PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12771381-4 2003 SC water content, measured by skin conductance and 3H2O accumulation, was 3-fold lower in AQP3 null vs. wild-type mice, but became similar after topical or systemic administration of glycerol in quantities that normalized SC glycerol content. Water 3-8 aquaporin 3 Mus musculus 90-94 12493699-2 2003 Aquaporin-3 is known as a water/solute channel that can transport water and neutral solutes such as glycerol. Water 26-31 aquaporin 3 Mus musculus 0-11 12493699-2 2003 Aquaporin-3 is known as a water/solute channel that can transport water and neutral solutes such as glycerol. Water 66-71 aquaporin 3 Mus musculus 0-11 12493699-3 2003 In this study we examined whether artificial expression of aquaporin-3 in mouse oocytes can improve water and glycerol permeability and oocyte survival after cryopreservation. Water 100-105 aquaporin 3 Mus musculus 59-70 11880378-2 2002 The water/small solute-transporting protein aquaporin-3 (AQP3) was found by immunofluorescence and immunogold electron microscopy to be expressed at the plasma membrane of epidermal keratinocytes in mouse skin. Water 4-9 aquaporin 3 Mus musculus 44-55 12270942-1 2002 Deletion of the epidermal water/glycerol transporter aquaporin-3 (AQP3) in mice reduced superficial skin conductance by approximately 2-fold (Ma, T., Hara, M., Sougrat, R., Verbavatz, J. M., and Verkman, A. S. (2002) J. Biol. Water 26-31 aquaporin 3 Mus musculus 53-64 12270942-1 2002 Deletion of the epidermal water/glycerol transporter aquaporin-3 (AQP3) in mice reduced superficial skin conductance by approximately 2-fold (Ma, T., Hara, M., Sougrat, R., Verbavatz, J. M., and Verkman, A. S. (2002) J. Biol. Water 26-31 aquaporin 3 Mus musculus 66-70 12270942-5 2002 Utilizing a novel (3)H(2)O distribution method, SC water content was reduced by approximately 50% in AQP3 null mice. Water 51-56 aquaporin 3 Mus musculus 101-105 12270942-7 2002 Although basal skin barrier function was not impaired, AQP3 deletion produced an approximately 2-fold delay in recovery of barrier function as measured by transepidermal water loss after tape stripping. Water 170-175 aquaporin 3 Mus musculus 55-59 12433939-7 2002 In the airways, AQP3 and AQP4 facilitate water transport; however, airway hydration, regulation of the airway surface liquid layer, and isosmolar fluid absorption are not impaired by AQP deletion. Water 41-46 aquaporin 3 Mus musculus 16-20 11880378-2 2002 The water/small solute-transporting protein aquaporin-3 (AQP3) was found by immunofluorescence and immunogold electron microscopy to be expressed at the plasma membrane of epidermal keratinocytes in mouse skin. Water 4-9 aquaporin 3 Mus musculus 57-61 11880378-5 2002 AQP3 deletion resulted in a > 4-fold reduced osmotic water permeability and > 2-fold reduced glycerol permeability in epidermis. Water 56-61 aquaporin 3 Mus musculus 0-4 11880378-7 2002 Surface conductance measurements showed remarkably reduced SC water content in AQP3 null mice in the hairless genetic background (165 +/- 10 versus 269 +/- 12 microsiemens (microS), p < 0.001), as well as in a CD1 genetic background (209 +/- 21 versus 469 +/- 11 microS). Water 62-67 aquaporin 3 Mus musculus 79-83 11880378-10 2002 Conductance measurements after serial tape stripping suggested reduced water content throughout the SC in AQP3 null mice. Water 71-76 aquaporin 3 Mus musculus 106-110 11880378-11 2002 Water sorption-desorption experiments indicated reduced water holding capacity in the SC of AQP3 null mice. Water 0-5 aquaporin 3 Mus musculus 92-96 11880378-11 2002 Water sorption-desorption experiments indicated reduced water holding capacity in the SC of AQP3 null mice. Water 56-61 aquaporin 3 Mus musculus 92-96 34205315-7 2021 The mRNA and protein expression levels of cutaneous aquaporin-3 (AQP3), which is involved in wound healing and increases in dermal water content, were significantly increased by treatment with Kumazasa extract. Water 131-136 aquaporin 3 Mus