PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32477057-7 2020 Results: Compared with WT mice, Trpv4-/- mice showed reduced ischemia-induced lesion volume and reduced water content and Evans blue leakage in the ipsilateral hemisphere alongside milder neurological symptoms. Water 104-109 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 32-37 32931478-5 2020 Genetic ablation of TRPV4 resulted in reduced expression of the water conducting aquaporin-5 (AQP-5) channel in ATI cells. Water 64-69 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 20-25 31048895-0 2019 TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice. Water 36-41 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 0-5 31150667-3 2020 Our pharmacological experiments suggested that Nax signals led to activation of neurons bearing TRPV4 by using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake. Water 177-182 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 96-101 31150667-9 2020 Collectively, these results indicate that Nax-positive glial cells produce EETs to activate TRPV4-positive neurons which may stimulate water intake, in response to increases in [Na+] of body fluids. Water 135-140 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 92-97 32372285-2 2020 We previously demonstrated that Nax signals are involved in the control of water intake behavior through the Nax/TRPV4 pathway. Water 75-80 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 113-118 31048895-14 2019 Our data provide evidence that water diffusion is increased in diabetic mouse retinas and that TRPV4 function contributes to retinal hydro-mineral homeostasis and structure under control conditions, and to the development of BRB breakdown and increased water diffusion in the retina under diabetes conditions. Water 253-258 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 95-100 27252474-0 2016 Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation. Water 60-65 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 90-95 29793978-8 2018 Finally, we found that brain edema following traumatic brain injury was suppressed in TRPV4-deficient male mice in vivo Thus, our study proposes a novel mechanism: hyperthermia activates TRPV4 and induces brain edema after ischemia.SIGNIFICANCE STATEMENT Brain edema is characterized by an increase in net brain water content, which results in an increase in brain volume. Water 312-317 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 86-91 29793978-8 2018 Finally, we found that brain edema following traumatic brain injury was suppressed in TRPV4-deficient male mice in vivo Thus, our study proposes a novel mechanism: hyperthermia activates TRPV4 and induces brain edema after ischemia.SIGNIFICANCE STATEMENT Brain edema is characterized by an increase in net brain water content, which results in an increase in brain volume. Water 312-317 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 187-192 27364478-8 2016 However, Trpv4 (-/-) mice showed a significantly lower vasopressin synthesis and release after water deprivation, with a loss of the positive correlation between plasma osmolality and plasma vasopressin levels, and a delayed water intake upon acute administration of hypertonic saline. Water 95-100 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 9-14 27364478-8 2016 However, Trpv4 (-/-) mice showed a significantly lower vasopressin synthesis and release after water deprivation, with a loss of the positive correlation between plasma osmolality and plasma vasopressin levels, and a delayed water intake upon acute administration of hypertonic saline. Water 225-230 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 9-14 27252474-3 2016 We herein investigated voluntary water intake immediately induced after an intracerebroventricular administration of a hypertonic NaCl solution in TRPV1-, TRPV4-, Nax-, and their double-gene knockout (KO) mice. Water 33-38 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 155-160 27252474-6 2016 When TRPV4 activity was blocked with a specific antagonist HC-067047, water intake by WT mice was significantly reduced, whereas intake by TRPV4-KO and Nax-KO mice was not. Water 70-75 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 5-10 27252474-9 2016 These results suggest that the Na(+) signal generated in Nax-positive glial cells leads to the activation of TRPV4-positive neurons in sCVOs to stimulate water intake by using EETs as gliotransmitters. Water 154-159 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 109-114 26424896-12 2015 Therefore, TRPV4-AQP4 interactions constitute a molecular system that fine-tunes astroglial volume regulation by integrating osmosensing, calcium signaling, and water transport and, when overactivated, triggers pathological swelling. Water 161-166 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 11-16 26424896-13 2015 Significance statement: We characterize the physiological features of interactions between the astroglial swelling sensor transient receptor potential isoform 4 (TRPV4) and the aquaporin 4 (AQP4) water channel in retinal Muller cells. Water 196-201 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 162-167 26424896-15 2015 Specifically, water influx through AQP4 drives calcium influx via TRPV4 in the glial end foot, which regulates expression of Aqp4 and Kir4.1 genes and facilitates the time course and amplitude of hypotonicity-induced swelling and regulatory volume decrease. Water 14-19 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 66-71 34884463-1 2021 Lens water transport generates a hydrostatic pressure gradient that is regulated by a dual-feedback system that utilizes the mechanosensitive transient receptor potential vanilloid (TRPV) channels, TRPV1 and TRPV4, to sense changes in mechanical tension and extracellular osmolarity. Water 5-10 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 208-213 20385965-3 2010 Here, using a mouse model of baroreflex impairment, we show that the increase in blood pressure after water ingestion is mediated through sympathetic nervous system activation and that the osmosensitive transient receptor potential vanilloid 4 channel (Trpv4) is an essential component of the response. Water 102-107 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 253-258 20385965-4 2010 Although portal osmolality decreases after water ingestion in both wild-type and Trpv4(-/-) mice, only the wild-type animals show a pressor response. Water 43-48 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 81-86 14581612-5 2003 trpv4-/- mice drank less water and became more hyperosmolar than did wild-type littermates, a finding that was seen with and without administration of hypertonic saline. Water 25-30 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 0-5 25914628-5 2015 We found that the brain water content and Evans blue extravasation at 48 h post-MCAO were reduced by a TRPV4 antagonist HC-067047. Water 24-29 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 103-108 16571723-3 2006 We have examined the mechanism of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water permeability and cell volume. Water 248-253 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 142-147 16571723-3 2006 We have examined the mechanism of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water permeability and cell volume. Water 248-253 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 149-189 34719652-7 2021 Repeated intracerebroventricular administration of the specific TRPV4 antagonists HC-067047 and RN-1734 dose-dependently reduced brain water content and alleviated EB extravasation in FPI mice. Water 135-140 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 64-69 35107027-2 2022 In the mouse lens, this water transport through gap junction channels generates an intracellular hydrostatic pressure gradient, which is subjected to a dual feedback regulation that is mediated by the reciprocal modulation of the transient receptor potential vanilloid channels, TRPV1 and TRPV4. Water 24-29 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 289-294