PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30880180-0 2019 A novel, highly-water-soluble apigenin derivative provides neuroprotection following ischemia in male rats by regulating the ERK/Nrf2/HO-1 pathway. Water 16-21 NFE2 like bZIP transcription factor 2 Rattus norvegicus 129-133 32040235-0 2020 Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway. Water 14-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 83-87 32043502-10 2020 In addition, the H2O2-induced injury in Nrf2-knockdown PC12 cells was more serious than it was in control cells, and CA-mediated neuroprotection was exclusively inhibited by the knock down of Nrf2 in PC12 cells. Water 17-21 NFE2 like bZIP transcription factor 2 Rattus norvegicus 40-44 32043502-10 2020 In addition, the H2O2-induced injury in Nrf2-knockdown PC12 cells was more serious than it was in control cells, and CA-mediated neuroprotection was exclusively inhibited by the knock down of Nrf2 in PC12 cells. Water 17-21 NFE2 like bZIP transcription factor 2 Rattus norvegicus 192-196 31669938-6 2020 In the present study, we evaluated the use of several PC to prevent peroxidation of macromolecules and to elicit the activation of the Nrf2 transcription factor in H2O2-stresed IEC-6 enterocytic cell line. Water 164-168 NFE2 like bZIP transcription factor 2 Rattus norvegicus 135-139 29285131-0 2017 Effects of water extracts of Rehmannia glutinosa on antioxidant system of Nrf2 in paraquat-induced insulin resistance diabetic rat model. Water 11-16 NFE2 like bZIP transcription factor 2 Rattus norvegicus 74-78 30367509-11 2018 Hydrogen water can reduce tendon adhesion after tendon repairing and prohibit excessive inflammatory response, which could be associated with the activation of the Nrf2 pathway. Water 9-14 NFE2 like bZIP transcription factor 2 Rattus norvegicus 164-168 29907217-0 2018 Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway. Water 14-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 88-92 29907217-17 2018 Moreover, hydrogen-rich water caused Nrf2 to enter the cell nucleus, which resulted in increases in the expression of downstream factors such as HO-1 and NQO1. Water 24-29 NFE2 like bZIP transcription factor 2 Rattus norvegicus 37-41 29907217-18 2018 CONCLUSIONS: Our results indicate that hydrogen-rich water has neuroprotective effects against TBI by reducing oxidative stress and activating the Nrf2 pathway. Water 53-58 NFE2 like bZIP transcription factor 2 Rattus norvegicus 147-151 26992899-0 2016 Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats. Water 136-141 NFE2 like bZIP transcription factor 2 Rattus norvegicus 32-36 29745556-1 2017 With the oxidative damage model established in rat myocardial cells by hydrogen peroxide (H 2O 2), the expression of myocardin and nuclear factor erythroid 2-related factor 2 (Nrf2) during oxidative damage and effect of myocardin on Nrf2 were preliminarily explored. Water 90-94 NFE2 like bZIP transcription factor 2 Rattus norvegicus 176-180 26992899-8 2016 Fecal water activated Nrf2 in both cell lines, associated with the induction of Nrf2-target genes related to aldehydes detoxification. Water 6-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 22-26 26992899-8 2016 Fecal water activated Nrf2 in both cell lines, associated with the induction of Nrf2-target genes related to aldehydes detoxification. Water 6-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 80-84 26992899-10 2016 Taken together, our results suggest that Nrf2-dependent antioxidant response was involved in the resistance of preneoplastic cells upon exposure to fecal water of hemoglobin- and beef-fed rats. Water 154-159 NFE2 like bZIP transcription factor 2 Rattus norvegicus 41-45 26798423-0 2016 Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model. Water 14-19 NFE2 like bZIP transcription factor 2 Rattus norvegicus 88-92 26798423-3 2016 The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes. Water 61-66 NFE2 like bZIP transcription factor 2 Rattus norvegicus 104-108 26798423-9 2016 In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway. Water 29-34 NFE2 like bZIP transcription factor 2 Rattus norvegicus 106-110 24888323-1 2014 OBJECTIVE: This study was conducted to evaluate the effect of the synthetic water-soluble phenolic antioxidant TS-13 (sodium 3-(4"-methoxyphenyl)propyl thiosulfonate), an inducer of the redox-dependent Keap1/Nrf2/ARE signaling system, in experimental models of acute and chronic inflammation. Water 76-81 NFE2 like bZIP transcription factor 2 Rattus norvegicus 208-212 21602469-6 2011 In cultured aorta segments of young (3 mo old) rats treatment with H(2)O(2) and high glucose significantly increases nuclear translocation of Nrf2 and upregulates the expression of Nrf2 target genes. Water 67-72 NFE2 like bZIP transcription factor 2 Rattus norvegicus 142-146 21602469-6 2011 In cultured aorta segments of young (3 mo old) rats treatment with H(2)O(2) and high glucose significantly increases nuclear translocation of Nrf2 and upregulates the expression of Nrf2 target genes. Water 67-72 NFE2 like bZIP transcription factor 2 Rattus norvegicus 181-185 27132459-0 2015 [Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with traumatic brain injury]. Water 26-31 NFE2 like bZIP transcription factor 2 Rattus norvegicus 53-58 27132459-1 2015 OBJECTIVE: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI). Water 55-60 NFE2 like bZIP transcription factor 2 Rattus norvegicus 82-125 27132459-1 2015 OBJECTIVE: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI). Water 55-60 NFE2 like bZIP transcription factor 2 Rattus norvegicus 127-131 27132459-20 2015 CONCLUSIONS: Hydrogen rich water can up-regulate the expression of Nrf2, and reduce oxidative damage of traumatic brain injury in rats. Water 27-32 NFE2 like bZIP transcription factor 2 Rattus norvegicus 67-71 22548787-9 2012 Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes. Water 39-44 NFE2 like bZIP transcription factor 2 Rattus norvegicus 211-215