732-3 2019 In this study, a bioanalytical approach was used, measuring oxidative stress (Nrf2 activity), genotoxicity (micronucleus test), and aryl hydrocarbon receptor (AhR) activation to evaluate an innovative water treatment process, including suspended ion exchange, ozonation, in-line coagulation, ceramic microfiltration, and granular activated carbon. Water 201-206 aryl hydrocarbon receptor Homo sapiens 132-157 33338789-5 2021 Inlet water from the river exhibited AhR and AR antagonistic activities. Water 6-11 aryl hydrocarbon receptor Homo sapiens 37-40 32018941-10 2020 Our results demonstrate that AR and AhR activities are commonly found in Iowa drinking water, and that their detection varies by season and utility/sample characteristics. Water 87-92 aryl hydrocarbon receptor Homo sapiens 36-39 31543430-6 2019 RESULTS: In the present study, we found that H2O2-induced oxidative stress directly activated the AHR signaling pathway in melanocytes, whereas abnormal activation of AHR signaling pathway enhanced oxidative damage to mitochondria and melanocytes. Water 45-49 aryl hydrocarbon receptor Homo sapiens 98-101 32120108-6 2020 The aim of this study was to identify the toxic effects that the pollutants present in the water of the Madin Dam can generate on a human cell line (SH SY5Y) evaluating the cell viability and the participation of the Aril Hydrocarbon Receptor (AhR) and Pregnane X receptor (PXR) through of the expression of the CYP1A1 and CYP3A4 (canonical genes). Water 91-96 aryl hydrocarbon receptor Homo sapiens 244-247 30849732-12 2019 AhR activity was observed in the water produced by the conventional process and in the raw water, but the activity was clearly decreased by the ozonation step in the innovative water treatment process. Water 33-38 aryl hydrocarbon receptor Homo sapiens 0-3 30849732-12 2019 AhR activity was observed in the water produced by the conventional process and in the raw water, but the activity was clearly decreased by the ozonation step in the innovative water treatment process. Water 91-96 aryl hydrocarbon receptor Homo sapiens 0-3 30849732-12 2019 AhR activity was observed in the water produced by the conventional process and in the raw water, but the activity was clearly decreased by the ozonation step in the innovative water treatment process. Water 91-96 aryl hydrocarbon receptor Homo sapiens 0-3 30849732-3 2019 In this study, a bioanalytical approach was used, measuring oxidative stress (Nrf2 activity), genotoxicity (micronucleus test), and aryl hydrocarbon receptor (AhR) activation to evaluate an innovative water treatment process, including suspended ion exchange, ozonation, in-line coagulation, ceramic microfiltration, and granular activated carbon. Water 201-206 aryl hydrocarbon receptor Homo sapiens 159-162 27176940-8 2016 As effect-based sediment-water distribution ratios demonstrated, most of the bioactivity in the AhR-CAFLUX was attributable to hydrophobic chemicals while more hydrophilic chemicals activated AREc32, even though bioanalytical equivalents in the aqueous phase remained negligible. Water 25-30 aryl hydrocarbon receptor Homo sapiens 96-99 29486360-7 2018 The results indicate that the presence of NOM in water samples may lead to false positive results for AhR activity and false positive results for AR and Nrf2 activity, when assessing inhibition of induced bioactivities from anthropogenic substances. Water 49-54 aryl hydrocarbon receptor Homo sapiens 102-105 30464315-6 2018 Most water samples induced AhR activity, and all sampling sites showed a similar profile regarding this activity. Water 5-10 aryl hydrocarbon receptor Homo sapiens 27-30 24518984-9 2014 The results also implicate that intestinal AhR might act not only as a sensor for xenobiotics in diet and water but also for commensal bacterial activity because DHNA is a precursor of vitamin K2 produced by vitamin K2-synthesizing commensal bacteria as well as propionic bacteria. Water 106-111 aryl hydrocarbon receptor Homo sapiens 43-46 26988683-1 2016 OBJECTIVE: To investigate the relationship between blood aryl hydrocarbon receptor(AhR)mRNA and cytochrome P450(CYP)1A1 mRNA expression and corrected QT interval among residents exposed to arsenic via drinking water. Water 210-215 aryl hydrocarbon receptor Homo sapiens 57-82 26988683-1 2016 OBJECTIVE: To investigate the relationship between blood aryl hydrocarbon receptor(AhR)mRNA and cytochrome P450(CYP)1A1 mRNA expression and corrected QT interval among residents exposed to arsenic via drinking water. Water 210-215 aryl hydrocarbon receptor Homo sapiens 83-86 27131017-9 2016 The results suggested that both water and organic soluble fractions of dust caused cytotoxicity, oxidative damage, inflammatory response, and activation of AhR inducible genes, with organic extracts having higher potential to induce adverse effects on primary HCE cells. Water 32-37 aryl hydrocarbon receptor Homo sapiens 156-159 18853806-12 2008 These results indicate that the water samples contain substances that bind to AhR, and these substances contribute to ER signaling through AhR activation in the yeast reporter strain. Water 32-37 aryl hydrocarbon receptor Homo sapiens 78-81 23614742-3 2013 Tobacco smoke contains more than 3800 constituents, including numerous water-insoluble polycyclic aromatic hydrocarbons (PAHs) that trigger aryl hydrocarbon receptor (AhR) signalling pathways. Water 71-76 aryl hydrocarbon receptor Homo sapiens 167-170 24150760-0 2013 ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity. Water 90-93 aryl hydrocarbon receptor Homo sapiens 33-58 18853806-12 2008 These results indicate that the water samples contain substances that bind to AhR, and these substances contribute to ER signaling through AhR activation in the yeast reporter strain. Water 32-37 aryl hydrocarbon receptor Homo sapiens 139-142 18203687-6 2008 AhR agonist activity was observed for dimethyl sulfoxide (DMSO), ethanol, and water extracts of printed newspaper, unprinted virgin paper, and black printing ink, where activation of luciferase reporter gene expression was transient, suggesting that the AhR active chemical(s) was metabolically labile. Water 78-83 aryl hydrocarbon receptor Homo sapiens 0-3 16126234-0 2005 The stable aryl hydrocarbon receptor agonist potency of United Kingdom Continental Shelf (UKCS) offshore produced water effluents. Water 114-119 aryl hydrocarbon receptor Homo sapiens 11-36 16126234-1 2005 The in vitro aryl hydrocarbon receptor (AhR) agonist potency of offshore produced water effluents, collected from the United Kingdom Continental Shelf, was determined using the dioxin responsive (DR)-chemically activated luciferase expression (CALUX) assay. Water 82-87 aryl hydrocarbon receptor Homo sapiens 13-38 16126234-1 2005 The in vitro aryl hydrocarbon receptor (AhR) agonist potency of offshore produced water effluents, collected from the United Kingdom Continental Shelf, was determined using the dioxin responsive (DR)-chemically activated luciferase expression (CALUX) assay. Water 82-87 aryl hydrocarbon receptor Homo sapiens 40-43