musculus 65-69 12097826-6 2002 Mice lacking AQP3 are markedly polyuric due to low water permeability across the cortical and outer medullary collecting duct. Water 51-56 aquaporin 3 Mus musculus 13-17 11382807-7 2001 Osmotic water permeability in upper airways, measured by an in vivo instillation/sample method, was reduced by approximately 40% by AQP3/AQP4 deletion. Water 8-13 aquaporin 3 Mus musculus 132-136 10737773-1 2000 Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of kidney collecting-duct epithelial cells. Water 24-29 aquaporin 3 Mus musculus 0-11 10737773-1 2000 Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of kidney collecting-duct epithelial cells. Water 24-29 aquaporin 3 Mus musculus 13-17 10737773-7 2000 After 1-desamino-8-d-arginine-vasopressin administration or water deprivation, the AQP3 null mice were able to concentrate their urine partially to approximately 30% of that in wild-type mice. Water 60-65 aquaporin 3 Mus musculus 83-87 10737773-8 2000 Osmotic water permeability of cortical collecting-duct basolateral membrane, measured by a spatial filtering optics method, was >3-fold reduced by AQP3 deletion. Water 8-13 aquaporin 3 Mus musculus 150-154 10232700-1 1999 Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal tubule. Water 23-28 aquaporin 3 Mus musculus 145-149 11035042-1 2001 Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes. Water 16-21 aquaporin 3 Mus musculus 30-34 11035042-1 2001 Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes. Water 91-96 aquaporin 3 Mus musculus 30-34 10990371-4 2000 Mice lacking AQP3, a basolateral membrane water channel expressed mainly in the cortical collecting duct, are remarkably polyuric but are able to generate a partly concentrated urine after water deprivation. Water 42-47 aquaporin 3 Mus musculus 13-17 10990371-4 2000 Mice lacking AQP3, a basolateral membrane water channel expressed mainly in the cortical collecting duct, are remarkably polyuric but are able to generate a partly concentrated urine after water deprivation. Water 189-194 aquaporin 3 Mus musculus 13-17 34577578-9 2021 In addition, it is possible that increased expression of AQP3, which plays an important role in skin water retention, is a contributor to the mechanism. Water 101-106 aquaporin 3 Mus musculus 57-61 33168815-1 2020 Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H2O2) that is expressed in various epithelial cells and in macrophages. Water 39-44 aquaporin 3 Mus musculus 0-11 35559994-13 2022 We also identified a cluster of genes (Krt8, Krt7, Cldn4, and Aqp3) that exerted functional roles in cell-cell junctions and water homeostasis during hatching. Water 125-130 aquaporin 3 Mus musculus 62-66 33494453-2 2021 We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model db/db mice. Water 43-48 aquaporin 3 Mus musculus 70-74 34072552-6 2021 Subsequent to MP treatment, concentrations of chloride ion and expressions of its channel (CFTR and CIC-2) were decreased, whereas expressions of aquaporin (AQP)3 and 8 for water transportation were downregulated by activation of the mitogen-activated protein kinase (MAPK)/nuclear factor (NF)-kappaB signaling pathway. Water 173-178 aquaporin 3 Mus musculus 157-162 33168815-1 2020 Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H2O2) that is expressed in various epithelial cells and in macrophages. Water 39-44 aquaporin 3 Mus musculus 13-17 30324163-1 2018 Aquaporin (AQP) 3, a facilitated transporter of water and glycerol, expresses in placenta and fetal membranes, but the detailed localization and function of AQP3 in placenta remain unclear. Water 48-53 aquaporin 3 Mus musculus 0-17 32260143-4 2020 An assessment of the expression levels of functional genes in the skin revealed that only the expression of the water channel aquaporin-3 (AQP3) was significantly decreased in the erlotinib-treated group. Water 112-117 aquaporin 3 Mus musculus 139-143 32260143-7 2020 Dry skin due to erlotinib may be caused by the decreased expression of AQP3 in