PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17454565-2	2007	In this study, 101 plant extracts (methanol or water extracts) were screened for their inhibitory activities against tyrosinase, (L-3, 4,-dihydroxyphenylalanine) L-DOPA oxidation, and melanin biosynthesis in B16 mouse melanoma cells.	Water	47-52	tyrosinase	Mus musculus	117-127	
23781272-2	2013	Water extracts of Fructus Arctii were shown to inhibit tyrosinase activity in vitro and melanin content in alpha -melanocyte stimulating hormone-stimulated cells to similar levels as the well-known kojic acid and arbutin, respectively.	Water	0-5	tyrosinase	Mus musculus	55-65	
3111852-4	1987	When the enzyme was solubilised from a melanosomal fraction with detergent/water without any buffer, significant linear activity for 2 h was seen at an inhibitory concentration of tyrosine, indicating for the first time the presence of a form of tyrosinase without lag and inhibition by excess tyrosine.	Water	75-80	tyrosinase	Mus musculus	246-256	
16946515-11	2006	Among them, water extract of Galla Chinensis and ethanol extract of Radix Clematidis exhibited higher depigmentation activity and caused lower tyrosinase activity in cell culture assays and are worthy to be further studied.	Water	12-17	tyrosinase	Mus musculus	143-153	
15914904-3	2005	Its distilled water fraction (WEx) was found to stimulate tyrosinase activity in cultured mouse B16 melanoma cells and hair color pigmentation in C3H mice.	Water	14-19	tyrosinase	Mus musculus	58-68	
8395331-5	1993	Direct injection of the tk gene under control of the tyrosinase promoter into established tumors in mice, followed by treatment with ganciclovir, led to significant reductions in resultant tumor size relative to the size of tumor developing in mice treated with water (median tumor weight, 1.65 g versus 2.75 g).	Water	262-267	tyrosinase	Mus musculus	53-63	
3928149-6	1985	Administration of different doses of DFMO in drinking water to B16 melanoma tumor bearing mice also resulted in an increase in tyrosinase activity and a dose dependent inhibition (86-90%) of tumor growth.	Water	54-59	tyrosinase	Mus musculus	127-137	
32390848-2	2020	We found that the water extract of D. morbiferus leaves significantly inhibited tyrosinase activity and melanin formation in alpha-melanocyte stimulating hormone (MSH)-induced B16-F10 cells.	Water	18-23	tyrosinase	Mus musculus	80-90	
27829416-5	2016	METHODS: Three different extracts (water, methanol and ethanol) from leaves, flowers and tubers of A. microcarpus were evaluated for their inhibitory effect on tyrosinase activity using L-3,4-dihydroxyphenylalanine (L-DOPA) as substrate.	Water	35-40	tyrosinase	Mus musculus	160-170