PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3518294-1 1986 Lipopolysaccharide extracted with phenol-water from Leptospira interrogans serovar copenhageni strain Shibaura (L-LPS) showed various biological activities. Water 41-46 toll-like receptor 4 Mus musculus 114-117 33732014-10 2021 Results: The results illustrated that hydrogen-rich water could alleviate oxaliplatin-induced hyperalgesia, reduce the microbial diversity and alter the structure of gut microbiota, reverse the imbalance of inflammatory cytokines and oxidative stress, and decrease the expression of LPS and TLR4. Water 52-57 toll-like receptor 4 Mus musculus 291-295 3882561-2 1985 The phenol-water-extracted LPS from B. gingivalis 381 was composed of 46% carbohydrate, 23% hexosamine, 18% fatty acid, and 5% protein. Water 11-16 toll-like receptor 4 Mus musculus 27-30 3882561-5 1985 The butanol-water-extracted LPS from this strain was composed of 76% glucose, 7% fatty acid, and 13% protein, and it was associated with a number of polypeptides (13 to 56 kilodaltons). Water 12-17 toll-like receptor 4 Mus musculus 28-31 3882561-8 1985 Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli. Water 112-117 toll-like receptor 4 Mus musculus 13-16 3882561-8 1985 Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli. Water 112-117 toll-like receptor 4 Mus musculus 128-131 3882561-8 1985 Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli. Water 112-117 toll-like receptor 4 Mus musculus 128-131 3882561-8 1985 Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli. Water 112-117 toll-like receptor 4 Mus musculus 128-131 3882561-8 1985 Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli. Water 144-149 toll-like receptor 4 Mus musculus 13-16 3882561-8 1985 Furthermore, LPS-nonresponsive C3H/HeJ spleen cells were found to yield good mitogenic responses to both phenol-water-extracted LPS and butanol-water-extracted LPS from B. gingivalis or butanol-water-extracted LPS from E. coli. Water 144-149 toll-like receptor 4 Mus musculus 13-16 6357879-3 1983 After reextraction of these LPS preparations with phenol-water, the remaining LPS was either considerably less mitogenic or not mitogenic. Water 57-62 toll-like receptor 4 Mus musculus 28-31 6357879-3 1983 After reextraction of these LPS preparations with phenol-water, the remaining LPS was either considerably less mitogenic or not mitogenic. Water 57-62 toll-like receptor 4 Mus musculus 78-81 6357879-4 1983 Purified E. coli 055:B5 LPS, prepared by phenol water extraction, enzyme treatment and column chromatography, was not mitogenic. Water 48-53 toll-like receptor 4 Mus musculus 24-27 75941-1 1978 The lipopolysaccharide (LPS)-protein complex extracted from the cell wall of Escherichia coli K235 by the butanol-water technique has been shown to evoke a mitogenic response in bone marrow-derived (B) lymphocytes from the C3H/HeJ mouse strain. Water 114-119 toll-like receptor 4 Mus musculus 24-27 2411661-4 1985 In contrast, phenol- and water-extracted, protein-free preparations of LPS (Ph-LPS) markedly inhibited elastase secretion below basal levels in LPS-responsive macrophages. Water 25-30 toll-like receptor 4 Mus musculus 71-74 2411661-4 1985 In contrast, phenol- and water-extracted, protein-free preparations of LPS (Ph-LPS) markedly inhibited elastase secretion below basal levels in LPS-responsive macrophages. Water 25-30 toll-like receptor 4 Mus musculus 79-82 391702-1 1979 Lipopolysaccharide (LPS) was prepared by phenol/water extraction of bacterial membranes prepared from Acinetobacter and Escherichia coli. Water 48-53 toll-like receptor 4 Mus musculus 20-23 33732014-11 2021 Conclusion: Hydrogen-rich water may alleviate CINP by affecting the diversity and structure of the gut microbiota, and then the LPS-TLR4 pathway, which provides a direction for further research. Water 26-31 toll-like receptor 4 Mus musculus 132-136 32579133-4 2020 We combined intratumoral administration of the synthetic toll-like receptor 4 agonist glucopyranosyl lipid A (oil-in-water formulation, G100) with either active vaccination or adoptive transfer of tumor-specific CD8 T cells to mice bearing established melanomas or orthotopically inoculated glioblastomas. Water 117-122 toll-like receptor 4 Mus musculus 57-77 32315938-0 2020 TLR4-MyD88 signaling pathway is responsible for acute lung inflammation induced by reclaimed water. Water 93-98 toll-like receptor 4 Mus musculus 0-4 32315938-5 2020 In addition, conditional knockout of the Tlr4 gene in myeloid cells resulted in a