the skin, thereby limiting water transport from the vascular side to the corneum side. Water 106-111 aquaporin 3 Mus musculus 71-75 31382467-2 2019 In this study, we investigated the mechanism underlying the onset of diabetic xeroderma, focusing on aquaporin-3 (AQP3), which plays an important role in water transport in the skin. Water 154-159 aquaporin 3 Mus musculus 101-112 31382467-7 2019 The results of this study suggest that skin AQP3 expression decreases in diabetes, which may limit water transport from the vessel side to the corneum side, causing dry skin. Water 99-104 aquaporin 3 Mus musculus 44-48 30862673-2 2019 Aquaporin-3 (AQP3) has an important physiological function in renal water reabsorption, and AQP3-mediated hydrogen peroxide (H2O2) permeability can enhance cytokine signaling in several cell types. Water 68-73 aquaporin 3 Mus musculus 0-11 30862673-2 2019 Aquaporin-3 (AQP3) has an important physiological function in renal water reabsorption, and AQP3-mediated hydrogen peroxide (H2O2) permeability can enhance cytokine signaling in several cell types. Water 68-73 aquaporin 3 Mus musculus 13-17 30862673-5 2019 Here, using a calcein fluorescence quenching assay, we screened a library of 7360 drug-like small molecules for inhibition of mouse AQP3 water permeability. Water 137-142 aquaporin 3 Mus musculus 132-136 30862673-7 2019 Surprisingly, inhibitor specificity testing revealed that the methylurea-linked compound Z433927330, a partial AQP3 inhibitor (IC50, ~0.7-0.9 mum), is a potent and efficacious inhibitor of mouse AQP7 water permeability (IC50, ~0.2 mum). Water 200-205 aquaporin 3 Mus musculus 111-115 30324163-10 2018 These results suggest a role for AQP3 in supplying nutrients from yolk sac and maternal blood to developing fetus by facilitating transport of glycerol in addition to water, and its implication for the fetal growth in utero. Water 167-172 aquaporin 3 Mus musculus 33-37 28111811-4 2017 Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10. Water 46-51 aquaporin 3 Mus musculus 171-175 28111811-4 2017 Combining imiquimod with detergent-containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10. Water 46-51 aquaporin 3 Mus musculus 179-183 29259448-3 2017 In contrast, water, glycerol, and ethylene glycerol move rapidly through morulae and blastocysts, principally by facilitated diffusion via aquaporin 3, in the mouse and bovine; whereas, in the pig, the permeability to water and these cryoprotectants increases not at the morula stage but at the blastocyst stage and further increases at the expanded blastocyst stage. Water 13-18 aquaporin 3 Mus musculus 139-150 28344130-1 2017 Aquaporin-3 (AQP3), a transporter of water, glycerol and H2O2, is expressed in basolateral membranes of principal cells in kidney collecting duct. Water 37-42 aquaporin 3 Mus musculus 0-11 28344130-1 2017 Aquaporin-3 (AQP3), a transporter of water, glycerol and H2O2, is expressed in basolateral membranes of principal cells in kidney collecting duct. Water 37-42 aquaporin 3 Mus musculus 13-17 27138166-1 2016 Aquaporin-3 (AQP3) is an integral membrane protein that facilitates the transport of water and glycerol across cell membranes. Water 85-90 aquaporin 3 Mus musculus 0-11 27138166-1 2016 Aquaporin-3 (AQP3) is an integral membrane protein that facilitates the transport of water and glycerol across cell membranes. Water 85-90 aquaporin 3 Mus musculus 13-17 23966318-3 2013 We previously showed that an increase in the permeability of the plasma membrane in mouse oocytes to water and cryoprotectants, caused by the artificial expression of aquaporin 3, an aquaglyceroporin, enhanced tolerance to cryopreservation. Water 101-106 aquaporin 3 Mus musculus 167-178 25339224-0 2015 Glucocorticoids stimulate endolymphatic water reabsorption in inner ear through aquaporin 3 regulation. Water 40-45 aquaporin 3 Mus musculus 80-91 25339224-2 2015 Since dysregulation of water transport could account for the generation of this hydrops, we investigated the role of