PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31756041-2 2019 Rosiglitazone(RSG), a widely used antidiabetic drug that activates peroxisome proliferator-activated receptor-gamma (PPAR-gamma), has been shown to protect against cerebral ischemia through promoting poststroke microglial polarization toward the beneficial anti-inflammatory phenotype. rsg 14-17 peroxisome proliferator activated receptor gamma Mus musculus 67-115 31756041-2 2019 Rosiglitazone(RSG), a widely used antidiabetic drug that activates peroxisome proliferator-activated receptor-gamma (PPAR-gamma), has been shown to protect against cerebral ischemia through promoting poststroke microglial polarization toward the beneficial anti-inflammatory phenotype. rsg 14-17 peroxisome proliferator activated receptor gamma Mus musculus 117-127 31756041-9 2019 We further found that the expression of Arg-1 was also upregulated in those tPA and RSG-treated stroke mice and the protection against tPA-induced HT and BBB disruption in these mice were abolished in the presence of PPAR-gamma antagonist GW9662 (4 mg/kg, 1 hour before dMCAO through intraperitoneal injection). rsg 84-87 peroxisome proliferator activated receptor gamma Mus musculus 217-227 31756041-10 2019 CONCLUSIONS: RSG treatment protects against BBB damage and ameliorates HT in delayed tPA-treated stroke mice by activating PPAR-gamma and favoring microglial polarization toward anti-inflammatory phenotype. rsg 13-16 peroxisome proliferator activated receptor gamma Mus musculus 123-133