significant reduction of sensitivity to the reclaimed water in mutants, which indicates that myeloid cells play the most important role in the defensive immune system against the pollutants in the water. Water 136-141 toll-like receptor 4 Mus musculus 41-45 32315938-5 2020 In addition, conditional knockout of the Tlr4 gene in myeloid cells resulted in a significant reduction of sensitivity to the reclaimed water in mutants, which indicates that myeloid cells play the most important role in the defensive immune system against the pollutants in the water. Water 279-284 toll-like receptor 4 Mus musculus 41-45 32315938-6 2020 In general, this study demonstrated that the TLR4-MyD88 signaling pathway is responsible for the acute lung inflammation induced by reclaimed water, which excludes the possibility of other signaling pathway dependent inflammation inducers in reclaimed water. Water 142-147 toll-like receptor 4 Mus musculus 45-49 32346474-0 2020 Immunostimulatory effects of cell wall-based nanoparticles in boiled Glycyrrhizae radix water extracts involves TLR4. Water 88-93 toll-like receptor 4 Mus musculus 112-116 32346474-8 2020 The results of the present study suggested that the signaling pathway of nanoparticles obtained from boiled Glycyrrhizae radix water extracts, at least partially involved TLR4 and downstream signaling from this receptor, resulting in the immunostimulatory effects of these nanoparticles in RAW-blue cells. Water 127-132 toll-like receptor 4 Mus musculus 171-175 31926226-5 2020 We found that in high-fat diet model, native carrageenan in drinking water increased the disease activity index (DAI), myeloperoxidase (MPO) activity and the mRNA expression of TLR4 in colon, whereas carrageenan-supplemented diet has no visible effects. Water 69-74 toll-like receptor 4 Mus musculus 177-181 31938420-14 2018 Our results confirm that miR-182-5p alleviates inflammation and apoptosis via inactivation of TLR4/NF-kappaB pathway in an H2O2-induced cell model. Water 123-127 toll-like receptor 4 Mus musculus 94-98 31746021-9 2019 In addition, TLR4 overexpression considerably ablated the protective effects of miR-142 in terms of the cell viability of H2 O2 -treated NRCs. Water 122-127 toll-like receptor 4 Mus musculus 13-17 30850533-8 2019 Mechanistically, TLR4-dependent surface expression of P-selectin triggered an unconventional mechanism of complement activation by noncovalent anchoring of C3 activation fragments, including the typical fluid-phase C3(H2O), measured by surface plasmon resonance and flow cytometry. Water 218-221 toll-like receptor 4 Mus musculus 17-21 25185720-7 2015 ICH mice (TLR4-/-) had reduced water content and neurological injury compared with ICH mice (WT). Water 31-36 toll-like receptor 4 Mus musculus 10-14 29030247-2 2018 To date, little is known about the effect of gut microbiota generated lipopolysaccharide (LPS) on intestinal absorption of water-soluble vitamins. Water 123-128 toll-like receptor 4 Mus musculus 90-93 26645545-6 2016 Acetone and diethylether followed by water induced persistent upregulation of Tlr4 mRNA and increased TLR4 expression in GFAP-expressing astrocytes in spinal cord dorsal horn. Water 37-42 toll-like receptor 4 Mus musculus 78-82 26645545-6 2016 Acetone and diethylether followed by water induced persistent upregulation of Tlr4 mRNA and increased TLR4 expression in GFAP-expressing astrocytes in spinal cord dorsal horn. Water 37-42 toll-like receptor 4 Mus musculus 102-106 26571021-4 2015 We recently showed that this soluble CSP, combined with a synthetic Toll-like-receptor-4 (TLR4) agonist in stable oil-in-water emulsion (GLA/SE), induces a potent and protective immune response in mice against transgenic parasite challenge. Water 121-126 toll-like receptor 4 Mus musculus 90-94 27923288-3 2017 The present study found that TLR4 played a protective role in a mouse model of water immersion (23 C) restraint stress. Water 79-84 toll-like receptor 4 Mus musculus 29-33 25367751-7 2015 Thus, we demonstrate that IL-18 and caspase-1/11 are components of the response to immunization with the TLR4 agonist/squalene oil-in-water based adjuvant, GLA-SE, providing implications for other adjuvants that combine oils with TLR agonists. Water 134-139 toll-like receptor 4 Mus musculus 105-109 25367751-1 2015 The synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) is a potent Th1-response-inducing adjuvant when formulated in a squalene oil-in-water emulsion (SE). Water 143-148 toll-like receptor 4 Mus musculus 14-18 24992835-10 