aquaporin 3 (AQP3) in water transport into endolymph, the K-rich, hyperosmotic fluid that bathes the apical ciliated membrane of sensory cells, and we studied the regulatory effect of dexamethasone upon AQP3 expression and water fluxes. Water 139-144 aquaporin 3 Mus musculus 117-128 25339224-2 2015 Since dysregulation of water transport could account for the generation of this hydrops, we investigated the role of aquaporin 3 (AQP3) in water transport into endolymph, the K-rich, hyperosmotic fluid that bathes the apical ciliated membrane of sensory cells, and we studied the regulatory effect of dexamethasone upon AQP3 expression and water fluxes. Water 139-144 aquaporin 3 Mus musculus 130-134 25339224-2 2015 Since dysregulation of water transport could account for the generation of this hydrops, we investigated the role of aquaporin 3 (AQP3) in water transport into endolymph, the K-rich, hyperosmotic fluid that bathes the apical ciliated membrane of sensory cells, and we studied the regulatory effect of dexamethasone upon AQP3 expression and water fluxes. Water 139-144 aquaporin 3 Mus musculus 117-128 25339224-2 2015 Since dysregulation of water transport could account for the generation of this hydrops, we investigated the role of aquaporin 3 (AQP3) in water transport into endolymph, the K-rich, hyperosmotic fluid that bathes the apical ciliated membrane of sensory cells, and we studied the regulatory effect of dexamethasone upon AQP3 expression and water fluxes. Water 139-144 aquaporin 3 Mus musculus 130-134 24260356-1 2013 Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small solutes across the plasma membrane. Water 59-64 aquaporin 3 Mus musculus 0-11 24260356-1 2013 Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small solutes across the plasma membrane. Water 59-64 aquaporin 3 Mus musculus 13-17 27165276-2 2016 Aquaporin-3 (AQP3) is a small transmembrane water/glycerol channel that may facilitate the membrane uptake of hydrogen peroxide (H2O2). Water 44-49 aquaporin 3 Mus musculus 0-11 27165276-2 2016 Aquaporin-3 (AQP3) is a small transmembrane water/glycerol channel that may facilitate the membrane uptake of hydrogen peroxide (H2O2). Water 44-49 aquaporin 3 Mus musculus 13-17 25233074-1 2015 Aquaporin-3 (AQP3) is a water and glycerol channel expressed in epidermal keratinocytes. Water 24-29 aquaporin 3 Mus musculus 0-11 25233074-1 2015 Aquaporin-3 (AQP3) is a water and glycerol channel expressed in epidermal keratinocytes. Water 24-29 aquaporin 3 Mus musculus 13-17 21677305-2 2011 Previously, we showed in mice that the permeability to water and cryoprotectants of oocytes and embryos at early cleavage stages (early embryos) is low because these molecules move across the plasma membrane predominantly by simple diffusion through the lipid bilayer, whereas permeability of morulae and blastocysts is high because of a water channel, aquaporin 3 (AQP3). Water 55-60 aquaporin 3 Mus musculus 353-364 23912684-1 2013 Aquaporin-3 (AQP3) plays an important role in maintaining the normal water content of the skin. Water 69-74 aquaporin 3 Mus musculus 0-11 23912684-1 2013 Aquaporin-3 (AQP3) plays an important role in maintaining the normal water content of the skin. Water 69-74 aquaporin 3 Mus musculus 13-17 21865318-7 2011 Water and glycerol permeabilities in mRPMs from AQP3(-/-) mice were reduced compared to mRPMs from AQP3(+/+) mice. Water 0-5 aquaporin 3 Mus musculus 48-52 21865318-9 2011 These data implicate AQP3 as a novel determinant in macrophage immune function by a cellular mechanism involving facilitated water and glycerol transport, and consequent phagocytic and migration activity. Water 125-130 aquaporin 3 Mus musculus 21-25 21677305-2 2011 Previously, we showed in mice that the permeability to water and cryoprotectants of oocytes and embryos at early cleavage stages (early embryos) is low because these molecules move across the plasma membrane predominantly by simple diffusion through the lipid bilayer, whereas permeability of morulae