PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20183853-3	2010	Four kinase systems (Src family, Abl/c-Kit, Syk/ZAP-70, and CDK2/4) were investigated, and differences in predicted water molecule locations and energetics were able to explain the experimentally observed binding selectivity profiles.	Water	116-121	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	33-36	
24900720-4	2013	As expected, the uncleaved water-soluble prodrugs 7 and 8 showed no activity toward the enzymatic targets (c-Src and c-Abl) but revealed promising antiproliferative activity in myeloid cell lines, as a consequence of the in vitro hydrolysis of the selected solubilizing moiety, followed by the release of the active compounds (1 and 2).	Water	27-32	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	117-122	
20970221-0	2010	2-Hydroxypropyl-beta-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.	Water	52-57	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	135-138	
22570081-5	2012	In addition, to understand the structural changes that are associated with resistance, we describe the behavior of water molecules that interact simultaneously with specific residues (Glu286, Lys271 and Asp381) of c-ABL (wild type or mutant) and their relationship with drug resistance.	Water	115-120	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	214-219	
22570081-8	2012	Additionally, for c-ABL mutants, the observed number of water molecules being turned over while interacting with amino acids Glu286, Lys271 and Asp381 was associated with resistance to imatinib, resulting in a less effective inhibition of the kinase activity.	Water	56-61	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	18-23	
15890005-6	2005	c-Abl and Arg nonreceptor protein tyrosine kinases associate with catalase in cells treated with H(2)O(2) by mechanisms involving the SH3 domains of the kinases and the Pro(293)PheAsnPro motif of catalase and activate catalase by phosphorylating it on Tyr(231) and Tyr(386).	Water	97-102	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-5	
19906645-0	2010	Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.	Water	20-25	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	103-106	
17407569-10	2007	We suggest that the experimental differences in binding energetics can be at least partially ascribed to the absence in the R21A Spc-SH3:P41 complex of several buried water molecules, which have been proposed previously to contribute largely to the highly negative enthalpy and entropy of binding in the Abl-SH3:P41 complex.	Water	167-172	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	304-307	
20149665-0	2010	Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl.	Water	54-59	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	174-181	
34923994-2	2021	BACKGROUND: Aquagenic pruritus (AP), an intense sensation of scratching induced after water contact, is the most troublesome aspect of BCR-ABL1-negative myeloproliferative neoplasms (MPNs).	Water	86-91	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	139-143