2014 These data suggest that increases in TLR4 expression induced by drinking DSS-treated water might be directly or indirectly associated with NO overproduction. Water 85-90 toll-like receptor 4 Mus musculus 37-41 25493180-3 2014 Using ovariectomized (OVX) osteoporosis mice model, we investigated the effects of LPSp on the bone density and Ca concentration after ingesting LPSp-containing water for 4 weeks. Water 161-166 toll-like receptor 4 Mus musculus 145-149 19577625-3 2009 In the present study, we investigated the effects of Scutellariae Radix water extract (SR) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Water 72-77 toll-like receptor 4 Mus musculus 154-157 20107166-4 2010 RESULTS: TLR3-deficient and TLR2+4, TLR2+9, and TLR4+9 double-deficient mice were as susceptible to EAU as their control littermates. Water 100-103 toll-like receptor 4 Mus musculus 48-52 19637282-6 2009 In fructose-fed TLR-4 mutant mice, hepatic triglyceride accumulation was significantly reduced by approximately 40% in comparison to fructose-fed wildtype mice and plasma ALT levels were at the level of water-fed controls. Water 203-208 toll-like receptor 4 Mus musculus 16-21 20798981-8 2010 Furthermore, the LPS antibody was purified well using a water solution, salting-out and gel chromatography. Water 56-61 toll-like receptor 4 Mus musculus 17-20 10694534-9 2000 LPS-induced pulmonary leukocyte infiltration and increases in lung water content were also significantly attenuated in Tg mice. Water 67-72 toll-like receptor 4 Mus musculus 0-3 16741709-3 2007 Here, we show that early LPS-activated bone marrow derived DC (early DC, eDC), when administered subcutaneously to mice in vivo, promote tolerance to EAU induced via immunisation with interphotoreceptor retinol binding protein (IRBP) peptide 161-180. Water 150-153 toll-like receptor 4 Mus musculus 25-28 16272281-6 2005 Surprisingly, TLR2-/-, TLR4-/-, and TLR9-/- mice were fully susceptible to EAU and had unaltered adaptive responses to interphotoreceptor retinoid-binding protein. Water 75-78 toll-like receptor 4 Mus musculus 23-27 15611372-9 2005 In addition, LPS-induced increase in lung water content and pulmonary myeloperoxidase activity was significantly reduced. Water 42-47 toll-like receptor 4 Mus musculus 13-16 15596131-6 2005 Furthermore, LPS increased the osmotic water permeability of MLE-12 cells. Water 39-44 toll-like receptor 4 Mus musculus 13-16 15596131-7 2005 These findings demonstrate that LPS increases cell surface AQP5 expression by changing its subcellular distribution and increases membrane osmotic water permeability through activation of p38 MAP kinase. Water 147-152 toll-like receptor 4 Mus musculus 32-35 14670733-1 2003 Extraction of dry bacteria of Acinetobacter baumannii strain 24 by phenol-water yielded a lipopolysaccharide (LPS) that was studied by serological methods and fatty acid analysis. Water 74-79 toll-like receptor 4 Mus musculus 110-113 34090073-5 2021 Two types of reclaimed water, i.e., secondary effluent and MBR (membrane bioreactor) effluent, were found to induce pulmonary injury and inflammation in the wild-type mice and Tlr4-/- mutants. Water 23-28 toll-like receptor 4 Mus musculus 176-180 8366814-6 1993 Purified phenol-water LPS (2.5 micrograms) produced Arthus reactivity which could be confused with DTH. Water 16-21 toll-like receptor 4 Mus musculus 22-25 1500196-4 1992 Three forms of LPS (H+ form, Mg2+ salt, and triethanolamine salt) showed different solubilities in water, the acidic form of LPS, with the most pronounced hydrophobic properties, being capable of practically complete association with liposomal membranes. Water 99-104 toll-like receptor 4 Mus musculus 15-18 1500196-4 1992 Three forms of LPS (H+ form, Mg2+ salt, and triethanolamine salt) showed different solubilities in water, the acidic form of LPS, with the most pronounced hydrophobic properties, being capable of practically complete association with liposomal membranes. Water 99-104 toll-like receptor 4 Mus musculus 125-128 34090073-7 2021 In summary, non-TLR4 signalling pathways are related to lung inflammation caused by long-term exposure to reclaimed water. Water 116-121 toll-like receptor 4 Mus musculus 16-20 34104310-9 2021 The water extract was the most effective in counteracting lipopolysaccharide-induced neuroinflammation in microglial BV-2 cells by strongly reducing the expression of proinflammatory mediators through the modulation of the TLR4/NF-kappaB pathway. Water 4-9 toll-like receptor 4 Mus musculus 223-227