and blastocysts is high because of a water channel, aquaporin 3 (AQP3). Water 55-60 aquaporin 3 Mus musculus 366-370 21135872-4 2011 Here, we report that aquaporin3 (AQP3) is a sperm water channel in mice and humans. Water 50-55 aquaporin 3 Mus musculus 21-31 21871666-2 2011 Aquaporin 3 (AQP3), a water and glycerol transporting protein, is highly expressed in immature DCs. Water 22-27 aquaporin 3 Mus musculus 0-11 21871666-2 2011 Aquaporin 3 (AQP3), a water and glycerol transporting protein, is highly expressed in immature DCs. Water 22-27 aquaporin 3 Mus musculus 13-17 21135872-4 2011 Here, we report that aquaporin3 (AQP3) is a sperm water channel in mice and humans. Water 50-55 aquaporin 3 Mus musculus 33-37 19184071-1 2009 Aquaporin-3 (AQP3) is a water/glycerol transporting protein expressed strongly at the plasma membrane of keratinocytes. Water 24-29 aquaporin 3 Mus musculus 0-11 19184071-1 2009 Aquaporin-3 (AQP3) is a water/glycerol transporting protein expressed strongly at the plasma membrane of keratinocytes. Water 24-29 aquaporin 3 Mus musculus 13-17 19184071-2 2009 There is evidence for involvement of AQP3-facilitated water and glycerol transport in keratinocyte migration and proliferation, respectively. Water 54-59 aquaporin 3 Mus musculus 37-41 18312385-1 2008 Aquaporin-3 (AQP3) is a membrane transport protein that facilitates water and glycerol transport across cell plasma membranes in the basal layer of keratinocytes in normal skin. Water 68-73 aquaporin 3 Mus musculus 0-11 18312385-1 2008 Aquaporin-3 (AQP3) is a membrane transport protein that facilitates water and glycerol transport across cell plasma membranes in the basal layer of keratinocytes in normal skin. Water 68-73 aquaporin 3 Mus musculus 13-17 18312385-2 2008 Motivated by a relation between AQP3 expression and skin water content, several companies have marketed cosmetics containing ingredients that increase AQP3 expression. Water 57-62 aquaporin 3 Mus musculus 32-36 18548108-1 2008 Aquaporin-3 (AQP3) is a membrane transporter of water and glycerol expressed in plasma membranes in the basal layer keratinocytes of epidermis in normal skin. Water 48-53 aquaporin 3 Mus musculus 0-11 18548108-1 2008 Aquaporin-3 (AQP3) is a membrane transporter of water and glycerol expressed in plasma membranes in the basal layer keratinocytes of epidermis in normal skin. Water 48-53 aquaporin 3 Mus musculus 13-17 18548108-3 2008 AQP3-knockout mice have reduced stratum corneum water content and elasticity compared with wild-type mice, as well as impaired wound healing and epidermal biosynthesis. Water 48-53 aquaporin 3 Mus musculus 0-4 18241265-12 2008 CONCLUSIONS: This is the first demonstration that elevated AQP3 results in the retention of epidermal water, causing the taut, wrinkle-free skin phenotype of the DHCR24-/- mice. Water 102-107 aquaporin 3 Mus musculus 59-63 17968524-4 2008 After AQP3 knock-down in keratinocyte cell cultures, which reduced cell membrane water and glycerol permeabilities, cell migration was slowed by more than twofold, with reduced lamellipodia formation at the leading edge of migrating cells. Water 81-86 aquaporin 3 Mus musculus 6-10 17968524-8 2008 Our results provide evidence for involvement of AQP3-facilitated water transport in epidermal cell migration and for AQP3-facilitated glycerol transport in epidermal cell proliferation. Water 65-70 aquaporin 3 Mus musculus 48-52 18209479-1 2008 BACKGROUND/AIMS: Aquaporin-3 (AQP3), one isoform of water channel family, has been found to be expressed in mouse oocytes. Water 52-57 aquaporin 3 Mus musculus 17-28 18209479-1 2008 BACKGROUND/AIMS: Aquaporin-3 (AQP3), one isoform of water channel family, has been found to be expressed in mouse oocytes. Water 52-57 aquaporin 3 Mus musculus 30-34 18209479-11 2008 CONCLUSION: AQP3 might play an important role in controlling oocyte quality and a low in vitro fertilization rate of COH mice might, in part, result from reduced AQP3 expression and water permeability in mouse oocytes. Water 182-187 aquaporin 3 Mus musculus 12-16 17967887-1 2008 Aquaporin-3 (AQP3) is a water/glycerol-transporting protein expressed strongly at the plasma membranes of basal epidermal cells in skin. Water 24-29 aquaporin 3 Mus musculus 0-11 17967887-1 2008 Aquaporin-3 (AQP3) is a water/glycerol-transporting protein expressed strongly at the plasma membranes of basal epidermal cells in skin. Water 24-29 aquaporin 3 Mus musculus 13-17 17429015-0 2007 The role of aquaporin 3 in the movement of water and cryoprotectants in mouse morulae. Water 43-48 aquaporin 3 Mus musculus 12-23 17429015-2 2007 Previously, we have shown in mouse morulae that water and glycerol move across the plasma membrane by facilitated diffusion, and we have suggested that aquaporin 3 plays an important role in their movement. Water 48-53 aquaporin 3 Mus musculus 152-163 17429015-3 2007 In the present study, we clarify the contribution of aquaporin 3 to the movement of water and various cryoprotectants in mouse morulae by measuring the Arrhenius activation energies for permeability to cryoprotectants and water, through artificial expression of aquaporin 3 using Aqp3 cRNA in mouse oocytes, and by suppressing the expression of aquaporin 3 in morulae by injecting double-stranded RNA of Aqp3 at the one-cell zygote stage. Water 84-89 aquaporin 3 Mus musculus 53-64 17429015-4 2007 The results show that aquaporin 3 plays an important role in the facilitated diffusion of water, glycerol, and ethylene glycol, but not of acetamide and dimethylsulfoxide. Water 90-95 aquaporin 3 Mus musculus 22-33 17429015-5 2007 On the other hand, in a propylene glycol solution, aquaporin 3 in morulae transported neither propylene glycol nor water by facilitated diffusion, probably because of strong water-solute interactions. Water 115-120 aquaporin 3 Mus musculus 51-62 17429015-5 2007 On the other hand, in a propylene glycol solution, aquaporin 3 in morulae transported neither propylene glycol nor water by facilitated diffusion, probably because of strong water-solute interactions. Water 174-179 aquaporin 3 Mus musculus 51-62 16942765-1 2006 It has been shown that aquaporin-3, a water channel, is expressed in mouse embryos. Water 38-43 aquaporin 3 Mus musculus 23-34 15100356-4 2004 Fluorescence-based real-time reverse transcription-PCR and Northern blot analysis showed upregulation of the UT-A2 urea transporter and the aquaporin 2 (AQP2) and AQP3 water channel transcripts but no change in other urea transporters or AQP. Water 168-173 aquaporin 3 Mus musculus 163-167 17369110-6 2007 In the airways, though AQP3 and AQP4 facilitate osmotic water transport, their deletion does not impair airway hydration, regulation of airway surface liquid, or fluid absorption. Water 56-61 aquaporin 3 Mus musculus 23-27 16525162-1 2006 Aquaporin-1 (AQP1) and aquaporin-3 (AQP3) water channels expressed in the kidney play a critical role in the urine concentrating mechanism. Water 42-47 aquaporin 3 Mus musculus 23-34 16525162-1 2006 Aquaporin-1 (AQP1) and aquaporin-3 (AQP3) water channels expressed in the kidney play a critical role in the urine concentrating mechanism. Water 42-47 aquaporin 3 Mus musculus 36-40 16525162-11 2006 This solute-selective response could result from the capacity of AQP3 to transport not only water but also urea. Water 92-97 aquaporin 3 Mus musculus 65-69 15713911-7 2005 In contrast, there was increased expression of three proteins normally expressed at higher levels in the cortical collecting duct (CCD) than in IMCD: AQP3 (another basolateral water channel) and the epithelial sodium channel subunits beta-ENaC and gamma-ENaC. Water 176-181 aquaporin 3 Mus musculus 150-154 15705184-10 2005 CONCLUSION: Our results reveal that the water transport in urinary concentration involves the downregulation of AQP2 and AQP3 expression in STZ mice. Water 40-45 aquaporin 3 Mus musculus 121-125 14675200-1 2003 Aquaporin 3 is a channel that transports both water and glycerol. Water 46-51 aquaporin 3 Mus musculus 0-11